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Results for “AMITRIPTYLINE”

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At least 1,765 records · Page 98Linked to original sources
PubMed1976

[Amitriptyline in the treatment of anxiety and insomnia anal as a tranquilizer].

Thirty out patients were selected in a psychiatric hospital among those presenting insomnia, anxiety, psychomotor retardation, loss of drive and anxiety with somatic manifestations. Amytryptyline was administered in 25 mg tablets, one to four times a day, for twelve weeks. Results were satisfactory as observed from the second week; side effects were minimal. We can conclude that amytryptyline is of great effectiveness in the treatment of the neurotic illnesses most commonly observed in clinical practice.

Adolescent↗
PubMed1976

[Clinical evaluation of amitriptyline in the treatment of psychogenic disorders].

Clinical evaluation of amytyptiline in the treatment of psychogenic disorders was performed, using one or more 25 mg doses daily per os. Of the patients, 19 were male and 11 female; ages were between 18 and 55. Treatment for each lasted 12 weeks, and clinical improvement was observed from the second to the fifth week, with mild side effects that did not require treatment. Psychotherapy was instituted during treatment. ;inal results were: 23 good improvement, 4 some improvement and 3, no change.

Adolescent↗
PubMed1976

[Amitriptyline in the treatment of depression].

Oral tryptyline was evaluated clinically in the treatment of 14 male and 16 female patients; ages were 17 to 52 years the males and 32 to 59 years the females. Four had had no prior antidepressive treatment and the rest had had medication with poor to no results. The study ran for 12 weeks, with 15 patients showing improvement by the fourth week, 8 by the fifth week, 1 by the sixth; 5 showed no change. Side effects disappeared adjusting the dosage. Seventeen patients showed total improvement, 8 moderate improvement and 5 showed no change.

Administration, Oral↗
PubMed1976

[Amitriptyline hydrochloride in the treatment of anxiety and insomnia and as a tranquilizer].

An open, non-comparative study with weekly clinical evaluations was made in 30 patients of both sexes aged between 16 and 70 years. The only medication used to treat anxiety was Amytryptiline HCl. 23 patients completed 12 weeks of treatment and 7 abandoned it before completion. Dosages varied between 25 and 100 mg daily, with median dose being 50 mg. Twenty-three patients showed mild side effects that disappeared without specific treatment. Improvement began the first or second week; at the end of 12 weeks, 17 patients were considered cured, 16 improved and 7 with no change.

Adolescent↗
PubMedDate not supplied

[Effect of therapeutic drug monitoring of amitriptyline and genotyping on efficacy and safety of depression therapy].

Modern pharmacotherapy is based on precise adjustment of a dosage schedule to individual requirements of patient. Therapeutic drug monitoring is a method that allows for a more effective treatment approach, especially in the case of a narrow therapeutic index of a drug. Tricyclic antidepressant drugs are characterised by narrow therapeutic index as well as relationship between serum drug concentration and side effects. It was demonstrated that interindividual variability of blood concentrations of tricyclic antidepressant drugs is related to genetic polymorphism of oxidating enzymes participating in metabolism of these drugs. The aim of the study was to estimate the impact of therapeutic drug monitoring of tricyclic antidepressant drugs as well as genotyping on efficacy and safety of endogenous depression therapy. The study included 9 patients with established diagnosis of endogenous depression. Blood serum concentrations of amitryptyline was measured by fluorescence polarisation immune assay (FPIA, Abbott system). Genotype of cytochrome P450 isoenzyme CYP2D6 was determined using PCR-RFLP method. It was demonstrated that monitoring therapy of tricyclic antidepressant drugs in combination with determination of the genotype seems to be more safe and effective. Monitoring therapy and genotyping may be less expensive than the costs of prolonged hospitalisation and risk of side effects.

Adult↗
PubMed2001

Prolonged coma and loss of brainstem reflexes following amitriptyline overdose.

Severe tricyclic antidepressant (TCA) overdose is generally manifested by cardiovascular and/or central nervous system toxicity. Although the majority of patients who are comatose following these overdoses regain consciousness within 24 h, this case had 5-days of coma with associated loss of brainstem reflexes. Severe central nervous system depression can occur as a sole manifestation of TCA overdose without concomitant cardiovascular toxicity.

Adult↗