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PubMed2000

The foreign body reaction to a biodegradable biomaterial differs between rats and mice.

Before a biomaterial can be applied in the clinic, biocompatibility must be tested in in vivo models, by monitoring the foreign body reaction. In this study, we compared the foreign body reaction (FBR) to the biodegradable biomaterial hexamethylenediisocyanate crosslinked dermal sheep collagen (HDSC) between several strains of rats and mice. HDSC disks were implanted subcutaneously on the backs of AO, BN, F344, LEW, and PVG rats and on the backs of 129 SVEV, BALB/c, and C57BL/6 mice. Materials were explanted after 7, 14, 21, and 28 days and processed for (immuno) light and transmission electron microscopic evaluation. In all rat strains, giant cell formation and phagocytosis of HDSC bundles were comparable. In addition, in the PVG rat, many plasma cells infiltrated the HDSC disks. Only a few T cells were present in AO and PVG rats, whereas, in F344 and LEW rats, the presence of T cells was more pronounced. BN rats showed an intermediate T-cell infiltration. In mice, the FBR to HDSC was comparable between the different strains. Compared with rats, giant cell formation was limited, whereas stroma formation was more abundant. Phagocytosis of HDSC bundles rarely occurred in mice, whereas calcification was observed more often. It is concluded that the FBR to HDSC clearly differs between rats and mice. This has consequences for assessment studies on biocompatibility and also on fundamental biomaterial research.

Absorbable Implants↗
PubMed1977

Foreign body in the airways: a review of 90 cases.

Despite the progress made in the fields of endoscopy and anesthesia for children, as well as the accumulated experience, the inhalation of foreign bodies remains a serious and often dramatic problem. Every case varies to some extent, and only general conclusions may be drawn. The retroactive analysis of the documents from every case that was treated at the Ear, Nose, and Throat Clinic of the Aristotelian University from 1970 to 1975, as well as the comparative statistical study, show common characteristics shared by all 90 cases under consideration. In these cases, the foreign body was of organic origin (mainly seeds and dry fruits) and particularly pumpkin seeds (25% of all cases). Half of the patients sought hospitalization, with a delay varying from two days to four months, while localization varied (larynx, 11 cases; trachea, 10; bronchus, 69). Localization in the left bronchus was more frequent than in the right one, especially in children. The diagnosis was based on the case history, clinical examination, and radiologic findings, while in the majority of the cases, the treatment involved bronchoscopy, the removal of the foreign body, and treatment of lung problems in delayed cases.

Adolescent↗
PubMed2000

[Vesicovaginal fistula due to a vaginal foreign body: a case report].

An 18-year-old female consulted a clinic complaining of pollakisuria and urinary incontinence. She was referred to our department for operation under the diagnosis of vesicovaginal fistula due to a vaginal foreign body confirmed by intravenous pyelography and cystoscopic examination. About 7 months earlier, she inserted a hair spray can into the vagina but could not remove its cap. The vaginal foreign body was transvaginally removed. After 2 months, transabdominal repair of the vesicovaginal fistula was performed. After operation, dysuria and urinary incontinence were not observed. Few cases of vesicovaginal fistula due to a foreign body in the vagina have been reported, and there have been only 6 reported cases in Japan including ours.

Adolescent↗
PubMed1997

Oesophageal "cross"--a sinister foreign body.

A young jail inmate purposely ingested a foreign body formed of sewing needles, specially designed to be arrested in the gut and cause perforation. Immediate surgical removal of such ingested foreign objects is recommended because the chances of distal passage are nil.

Adult↗
PubMedDate not supplied

Removal of a colonic foreign body by enteral lavage.

A 14-year-old boy was evaluated for the presence of a foreign body in the descending colon. It successfully passed after oral colonic lavage solution (Golytely), obviating endoscopic intervention. The approaches to colonic foreign body removal are reviewed.

Adolescent↗
PubMedDate not supplied

Unexplained heterochromia. Intraocular foreign body demonstrated by computed tomography.

Standard radiographic techniques are often inadequate in demonstrating the presence and location of intraocular foreign bodies. Computerized axial tomography was used to confirm the presence of a metallic foreign body in a patient with heterochromia iridis and suspected ocular siderosis in whom no foreign material was found by conventional examination methods.

Adult↗
PubMed2000

Encounters with challenging bronchial foreign bodies: impromptu adaptation of technique.

We present a retrospective review of 2 cases of unusual foreign bodies and discuss methods needed for successful removal of the objects. The review stresses the need for preparation in managing difficult and unexpected situations. Specific instrumentation as well as surgical resourcefulness provided for successful removal of a carrot fragment in one instance and a plastic bead in the other. The need to individualize tracheobronchial foreign body extraction is stressed, as is the importance of keeping some of the "old-time" instruments in one's instrument cabinet.

Bronchi↗
PubMedDate not supplied

Impression materials for removal of aural foreign bodies.

A new method for removal of aural foreign bodies is introduced, employing the injection of a semifluid impression material into the external auditory canal, and its removal after curing with the engulfed foreign matter. This technique obviated the need for a general anesthetic in some pediatric cases, while in others it was just a more pleasant experience.

Acrylic Resins↗
PubMed1999

Respiratory foreign bodies and Eikenella corrodens brain abscess in two children.

We report the coexistence of aspirated foreign bodies and brain abscess in two boys. One child had aspirated a metallic needle, and in the other boy partially embedded sunflower seeds were found in the bronchial wall. Both patients had growth of Eikenella corrodens (oral gram-negative flora) from the abscess. Aspirated foreign body in the respiratory tract should be one of the diagnostic considerations if any of the normal oropharyngeal organisms such as E. corrodens is the causative organism of brain abscess.

Anti-Bacterial Agents↗
PubMed2004

Large wooden foreign body in the hand: recognition of occult fragments with ultrasound.

A 37-year-old man with pain and swelling of the thenar was referred to the emergency department. On ultrasound a 3 x 1 x 0.2 cm large wooden foreign body was depicted in the thenar region. In addition, ultrasonography (US) was able to show multiple smaller fragments adjacent to the larger foreign body. To give a better overview of the position relative to tendons and muscles, CT with soft tissue window settings was performed. CT gave a good anatomic overview but was not able to show the smaller fragments. A total of six additional fragments were depicted at US. Performing US is mandatory in patients with penetrating injuries by foreign bodies because it is very sensitive. Using US in an emergency setting can avoid retained fragments and depict other soft tissue complications.

Adult↗
PubMed1983

[Role of a microbial factor, necrotic tissue and a foreign body in the development of wound suppuration].

The effect of microorganisms, necrotic tissues and a foreign body on the development of festering process in rat wounds was studied. It was found that the presence of necrotic tissues is the necessary and sufficient condition for a clinical manifestation of infection in rat wounds. Additional infection of the wounds and introduction of a foreign body did not appreciably change the clinical picture. A model is suggested of a festering wound in rats without artificial infecting. In the festering wound, one could observe the replacement of the gram-positive coccal microflora by the gram-negative one. Meanwhile the gram-positive coccal microflora was predominant in the non-festering wound. The level of potential biochemical indicators of infection in the blood of animals with festering wounds was higher than in the blood of those with non-festering wounds. The morphology, and the content of microbial cells, the content of nucleic acids, and total proteolytic activity in festering wound tissues were examined over time.

Animals↗
PubMed2002

Impacted foreign body in the hypopharynx and oesophagus.

We report a rare case of an unusual impacted foreign body (titanium mesh stent) in the hypopharynx and upper oesophagus of a 66-year-old gentleman. He was a known patient with carcinoma of the mid-oesophagus admitted under the gastroenterologists for dilatation of the carcinomatous stricture with a stent. During the procedure the titanium mesh spring coil got displaced and was impacted in the retropharyngeal space, submucosally in the hypopharynx and upper oesophagus. He was referred to us for surgical removal of the stent, which he underwent successfully. We believe this to be the first case of such an unusual foreign body to be reported in the literature.

Aged↗
PubMed2002

Management of tracheo-bronchial foreign bodies in children.

OBJECTIVES: To review alternative surgical and anaesthetic options in the management of foreign bodies lodged in the tracheobronchial tree in children aged below 10 years. DESIGN: A five year retrospective secondary data analysis. SETTING: Three hospitals based in Eldoret Municipality, Kenya. MAIN OUTCOME MEASURES: Outcome variables included morbidity and mortality. RESULTS: Of the thirty two children studied, 74.1% had bronchoscopy and 25.9% thoracotomy. The overall mortality rate was 3.3%. CONCLUSION: Foreign bodies in the tracheo-bronchial tree are a major cause of morbidity and mortality in children aged below 10 years. In settings where appropriate equipment is inadequate, timely thoracotomy may be life saving.

Age Distribution↗
PubMed1987

Retained foreign body in a child.

We present the case of a child who ingested or inhaled a foreign body that lodged between the esophagus and the trachea for more than 23 months. The only presenting complaint was of recurrent upper respiratory tract infections. The patient, a 3-year-old girl, required a tracheostomy to alleviate respiratory distress. She made a complete recovery after surgical removal of the foreign body through a neck incision.

Child, Preschool↗
PubMed1979

Chronic foreign body aspiration diagnosed by lung scan.

The case of a two-year-old child with foreign body aspiration is presented. It was complicated by a delay in diagnosis and treatment. Lung scan was helpful in eventually establishing the diagnosis. Key points in the management of patients with foreign body aspiration are reviewed and pathophysiologic mechanisms are discussed.

Bronchoscopy↗
PubMed1983

Management of foreign bodies and trauma of the rectum.

A series of 101 patients with trauma of the rectum, secondary to homosexual practices, presenting at this hospital and medical center is reviewed. Two patients were injured twice. Thirty-six patients had retained foreign bodies in the rectum, 55 had lacerations of the mucosa, two had disruptions of the anal sphincter and ten had perforations of the rectosigmoid. The majority of retained foreign bodies can be removed on an outpatient basis. If removal is not immediately possible, the patient should be admitted for observation and removal of the foreign body transanally under anesthesia. Routine sigmoidoscopic examination is performed after removal. Removal seldom requires laparotomy. Simple nonbleeding lacerations of the mucosa can be managed on an outpatient basis. Patients with abdominal pain, fever, continued bleeding, large lacerations or tear of the sphincter should be admitted and observed or operated upon, or both, as needed. Serious injuries, secondary to homosexual acts, can and do occur, as evidenced by the mortality reported in this series. Perforations of the rectosigmoid above the peritoneal reflection can be treated by laparotomy, repair of the perforation, removal of gross contamination by irrigation, proximal loop colostomy and appropriate antibiotic therapy. Perforations below the peritoneal reflection are challenging instances which require individualized management.

Adolescent↗