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PubMed2000

Yeast two-hybrid systems and protein interaction mapping projects for yeast and worm.

The availability of complete genome sequences necessitates the development of standardized functional assays to analyse the tens of thousands of predicted gene products in high-throughput experimental settings. Such approaches are collectively referred to as 'functional genomics'. One approach to investigate the properties of a proteome of interest is by systematic analysis of protein-protein interactions. So far, the yeast two-hybrid system is the most commonly used method for large-scale, high-throughput identification of potential protein-protein interactions. Here, we discuss several technical features of variants of the two-hybrid systems in light of data recently obtained from different protein interaction mapping projects for the budding yeast Saccharomyces cerevisiae and the nematode Caenorhabditis elegans.

Animals↗
PubMed1990

Mortality and population ageing.

The authors examine the effects of mortality trends on age structure and how fertility and migration affect demograpnic aging. "Computations are done for both France and Italy on population ageing during the last 30 years as well as until the end of the official population projections around 2040. Though the ageing effect of fertility decline is usually emphasized, we can see here that the consequences of mortality changes are at least equally (and sometimes more) important. The case of the Italian projection is particularly fascinating. Even if the very low fertility level of 1.4 children per capita is maintained until the year 2040, more than half the increase in the proportion of the population aged 60 and over (from 21% to 43% for females) would be due to mortality change and slightly less to fertility change." (SUMMARY IN FRE)

Age Distribution↗
PubMed2004

Identifying undiagnosed dementia in residential care veterans: comparing telemedicine to in-person clinical examination.

BACKGROUND: Dementia is a common but frequently undiagnosed problem in aging. Barriers to early diagnosis include a lack of routine screening for dementia and a lack of access to specialty consultative services. We conducted a pilot study to see if telemedicine could provide reliable, accurate geriatric consultative services to evaluate patients for dementia who were residing at remote sites. METHODS: This was a prospective cohort study that compared the diagnostic reliability of telemedicine to an in-person examination for dementia. Eligible subjects were residents of a Washington State Veterans' Home, age 60 years or older, with no prior diagnosis of dementia. Eligible subjects were screened for dementia using the 7-Minute Screen. Veterans who screened positive and consented to participate in the study received an in-person neuropsychiatric evaluation at baseline, and then both telemedicine and in-person examinations for dementia conducted by experienced geriatric psychiatrists. The accuracy of the telemedicine diagnosis was estimated by comparing it to the diagnosis from the clinical examination. Three geriatric psychiatrists who were blinded to the results of the clinical examination conducted the telemedicine and in-person examinations. We also assessed attitudes of the subjects and geriatric psychiatrists towards the telemedicine sessions. RESULTS: Eighteen of 85 subjects screened were 'positive' for dementia on the 7 Minute Screen. Of these, 16 consented to participate in the telemedicine study. Twelve of the 16 subjects were subsequently diagnosed with dementia by the telemedicine examination. The telemedicine diagnoses were in 100% agreement with the diagnoses from the in-person clinical examinations. Moreover, the subjects reported a high degree of satisfaction with the telemedicine experience and that they would like to have further care through telemedicine in the future. The geriatric psychiatrists reported technical difficulties with the audio-visual quality of telemedicine in the initial phases of the project that resolved as familiarity with the telemedicine equipment increased. None of these problems had an adverse impact on the diagnostic accuracy of telemedicine. CONCLUSIONS: We found that telemedicine was as accurate as an in-person clinical examination in establishing the diagnosis of dementia. In addition, subjects reported a high degree of satisfaction with telemedicine and a willingness to participate in telemedicine clinical care in the future. Given the large increase in the aging population and the shortage of geriatric psychiatrists nationally, it appears that telemedicine may be a promising means to expand the availability of geriatric psychiatric consultation to remote areas.

Aged↗
PubMed1993

On the confounding effects of phosphor persistence in oscilloscopic displays.

Phosphor persistence has been a source of confounding in studies of temporal integration in vision. We examined the confounding by assessing the effects of the persistence of two commonly-used phosphors (P15 and P31) on performance of a temporal-integration task. In one experiment we eliminated the visibility of phosphor persistence by closing two mechanical shutters upon display termination. In a second experiment we estimated the duration of phosphor persistence by displaying the image behind closed shutters which opened upon display termination. No detectable persistence was every produced by P15 phosphor. By contrast, P31 phosphor produced persistence that lasted several hundred milliseconds even when a veiling light was projected on the screen. We ascribe the earlier instances of confounding to inadequate interpretation of the technical data on phosphor decay.

Humans↗
PubMed1992

Forecasting U.S. population totals with the Box-Jenkins approach.

"The use of the Box-Jenkins approach for forecasting the population of the United States up to the year 2080 is discussed. It is shown that the Box-Jenkins approach is equivalent to a simple trend model when making long-range predictions for the United States. An investigation of forecasting accuracy indicates that the Box-Jenkins method produces population forecasts that are at least as reliable as those done with more traditional demographic methods."

Americas↗
PubMed2006

Intimate examination teaching with volunteers: implementation and assessment at the University of Antwerp.

OBJECTIVES: Teaching intimate physical examinations in medical schools generates practical, didactical and ethical problems. At the University of Antwerp, a unique program with intimate examination assistants (IEA) was implemented for fifth year's undergraduate students. They learn gynaecological and urological skills in healthy volunteers. Technical, communicative and attitude aspects are taken into account. METHODS: Description of the implementation of the project. Assessment of the project by questionnaires, written reflections and round table conferences. RESULTS: The results provide detailed information about the student's perceptions of each component of the program as well as the perceptions of the IEA's and the teachers. CONCLUSION: The multilevel evaluation of the program supports the surplus value of working with IEA's in medical education. The eye-catcher in this program is the integration of clinical skills with communicative skills and attention for students' attitude. PRACTICE IMPLICATIONS: Working with IEA's for intimate examinations represents a benefit in medical education by lowering the student's threshold to perform the intimate physical examination on both men and women during their fulltime clerkships.

Adult↗
PubMed1999

Secretin-enhanced MR pancreatography.

MR cholangiopancreatography has now emerged as a noninvasive diagnostic technique that can replace diagnostic endoscopic retrograde cholangiopancreatography in many instances. Recent technical issues include the use of fast single-shot T2-weighted single-slice projections in combination with a negative oral contrast agent and secretin stimulation for assessment of pancreatic flow dynamics and duodenal filling. Potential clinical applications include the evaluation of patients with recurrent pancreatitis and inconclusive CT examination as well as the evaluation of chronic pancreatitis complications whenever endoscopic treatment is suggested. In combination with cross-sectional MR sequences, secretin-enhanced MR pancreatography offers the possibility of a comprehensive examination of the pancreas that provides parenchymal, ductal, and functional information within a single diagnostic modality.

Humans↗
PubMed2000

[Psychoeducational intervention for schizophrenic patients and subsequent long-term ambulatory care. A four-year follow-up] .

A subset of schizophrenic inpatients and families participated in an eight-sessions bifocal psychoeducational intervention, followed by treatment in a corresponding outpatient department. These patients were a part of the multicenter and randomized Münchner Psychosis-Information-Project (PIP). The course of illness in 88 patients treated in the outpatient department of the Technical University of Munich has been recorded in a 4-year follow-up study. 60% of the patients continued outpatient treatment while 40% lost contact with the outpatient department. Predictors for patient drop-out were assessed and the course of illness of both groups was compared. There was no significant difference between the relapse rate of the patients who dropped out (66%) and those who continued the long-term treatment (53%). However, within the 4-year period the drop-out patients had more than twice as many hospital days compared to the patients who maintained the outpatient treatment. The improved social adjustment and quality of life of these patients, along with the 50% reduction of readmission days demonstrates the impact of the long-term treatment in this study.

Adolescent↗
PubMed1995

Simple versus complex models: evaluation, accuracy, and combining.

"This paper argues that it is premature to decide whether simple forecasting models in demography are more (or less) accurate than complex models and whether causal models are more (or less) accurate than noncausal models. It is also too early to say under what conditions one type of model can outperform another. The paper also questions the wisdom of searching for a single best model or approach. It suggests that combining forecasts may improve accuracy." (SUMMARY IN FRE)

Evaluation Studies as Topic↗
PubMed2002

Changes in the use and management of forests for abating carbon emissions: issues and challenges under the Kyoto Protocol.

The global carbon cycle is significantly influenced by changes in the use and management of forests and agriculture. Humans have the potential through changes in land use and management to alter the magnitude of forest-carbon stocks and the direction of forest-carbon fluxes. However, controversy over the use of biological means to absorb or reduce emissions of CO(2) (often referred to as carbon 'sinks') has arisen in the context of the Kyoto Protocol. The controversy is based primarily on two arguments: sinks may allow developed nations to delay or avoid actions to reduce fossil fuel emissions, and the technical and operational difficulties are too threatening to the successful implementation of land use and forestry projects for providing carbon offsets. Here we discuss the importance of including carbon sinks in efforts to address global warming and the consequent additional social, environmental and economic benefits to host countries. Activities in tropical forest lands provide the lowest cost methods both of reducing emissions and reducing atmospheric concentrations of greenhouse gases. We conclude that the various objections raised as to the inclusion of carbon sinks to ameliorate climate change can be addressed by existing techniques and technology. Carbon sinks provide a practical available method of achieving meaningful reductions in atmospheric concentrations of carbon dioxide while at the same time contribute to national sustainable development goals.

Air Pollutants↗
PubMed1981

Forecasting Australian marriage rates.

"The paper discusses the problem of modelling demographic variables for the purpose of forecasting. Two empirical model selection procedures are applied to suggest final form forecasting equations for Australian marriage rates. The suggested models are then assessed by comparing their post-sample forecast performance with that of univariate ARMA-type models of marriage rates which are regarded as approximations to marriage rate final equation models. In this instance the ARMA models are preferred for forecasting purposes. The properties of the ARMA model forecasts are then examined and the modelling strategy is contrasted with the regression method used by Withers."

Australia↗
PubMed1995

The simulation of urban system dynamics in Atlantic Canada, 1951-1991.

"A dynamic urban model is used to study the post-war evolution of the Atlantic Canada urban system. The computer-based simulation model is calibrated for the period 1951-86 and then employed to predict the 1991 population of each CMA and CA within the system. The simulation results show that, to a large extent, the evolution of the system can be understood in terms of endogenous system dynamics rather than exogenous events. Specifically, competition among the cities of the region is a significant factor in the urban system evolution. The high degree of abstraction of the model means that data requirements for application are minimal, and the calibration procedure is relatively simple. The successful predictions show that the model can yield useful results in spite of its simplicity." (SUMMARY IN FRE)

Americas↗
PubMed2002

Pattern recognition techniques in microarray data analysis: a survey.

Recent development of technologies (e.g., microarray technology) that are capable of producing massive amounts of genetic data has highlighted the need for new pattern recognition techniques that can mine and discover biologically meaningful knowledge in large data sets. Many researchers have begun an endeavor in this direction to devise such data-mining techniques. As such, there is a need for survey articles that periodically review and summarize the work that has been done in the area. This article presents one such survey. The first portion of the paper is meant to provide the basic biology (mostly for non-biologists) that is required in such a project. This part is only meant to be a starting point for those experts in the technical fields who wish to embark on this new area of bioinformatics. The second portion of the paper is a survey of various data-mining techniques that have been used in mining microarray data for biological knowledge and information (such as sequence information). This survey is not meant to be treated as complete in any form, since the area is currently one of the most active, and the body of research is very large. Furthermore, the applications of the techniques mentioned here are not meant to be taken as the most significant applications of the techniques, but simply as examples among many.

Algorithms↗
PubMed2004

Implementation of an international teleradiology staffing model.

Although teleradiology is presently being used extensively in the United States-for both overseas subspecialty consultations and overnight coverage of imaging services at domestic medical centers-there has been limited investigation of its potential to help provide staffing support to U.S. medical centers from offshore locations. In this review, the authors describe an empirical assessment of the clinical feasibility and applicability of body computed tomographic (CT) image cases that originated at a U.S. university hospital being interpreted nearly contemporaneously by a staff radiologist in India. During a 3-month period, nonemergent CT cases obtained at a tertiary care institution (Yale-New Haven Hospital) were transmitted daily to a satellite reading facility in Bangalore, India. The cases were interpreted at the satellite reading facility by a faculty member radiologist who maintained hospital privileges and academic appointment at the parent institution in the United States. CT imaging reports were transcribed and uploaded directly to the parent institution's radiology information system. Technical problems temporarily prevented the transfer of image cases twice during the study period. Overall, the project results demonstrated the feasibility and reliability of an international teleradiology staffing model.

Abdominal Neoplasms↗
PubMed2005

Proposed methods for testing and selecting the ERCC external RNA controls.

The External RNA Control Consortium (ERCC) is an ad-hoc group with approximately 70 members from private, public, and academic organizations. The group is developing a set of external RNA control transcripts that can be used to assess technical performance in gene expression assays. The ERCC is now initiating the Testing Phase of the project, during which candidate external RNA controls will be evaluated in both microarray and QRT-PCR gene expression platforms. This document describes the proposed experiments and informatics process that will be followed to test and qualify individual controls. The ERCC is distributing this description of the proposed testing process in an effort to gain consensus and to encourage feedback from the scientific community. On October 4-5, 2005, the ERCC met to further review the document, clarify ambiguities, and plan next steps. A summary of this meeting and changes to the test plan are provided as an appendix to this manuscript.

Bacteria↗
PubMedDate not supplied

Motion segmentation in artificial and biological system.

In the early steps of visual information processing motion is one of the most important queues for the development of spatial representations. Obstacle detection and egomotion estimation are only two examples of the powerfulness of visual motion detection systems. The underlying process of information extraction has to be active due to the observer's capabilities of egomotion. This means that the observer's motion has an impact on the projected retinal motion field. Therefore one of the challenging tasks for biological as well as for technical vision systems is to couple retinal motion and egomotion and to uncouple egomotion and object motion. The following sections describe a model that couples visual motion processing with the egomotion parameters of a moving observer. Beneath a theoretical introduction of the model an application to traffic scene analysis is presented. At last the paper relates the model to biological motion processing systems.

Animals↗
PubMed2005

[Pathological diagnosis of leprosy in developing countries].

In the developing countries where leprosy is prevalent, diagnosis of leprosy is made from clinical signs and symptoms. However, when difficult and doubtful cases increase after the advance of leprosy control programs, definitive diagnosis of leprosy by histopathology become necessary. This report describes our experience of technical support to re-establish histopathology service and introduction of immunohistochemistry in the leprosy referral center of Myanmar, and we discuss the ideal way of international technical support. This activity was performed as a part of leprosy control and basic health services project of Japan International Cooperation Agency (JICA) since 2000 to 2005.

Clinical Laboratory Techniques↗