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Mountains: top down.

Mountainous regions offer not only essential habitat and resources, including water, to the earth's more than 6 billion inhabitants, but also insights into how the global human habitat works, how it is being changed at the moment as global climates are disrupted, and how the disruption may lead to global biotic and economic impoverishment. At least 600 million of the earth's more than 6 billion humans dwell in mountainous regions. Such regions feed water into all the major rivers of the world whose valleys support most of the rest of us. At least half of the valley dwellers receive part or all of their water from montane sources, many from the melt water of glaciers, others from the annual snow melt. Glaciers are retreating globally as the earth warms as a result of human-caused changes in the composition of the atmosphere. Many are disappearing, a change that threatens municipal water supplies virtually globally. The warming is greatest in the higher latitudes where the largest glaciers such as those of Greenland and the Antarctic Continent have become vulnerable. The melting of ice in the northern hemisphere raises serious concerns about the continued flow of the Gulf Stream and the possibility of massive climatic changes in Scandinavia and northern Europe. Mountains are also biotic islands in the sea life, rich in endemism at the ecotype level. The systematic warming of the earth changes the environment out from under these genetically specialized strains (ecotypes) which are then maladapted and vulnerable to diseases of all types. The process is systematic impoverishment in the pattern conspicuous on mountain slopes with increasing exposure to climatic extremes. It is seen now in the increased mortality and morbidity of plants as climatic changes accumulate. The seriousness of the global climatic disruption is especially clear in any consideration of mountains. It can and must be addressed constructively despite the adamancy of the current US administration.

Altitude↗

[Mesangial glomerulonephritis and intermediate uveitis].

Uveitis in children are less frequent than in adults. Their prognosis is variable because it may be found as an isolated and idiophatic condition or in association with definite clinical entities. The associated noninfectious diseases with predominantly renal involvement are tubulointerstitial nephritis and uveitis syndrome (TINU syndrome), mesangial glomerulonephritis isolated or in association with Behçet's disease. A case of 14-years-old girl with intermediate uveitis (pars planitis) and mesangial glomerulonephritis is presented. The ocular symptoms was eye redness and ocular pain and she has snow-banks in pars plana. She showed microscopic hematuria and intermitent proteinuria that increased during the ocular clinical exacerbation. Renal biopsy revealed both mild mesangial matrix increase and mesangial celullarity with normal tubulointerstitial structure and mesangial deposition of IgA and IgG immunoglobulins. This case is de first pediatric patient report in the literature with intermediate uveitis and mesangial glomerulonephritis with immune deposition. Mesangial glomerulonephritis were observed in patients whit Behçet disease, known etiological cause of uveitis in adults and children. These findings may suggest that uveitis and glomerulonephritis have common immunological pathogenesis including circulatory immune complexes. In uveitis patients, screening for associated extra-ocular and renal manifestations is mandatory and should have careful long-term follow-up with regular systemic evaluation.

Adolescent↗

[Cerebral malaria, a key role for endothelial cells?].

Five to six hundred millions of people, throughout the world, suffer from malaria and more than one million die each year as a consequence, in about 20% of the cases, of cerebral malaria, an important complication of Plasmodium falciparum infection (Holding & Snow, 2001). Despite many studies, the physiopathology of these cerebral occurrences is not understood, especially concerning the intricacy and respective roles of the various mechanisms identified: sequestration of parasitized red cells in microvessels, cytokine secretion, changes in the T lymphocyte repertoire, host genetic factors driving sensitivity pathogenic factors from Plasmodium (Mazier et al., 2000).

Animals↗

[Laser Doppler flowmetry for vitality testing of traumatized maxillary incisors].

Pulp sensitivity and vitality changes were evaluated in 69 traumatized maxillary incisors and in 38 control teeth during a follow-up period of 20 months. Examinations included thermal testing using carbon dioxide snow (CO2) and the laser Doppler flowmetry (LDF). These measurements were compared to the clinical and radiological findings. In 47.8% of the traumatized teeth and in 55.3% of the control group the three LDF measurements corresponded with the sensitivity testing using CO2 and with the clinical and radiological findings. In 31.9% of the traumatized teeth and in 7.9% of the control group the LDF-measurements differed from the CO2-measurements, but were in agreement with the other clinical and radiographic findings. The information obtained by laser Doppler flowmetry is of additional importance for the treatment planning. Since the clinical examination of traumatized teeth is sometimes inconclusive, the laser Doppler flowmetry is a further diagnostic tool but it cannot replace the radiological or clinical examination.

Adolescent↗

Vegetation pattern related tc grazing pressure in alpine meadows of Nanda Devi Biosphere Reserve.

The present study aims to analyze the interaction of prevailing biotic pressure on plant species diversity in Nanda Devi Biosphere Reserve (NDBR) which lies in northern part of Uttaranchal hills between 79 degrees 40'E to 80 degrees 05'E longitude and 30 degrees 17' N to 30 degrees 41'N latitude and covers an area of 2236.7 km2. A total of 75 species has been found which included the herbaceous plants viz., grasses, sedges and forbs. Generally, the plants have a short life span of 3-4 months. However, few species persist throughout the growth period i.e. May-October. Phytosociological study performed in plots of varying slope and grazing pressure intensity revealed that the dominant grasses were Danthonia cachemyriana and Poa annua and dominant forbs were Trachydium roylei and Geum elatum in all the plots. Grasses were abundant on west facing slopes while forbs preferred the even topography of east facing meadows. The grasses and sedges together had optimum density during July and August. In general, short lived species exhibited more diversity for one or two months whilst the long lived species exhibited optimum diversity althrough the snow free period. The species diversity is maximum (100%) in moderately grazed bughiyals i.e. Pacchu and minimum in intensively grazed bughiyals i.e. Martoli. The species distribution among the plots was 60-90% contagious and 11.2-38.0% randomirrespective of grazing pressure, thus highlighting the significance of grazing pressure in management of alpine meadows.

Altitude↗

Molecular diversity - fifth Lake Tahoe symposium.

This annual conference has been designed to improve communication on chemical and biological molecular diversity research between scientists from industrial and academic sectors. Approximately 150 participants attended, including a mix of physicists, biologists, molecular biologists, chemists, engineers and informaticians. Lake Tahoe, which is surrounded by snow-covered mountains, was a beautiful setting for the conference. Those who enjoy skiing could do so during the afternoon breaks, while others could enjoy walks, visit the local town and take time out for informal scientific discussions.

Journal Article↗

The causal agents of damping-off disease of buglosse from Iran.

Iran is considered a major genetic for medicinal plant in the world. Because of this significant diversity and historical background in identification and utilization to remedy human and animal diseases, export of medicinal plant can help to strengthen local as well as natural economy. Buglosse (Fig. 1) is one of the most important and common medicinal plants in Iran and exist as Echium amoneum and Borago officinalis. This work was conducted in order to identify the causal agent(s) of damping off disease in buglosse. Plant disease samples were taken from Esfahan and Tehran provinces. Symptoms on original plant including root, crown rot, dark tissue, pith and hallow root were collected in order to isolate disease agent(s). Symptomatic root and crown tissues after surface sterilization with 96% ethanol were transferred on to PDA and WA media and also on moist filter paper in petri dishes. Two fungal colonies grew from tissue segments and spore culture was subsequently purified. The fungal isolate identified as Rhizoctonia solani based on the following test. Hyphal tip was removed from colony margin placed on PDA and PSA media and incubated in dark. Colony diameter of one hundred hyphae measured and nucleus was stained according to Bandoni (1979), Kronland and Stanghellini (1988). It was observed that in each cell of hyphae there are more than two nuclei. Single spore culture were obtained from macroconidia of Fusarium isolate. After 24 hr of incubation, growing single spore were transferred to KCL medium to detect spore chains. Fungal isolates transferred to PSA and PDA media for sporulation. After 7 days colonies appeared as white cream to pinkish on top and cream to dark pink at the bottom of petri dish with abundant micro and macro conidia. Colonies were snow white, felting shape, with ample causal hyphae on PSA medium. On KCL medium, fungal growth was superficial and colonies were colorless with long macroconidia and individual sausage-shape macroconidia being thinner one side and having maximum four septa. Microconidia were long double compartment round on both side, straight to slightly curved. Base on morphology and dimension of conidia and production of chlamidospore the funguses identify as Fusarium solani.

Borago↗

[Analysis of accidental deaths in mountain tourism and sport according to statistics from the Republic of Kabardino-Balkariia].

Lethal cases in mountain tourism and sports in the Republic of Kabardino-Balkaria were studied for 1978-1995. A total of 152 accidental deaths were analysed. Most of the victims were males under 30 years of age. The greatest number of the accidents took place on Monday, in July and August. Many amateur visitors from abroad were among the victims. The main cause of death in the mountains of Kabardino-Balkaria for the 18 years studied was multitrauma of the body (69.7%). Hypothermia and obturation asphyxia with snow and compression asphyxia due to snowbreak account for 11.8 and 13.2% deaths, respectively; lightning killed 4%. Combination of high mountain hypoxia with exacerbated chronic somatic disease or hypothermia caused death in 1% victims. The authors propose how to improve forensic-medical expert examination of accidental death and safety in the mountains.

Accidents↗

Urban planning and public health at CDC.

Urban planning, also called city and regional planning, is a multidisciplinary field in which professionals work to improve the welfare of persons and communities by creating more convenient, equitable, healthful, efficient, and attractive places now and for the future. The centerpiece of urban planning activities is a "master plan," which can take many forms, including comprehensive plans, neighborhood plans, community action plans, regulatory and incentive strategies, economic development plans, and disaster preparedness plans. Traditionally, these plans include assessing and planning for community needs in some or all of the following areas: transportation, housing, commercial/office buildings, natural resource utilization, environmental protection, and health-care infrastructure. Urban planning and public health share common missions and perspectives. Both aim to improve human well-being, emphasize needs assessment and service delivery, manage complex social systems, focus at the population level, and rely on community-based participatory methods. Both fields focus on the needs of vulnerable populations. Throughout their development, both fields have broadened their perspectives. Initially, public health most often used a biomedical model (examining normal/abnormal functioning of the human organism), and urban planning often relied on a geographic model (analysis of human needs or interactions in a spatial context). However, both fields have expanded their tools and perspectives, in part because of the influence of the other. Urban planning and public health have been intertwined for most of their histories. In 1854, British physician John Snow used geographic mapping of an outbreak of cholera in London to identify a public water pump as the outbreak's source. Geographic analysis is a key planning tool shared by urban planning and public health. In the mid-1800s, planners such as Frederick Law Olmsted bridged the gap between the fields by advancing the concept that community design contributes to physical and mental health; serving as President Lincoln's U.S. Sanitary Commission Secretary; and designing hundreds of places, including New York's Central Park. By 1872, the disciplines were so aligned that two of the seven founders of the American Public Health Association were urban designers (an architect and a housing specialist). In 1926, the U.S. Supreme Court, in validating zoning and land-use law as a legal government authority in Village of Euclid v. Ambler Realty, cited the protection of public health as part of its justification. Other connections have included 1) pioneering urbanist Jane Jacobs, who during the 1960s, called for community design that offered safe and convenient options for walking, biking, and impromptu social interaction; and 2) the Healthy Cities movement, which began in Europe and the United States during the 1980s and now includes projects in approximately 1,000 cities that in various ways highlight the role of health as much more than the presence of medical care.

Centers for Disease Control and Prevention, U.S.↗

Psychosocial profile of cultists in a Nigerian university: a preliminary report.

AIMS AND OBJECTIVES: To help stem cult activities on campuses by identifying motives for joining cult groups and highlighting psychosocial attributes/profile of a potential or already initiated cult member. METHOD: Using snow-balling method, 25 consecutive consenting cult members of University of Ilorin were interviewed over a six month period using a semi-structured questionnaire. Those who had symptoms suggestive of psychiatric disorders were further assessed based on ICD-10 criteria. All patients with previous psychiatric illness were excluded. RESULT: A significant proportion of the respondents were first year, male, previously shy students from high socioeconomic background. There was a significant increase in the proportion of respondents who had palpitation, sweated more, felt bolder, and became current users of alcohol and tobacco after initiation. Also, there was a significant decrease in the proportion of respondents who slept well, felt accepted by friends and performed well in academic activities after initiation. CONCLUSION: In spite of the small sample size and method of data collection, the preliminary findings in this study, could be useful in stemming the increasing menace of cultism among students in tertiary institutions. It was suggested that control of cult activities should be multidimensional with students, parents and university administration taking active parts. Establishment of 'Help Centres' on campuses was suggested.

Adult↗

Strategies of thermal protection in arctic animals.

Anatomical, physiological and behavioural adaptations to cold and lack of food combined with long periods of darkness are discussed. In large animals such adaptations comprise body size and insulation and controlled peripheral cooling in the legs and heat exchange in the nasal passages, whereby expiratory heat and water loss is minimized. In such animals grave thermal problems are incurred when the animal is forced to run. In some species the heat exchanger in the nose is operated in conjunction with a carotid rete for selective cooling of the brain. Small and poorly insulated mammals evade the brunt of the cold arctic winter in nests under the snow were convective heat loss is eliminated and ground heat creates a relatively comfortable micro-climate. Most newborn mammals are poorly insulated, but some survive birth, wet and miserable, at ambient temperatures down to -30 degrees C. Precocious forms depend heavily on NST in brown fat and skeletal muscle. Altricial forms are born very small and naked and are virtually ecto-thermic at birth. They depend on shelter and/or huddling, but survive a cooling of body core down to +2 degrees C.

Animals↗

Working in the cold.

Physiologically speaking, working in the cold is primarily a matter of maintaining thermal balance, since both energy metabolism and neuromuscular function is temperature dependent. Body temperature is also subject to variations due to circadian rhythms. While local acclimatization to cold is well established, and may be of considerable practical benefit, general acclimatization to cold, if in fact a reality, is at best of limited practical value compared to know-how, experience, and environmental protection. Some of the major problems associated with the performance of physical work in the cold, are consequences of the hobbling effect of the protective clothing, as well as the obstructive effects of snow and ice, and the chilling effect of wind.

Body Temperature Regulation↗

Exertional intensities and energy requirements of technical mountaineering at moderate altitude.

The purpose of this study was to determine the exertional energy requirements of technical mountaineering at moderate altitude. Six subjects completed maximum graded exercise tests (MGXT) prior to a 7-day ice climbing seminar conducted in the North Cascade Range of the United States. Mean weight, percent body fat, and maximum oxygen uptake (VO2max) were 71.3 (+/- 15.1) kg, 11.7 (+/- 4.2) %, and 53.7 (+/- 5.4) ml.kg-1.min-1 respectively. Heartrates (HR) were recorded and averaged over 5-second to 1-minute intervals during selected mountaineering activities of the ice climbing seminar. Average and peak estimated VO2 (EstVO2) and estimated energy expenditure (EstEE) were calculated from HR utilizing regression equations generated from the MGXT results. Trail hiking with loads averaging 45% of individual body weight required an average EstVO2 of 21.8 (+/- 3.0) ml.kg-1.min-1 and average EstEE of 7.5 (+/- 1.9) kcal.min-1 over a 2.2 hr period. Mean peak EstVO2 was 37.4 (+/- 3.4) ml.kg-1.min-1 and mean peak EstEE was 13.4 (+/- 3.0) kcal.min-1 during this period. Technical ice climbing involving movement up and down a 12 m vertical height for a mean time of 14.3 (+/- 2.6) min required an average EstVO2 and EstEE of 25.7 (+/- 7.6) ml.kg-1.min-1 and 9.5 (+/- 3.4) kcal.min-1 respectively. Peak EstVO2 and EstEE means were 38.4 (+/- 7.7) ml.kg-1.min-1 and 14.6 (+/- 3.5) kcal.min-1. Two subjects were monitored during a 6-hour summit ascent on snow and ice from 1636 m to 3266 m. Means for average EstVO2 and EstEE were 21.6 (+/- 3.3) ml.kg-1.min-1 and 7.2 (+/- 0.8) kcal.min-1 respectively while peak EstVO2 and EstEE means were 38.0 (+/- 6.1) ml.kg-1.min-1 and 13.3 (+/- 1.6) kcal.min-1. The total EstEE was 3096.8 and 2485.4 kcal for these two subjects over the 6-hour ascent. The most experienced climber averaged 0.078 kcal.kg-1.min-1 and the least experienced subject averaged 0.105 kcal.kg-1.min-1 while climbing at identical paces over the same terrain. This indicates a possible experience factor which may increase climbing efficiency.

Adult↗

[Medico-legal statistics on occupational asthmna in Quebec between 1986 and 1988].

The authors have carried out a statistical analysis of cases of occupational asthma and other occupational lung diseases submitted to the Ministry of Labour in Quebec between 1986 and 1988. The total number of claims was 913, 993, and 866 respectively for the 3 years of which 61% to 71% were accepted. 41% to 55% were new assessments. Of 228 new claims accepted in 1988, 81 (36%) were for occupational asthma. This number surpassed the number of claims accepted for traditional pneumoconiosis (asbestos = 30, and silicose = 36). Isocyanates were the principle cause of occupational asthma (23% of cases were recognised in 1988) followed by flour, red and white cedar, snow crab process workers, and various pharmaceutical products and grains. In comparison with statistics in 1977, one noticed there was a large reversal of the frequency of certain occupational lung diseases that are recognised, because at that time asbestosis and silicosis were the principle causes of claims put forward and accepted. The authors discuss the statistical bias of occupational lung disease obtained by medico-legal agencies. Although occupational asthma has not been the object of the systematic screening program in the work place and although there is a tendency for workers to avoid or abandon their occupation more often than in the traditional pneumoconioses current protection is sufficient in Quebec to motivate individuals who are possibly suffering from occupational asthma to put in a claim for compensation.

Asthma↗

[Bone infarction, or idiopathic metaphyseal and diaphyseal aseptic osteonecrosis of the long bones. Update and contribution of new imaging technics].

Twenty patients with "idiopathic" bone infarction were studied. There were 18 men and 2 women, age 30 to 69 years, at the time of the diagnosis (mean age = 49 years). Sixty-five lesions were recorded with a marked predominance to the lower extremities (77 p. cent are located around the knees) and to the metaphysis (only three pure diaphyseal lesions). Considered asymptomatic, these lesions were painful in 6 patients. They are multiple, and in this case symmetrical, in 12 patients (60 p. cent). X-Rays disclose the classic heterogeneous ball-like, smoke twirled or encapsulated calcifications. A periosteal thickening opposite the lesions was observed in 6 patients; this may be the only radiological sign. Finally, 18 of the 65 lesions were not visible on standard X-Rays, and obvious on MRI. The MRI aspect is characteristic and may be superposed on the basic lesions already described in the course of aseptic osteonecroses of the femoral head. This is, besides, the most sensitive test, snowing a larger number of more extended necroses than the other examinations. CT scanning as well as scintigraphy present a limited advantage. More than half of the patients also present epiphyseal aseptic osteonecroses, often multiple (55 sites for 13 patients), and often unrecognized. The etiological factors are in fact common to both of these diseases: steroid therapy, alcoholism, dyslipidemia, idiopathic forms. Among the possible causes, the literature mentions lupus erythematosus, renal transplant, cytosteatonecrosis, arteriopathies while there is no post-traumatic form. All of the characteristics of these bone infarctions determine a topographic form of the osteonecrotic disease.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Strategic change in hospitals: an examination of the response of the acute care hospital to the turbulent environment of the 1980s.

Changes in strategies of hospitals responding to the turbulent health care environment of the 1980s are examined both in the aggregate and from the perspective of the individual hospital. The Miles and Snow typology is used to determine strategy type. Both investor-owned and not-for-profit hospitals were well represented in the broad mix of hospital types sampled. In addition, freestanding hospitals and members of multihospital systems were present in the sample. Last, hospitals of all sizes were included. Strategic change was evaluated by classifying hospitals by strategy type in each of two consecutive five-year time periods (1976 through 1980 and 1981 through 1985). Changes in reimbursement policies, the emergence of new technologies, changing consumer expectations, and new sources of competition made the environment for hospitals progressively more turbulent in the latter period and provided an opportune setting to evaluate strategic change. Results showed that a significant number of hospitals did change strategy as the environment changed, and in the direction anticipated. Logistic regression was used to determine whether prior strategy, type of ownership, system membership, or size would predict which hospitals would change strategy as the environment changed: only prior strategy was found to be a predictor of strategy change.

Economic Competition↗

Effects of biological and environmental factors on activity rhythms of wild animals.

This paper reviews information on the effects of biological and environmental factors on activity rhythms of wild animals monitored by radio telemetry. Variations in radio signals received from free-ranging animals are used to determine the pattern of activity and rest. Telemetry is especially effective for obtaining activity data from wild animals at night and from those living in dense vegetation or underground. Biological factors such as breeding behavior, care of young, time of last eating, and food storage cause changes in daily activity patterns. Similarly, environmental factors such as temperature, snow cover, food supply and disturbance caused by humans in an urban setting also cause changes in daily activity patterns. The observed modifications of activity rhythms show that controlling mechanisms allow wild animals to quickly respond to changing biological and environmental factors.

Animals↗

[Changes in skiing accidents during the last 20 years].

Since 23 years the skiing-accidents are statistically surveyed in the private practice of the author. The number of injured patients is continuously decreasing. Specially the injuries in years with little snow fall are analyzed. It is evident that leg fractures are quite rare but severe injuries of the knee are increasing. 50% of ski accidents are minor injuries.

Accidents↗