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PubMed2000

Implications of the distribution of Albumin Naskapi and Albumin Mexico for new world prehistory.

The known distributions of two mutational variants of the albumin gene that are restricted to Mexico and/or North America, Albumin Mexico (AL*Mexico) and Albumin Naskapi (AL*Naskapi), were expanded by the electrophoretic analysis of sera collected from more than 3, 500 Native Americans representing several dozen tribal groups. With a few exceptions that could be due to recent, isolated cases of admixture, AL*Naskapi is limited to groups that speak Athapaskan and Algonquian, two widely distributed language families not thought to be related, and to several linguistically unrelated groups geographically proximate to its probable ancestral homeland. Similarly, AL*Mexico is limited to groups that speak Yuman or Uto-Aztecan, two language groups in the American Southwest and Baja California not thought to be closely related to each other, and to several linguistically unrelated groups throughout Mexico. The simultaneous consideration of genetic, historical, linguistic, and archaeological evidence suggests that AL*Naskapi probably originated on the northwestern coast of North America, perhaps in some group ancestral to both Athapaskans and Algonquians, and then spread by migration and admixture to contiguous unrelated, or distantly related, tribal groups. AL*Mexico probably originated in Mexico before 3,000 years BP then spread northward along the Tepiman corridor together with cultural influences to several unrelated groups that participated in the Hohokam culture.

Albumins↗

PubMed1999

Deaf murderers: clinical and forensic issues.

Data are reported on 28 deaf individuals who were convicted, pled guilty, or have been charged and awaiting trial for murder. The unique forensic issues raised by these cases are discussed, and their clinical picture presented. A significant percentage of these deaf murderers and defendants had such severely limited communication skills in both English and American Sign Language that they lacked the linguistic ability to understand the charges against them and/or to participate in their own defense. As such, they were incompetent to stand trial, due not to mental illness or mental retardation, but to linguistic deficits. This form of incompetence poses a dilemma to the courts that remains unresolved. This same linguistic disability makes it impossible for some deaf suspects to be administered Miranda Warnings in a way comprehensible to them. This paper identifies the reasons for the communication problems many deaf persons face in court and offers remedial steps to help assure fair trials and police interrogations for deaf defendants. The roles and responsibilities of psychiatric and psychological experts in these cases are discussed. Data are provided on the etiology of the 28 individuals' hearing losses, psychiatric/psychological histories, IQs, communication characteristics, educational levels, and victim characteristics.

Adolescent↗

PubMed1976

Genetic structure and heterozygosity in the kuru region, eastern highlands of New Guinea.

Genetic structure of 20 of the 37 linguistic groups in the Eastern Highlands of New Guinea including the kuru region is analyzed using information on blood groups and serum protein polymorphisms. The average individual is heterozygous at 28.6% of loci and the average number of alleles per locus is 1.234. Coefficients of kinship for linguistic groups range from 0.005 for the sweet potato cultivating North Fore to 0.075 for the isolated Pawaians whose dietary staple is sago and who depend more on hunting and gathering. As one selects linguistic groups with smaller and smaller population size and increasing isolation, one finds that kinship coefficients rise as much as tenfold, but there is no concomitant loss of heterozygosity or trend toward fixation of alleles. Genetic relationships established by genetic distance trees and by principal components analysis are comparable and are consistent with other anthropological observations.

Alleles↗

PubMed2006

Broca's arrow: evolution, prediction, and language in the brain.

Brodmann's areas 44 and 45 in the human brain, also known as Broca's area, have long been associated with language functions, especially in the left hemisphere. However, the precise role Broca's area plays in human language has not been established with certainty. Broca's area has homologs in the great apes and in area F5 in monkeys, which suggests that its original function was not linguistic at all. In fact, great ape and hominid brains show very similar left-over-right asymmetries in Broca's area homologs as well as in other areas, such as homologs to Wernicke's area, that are normally associated with language in modern humans. Moreover, the so-called mirror neurons are located in Broca's area in great apes and area F5 in monkeys, which seem to provide a representation of cause and effect in a primate's environment, particularly its social environment. Humans appear to have these mirror neurons in Broca's area as well. Similarly, genetic evidence related to the FOXP2 gene implicates Broca's area in linguistic function and dysfunction, but the gene itself is a highly conserved developmental gene in vertebrates and is shared with only two or three differences between humans and great apes, five between humans and mice, and eight between humans and songbirds. Taking neurons and portions of the brain as discrete computational segments in the sense of constituting specific Turing machines, this evidence points to a predictive motor and conceptual function for Broca's area in primates, especially for social concepts. In human language, this is consistent with evidence from typological and cognitive linguistics.

Biological Evolution↗

PubMed2004

The language of the psychopath: characteristics of prisoners' performance in a sentence completion test.

AIM AND BACKGROUND: Verbal productions of prisoners were studied as possible correlates of psychopathic personality. METHOD: A sample of 76 inmates of a German high-security prison were administered a new sentence completion test (SCT). The subjects' verbal responses to 63 sentence cues were coded using 23 content and linguistic categories which had been derived from Loevinger's stage model of ego development. Moreover, the Psychopathy Checklist Revised (PCL R) was scored for each subject after a clinical interview and a perusal of the prisoner's file. RESULTS: Moderate positive correlations were found between PCL R scores and cognitive and linguistic characteristics in the SCT (concerns with exerting power and being dominated, use of coarse language and the expression of dysphoric emotions). These characteristics were highly sensitive but not specific to psychopaths. CONCLUSIONS: In the context of recent research, verbal patterns are seen, together with interpersonal behaviour patterns and linguistic properties, as valid indicators of psychopathy and might be particularly useful when biographical information is lacking.

Adult↗

PubMed1996

Cerebral lateralization in random letter task in the visual modality: a transcranial Doppler study.

Seven right handed volunteers were studied to determine cerebral lateralization patterns for a visually presented random letter task. The subjects participated in three conditions, which included resting baseline, passive fixation (nonlinguistic), and random letter (linguistic) tasks. Mean blood flow velocity (MBFV) was recorded using bilateral simultaneous transcranial Doppler measurements in the posterior cerebral arteries in these conditions. The experimental conditions produced an increase in MBFV during both tasks but the linguistic task showed a greater change. There was a tendency toward right lateralization with the linguistic compared to the nonlinguistic tasks. There is a physiological correlate of right hemisphere participation in the processing of the random letter task.

Adolescent↗

PubMed1997

A theory of neurolinguistic development.

This article offers a developmental theory of language and the neural systems that lead to and subserve linguistic capabilities. Early perceptual experience and discontinuities in linguistic development suggest that language develops in four phases that occur in a fixed, interdependent sequence. In each phase of language, a unique ontogenetic function is accomplished. These functions have proprietary neural systems that vary in their degree of specialization. Of particular interest is an analytical mechanism that is responsible for linguistic grammar. This mechanism is time-locked and can only be turned on in the third phase. Confirming evidence is provided by children who are delayed in the second phase of the language learning process. These children store insufficient lexical material to activate their analytic mechanism. Inactivation behaves like damage, shifting language functions to homologous mechanisms in the nondominant hemisphere, thereby increasing functional and anatomical symmetry across the hemispheres. This atypical assembly of neurolinguistic resources produces functional but imperfect command of spoken language and may complicate learning of written language. The theory thus offers a different role for genetics and early experience, and a different interpretation of neuroanatomic findings, from those entertained in most other proposals on developmental language disorders.

Brain↗

PubMed1998

Levels of sentence constraint and lexical decision in the two hemispheres.

This study used a lexical decision-priming paradigm to investigate the relative sensitivity of the two cerebral hemispheres to linguistic constraint. Level of constraint of syntactically and semantically correct priming sentences was determined by the Cloze procedure and constraint was manipulated by means of these sentences. High-, medium-, and low-constraining as well as neutral incomplete sentences were presented centrally prior to the appearance of a target word or nonword either to the left or to the right visual field of sixteen righthanded subjects. The hypothesis tested was that the left hemisphere benefits more from linguistic constraint than the right hemisphere. Although reaction time data generally supported this hypothesis, the right hemisphere also seemed to benefit from the constraint produced by high-constraint sentences. The relevance of these findings to the manner in which the two hemispheres process different kinds of linguistic material is discussed.

Adult↗

PubMed1995

Words as invitations to form categories: evidence from 12- to 13-month-old infants.

Recent research has documented specific linkages between language and conceptual organization in the developing child. However, most of the evidence for these linkages derives from children who have made significant linguistic and conceptual advances. We therefore focus on the emergence of one particular linkage--the noun-category linkage--in infants at the early stages of lexical acquisition. We propose that when infants embark upon the process of lexical acquisition, they are initially biased to interpret a word applied to an object as referring to that object and to other members of its kind. We further propose that this initial expectation will become increasingly specific over development, as infants begin to distinguish among the grammatical categories as they are marked in their native language and assign them more specific types of meaning. To test this hypothesis, we conducted three experiments using a modified novelty-preference paradigm to reveal whether and how novel words influence object categorization in 12- to 13-month old infants. The data reveal that a linkage between words and object categories emerges early enough to serve as a guide in infants' efforts to map words to meanings. Both nouns and adjectives focused infants' attention on object categories, particularly at the superordinate level. Further, infants' progress in early word learning was associated with their appreciation of this linkage between words and object categories. These results are interpreted within a developmental and cross-linguistic account of the emergence of linkages between linguistic and conceptual organization.

Female↗

PubMed1999

Time course of fMRI-activation in language and spatial networks during sentence comprehension.

Functional neuroimaging previously has been considered to provide inadequate temporal resolution to study changes of brain states as a function of cognitive computations; however, we have obtained evidence of differential amounts of brain activity related to high-level cognition (sentence processing) within 1.5 s of stimulus onset. The study used an event-related paradigm with high-speed echoplanar functional magnetic resonance imaging (fMRI) to trace the time course of the brain activation in the temporal and parietal regions as participants comprehended single sentences describing a spatial configuration. Within the first set of images, on average 1 s from when the participant begins to read a sentence, there was significant activation in a key cortical area involved in language comprehension (the left posterior temporal gyrus) and visuospatial processing (the left and right parietal regions). In all three areas, the amount of activation during sentence comprehension was higher for negative sentences than for their affirmative counterparts, which are linguistically less complex. The effect of negation indicates that the activation in these areas is modulated by the difficulty of the linguistic processing. These results suggest a relatively rapid coactivation in both linguistic and spatial cortical regions to support the integration of information from multiple processing streams.

Adult↗

PubMed1999

Functional roles of Broca's area and SMG: evidence from cortical stimulation mapping in a deaf signer.

The importance of the left hemisphere in language function has been firmly established and current work strives to understand regional specializations within the perisylvian language areas. This paper reports a case study of a deaf user of American Sign Language undergoing an awake cortical stimulation mapping procedure. Patterns of sign errors accompanying electrical stimulation of Broca's area and the supramarginal gyrus (SMG) are reported. Our findings show Broca's area to be involved in the motor execution of sign language. These data demonstrate that the linguistic specificity of Broca's area is not limited to speech behavior. In addition, unusual semantic-phonological errors were observed with stimulation to the SMG; these data may implicate the SMG in the binding of linguistic features in the service of language production. Taken together, these findings provide important insight into the linguistic specificity of Broca's area and the functional role of the supramarginal gyrus in language processing.

Anomia↗

PubMed1993

Processing a dynamic visual-spatial language: psycholinguistic studies of American Sign Language.

American Sign Language (ASL) has evolved within a completely different biological medium, using the hands and face rather than the vocal tract and perceived by eye rather than by ear. The research reviewed in this article addresses the consequences of this different modality for language processing, linguistic structure, and spatial cognition. Language modality appears to affect aspects of lexical recognition and the nature of the grammatical form used for reference. Select aspects of nonlinguistic spatial cognition (visual imagery and face discrimination) appear to be enhanced in deaf and hearing ASL signers. It is hypothesized that this enhancement is due to experience with a visual-spatial language and is tied to specific linguistic processing requirements (interpretation of grammatical facial expression, perspective transformations, and the use of topographic classifiers). In addition, adult deaf signers differ in the age at which they were first exposed to ASL during childhood. The effect of late acquisition of language on linguistic processing is investigated in several studies. The results show selective effects of late exposure to ASL on language processing, independent of grammatical knowledge.

Age Factors↗

PubMed1981

Dissociations between language and cognition: cases and implications.

An important issue for the cognitive sciences is whether grammar is to any nontrivial extent an autonomous cognitive system. Current cognitive hypotheses of language acquisition would argue against an autonomous linguistic system and would support the notion that language emerges from more general cognitive knowledge and is throughout its development fundamentally tied to a nonlinguistic cognitive base. This paper explores this issue and presents data from case studies of children showing clear dissociations between language and nonlanguage cognitive abilities. The implications of such data are discussed. The major implications appear to be that lexical and relational semantic abilities are deeply linked to broader conceptual development but morphological and syntactic abilities are not. The development of a normal linguistic system, however, one in which grammar is systematically related to meaning, requires concurrent and concomitant linguistic and nonlingustic cognitive development.

Adolescent↗

PubMed2002

Testing hypotheses of language replacement in the Caucasus: evidence from the Y-chromosome.

A previous analysis of mtDNA variation in the Caucasus found that Indo-European-speaking Armenians and Turkic-speaking Azerbaijanians were more closely related genetically to other Caucasus populations (who speak Caucasian languages) than to other Indo-European or Turkic groups, respectively. Armenian and Azerbaijanian therefore represent language replacements, possibly via elite dominance involving primarily male migrants, in which case genetic relationships of Armenians and Azerbaijanians based on the Y-chromosome should more closely reflect their linguistic relationships. We therefore analyzed 11 bi-allelic Y-chromosome markers in 389 males from eight populations, representing all major linguistic groups in the Caucasus. As with the mtDNA study, based on the Y-chromosome Armenians and Azerbaijanians are more closely-related genetically to their geographic neighbors in the Caucasus than to their linguistic neighbors elsewhere. However, whereas the mtDNA results show that Caucasian groups are more closely related genetically to European than to Near Eastern groups, by contrast the Y-chromosome shows a closer genetic relationship with the Near East than with Europe.

Adult↗

PubMed2004

[Initial consultation between physician and patients with chronic facial pain].

BACKGROUND: For various reasons, the initial medical (dental) consultation with patients suffering from chronic pain often does not meet the needs of a "medical dialogue." The aim of this study was to determine whether additional, diagnostically relevant information could be gained from a nonmedical interview. METHODS: The initial dental consultation and an additional conversation with a linguist were taped, transcribed, and compared regarding information obtained. RESULTS: During the interview with the linguist, additional information was provided pertaining to all important aspects of the patient's history that had not been mentioned during the consultation with the physician. This was particularly prominent with regard to the subjects of "complaint history," "impairment/extent of distress," and "biopsychosocial history," for which four to ten times more keywords were mentioned to the linguist than to the physician. CONCLUSION: The result of this study emphasizes the need for improvement of the dentist's method for taking history to diagnose chronic pain and if necessary arrange an additional interview with a medical layman.

Chronic Disease↗

PubMed2005

Human mtDNA hypervariable regions, HVR I and II, hint at deep common maternal founder and subsequent maternal gene flow in Indian population groups.

We have analysed the hypervariable regions (HVR I and II) of human mitochondrial DNA (mtDNA) in individuals from Uttar Pradesh (UP), Bihar (BI) and Punjab (PUNJ), belonging to the Indo-European linguistic group, and from South India (SI), that have their linguistic roots in Dravidian language. Our analysis revealed the presence of known and novel mutations in both hypervariable regions in the studied population groups. Median joining network analyses based on mtDNA showed extensive overlap in mtDNA lineages despite the extensive cultural and linguistic diversity. MDS plot analysis based on Fst distances suggested increased maternal genetic proximity for the studied population groups compared with other world populations. Mismatch distribution curves, respective neighbour joining trees and other statistical analyses showed that there were significant expansions. The study revealed an ancient common ancestry for the studied population groups, most probably through common founder female lineage(s), and also indicated that human migrations occurred (maybe across and within the Indian subcontinent) even after the initial phase of female migration to India.

DNA, Mitochondrial↗

PubMed1995

Spatial language and spatial representation.

This study explores the commonalities between linguistic and visual representations of space. In particular, because common types of spatial relations, specifically closed-class spatial forms in language and qualitative spatial relations in perception, have been proposed in both representational systems, we investigate whether they share underlying structural similarities. Moreover, while visual spatial relations are a basic element of several theories of object representation, they have been characterized mainly in terms of their linguistic counterparts and without direct evidence about their organization. In order to illuminate the nature of these structures, as well as demonstrate possible correspondences between the two systems, we compare how the spatial relationship between pairs of objects in a scene is encoded linguistically and visually. Spatial language was investigated by having subjects either generate (Experiment 1) or rate the applicability of (Experiment 2) spatial terms for describing the spatial relationship between object pairs. Both the frequency of use and the applicability of spatial terms were highest when the two objects were in vertical or in horizontal alignment. Spatial representation was investigated by paradigms in which subjects either recalled the position of one object relative to the other (Experiment 3) or judged whether one object presented sequentially was in the same or a different position relative to the other (Experiment 4). The accuracy of position estimates and the sensitivity to shifts in position were both highest when the rated object was in a spatial location where spatial terms had been judged to have high applicability in Experiments 1 and 2. These results indicate that the structure of space as encoded by language may be determined by the structure of spatial relations in visual representation.

Adult↗

PubMedDate not supplied

Language and connectionism: the developing interface.

After a difficult initial period in which connectionism was perceived as either irrelevant or antithetical to linguistic theory, connectionist concepts are now beginning to be brought to bear on basic issues concerning the structure, acquisition, and processing of language, both normal and disordered. This article describes some potential points of further contact between connectionism and linguistic theory. I consider how connectionist concepts may be relevant to issues concerning the representation of linguistic knowledge; the role of a priori constraints on acquisition; and the poverty of the stimulus argument. I then discuss whether these models contribute to the development of explanatory theories of language.

Brain↗