Greater resistance to development of severe schistosomiasis in Brazilian Negroes.
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1008 Bantu and 295 Nilotes of Kenya were tested with regard to protanopia-deuteranopia by means of the ISHIHARA-Plate No. 11 (16 plates edition). Four (0.55%) of the male Bantu and two (1.03%) of the male Nilotes showed a partial or total red-green-blindness. With the females of these samples no case of defective colour vision was observed.
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A Black patient in whom an acute febrile illness was followed by a haemolytic crisis is presented. Investigation of the haemolytic anaemia showed the presence of an unstable haemoglobin which was found to be haemoglobin Leiden. Those members of the family who were available for investigation also had the unstable haemoglobin but showed no haemolysis. Radio-isotope studies on the patient confirmed haemolysis but showed that the spleen was not the main site of cell destruction.
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An analysis of the IgG4-CH3 antigenic determinants by means of specific antisera using a hemagglutination-inhibition procedure among different populations has been done. Thus 3.67% of sera from Negroids have been found completely deficient in normal IgG4 subclass. Sera without normal IgG4 contained the other IgG subclasses. Family studies shown the transmission of an abnormal Cgamma 4 gene. Hypothesis of gene deletion, point mutation or gene hybridization were postulated. This last hypothesis seems the most valuable.