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Formal dominance: the emperor's new clothes?

I previously argued that formal dominance requires the ability to attribute knowledge to other individuals (D. Maestripieri, 1996). Formal dominance is otherwise indistinguishable from the way dominance has previously been conceptualized. For example, the notion that nonhuman primates have social relationships and that 2 individuals express their knowledge about the state of their relationship with signals of dominance and submission is intrinsic to the concept of dominance and not peculiar to formal dominance. Moreover, the claims made by formal dominance supporters that macaque signals such as the bared-teeth display are always displayed unidirectionally to other group members and never directed to predators are incorrect. If the mentalistic terms used to describe formal dominance must not be taken literally, then the interpretation of submissive signals such as the bared-teeth display from a formal dominance perspective remains unclear.

Animals↗

Neuroendocrine differentiation in prostate cancer: a sheep in wolf's clothing?

Neuroendocrine differentiation of the prostate is often associated with a dismal prognosis. Whilst it is relatively rare compared with other forms of prostate cancer, it nevertheless remains difficult to treat these cancers effectively and to maintain a durable response. Research aimed at understanding the complexity of neuroendocrine differentiation of the prostate has been conducted for some time. The cells involved in this process secrete a variety of factors that can influence growth patterns and regulatory pathways. Many of these factors can be monitored serologically, but the relationship between the biology of the tumor and clinical response is often discordant. This review outlines the difficulties in treating this disease, both at the time of diagnosis and in the metastatic setting, and focuses on an area of research that remains challenging to both the researcher and clinician.

Carcinoma, Neuroendocrine↗