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PubMedDate not supplied

Life stress and cervical squamous intraepithelial lesions in women with human papillomavirus and human immunodeficiency virus.

OBJECTIVE: Human immunodeficiency virus (HIV)-infected women are at risk for cervical intraepithelial neoplasia (CIN) and cancer due to impaired immunosurveillance over human papillomavirus (HPV) infection. Life stress has been implicated in immune decrements in HIV-infected individuals and therefore may contribute to CIN progression over time. The purpose of this study was to determine whether life stress was associated with progression and/or persistence of squamous intraepithelial lesions (SIL), the cytologic diagnosis conferred by Papanicolaou smear, after 1-year follow-up among women co-infected with HIV and HPV. METHOD: Thirty-two HIV-infected African-American and Caribbean-American women underwent a psychosocial interview, blood draw, colposcopy, and HPV cervical swab at study entry. Using medical chart review, we then abstracted SIL diagnoses at study entry and after 1-year follow-up. RESULTS: Hierarchical logistic regression analysis revealed that higher life stress increased the odds of developing progressive/persistent SIL over 1 year by approximately seven-fold after covarying relevant biological and behavioral control variables. CONCLUSIONS: These findings suggest that life stress may constitute an independent risk factor for SIL progression and/or persistence in HIV-infected women. Stress management interventions may decrease risk for SIL progression/persistence in women living with HIV.

Black or African American↗
PubMed2005

Neuropsychological functioning and alcohol dependence.

PURPOSE OF REVIEW: Alcohol dependence is a significant challenge to society and health-care services. The associated cognitive deficits are thought to affect behavioral control, therapy and liability to relapse. The present review demonstrates important new findings. RECENT FINDINGS: Recent interest focused on compensatory functional circuits, components of executive functioning, externally induced attentional biases and the relevance of the cognitive deficits for therapy and rehabilitation. SUMMARY: Recent studies found widespread compromised fronto-cortico-cerebellar circuits to underlie cognitive deficits. The inclusion of cerebellar structures to support functions traditionally associated with cortical and even prefrontal structures is important. However, most importantly, alcohol-dependent patients use additional and generally higher-order executive functions to compensate for deficient task performance. The compensatory mechanisms might help to explain close to normal functioning in basic cognitive domains enabled by support of executive components. But deficits in executive functions themselves might emerge more directly. New approaches concerning executive functioning, analyzing functional components of executive tasks, found response inhibition and decision-making to be impaired but normal performance in simple working memory tasks. Multiple withdrawals have been shown to lead to a higher degree of executive deficit. The causing mechanism underlying the attentional bias induced by alcohol-related words (stroop effect) is still under debate. Correlation of cognitive deficits with therapy outcome turned out to be weak. However, important interactions of cognitive deficits with personality, therapy-setting and successful coping, together with the finding that cognitive performance of alcohol-dependent patients could be enhanced by motivating instructions, might open new strategies in treatment planning and cognitive rehabilitation.

Journal Article↗
PubMed2006

Possible association between response inhibition and a variant in the brain-expressed tryptophan hydroxylase-2 gene.

UNLABELLED: The ability to inhibit a response is an important component of normal behavioral control and is an aspect of psychopathology when diminished. Converging evidence implicates the serotonergic neurotransmitter system in response inhibition circuitry. OBJECTIVES: The present study examined potential associations between serotonergic genetic markers and response inhibition as indexed by Stop Task performance. METHODS: College-age participants (N=199) completed self-report questionnaires, the computerized Stop Task, and donated buccal cells for genetic analyses. Statistics were analyzed by ANOVA. RESULTS: Stop Signal reaction time was not associated with allelic variation at a monoamine oxidase A promoter length polymorphism or a serotonin 1B terminal autoreceptor polymorphism (G861C). An intronic genetic marker of the neuronal tryptophan hydroxylase-2 (the rate-limiting enzyme for serotonin biosynthesis) gene, however, was associated with the Stop Signal reaction time. Individuals homozygous for the T variant at an intron-8 polymorphism had the longest Stop Signal reaction time (i.e. greater impulsivity, P=0.01), and this effect was stronger in males (P=0.01) than in females (P=0.10). CONCLUSIONS: A genotype at an intron-8 tryptophan hydroxylase-2 polymorphism was associated with response inhibition as indexed by the Stop Task. These results, if replicated, would implicate dorsal raphe serotonin neurons in response inhibition. It may be that individuals with the T/T genotype may have reduced tryptophan hydroxylase-2 function and correspondingly lower central serotonin levels; however, further investigation of the reported association is required.

Adult↗
PubMed2006

A review of delay-discounting research with humans: relations to drug use and gambling.

Delay discounting represents the extent to which consequences, or outcomes, decrease in effectiveness to control behavior as a function of there being a delay to their occurrence. Higher rates of delay discounting are often operationalized as an index of impulsivity, and as such impulsive discounting may hold considerable potential for understanding fundamental behavioral processes associated with a range of problematic behaviors - including drug use and pathological gambling. This paper first provides a review of several assessment methods used in delay-discounting research with humans. Following, the delay-discounting literature related to drug use and gambling is reviewed. Consistencies across this literature are identified; and future research directions are discussed, which include (a) improving methods of assessment for delay discounting and (b) moving drug-use research progressively to causal interpretations, with high rates of delay discounting either predisposing to drug use or resulting from drug use itself.

Gambling↗
PubMedDate not supplied

A role for Synapsin in associative learning: the Drosophila larva as a study case.

Synapsins are evolutionarily conserved, highly abundant vesicular phosphoproteins in presynaptic terminals. They are thought to regulate the recruitment of synaptic vesicles from the reserve pool to the readily-releasable pool, in particular when vesicle release is to be maintained at high spiking rates. As regulation of transmitter release is a prerequisite for synaptic plasticity, we use the fruit fly Drosophila to ask whether Synapsin has a role in behavioral plasticity as well; in fruit flies, Synapsin is encoded by a single gene (syn). We tackled this question for associative olfactory learning in larval Drosophila by using the deletion mutant syn(97CS), which had been backcrossed to the Canton-S wild-type strain (CS) for 13 generations. We provide a molecular account of the genomic status of syn(97CS) by PCR and show the absence of gene product on Western blots and nerve-muscle preparations. We found that olfactory associative learning in syn(97CS) larvae is reduced to approximately 50% of wild-type CS levels; however, responsiveness to the to-be-associated stimuli and motor performance in untrained animals are normal. In addition, we introduce two novel behavioral control procedures to test stimulus responsiveness and motor performance after "sham training." Wild-type CS and syn(97CS) perform indistinguishably also in these tests. Thus, larval Drosophila can be used as a case study for a role of Synapsin in associative learning.

Animals↗
PubMed2003

Jamming at zero temperature and zero applied stress: the epitome of disorder.

We have studied how two- and three-dimensional systems made up of particles interacting with finite range, repulsive potentials jam (i.e., develop a yield stress in a disordered state) at zero temperature and zero applied stress. At low packing fractions phi, the system is not jammed and each particle can move without impediment from its neighbors. For each configuration, there is a unique jamming threshold phi(c) at which particles can no longer avoid each other, and the bulk and shear moduli simultaneously become nonzero. The distribution of phi(c) values becomes narrower as the system size increases, so that essentially all configurations jam at the same packing fraction in the thermodynamic limit. This packing fraction corresponds to the previously measured value for random close packing. In fact, our results provide a well-defined meaning for "random close packing" in terms of the fraction of all phase space with inherent structures that jam. The jamming threshold, point J, occurring at zero temperature and applied stress and at the random-close-packing density, has properties reminiscent of an ordinary critical point. As point J is approached from higher packing fractions, power-law scaling is found for the divergence of the first peak in the pair correlation function and in the vanishing of the pressure, shear modulus, and excess number of overlapping neighbors. Moreover, near point J, certain quantities no longer self-average, suggesting the existence of a length scale that diverges at J. However, point J also differs from an ordinary critical point: the scaling exponents do not depend on dimension but do depend on the interparticle potential. Finally, as point J is approached from high packing fractions, the density of vibrational states develops a large excess of low-frequency modes. Indeed, at point J, the density of states is a constant all the way down to zero frequency. All of these results suggest that point J is a point of maximal disorder and may control behavior in its vicinity-perhaps even at the glass transition.

Journal Article↗
PubMed1977

Cutaneous stimulus registration and information processing in the somesthetic cortex.

The author reviews the evidence that the acquisition of sequential tactile information and stereometric object identification by manual exploration is a process which is analogous to the scanning of visual scenes. The hypothesis that somatosensory and visual maps in the respective primary cortical projection areas are of the same analytical structure is argued. New experimental data documented in subhuman primates demonstrate that neural responses to cutaneous stimuli depend on situational factors and on behavior-controlling instructions conveyed over another sense modality and that as a result the redundancy of cutaneous stimulus encoding in the somesthetic cortex is reduced.

Afferent Pathways↗
PubMed2001

Linear mixed models with flexible distributions of random effects for longitudinal data.

Normality of random effects is a routine assumption for the linear mixed model, but it may be unrealistic, obscuring important features of among-individual variation. We relax this assumption by approximating the random effects density by the seminonparameteric (SNP) representation of Gallant and Nychka (1987, Econometrics 55, 363-390), which includes normality as a special case and provides flexibility in capturing a broad range of nonnormal behavior, controlled by a user-chosen tuning parameter. An advantage is that the marginal likelihood may be expressed in closed form, so inference may be carried out using standard optimization techniques. We demonstrate that standard information criteria may be used to choose the tuning parameter and detect departures from normality, and we illustrate the approach via simulation and using longitudinal data from the Framingham study.

Biometry↗
PubMed2006

Abnormal associative encoding in orbitofrontal neurons in cocaine-experienced rats during decision-making.

Recent evidence has linked exposure to addictive drugs to an inability to employ information about adverse consequences, or outcomes, to control behavior. For instance, addicts and drug-experienced animals fail to adapt their behavior to avoid adverse outcomes in gambling and reversal tasks or after changes in the value of expected rewards. These deficits are similar to those caused by damage to the orbitofrontal cortex, suggesting that addictive drugs may cause long-lasting changes in the representation of outcome associations in a circuit that includes the orbitofrontal cortex. Here we test this hypothesis by recording from orbitofrontal neurons in a discrimination task in rats previously exposed to cocaine (30 mg/kg i.p. for 14 days). We found that orbitofrontal neurons recorded in cocaine-experienced rats failed to signal the adverse outcome at the time a decision was made in the task. The loss of this signal was associated with abnormal changes in response latencies on aversive trials. Furthermore, upon reversal of the cue-outcome associations, orbitofrontal neurons in cocaine-treated rats with enduring reversal impairments failed to reverse their cue-selectivity, while orbitofrontal neurons in cocaine-treated rats with normal performance showed an increase in the plasticity of cue-selective firing after reversal. These results provide direct neurophysiological evidence that exposure to cocaine can cause behaviorally relevant changes in the processing of associative information in a circuit that includes the orbitofrontal cortex.

Animals↗
PubMed1991

The ethics of conversion therapy.

... Both the past and present have seen a number of methods being used to extinguish homoerotic desire and behavior and to inaugurate heteroeroticism in their place, methods I will here call conversion therapies... The typical defense of such therapy holds that even if homoeroticism is not necessarily a disease or evil, neither is it a universal good... Conversion therapy is morally defensible, on such a view, because some people suffer from the perceived consequences of homoerotic orientations despite the freedom and toleration extended to gay men and lesbians in certain areas... Against the view that conversion therapy is morally defensible as a matter of personal preference, I here argue that such therapy is morally suspect and should be resisted for a number of reasons....

Adult↗
PubMed1989

Authoritative parenting, psychosocial maturity, and academic success among adolescents.

The over-time relation between 3 aspects of authoritative parenting--acceptance, psychological autonomy, and behavioral control--and school achievement was examined in a sample of 120 10-16-year-olds in order to test the hypothesis that authoritative parenting facilitates, rather than simply accompanies, school success. In addition, the mediating role of youngsters' psychosocial maturity was studied. Results indicate that (1) authoritative parenting facilitates adolescents' academic success, (2) each component of authoritativeness studied makes an independent contribution to achievement, and (3) the positive impact of authoritative parenting on achievement is mediated at least in part through the effects of authoritativeness on the development of a healthy sense of autonomy and, more specifically, a healthy psychological orientation toward work. Adolescents who describe their parents as treating them warmly, democratically, and firmly are more likely than their peers to develop positive attitudes toward, and beliefs about, their achievement, and as a consequence, they are more likely to do better in school.

Achievement↗
PubMed2005

The prevalence and incidence of intimate partner violence in older women in primary care practices.

OBJECTIVE: Identify the incidence and prevalence of intimate partner violence (IPV) in women over 55 years of age in primary care offices. DESIGN: Telephone survey conducted between March and June 2003 by trained female interviewers who gathered self-report information about health and abuse. PATIENTS: A total of 3,636 women over 55 years of age had at least 1 visit in the past 12 months to primary care offices affiliated with an academic center in Southwestern Ohio were contacted by phone; 995 were deemed competent and completed the interview. INTERVENTION/INSTRUMENT: Thirty-eight page instrument that explored health, history of psychological (controlling behavior and threat of physical harm), physical, and sexual abuse since age 55 years. Interviews lasted 20 to 45 min. MAIN RESULTS: The mean age was 69 years (SD 8.35). Physical abuse in intimate relationships was reported by 1.52% since age 55 years (prevalence) and 0.41% in the past year (incidence). Prevalence and incidence rates for sexual abuse were 2.14% and 1.12%, threat of physical harm 2.63% and 1.62%, respectively. Less than half of the victims told someone else about the abuse. The mean number of health conditions was 3.84 for victims and 3.21 for nonvictims (P<.055) with significantly larger percentages of IPV victims reporting problems with chronic pain and depression. CONCLUSIONS: Physical and sexual abuse by an intimate partner does occur in women over 55 years, but rates are lower than those of younger women. Health care providers are reminded to think about IPV in older women and to ask about abuse as disclosure is rare.

Aged↗
PubMedDate not supplied

Recurrent syncope, hypotension, asthma, and migraine with aura: role of metoclopramide.

Migraine associated with asthma or symptomatic orthostatic hypotension is a particularly difficult subgroup to manage. Metoclopramide is a useful pharmacological agent for orthostatic hypotension. I present the case report of a migraine patient with asthma and recurrent hypotensive syncope. Metoclopramide relieved recurrent syncope as well as migraine attacks in this patient. Metoclopramide has a striking influence on arginine vasopressin (AVP) secretion. AVP promotes antinociception and influences vasomotor and behavior control, which actions possibly keep migraine in remission. Further studies are necessary to confirm the migraine prophylactic value of metoclopramide.

Adult↗
PubMed1994

Localization of genes affecting alcohol drinking in mice.

The genomic map locations of specific genes controlling behaviors can be identified by studying a panel of recombinant inbred (RI) mouse strains. The progenitor C57BL/6J (B6) and DBA/2J (D2) strains, and 19 of the BXD RI strains derived from an F2 cross of these progenitors, were tested for 3% and 10% ethanol (EtOH) intake. The test sequence began with two-bottle free choice between tap water and unsweetened ethanol, and ended with free choice between water and saccharin-sweetened ethanol. Saccharin preference was also measured. Correlational analyses indicated that 59% of the genetic variance in 10% ethanol and sweetened 10% ethanol consumption was held in common, 24% of the genetic variance in saccharin and sweetened 10% ethanol consumption was held in common, and only 7% of the genetic variance in saccharin and unsweetened 10% ethanol consumption was held in common. These percentages for 3% ethanol solutions were 21%, 36%, and 14%. In addition, the severity of handling-induced convulsions during ethanol withdrawal was found to be significantly associated with the amount of ethanol consumed from the sweetened ethanol drinking tubes, suggesting that genetic differences in avidity for ethanol could lead to the development of physical dependence. Quantitative trait loci (QTL) analyses revealed that several genetic markers were associated with ethanol consumption levels, including markers for the D2 dopamine receptor. QTL analyses of saccharin and sweetened ethanol consumption identified the sac locus, thought to determine the ability to detect saccharin. In general, our results suggest that saccharin and ethanol consumption are determined by the actions of multiple genes (QTL), some in common, and suggest specific map locations of several such QTL on the mouse genome.

Alcohol Drinking↗
PubMed1989

Family functioning of male alcoholics and their female partners during periods of drinking and abstinence.

Family functioning of 20 alcoholic male veterans and their female partners was assessed in relation to drinking (wet) and abstinent (dry) intervals. Repeated measures analyses performed on the McMaster Family Assessment Device (FAD) indicated that on all 7 scales of the FAD, alcoholics and their mates perceived family functioning to be better during dry than wet periods. In contrast to their alcoholic mates, female partners gave healthier ratings to all FAD scales except Roles in the dry condition and Affective Involvement in the wet condition. According to published cutoff scores for healthy and unhealthy family functioning, alcoholics as a group viewed their wet and dry family functioning as unhealthy, although the female group regarded the family's dry Problem Solving and Behavioral Control as healthy. These findings suggest that the family functioning of alcohol-involved couples is biphasic, oscillating between drinking and abstinent periods.

Affect↗
PubMed1995

The McMaster Model of Family Functioning: observer and parental ratings in a nonclinical sample.

The McMaster Model of Family Functioning defines seven dimensions, which may be assessed either by an observer applying a Clinical Rating Scale (CRS) to a semi-structured interview of the family and/or by family members completing a questionnaire, the Family Assessment Device (FAD). The present article applied both methods of assessment, as well as the Dyadic Adjustment Scale (DAS), to a nonclinical sample (N = 105). Interobserver reliability on the CRS was highly significant. Parent (FAD) vs. observer (CRS) agreement was also highly significant, except for Affective Responsiveness and Behavior Control, for which agreement was barely significant. When families were labeled as "healthy" or "unhealthy" according to cut-offs, agreement between observers and parents was high (87%), and disagreements illuminated dynamics of individual families. Finally, the DAS (completed by mothers) was significantly correlated with both the CRS and the FAD, particularly for General Functioning.

Adult↗
PubMed2001

The theory of planned behavior and postpartum smoking relapse.

PURPOSE: To explore the applicability of Ajzen's theory of planned behavior to postpartum smoking relapse. ORGANIZING FRAMEWORK: The theory of planned behavior is proposed as an appropriate framework for the study of postpartum smoking relapse. METHODS: The literature on smoking cessation, postnatal smoking, and the theory of planned behavior were reviewed. References included electronic database and manual search results. CONCLUSIONS: The theory of planned behavior provides a framework for explaining, predicting, and influencing human behaviors based on modifiable factors of attitude, subjective norm, and perceived behavioral control. The inclusion of instrument development guidelines significantly strengthens the usefulness of the framework. A theoretically based understanding of postpartum smoking relapses can guide and strengthen appropriate interventions directed toward significantly reducing postpartum smoking, thereby increasing the number of women who are able to remain smoke-free for life.

Attitude↗