Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Alcoholic Intoxication”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,765 records · Page 98Linked to original sources
PubMed1996

Traumatic baso-brainstem subarachnoid haemorrhage.

Traumatic basal subarachnoid haemorrhage is an uncommon disorder that is well described in the forensic literature. The aetiology traditionally has been a relatively minor blunt trauma which is sustained typically at the level of the base of head and injures the arterial system to the brain. The site of trauma may be occult and not always demonstrable. In the case discussed, an acute baso-brainstem subarachnoid haemorrhage was caused by a severed extracranial vertebral artery due to a stabwound injury to the upper neck. A gravitational factor and alcohol intoxication, which might contribute to the basal intracranial haematoma, is given a novel thought.

Adult↗
PubMed1981

A non-invasive method of qualitative and quantitative measurement of drugs.

Methods for quick qualitative and quantitative evaluation of drug intake are needed, especially during emergency situations such as drug overdose and alcohol intoxication. The electronystagmograph was used in an attempt to develop a non-invasive method for identification of drug intake, and to study the effects of alcohol and other drugs on the vestibular system. Results of the study reveal that alcohol, diazepam, opiates, barbiturates, cocaine, marijuana, and hallucinogenic drugs produce a characteristic printout pattern which can be evaluated qualitatively. This method is a practical, non-invasive, objective procedure that provides rapid assessment of quality of drug intake. Its potential uses are extensive, including such possibilities as evaluation of drug intake in emergency drug overdose situations, monitoring anesthesia during surgery, evaluating drug intake in women about to deliver, (as well as the effects on the newborn), and determining whether or not persons who are being tested on a polygraph are under the influence of drugs.

Alcoholic Intoxication↗
PubMed1993

Alcohol and cocaine interactions in humans.

The effects of 100 mg of intranasal cocaine (COC) in acute alcohol intoxication (1 g/kg) was assessed in nine experienced and non-dependent healthy volunteers in a double-blind, controlled, randomized, cross-over clinical trial. Alcohol alone impaired psychomotor performance, whereas COC alone produced subjective effects related to euphoria and well-being, improved the reaction time and increased heart rate and blood pressure. The combination of COC and alcohol induced a nonsignificant decrease in the subjective feelings of drunkeness, an increase in COC-induced euphoria, a significant improvement in alcohol-related changes in psychomotor performance and a marked increase in heart rate. Subjects experienced subjective and performance effects that could be self-interpreted as more pleasant compared to the effects of alcohol alone. When alcohol was given simultaneously, COC plasma levels were higher (possibly as a result of an inhibition of hepatic metabolism of COC produced by alcohol), norcocaine plasma levels almost doubled and cocaethylene was detected in plasma, so that its basic pharmacokinetic profile could be described. The simultaneous use of both drugs produced changes in heart rate and blood pressure that could increase the risk of cardiovascular toxicity associated with the use of COC.

Adult↗
PubMed1998

Effect of alcohol on bacterial translocation in rats.

Bacterial translocation has been proposed to be important in the pathophysiology of sepsis, as well as to be a consequence of sepsis. To study the effect of alcohol on bacterial translocation from the gut, normal Sprague-Dawley rats were administered alcohol by gavage by two regimens: Acute (3.7 g/kg, one dose) or Subacute (1 of 2 doses, 2.4 or 3.7 g/kg/day once daily for 14 days). Mesenteric lymph node cultures were performed, and portal venous blood was assayed for endotoxin. Ileal and cecal permeability studies were performed in the Acute and Subacute groups using fluorescein isothiocyanate-labeled dextrans of either 4,000 or 70,000 kDa size. As an index of the effect of systemic endotoxin, tissues from mesenteric lymph nodes, liver, and intestinal Peyer's patches were assayed for the presence of mRNA for tumor necrosis factor. Additionally, because extrapulmonary sepsis has been shown to suppress pulmonary antibacterial defenses, animals in the Subacute group were challenged by aerosol inoculation with Pseudomonas aeruginosa to determine bacterial clearance and alveolar cellular responses. The results show that neither of the alcohol regimens resulted in bacterial growth from mesenteric lymph nodes or portal blood. Animals in the Subacute group had more endotoxin present in portal blood than did the Control group (92.9 pg/ml vs. 40.2 pg/ml; p < 0.02). None of the animals had demonstrable mRNA for tumor necrosis factor in any of the tissues assayed. There were no demonstrable increases in ileal or cecal permeability for either the small or large molecular weight dextran in either alcohol group. Furthermore, there was no delay in the clearance of P. aeruginosa from the lung in the Subacute group, but these animals recruited fewer neutrophils into the airspaces in response to this challenge than did the Control animals. Thus, alcohol intoxication does not result in bacterial translocation from the gut in this model. Despite higher levels of portal venous endotoxin in the animals in the Subacute alcohol group, no adverse systemic consequences of this phenomenon could be demonstrated.

Alcohol Drinking↗
PubMed1994

Alcohol and aggression: effects of personal threat on human aggression and affective arousal.

Theorists have attempted to account for the relationship between alcohol intoxication and a wide range of aggressive behaviors by ascribing alcohol-related aggression to the disinhibiting effects of alcohol and to its disruptive effects on cognitive processes. Allocation of attention and situational threat have been thought to mediate alcohol-related aggression. In the present study, 72 male social drinkers received either alcohol, a placebo, or a nonalcoholic beverage and were exposed to either threatening or nonthreatening personal information. Measuring levels and duration of aggressive responses on a Taylor-Buss aggression machine, intoxicated subjects were found to be generally more aggressive under threatening than under nonthreatening information conditions. Intoxicated subjects also reported relatively large increases in anger, depression, and tension following the aggression task, which appeared to be affected by the type of information received. These findings concur with and refine previous models suggesting that alcohol focuses the drinker's attention to salient cues in threatening circumstances, thus increasing the likelihood of aggressive behavior.

Adult↗
PubMed2004

[Morphometric characteristic of some structures of the human brain in normal conditions and in acute ethanol intoxication].

In order to establish the neuro-stromal interrelations in the human brain under normal conditions and after extreme influences, different parts of this organ were studied in 14 persons who died suddenly and in 20 persons who died of ethyl alcohol poisoning. A complex of histological, histochemical, planimetric and morphometric methods were used. The specific area of normal neurocytes was shown to be the largest in the medulla oblongata, while that one of the fibers--in the cerebral cortex. Vascularization of the latter is minimal, being much higher in the medulla oblongata. In alcohol intoxication, the area, occupied by neurocytes, was decreased in the cerebral cortex, thalamus and cerebellum due to the destruction of some portion of these cells. In the medulla oblongata neurocytes appear to be more resistant to ethanol. The capillary diameter in the brain areas studied decreased because of the drop in the tone of cerebral arteries, but the number of these vessels per standard area of section was increased as a result of compensatory opening of reserve capillaries.

Adult↗
PubMed1999

Q.E.D. Alcohol test: a simple and quick method to detect ethanol in saliva of patients in emergency departments. Comparison with the conventional determination in blood.

OBJECTIVE: The aim of this pilot study was to assess whether ethanol concentrations in saliva are comparable to those in blood and to evaluate whether this new non-invasive saliva alcohol test is suitable for use in emergency departments. DESIGN: Prospective, open, non-randomised study. SETTING: University hospital emergency department. PATIENTS AND METHODS: 100 consecutive patients who were admitted to the emergency department whose smell and/or behaviour indicated alcohol abuse. Fifteen patients participated as a control group after they were asked to abstain from alcohol consumption for 24 h before the study. INTERVENTIONS: Blood and saliva samples were obtained at the same time for ethanol measurement. The Q.E.D. Alcohol Test A350 was used in order to measure the concentration of ethanol in saliva. Blood samples were analysed by the alcohol dehydrogenase method. RESULTS: The mean difference between the ethanol levels in blood and saliva was -0.1 mg/dl, whereas the values measured in saliva were on average 0.1 mg/dl higher than those measured in blood (p = 0.002). CONCLUSION: The Q.E.D. Alcohol Test A 350, which uses saliva, is well suited for quantitative determination of alcohol levels. The levels measured in saliva correlate well with those measured in blood at both the lower and the upper end of the scale. Because this test is quick and easy to perform by emergency room personnel and the results are accurate enough for clinical purposes, it should prove valuable to determine whether impaired consciousness is related to alcohol intoxication or to other likely causes.

Adolescent↗
PubMed1992

Enzymatic production of acetaldehyde from ethanol in rat brain tissue.

The capacity for the brain to produce acetaldehyde (AcHO) from ethanol was determined in rat brain homogenates. Rat brains were perfused with saline-heparin solution and homogenized in a phosphate buffer. Varying amounts of tissue were incubated with ethanol (0-100 mM) for periods of up to 60 min. The reaction was stopped by the addition of desferrioxamine and ice-cold perchloric acid. Supernatants were treated with dinitrophenylhydrazine reagent, extracted with isooctane in the presence of an internal standard, and the derivatives were separated by HPLC. The addition of 4-methyl pyrazole (an alcohol dehydrogenase inhibitor) or metyrapone (a cytochrome P450 inhibitor) had no effect on the amount of recovered AcHO. On the other hand, treatment with the catalase inhibitors sodium azide, cyanamide, or 3-amino-1,2,4-triazole blocked the production of AcHO while the addition of exogenous peroxide or a peroxide-generating system enhanced the production of AcHO. Overall, these results suggest that AcHO may be produced in the brain during alcohol intoxication, through the action of the enzyme catalase.

Acetaldehyde↗
PubMed1983

Validity of injury data collected by interview: a study of men born in 1913 and 1923.

An investigation of the validity of anamnestic injury data with special reference to head injuries, was performed, as part of an epidemiological population study of middle aged men. Injury data collected by interview were checked against control data from an emergency department, covering a 7-year period. About 65% of head injuries in the control data set, and 60% of all types of injuries were reported. Injury severity, alcohol intoxication, ambulance transportation and recall period were factors which tended to influence the reporting frequency.

Aged↗
PubMed1994

Decerebrate posturing in alcoholic coma.

Two cases of alcoholic coma are presented where extensor responses to noxious stimuli are demonstrated. Decerebrate posturing normally indicates severe structural or functional depression of midbrain function but can be caused by depressant drugs. Blood alcohol measurements are a vital test in the comatose patient as the clinical picture may be caused, or temporarily significantly worsened, by severe alcohol intoxication. The preservation of pupillary light reflexes in the presence of deep coma with decerebrate posturing should alert the clinician to a possible metabolic cause for the coma, including alcohol. Nevertheless, a diagnosis of alcoholic coma should not be made unless the blood alcohol concentration is grossly elevated and other causes of coma have been excluded by careful physical examination, blood glucose and electrolyte measurement, skull radiography and, in the absence of a rapid improvement, computerized tomography.

Adult↗
PubMed1985

Alcohol effects on plasma luteinizing hormone levels in menopausal women.

Plasma luteinizing hormone (LH) levels were determined in five healthy post-menopausal adult females prior to, during, and following a period of acute alcohol intoxication. LH levels were also determined in the same women following acute administration of a nonalcoholic beverage which had identical isocaloric value of alcohol. Plasma samples were collected at 30-minute intervals from an indwelling intravenous catheter from 120 minutes prior to alcohol or isocaloric beverage administration to 300 minutes following beverage intake. All women became moderately intoxicated after acute alcohol administration and developed peak blood alcohol levels of 94 mg per dl between 60 to 90 minutes following alcohol intake. LH levels determined before administration of alcohol or isocaloric beverage were not significantly different and were within the range of normal values for healthy, post-menopausal women. No significant differences were found between LH levels following alcohol administration when compared with LH values after isocaloric beverage. These data indicate that acute alcohol intake which produces blood alcohol levels slightly below usual legal limits of intoxication does not suppress LH in post-menopausal females. Since post-menopausal females do not have significant estradiol feedback control of LH secretory activity, and since LH secretory activity in post-menopausal women (in contrast to pre-menopausal females) is more sensitive to the inhibitory actions of drugs which may affect adrenergic and dopaminergic pathways in brain, the findings obtained in this study do not support an acute alcohol effect upon hypothalamic-pituitary modulation of gonadotrophin release in humans.

Ethanol↗
PubMed1993

[The clinical and sociodemographic characteristics of alcoholism patients who have committed illegal acts].

Clinical and statistical surveys of 330 patients with alcoholism who made illegal acts when they were alcohol-intoxicated have revealed that there is a relationship of the frequency and degree of illegal acts with clinical progressive features of a diseases and sociodemographic characteristics of patients and defined organizational measures for their prevention. The most severe illegal acts are made by patients with Stage II alcoholism with a progressive course and a short disease duration. The changed pattern of intoxication with its involvement into the clinical picture of epileptoidicity phenomena increases risks for them to make illegal acts. There is a relationship between the making criminogenic acts by alcoholics and their age, education level, social activity, and marital status. A risk group as to illegal acts has been identified among alcoholic patients.

Adult↗
PubMed1983

Effect of acute ethanolism on the hospital course and outcome of injured automobile drivers.

Acute ethanolism in automobile drivers is purported to be both protective and detrimental in susceptibility to injury from an accident. The potential influence of acute intoxication (serum ethanol greater than 100 mg/dl) on pattern and severity of injury, hospital course, and long-term outcome, including mortality, was examined in 182 consecutive automobile drivers requiring admission to a regional university trauma center during 1980. Significantly more drivers were intoxicated than not, 61% vs. 39%. Similarly, more than 75% of the intoxicated drivers were young males and more than 80% of the intoxicated drivers were felt to be negligent and at cause for the accident. However in this series, the patterns and severity of injuries, hospital course, and late outcome were unaffected by the patient's blood alcohol level. Acute alcohol intoxication apparently neither protected nor hindered the response to injury in these motor vehicle drivers.

Accidents, Traffic↗
PubMed1996

[Changes in the spectrum of alcohol-induced traffic accidents in relation to blood alcohol level].

A retrospective study was undertaken to determine whether the degree of alcohol intoxication has an effect on the driving performance with regards to both the quantity and quality. A total of 625 accidents caused by drivers who were under the influence of alcohol were reviewed. They were divided into three groups according to the blood alcohol concentration (BAC):0.30 - 1.09 g/kg, 1.10 - 1.99 g/kg and > 2.00 g/kg. In order to exclude the influence of factors unrelated to alcohol, the groups were matched for age, sex, location of accident and the light and road conditions. This resulted in a total of 85 accidents in each group. The accidents were classified with reference to the "Register of causes of accidents" used in road accident statistics. The three groups differed significantly in their causes of accidents (p < 0.025), although those due to speeding dominated in each group. In the group with low BAC, the next most common accidents were the ones caused by failure to give way. In the group with medium BAC, rear-end collisions and accidents occurring during low speed manoeuvres were the second most common. In the group with highest BAC, the next most common causes of accidents were the leaving of the correct traffic lane unassociated with speeding.

Accidents, Traffic↗
PubMed1981

Acute alcohol intake and pituitary gonadal hormones in normal human females.

Plasma prolactin, luteinizing hormone and estradiol levels were determined in six normal adult females before and during a period of acute alcohol intoxication. Plasma hormone levels found in these studies were compared with values obtained after administration of an isocaloric beverage. Each woman served as her own control for both studies which were carried out on the same day of the menstrual cycle (day 8, 9 or 10) over two consecutive menstrual cycles. Integrated plasma samples were obtained every 20 min for 6 consecutive hr before acute alcohol administration and during the ascending, peak and descending portions of the blood alcohol curve. After acute alcohol administration, all women achieved a moderate degree of intoxication, with mean peak blood alcohol levels of 88 mg/100 ml. No significant differences in levels of luteinizing hormone and estradiol were detected during any phase of the blood alcohol curve when compared to prealcohol administration values. No significant differences were found between luteinizing hormone and estradiol after alcohol administration when compared with values obtained after isocaloric beverage. The only significant difference in hormone levels was a small elevation in prolactin during the descending phase of the blood alcohol curve when nausea and vomiting coincident with alcohol-induced intoxication occurred. These data contrast sharply with the significant effects of acute alcohol intake on pituitary gonadal hormones in normal human males.

Adult↗
PubMed1991

For better or worse: attributions about drunken aggression toward male and female victims.

Research on attributions about drunken violence has suggested that intoxication serves to decrease responsibility attributed to aggressors while increasing responsibility attributed to victims. In this study, we used a scenario depicting a violent interaction in which intoxication of aggressor and victim and victim sex were varied. Subjects made attributions of blame, causality, responsibility, and normative judgements about aggressor and victim. In general, drunkenness made things worse for the intoxicated person in terms of observers' judgments: A drunken aggressor was blamed more than a sober aggressor, an intoxicated victim--whether male or female--was blamed more than a sober victim, and aggression toward a drunken victim was rated as more acceptable than aggression toward a sober victim. Results are discussed in terms of the use of alcohol intoxication as a gender-independent cue to blame the victim, and the increasing societal disapproval of drunkenness.

Aggression↗