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PubMed1994

Working memory tasks in five-choice operant chambers: use of relative and absolute spatial memories.

Rats were trained to nose poke into illuminated holes to perform 1 of 2 different spatial working memory tasks (relative recency or reward history) in a 5-choice operant chamber. A series of experiments indicated that choice accuracy on both tasks depended on (a) the holes' spatial separation, and (b) their relative rather than absolute positions. The results suggest that accurate choice depended on using a motor mediation strategy to turn, so as to encounter the target (correct) hole before encountering the alternative (wrong) hole. The drugs administered to the rats, d-amphetamine, scopolamine, and CGP-37849 impaired choice accuracy on these tasks, even though task performance had not appeared to depend on explicit memory for the sample responses. This suggests that parallel drug effects obtained on other operant matching- or nonmatching-to-position tasks may not have reflected truly amnesic effects of the drug treatments.

2-Amino-5-phosphonovalerate↗
PubMed2005

Working memory and intelligence: the same or different constructs?

Several investigators have claimed over the past decade that working memory (WM) and general intelligence (g) are identical, or nearly identical, constructs, from an individual-differences perspective. Although memory measures are commonly included in intelligence tests, and memory abilities are included in theories of intelligence, the identity between WM and intelligence has not been evaluated comprehensively. The authors conducted a meta-analysis of 86 samples that relate WM to intelligence. The average correlation between true-score estimates of WM and g is substantially less than unity (p=.479). The authors also focus on the distinction between short-term memory and WM with respect to intelligence with a supplemental meta-analysis. The authors discuss how consideration of psychometric and theoretical perspectives better informs the discussion of WM-intelligence relations.

Aged↗
PubMed2004

The relationship between age, verbal working memory, and language comprehension.

A structural modeling approach was used to examine the relationships between age, verbal working memory (vWM), and 3 types of language measures: online syntactic processing, sentence comprehension, and text comprehension. The best-fit model for the online-processing measure revealed a direct effect of age on online sentence processing, but no effect mediated through vWM. The best-fit models for sentence and text comprehension included an effect of age mediated through vWM and no direct effect of age. These results indicate that the relationship among age, vWM, and comprehension differs depending on the measure of language processing and support the view that individual differences in vWM do not affect individuals' online syntactic processing.

Adolescent↗
PubMed1993

The neural correlates of the verbal component of working memory.

By repeating words 'in our head', verbal material (such as telephone numbers) can be kept in working memory almost indefinitely. This 'articulatory loop' includes a subvocal rehearsal system and a phonological store. Little is known about neural correlates of this model of verbal short-term memory. We therefore measured regional cerebral blood flow, an index of neuronal activity, in volunteers performing a task engaging both components of the articulatory loop (short-term memory for letters) and a task which engages only the subvocal rehearsal system (rhyming judgement for letters). Stimuli were presented visually and the subjects did not speak. We report here that comparisons of distribution of cerebral blood flow in these conditions localized the phonological store to the left supramarginal gyrus whereas the subvocal rehearsal system was associated with Broca's area. This is, to our knowledge, the first demonstration of the normal anatomy of the components of the 'articulatory loop'.

Brain Mapping↗
PubMed2003

An investigation of working memory rehearsal in multiple sclerosis using fMRI.

The present study examined patterns of cerebral activation during a working memory (WM) rehearsal task in individuals diagnosed with multiple sclerosis (MS) and in healthy adults. BOLD functional magnetic resonance imaging (fMRI) was performed using a 1.5 T GE scanner to assess activation during a WM task adapted from the Sternberg paradigm (Sternberg, 1969). Participants included 8 individuals diagnosed with MS, and 5 healthy controls (HCs) matched for age and education. Task difficulty was manipulated by increasing the length of time that strings of letters were to be rehearsed. Findings revealed increased right prefrontal cortex activation and increased right temporal lobe activation in individuals diagnosed with MS compared to HCs. The potential explanations for increased right hemisphere activation in persons with MS are discussed.

Adolescent↗
PubMed1995

The object delayed non-matching to sample task in rats does not depend on working memory.

Four rats were trained on an object delayed non-matching to sample task to measure working memory (WM). On separate trials a sample object was presented to the rat, which was presented again along with another object after a 3 s delay rats were rewarded with food if they chose the novel object. In this procedure the choice objects are positioned in a fixed order (the novel object was positioned at first, followed by the sample object). When the order of placement of the choice objects was reversed performance dropped from 87% to 28% correct, showing that the rats always chose the object that was first positioned into the choice area. When the order of positioning of the choice objects was randomized during training, rats were not able to learn the task. It is suggested that performance is based on a discrimination between choice objects instead of WM.

Animals↗
PubMedDate not supplied

Are working memory deficits in readers with learning disabilities hard to change?

This study investigated whether changes in the working memory (WM) performance of readers with learning disabilities (LD) is related to a general or domain-specific system. The study compared readers with LD, chronologically age-matched (CA-M), and reading level-matched (RL-M) children's WM performance for phonological, visual-spatial, and semantic information under initial (no probes or cues), gain (cues that bring performance to an asymptotic level), and maintenance (asymptotic conditions without cues) conditions. The main findings indicated that (a) CA-M children were superior in performance to readers with LD across initial, gain, and maintenance conditions, (b) readers with LD showed less change (as reflected in effect size scores, slopes for the quadratic curve) on both visual-spatial and verbal (phonological and semantic) WM tasks across gain and maintenance conditions than the CA-matched children, and (c) the performance of readers with LD was superior to the RL-M children's performance on initial conditions, but inferior on gain and maintenance conditions. Taken together, the results suggest that a general system moderated the changes in retrieval of phonological, visual-spatial, and semantic information in readers with LD.

Adolescent↗
PubMed2002

Working memory and stroop interference: an individual differences investigation.

We investigated the claim that individual differences in working-memory capacity reflect limitations on the ability to inhibit task-irrelevant information and/or to maintain activation in the face of distracting or interfering events. Specifically, we investigated whether high- and low-capacity individuals differed in their susceptibility to interference on the Stroop task and whether high-capacity individuals employed a strategy for minimizing Stroop interference. In Experiment 1, we found that high-capacity participants showed substantial interference when conflict trials were infrequent, but almost no interference when conflict trials were frequent. In contrast, low-capacity participants showed substantial interference irrespective of the proportion of conflict trials. In Experiment 2, we found that high-capacity participants experienced substantial negative priming, slow responses when the to-be-named color was the irrelevant word on the previous trial. We discuss these results and their implications for high-capacity individuals' ability to reduce Stroop interference in light of both inhibitory and noninhibitory accounts of negative priming.

Cognition↗
PubMed1994

[Working memory capacity related to reading: measurement with the Japanese version of reading span test].

The efficiency of working memory capacity was measured with the Japanese reading span test (Japanese RST), which was developed based on the Carnegie-Mellon RST (Daneman & Carpenter, 1980). The correlation between the Japanese and the CMU RST was found to be highly significant. The present Japanese RST seems to predict reading efficiency in the same way as does the CMU RST. The Japanese RST was found to be correlated not only with memory span but with reading comprehension. However, it was not correlated with existing verbal intelligence tests.

Adult↗
PubMed2001

Working memory and focal attention.

Measures of retrieval speed indicated that only a small subset of representations in working memory falls within the focus of attention. An n-back task, which required tracking an item 1, 2, or 3 back in a sequentially presented list, was used to examine the representation and retrieval of recent events and how control processes can be used to maintain an item in focal attention while concurrently processing new information. A speed-accuracy trade-off procedure was used to derive measures of the availability and the speed with which recent events can be accessed. Results converge with other time course studies in demonstrating that attention can be concurrently allocated only to a small number of memory representations, perhaps just 1 item. Measures of retrieval speed further demonstrate that order information is retrieved by a slow search process when an item is not maintained within focal attention.

Adult↗
PubMed2006

Working memory and long-term memory for faces: Evidence from fMRI and global amnesia for involvement of the medial temporal lobes.

Behavioral studies with amnesic patients and imaging studies with healthy adults have suggested that medial temporal lobe (MTL) structures known to be essential for long-term declarative memory (LTM) may also be involved in the maintenance of information in working memory (WM). To examine whether MTL structures are involved in WM maintenance for faces, and the nature of that involvement, WM and LTM for faces were examined in normal participants via functional magnetic resonance imaging (fMRI) and in amnesic patients behaviorally. In Experiment 1, participants were scanned while performing a WM task in which they determined if two novel faces, presented 7 s apart, were the same or different. Later, participants' LTM for the faces they saw during the WM task was measured in an unexpected recognition test. During WM maintenance, the hippocampus was activated bilaterally, and there was greater activation during maintenance for faces that were later remembered than faces later forgotten. A conjunction analysis revealed overlap in hippocampal activations across WM maintenance and LTM contrasts, which suggested that the same regions were recruited for WM maintenance and LTM encoding. In Experiment 2, amnesic and control participants were tested on similar WM and LTM tasks. Amnesic patients, as a group, had intact performance with a 1-s maintenance period, but were impaired after a 7-s WM maintenance period and on the LTM task. Thus, parallel neuroimaging and lesion designs suggest that the same hippocampal processes support WM maintenance, for intervals as short as 7 s, and LTM for faces.

Adolescent↗
PubMed2002

Impaired learning in a spatial working memory version and in a cued version of the water maze in rats with MPTP-induced mesencephalic dopaminergic lesions.

A lesion in the substantia nigra pars compacta (SNc) of rats induced by intra-nigral administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) caused specific loss of dopamine and its nonconjugated metabolites in the dorsal striatum and in the prefrontal cortex (PFC), but not in the hippocampus or the ventral striatum (nucleus accumbens). This lesion did not alter the motor performance of the rats or learning of a spatial reference memory task in the water maze but impaired learning of a spatial working memory task and also of a cued version of the water maze. The results are discussed by relating the selective memory deficits observed in these water maze tasks to the PFC, dorsal striatum, and hippocampus. Some parallels between the memory deficits in these SNc-lesioned rats and Parkinson's disease patients are also discussed.

Animals↗
PubMed2007

Taxing working memory with syntax: bihemispheric modulations.

Motivated by claims that relegate the syntactic functions of Broca's region to working memory (WM) and not to language-specific mechanisms, we conducted an fMRI and an aphasia study that featured two varieties of intrasentential dependency relations: One was syntactic movement (e.g., Which boy does the girl think [symbol in text] examined Steven?), the other was antecedent-reflexive binding (e.g., Jill thinks the boy examined himself). In both, WM is required to link two nonadjacent positions. Syntactically, they are governed by distinct rule systems. In health, the two dependencies modulated activity in distinct brain regions within the left inferior frontal gyrus and the left middle temporal gyrus. Binding uniquely modulated activation in the right frontal lobe. Receptive abilities in brain damaged patients likewise distinguished among these syntactic types. The results indicate that sentence comprehension is governed by syntactically carved neural chunks and provide hints regarding a language related region in the right hemisphere.

Adult↗
PubMedDate not supplied

Oral language deficits in dyslexic children: weaknesses in working memory and verbal planning.

This paper focuses on the relationships among language processing (word- and sentence-level), working memory, and verbal/nonverbal linguistic output. The study examined oral language abilities in a group of 26 French-speaking dyslexic children, compared to two control groups (26 normally developing age-matched children and 26 normally developing younger children). The experimental procedure consisted of tasks involving auditory memory skills (digit span, unfamiliar word repetition, sentence repetition), word retrieval (with semantic, phonological and grammatical criteria), and sentence processing (with verbal and act-out production). The major findings reveal that (a) compared with their age-mates, the dyslexic children exhibited a significant deficit affecting all tasks; and (b) the dyslexic children and the younger controls performed similarly on several tasks. The results are consistent with the processing limitation hypothesis and suggest that the core deficit is the formulation of cognitive plans from auditory input to verbal output.

Child↗
PubMed2005

Event-related theta oscillations during working memory tasks in patients with schizophrenia and healthy controls.

Altered frontal lobe activity and executive control associated with working memory (WM) dysfunction are recognized as core deficits in schizophrenia. These impairments have been discussed as being associated with deficits in self-regulated action monitoring and anticipatory action plan generation. To study electrophysiological correlates of executive control -- specifically action monitoring and action rule switching -- under varying WM load, we used a paradigm derived from classic N-back (WM) tasks and requiring monitoring of simple actions. We focused on event-related changes in post-stimulus theta oscillatory activity during varying cognitive and WM demand in healthy controls and schizophrenia patients. The results show significant WM load and rule-switching-related increases of post-stimulus theta amplitude at fronto-central locations in controls. In patients with schizophrenia, there was no such modulation, but -- apart from an increased early theta at left temporal locations -- generally reduced late theta responses in all tasks and at all locations. Furthermore, the patients with schizophrenia showed significant differences in their error patterns, which imply differences in automation and anticipation of actions between controls and patients. These findings suggest that theta oscillations are involved in mediating frontal lobe activity and functions related to enhanced executive control. We conclude that the patients with schizophrenia showed deficits in acquiring a mental task set which appear to be associated with impairments in action monitoring and task-specific regulation of executive control.

Adult↗
PubMed2003

Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI.

This study describes the neural circuitry underlying temporally separated components of working memory (WM) performance-stimulus encoding, maintenance of information during a delay, and the response to a probe. While other studies have applied event-related fMRI to separate epochs of WM tasks, this study differs in that it employs a methodology that does not make any a priori assumptions about the shape of the hemodynamic response (HDR). This is important because no one model of the HDR is valid across the range of activated brain regions and stimulus types. Systematic modeling inaccuracies may lead to the misattribution of activity to adjacent events. Twelve healthy subjects performed a numerical version of the Sternberg Item Recognition Paradigm adapted for rapid presentation event-related fMRI. This paradigm emphasized maintenance rather than manipulative WM processes and used a subcapacity WM load. WM trials with different delay lengths were compared to fixation. The HDR of the entire WM trial for each trial type was estimated using a finite impulse response (FIR). Regional activity associated with the Encode, Delay, and Probe epochs was identified using contrasts that were based on the FIR estimates and by examining the HDRs. Each epoch was associated with a distinct but overlapping pattern of regional activity. Activation of the dorsolateral prefrontal cortex, thalamus, and basal ganglia was exclusively associated with the probe. This suggests that frontostriatal neural circuitry participates in selecting an appropriate response based on the contents of WM.

Adult↗
PubMed2006

Differential activation of ventrolateral prefrontal cortex during working memory retrieval.

Brain imaging studies have suggested a predominant involvement of prefrontal areas during retrieval of information from working memory (WM). This study used event-related functional magnetic resonance imaging to assess the gradual recruitment of brain areas during verbal WM-retrieval with a parametrically varied modified version of the Sternberg Item Recognition Paradigm. In particular, we were interested in activation differences during retrieval of negative and positive probes. Fifteen subjects performed a WM-task which required the retrieval of a probe letter from a set of a maximum of three letters. The analysis of the retrieval period regardless of probe type revealed bilateral VLPFC activation during retrieval from a single remembered item. These initially activated regions showed a gradual activation increase of left VLPFC (BA 47) and anterior PFC (BA 10) as well as and bilateral DLPFC (BA 9) with increasing retrieval demand, i.e. during retrieval of two and three previously remembered letters. The comparison of negative and positive probes (non-targets versus targets) revealed greater activity in VLPFC (BA 47) in response to negative than to positive probes. These findings demonstrate that ventral areas of prefrontal cortex seem to be differentially engaged during the discrimination of a non-target from a previously manipulated set.

Adult↗
PubMed1987

Vasopressin injections impair working memory in a delayed matching to sample task in rats.

Effects of vasopressin were measured in a nonspatial working memory task: food-reinforced, delayed matching to sample. Subcutaneous injections of 0.2 microgram of lysine vasopressin (LVP) or saline were alternately administered to Sprague-Dawley rats after the presentation of the sample and compared to the effect of the same treatments given to a yoked control group of rats. Different durations of sample presentation (5 and 30 min) and various retention intervals (10 min, 3 h, 24 h) were selected. The results showed that LVP never facilitated retention performance: there was no improvement under conditions of weak memory (short presentation of the sample and long retention interval); moreover LVP abolished the facilitation normally obtained when either the length of the sample presentation was longer or the duration of the retention interval was shorter. The performance after the injection of the peptide was differentially impaired, according to brightness of the sample which had been presented: after the presentation of the white box, LVP injections lead to more errors and after that of the black one the treatment induced an increase in latencies of response. All these data may suggest that the physiological consequences of hormonal modifications triggered by the LVP injection are processed along with the stimuli of the learning episode and interfere with the learned positive value of the sample.

Animals↗