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PubMed1978

A comparative study of functional activity and cytochemical characteristics of human and rabbit microphages.

Substantial differences were found in the cytochemical indices of human and rabbit microphages. Regular changes in the enzymic activity and the levels of some biopolymers were observed in the microphages in the process of phagocytosis. The extent and (in some cases) tendency of these changes in human and rabbit microphages are not the same. Cytochemical indices provide significant information on the functional activity of the microphage system within one species. At the interspecies level, such information proves to be inadequate for the characteristic of the phagocytic ability of microphages unless humoral non-specific means of protection are taken into account.

Acid Phosphatase↗
PubMed1975

Increased susceptibility to infection in sickle cell disease: defects of opsonization and of splenic function.

Patients with sickle cell disease (SCD) have an increased susceptibility to bacterial infections and die more frequently from infection than any other cause. Their sera do not promote the phagocytosis of pneumococci normally, apparently because of an inability to utilize the alternate pathway for C3 fixation as a means of opsonization. The splenic dysfunction which exists in SCD may result in depressed synthesis of alternate pathway factor(s), as well as in decreased phagocytic clearance of bacteria.

Anemia, Sickle Cell↗
PubMed1975

Heat labile opsonin system to pneumococcus.

Normal mammalian sera contain the heat labile opsonin system that promotes the phagocytosis of various microorganisms by polymorphonuclear leukocytes. Because the heat labile opsonin system is present in normal nonimmune sera and because it operates against various microorganisms in an apparently nonspecif manner, it is considered to play an important role during the early phase of an acute bacterial infection. The role of various factors participating in the heat labile opsonin system, and its in vivo significance are discussed.

Animals↗
PubMed1976

The alternate complement pathway in inflammatory bowel disease. Quantitation of the C3 proactivator (factor B) protein.

A component of the complement system's alternate pathway was investigated in ulcerative colitis and Crohn's disease. The mean C3PA (Factor B) titer in normals was 74 +/- 15%; in ulcerative colitis, 92 +/- 18%; and in Crohn's disease, 119+/- 24%. Significance was at the P less than 0.001 level when the mean values for the ulcerative colitis and the Crohn's disease groups were compared to normal subjects. Titers did not change significantly with exacerbation or amelioration of the diseases or when patient groups were analyzed according to the mode of treatment received.

Blood Proteins↗
PubMed1985

Prevention of immune precipitation by purified components of the alternative pathway.

The role of the alternative pathway in complement-mediated prevention of immune precipitation has been investigated by the use of BSA-anti-BSA immune complex (IC) purified components. For immune precipitation to be prevented all six alternative pathway components (C3, factors B D, P, H and I) were required. In the absence of one or both of the control proteins H and I, excessive fluid phase turnover of C3 occurred with precipitation of IC. Kinetic studies showed that in the presence of the control proteins, an initial phase of precipitation occurred, and was followed by a phase of resolubilization of IC. When the efficiency of classical and alternative pathways in the prevention of immune precipitation was compared it was found that the classical pathway proteins were more effective than the alternative pathway components. A reaction mixture containing the components of both pathways was no better than the classical pathway protein alone. 125I-C3 was bound to IC which had been rendered soluble in the presence of classical or alternative pathway components. A molar ratio of two molecules C3b:five molecules IgG was calculated. Other complement components which were bound to IC which had been formed in the presence of serum were C1q, C4, C2, C3, C5, P and H. Factors B and I were not detected. Our findings suggest that the alternative pathway is of secondary importance to the classical pathway in the prevention of immune precipitation.

Antigen-Antibody Complex↗
PubMedDate not supplied

[Tachyphylaxis].

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Animals↗