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PubMed2005

Thoracic adolescent idiopathic scoliosis curves between 70 degrees and 100 degrees: is anterior release necessary?

STUDY DESIGN: A retrospective review of adolescents with main thoracic scoliotic curves surgically treated with either anterior release and posterior fusion or posterior fusion only. OBJECTIVES: To compare the radiographic and clinical outcomes of two surgical treatments: anterior-posterior spinal fusion (APSF) versus posterior spinal fusion (PSF) alone in patients with large 70 degrees to 100 degrees thoracic adolescent idiopathic scoliosis (AIS) curves. SUMMARY OF BACKGROUND DATA: Surgical treatment of thoracic AIS curves between 70 degrees and 100 degrees often consists of anterior and posterior fusion to improve the coronal correction and fusion rate, with the anterior release and fusion performed through either an open thoracotomy or by video-assisted thoracoscopy. METHODS: All patients (n = 84) with main thoracic major AIS curves between 70 degrees and 100 degrees who underwent spinal fusion (APSF or PSF) at one center between 1987 and 2001 were included for analysis. The minimum follow-up was 2 years after surgery (mean, 4.5 years; range, 2.0-10.2 years). The mean age of patients was 13.8 years (range, 10.7-18.2 years), with 66 females and 18 males. Multiple radiographic measures were assessed. The primary and secondary statistical analyses performed were nonparametric analyses, using the Wilcoxon-Mann-Whitney tests for the primary analysis of APSF and PSF groups. The PSF subgroup analysis was performed with the Kruskal-Wallis test. RESULTS: There were 22 patients in the APSF (open ASF in 18, and video-assisted thoracoscopy in 4) group and 62 patients in the PSF group. There were no statistically significant differences between the groups for gender, age, number of levels fused, Cobb measurement of preoperative coronal or sagittal thoracic curve magnitude, or coronal curve flexibility. The APSF group, when compared with the PSF group, had greater intraoperative correction of the coronal curve (48.3 degrees vs. 38.7 degrees, P = 0.0087) as well as final overall correction (47.2 degrees vs. 34.2 degrees, P = 0.0008). There were no significant differences seen in the sagittal alignment from T5-T12 (P = 0.3150) or the SRS outcomes data between the APSF and PSF only groups. Subanalysis of the PSF only group identified three distinct groups based on implants: hook-only constructs (n = 36), hybrid constructs of proximal hooks and distal pedicle screws (n = 15), and pedicle screw-only constructs (n = 11). Pedicle screw-only constructs corrected the coronal Cobb measurements more than the other two groups (47.5 degrees vs. hooks 37.7 degrees vs. hybrid 34.4 degrees , P = 0.0110), and to a similar extent as to the APSF group with no statistically significant difference in coronal correction (PSF, 47.5 degrees; APSF 48.3 degrees; P = 0.9014), nor any other parameter except for sagittal T5-T12 changes. There were no reoperations for implant failure/pseudarthroses in any of the patients. CONCLUSION: APSF of large thoracic curves allows greater coronal correction of thoracic curves between 70 degrees and 100 degrees, when compared with PSF alone using thoracic hook constructs, but not with the use of thoracic pedicle screw constructs. Scoliosis surgeons not using pedicle screw constructs need to decide if the modest improvement in coronal correction with a combined approach justifies its routine use in this patient population.

Adolescent↗
PubMed2005

Anatomic changes in lateral spondylolisthesis associated with adult lumbar scoliosis.

STUDY DESIGN: Prospective consecutive series. OBJECTIVE: To analyze the anatomic changes in lateral spondylolisthesis. SUMMARY OF BACKGROUND DATA: Previous studies have focused on the correlation between lateral spondylolisthesis, and curve progression and pain. To our knowledge, there has not been any detailed report concerning anatomic changes in lateral spondylolisthesis. METHODS: We examined 24 consecutive patients (mean age 66 years), with lateral spondylolisthesis associated with lumbar scoliosis who had computerized tomography (CT) after myelography. Coronal reconstruction CT was used to measure the vertebral translation. Vertebral rotation was measured by the Aaro method using transaxial CT. RESULTS: The Cobb angle averaged 26 degrees (range 13 degrees-75 degrees). Lateral spondylolisthesis was found most commonly at the lower-end vertebra. The cephalad-slipped vertebra rotated toward the convex side of the main curve, whereas the caudal vertebra rotated toward the convex side of the lumbosacral hemi (or fractional) curve below. Mean lateral translation and vertebral rotation were 7 mm and 8 degrees, respectively. There was a significant correlation between lateral translation and vertebral rotation (r = 0.49; P = 0.018). The convex superior articular process of the caudal vertebra had compressed the nerve root laterally in 21 patients, of whom 10 had radicular pain. The concave, inferior articular process of the cephalad vertebra had compressed the dural sac posteriorly, and 2 patients had radicular pain. CONCLUSIONS: To our knowledge, this study has been the first attempt to analyze anatomic changes in lateral spondylolisthesis using CT. It may offer further insight into the pathogenesis of adult lumbar scoliosis.

Aged↗
PubMed2006

Relative shortening and functional tethering of spinal cord in adolescent idiopathic scoliosis?: study with multiplanar reformat magnetic resonance imaging and somatosensory evoked potential.

STUDY DESIGN: MR imaging and multiplanar reconstruction were used to evaluate relative length of the spinal cord to the vertebral column in adolescent idiopathic scoliosis (AIS). OBJECTIVES: Ratio of spinal cord length to vertebral column length and position of the cerebellar tonsils were evaluated and correlated with somatosensory cortical evoked potentials (SSEP). SUMMARY OF BACKGROUND DATA: Tonsillar herniation, abnormal anthropometric growth, relative spinal overgrowth, and abnormal somatosensory function have been reported in AIS. All these observations suggest a possible neural origin of the etiopathogenesis of AIS, which can be linked to a disproportional growth between spinal column and cord. METHODS: Two-dimensional sagittal MRI of the spine was performed in 28 AIS patients (14 mild curve; 14 severe curve) and 14 age-matched controls. Measurements of spinal cord, vertebral column length, and tonsillar position were made on reformat images and correlated with SSEP studies. RESULTS: No significant differences in the absolute spinal cord length were found. However, there was significant relative segmental lengthening of the spinal column at the thoracic level in AIS patients with severe curve; hence, ratios of cord to vertebral column length were significantly reduced (P < 0.01). There was high interobserver reliability (0.9); 28% (8 of 28) scoliosis patients had low-lying cerebellar tonsils and abnormal SSEP, respectively. CONCLUSION: There was significantly reduced spinal cord to vertebral column ratios in the AIS patients with severe curve, suggesting a disproportional growth between the skeletal and the neural systems. The relative shortening and functional tethering of spinal cord may play an important role in the etiopathogenesis of AIS.

Adolescent↗
PubMed2006

Spontaneous correction and derotation of secondary curves after selective anterior fusion of idiopathic scoliosis.

STUDY DESIGN: Clinical, rasterstereographic, and radiographic evaluation of spontaneous vertebral derotation of secondary curves in idiopathic scoliosis following selective anterior correction and fusion of the primary curve. OBJECTIVE: To quantify spontaneous vertebral derotation in secondary curves after selective anterior correction with attention to cosmetic outcome. SUMMARY OF BACKGROUND DATA: While the derotational effect of anterior instrumentation techniques on the instrumented curve is well understood, there is a paucity on data of the rotational behavior of the noninstrumented secondary curves. METHODS: A total of 43 patients with idiopathic scoliosis (16 with thoracic curves in group 1 and 27 with thoracolumbar/lumbar curves in group 2) underwent selective anterior instrumentation. Vertebral rotation was analyzed before surgery and, on average, 20 months after surgery using digital radiometric rotation analysis, back shape analysis with rasterstereography, and scoliometer measurement. RESULTS: In Group 1, there was a significant spontaneous vertebral derotation of the secondary lumbar curves by 14.2% (range from 12.7 degrees to 10.9 degrees) in the digital radiometric rotation analysis, surface derotation amounted to 49% (range from 9.6 degrees to 4.9 degrees) in the rasterstereography, and to 70% in the clinical scoliometer measurement (range from 8.0 degrees to 2.4 degrees ). In group 2, there was an increase of rotation of the noninstrumented secondary thoracic curves by 30% (range from 5.0 degrees to 6.5 degrees ) in digital radiometry, by 32.9% in the rasterstereography (range from 8.5 degrees to 11.3 degrees), and a 28.3% increase in scoliometer measurement (range from 6.0 degrees to 7.7 degrees). CONCLUSION: Selective anterior instrumentation and fusion of primary thoracic curves results in satisfactory spontaneous vertebral and high surface derotation of the secondary lumbar curves. However, in primary thoracolumbar or lumbar curves, an increase of both vertebral and surface rotation of the secondary thoracic curve was noted. This increase can impair cosmetic outcome.

Adolescent↗
PubMed2006

Comparison of manual and digital measurements in adolescent idiopathic scoliosis.

STUDY DESIGN: Comparison of manual and digital measurement of radiographic parameters in patients with adolescent idiopathic scoliosis (AIS). OBJECTIVE: To assess the reliability of digital measures as compared to manual measures in the evaluation of AIS. SUMMARY OF BACKGROUND DATA: Radiographic parameters are critical to the evaluation of patients with AIS, and are frequently used to monitor curve progression and guide treatment decisions. The reliability of many of the more common radiographic measures has only recently been elucidated for both manual and digital measures. However, a comparative analysis of manual versus digital measures has been performed only for coronal Cobb angles. The inter-technique reliability of these parameters will have increasing importance as digital radiographic viewing and analysis become commonplace. METHODS: There were 2 independent, blinded observers that measured 30 complete sets of preoperative (posterior-anterior, lateral, and both side-bending) and postoperative (posterior-anterior and lateral) radiographs on 4 different occasions. For the first 2 iterations, manual measurements were taken using the same pencil and protractor. For the last 2 iterations, measurements of digitized radiographs were taken on a software measurement program (PhDx, Albuquerque, NM). Coronal measures included the main thoracic and thoracolumbar/lumbar standing and side-bending Cobb angles, apical vertebral translation, coronal balance, T1 tilt angle, lowest instrumented vertebrae angle, angulation of the disc inferior to the lowest instrumented vertebrae, apical Nash-Moe vertebral rotation, and Risser grade. Sagittal parameters included T2-T5 and T5-T12 regional thoracic kyphosis, T2-T12 thoracic kyphosis, T10-L2 thoracolumbar junction sagittal curvature, T12-S1 lumbar lordosis, and global sagittal balance. The technique-dependent measurement variability and the inter-technique (manual vs. digital), intraobserver reliability were evaluated for each radiographic parameter (within 3 degrees ). RESULTS: Digital measurement showed decreased intraobserver variability for many (9 of 15) of the radiographic parameters assessed. Likewise, digital measures indicated good or excellent correlation with the absolute values obtained with manual measurement for many (10 of 15) parameters. All but 1 of those parameters having moderate-to-poor correlation had been previously shown to have poor reliability, regardless of measurement technique. Statistically significant differences between measurement variability were noted for 6 measures, including 2 favoring digital and 4, manual. Significant differences in the absolute values were noted for 5 measures, determined at a difference of 3 degrees . However, the differences in both parameter variability and absolute values tended to be small and of little clinical significance for manual versus digital measurement. CONCLUSIONS: Digital measurement showed improved measurement precision and good correlation with manual measurements for the majority of AIS parameters. Absolute differences between manual and digital measurements were generally small. Therefore, digital measures are acceptable as a valid technique for scoliosis evaluation. The importance of digital versus manual measurement reliability will increase as digital radiographic viewing becomes more prevalent.

Adolescent↗
PubMed2006

Lack of association between the aggrecan gene and familial idiopathic scoliosis.

STUDY DESIGN: A study was conducted to determine the potential association between a specific aggrecan gene polymorphism and familial idiopathic scoliosis (FIS). OBJECTIVES: To determine the allelic distribution of the exon 12 polymorphism within a sample of families with FIS. SUMMARY OF BACKGROUND DATA: FIS is a structural curvature of the spine where the underlying genetic etiology has not been established. The aggrecan locus has been linked to multiple skeletal disorders. A polymorphism, within the aggrecan gene, was previously reported to be associated with curve severity in individuals with scoliosis. METHODS: Fifty-eight families with FIS were genotyped for the aggrecan exon 12 polymorphism using a polymerase chain reaction method. Model-independent sib-pair linkage analyses and tests of association were performed to analyze the genetic effects of the exon 12 polymorphism. RESULTS: Linkage analyses of a genomic screen performed on a subgroup of 48 families with a most likely to be X-linked dominant mode of inheritance of FIS showed marginally significant results on chromosome 15q25-26 (P < 0.05). The overall distribution of the alleles was consistent with previously reported literature; no evidence of association and marginal significance of linkage was found between the polymorphism and FIS or the degree of lateral curvature. CONCLUSIONS: Despite the negative association reported here, further investigation of the gene and its potential association to FIS is required.

Adult↗
PubMed2006

Prospective radiographic and clinical outcomes of dual-rod instrumented anterior spinal fusion in adolescent idiopathic scoliosis: comparison with single-rod constructs.

STUDY DESIGN: Anterior single or dual-rod instrumentation may be performed for the treatment of main thoracic, thoracolumbar, or lumbar adolescent idiopathic scoliosis (AIS) curves. OBJECTIVE: To compare the results of anterior dual-rod instrumentation in single-major AIS curves with our previous experience using single-rod constructs. SUMMARY OF BACKGROUND DATA: Several reports have described the use of anterior single-rod instrumentation for the treatment of AIS curves with acceptable correction rates but with pseudarthroses/implant failures of up to 31%. METHODS: A total of 60 consecutive patients with AIS (12 males and 48 females; average age 15.3 years) with major thoracic (n = 18) or thoracolumbar/lumbar (n = 42) curves were treated with dual-rod instrumented anterior spinal fusion. Follow-up was 2-5 years. Patients were evaluated prospectively with Scoliosis Research Society (SRS) questionnaires. RESULTS: Major thoracic curves were corrected from a mean of 55 degrees to 27 degrees (51% correction), while major thoracolumbar/lumbar curves were corrected from an average of 51 degrees to 17 degrees at latest follow-up (67% correction). No pseudarthroses were identified. With the use of single-rod constructs, a similar amount of coronal correction was obtained for both thoracic (47%) and thoracolumbar/lumbar curves (70%). However, the pseudarthrosis rate for single-rod constructs was 5.5%. The obvious trend toward a lower pseudarthrosis rate in dual-rod (0/60) versus single-rod (5/90) constructs was not statistically significant (P = 0.07). Follow-up SRS questionnaire data for patients with dual-rod instrumentation showed 95% satisfaction, and 93% would choose the same treatment with similar results in the single-rod instrumentation study, 88% patient satisfaction, and 89% choosing the same treatment. Overall SRS scores improved after treatment (P < 0.01). SRS domain scores improved at a significant level for pain (P = 0.05), self-image (P < 0.01), and function (P = 0.01). CONCLUSION: In this largest, to our knowledge, single-center report of dual-rod constructs for patients with AIS, a similar amount of radiographic deformity correction was obtained when compared to single-rod implants. However, the absence of any pseudarthroses in the 60 patients with dual-rod is a distinct advantage.

Adolescent↗
PubMed2006

Fusionless surgery for scoliosis: 2-17 year radiographic and clinical follow-up.

STUDY DESIGN: Descriptive case series. OBJECTIVE: To determine whether fusionless, multiple vertebral wedge osteotomy can safely obtain correction of the deformity with adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: To our knowledge, no such attempts to manage the AIS with fusionless, vertebral osteotomies have been reported. METHODS: A total of 20 consecutive patients were treated since 1987. Deformity correction, complications, respiratory function, and patient-oriented outcome were investigated. RESULTS: There were 20 patients (17 females and 3 males), including 19 with idiopathic and 1 with syringomyelia scoliosis, who underwent surgery at an average age of 16.4 years and were followed for 8.9 years (range 2-17) on average. There were no neurologic complications. One superficial wound infection necessitated debridement. There were 2 patients converted to posterior instrumentation surgery because of deterioration of the deformity. The average Cobb angle of 64.0 degrees before surgery was corrected to 48.2 degrees at 8.9 years after surgery. Decline of the pulmonary function test after surgery was not statistically significant. The patients' responses to questions about function and pain were favorable. CONCLUSION: Deformity with AIS was safely corrected with fusionless, multiple vertebral wedge osteotomy.

Adolescent↗
PubMed2006

A relook into the association of the estrogen receptor [alpha] gene (PvuII, XbaI) and adolescent idiopathic scoliosis: a study of 540 Chinese cases.

STUDY DESIGN: A genetic association study of estrogen receptor-[alpha] gene (ESR1) with adolescent idiopathic scoliosis (AIS) in Chinese. OBJECTIVES: To investigate whether: 1) PvuII and XbaI polymorphisms in ESR1 are predisposition factor for AIS and 2) these polymorphisms correlate with the severity of curvature in AIS. SUMMARY OF BACKGROUND DATA: A common single nucleotide polymorphism (SNP) in ESR1 (XbaI) was found to be associated with curve severity in Japanese AIS patients recently. The role of ESR1 as a predisposition gene using a case-control design in other ethnic groups is required to confirm the previous associations. METHODS: A total of 540 Chinese AIS girls with Cobb angle above 20 degrees were recruited as cases together with 260 healthy controls. The effect of ESR1 SNPs on severity of scoliosis was analyzed in a subgroup of AIS patients (n = 364) followed up until skeletal maturity with the maximum Cobb angle recorded. Two SNPs in ESR1 were genotyped by PCR-restriction fragment length polymorphism in all subjects. RESULTS: The allelic frequency of X allele was 23% in both case and control groups. The P allele was found at allelic frequency of 40% and 36% in the case and control groups, respectively. No association between the two ESR1 SNPs and the occurrence of AIS by both genotype and haplotype analysis could be established, suggesting that both SNPs were not predisposition alleles for AIS. AIS patients with different genotypes showed no difference in the maximum Cobb angle. No association was found between the genotype and anthropometric measurements in AIS patients. CONCLUSION: The previously reported association with curve severity could not be replicated in our large series of Chinese AIS patients. The current study also did not show any association of the 2 SNPs with increased risk of having AIS.

Adolescent↗
PubMed2006

A prospective assessment of SRS-24 scores after endoscopic anterior instrumentation for scoliosis.

STUDY DESIGN: Prospective clinical case series. OBJECTIVE: To evaluate the clinical outcome of anterior endoscopic instrumention for scoliosis using the SRS-24 questionnaire and to examine how these scores change over a 2-year follow-up period. SUMMARY OF BACKGROUND DATA: Anterior endoscopic instrumentation correction has several advantages compared with open procedures. However, the clinical results of this technique using a validated outcome measure have rarely been reported in the literature. METHODS: A total of 83 consecutive patients underwent endoscopic anterior instrumentation performed at a single unit. Patients completed the SRS-24 questionnaire before surgery and at 3, 6, 12, and 24 months after surgery. The SRS-24 scores were compared between each of the follow-up intervals. RESULTS: The pain, general self-image, and function from back condition domains improved after surgery (P < 0.05). Activity level significantly improved between 3 and 6 months, and both function domains improved between 6 and 12 months (P < 0.05). None of the domains increased significantly after 1 year. CONCLUSIONS: Endoscopic anterior instrumentation for scoliosis significantly improved pain, self-image, and function. The greatest improvement in function occurred between 6 and 12 months after surgery. The SRS-24 scores at 1 year from surgery may provide a good indicator of patient outcome in the long-term.

Adolescent↗
PubMed2006

Comparison of 1-stage versus 2-stage anterior and posterior spinal fusion for severe and rigid idiopathic scoliosis--a randomized prospective study.

STUDY DESIGN: A randomized prospective study. OBJECTIVE: To compare safety, efficacy, and cost between 1-stage and 2-stage anterior and posterior spinal fusion in treating rigid thoracic adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: Retrospective study issued different outcomes comparing 1-stage with 2-stage surgical procedures in treating neuromuscular and congenital scoliosis. A randomized prospective study in AIS has rarely been reported. METHODS.: Twenty-four patients were randomly divided into 2 groups. Group A underwent a 2-stage procedure, group B a 1-stage procedure. Inclusion criteria were: (1) AIS; (2) rigid single thoracic curve, > or =90 degrees on anteroposterior and > or =60 degrees on side bending view; and (3) pulmonary function tests, vital capacity > or =500 mL or FEV1 > or =50%. Exclusion criteria were: (1) curves either <90 degrees on anteroposterior or <60 degrees on bending view; and (2) pulmonary function tests, both vital capacity <500 mL and FEV1 <50%. The mean follow up was 3.3 years (range 2-5.1). Clinical outcomes between the 2 groups were analyzed. RESULTS: A statistical t test demonstrated no significant difference in age (P = 0.299), curves on anteroposterior (P = 0.908), on bending (P = 0.905), after surgery (P = 0.699), and at last follow-up (P = 0.946). No significant difference in blood loss (P = 0.089), transfusion (P = 0.334), operation time (P = 0.172), fusion segments anterior (P = 0.161), posterior (P = 0.546), wound drainage (P = 0.557), thoraco drainage (P = 0.948), and loss of correction at follow-up (P = 0.596). However, significant differences were found in length of stay (P < 0.001), patient cost of hospitalization (P < 0.001) between 2 groups, and curve correction (P < 0.001) in each group. Perioperative complications included 1 patient each with pneumonia, pneumothorax (group A), and ileus (group B). Screw nut loosing was found in 1 patient in group B, but no curve deteriorated. No neurologic deficit occurred in either group. CONCLUSION: A comparison of 1-stage versus 2-stage fusion in treating rigid thoracic curves in AIS did not show significant differences in safety or efficacy but did demonstrate significant difference in length of stay and patient cost.

Adolescent↗
PubMed2006

New rod-plate anterior instrumentation for thoracolumbar/lumbar scoliosis: biomechanical evaluation compared with dual-rod and single-rod with structural interbody support.

STUDY DESIGN: A new rod-plate anterior implant was designed to provide plate fixation at the cephalad and caudal-end segments of a 5-level anterior spine construct. Biomechanical testing was performed on calf spines instrumented with 5-segment anterior scoliosis constructs. OBJECTIVES.: To analyze the initial and post-fatigue biomechanical performance of the new implant, and compare it to an anterior dual-rod construct and a single-rod construct with interbody cages. SUMMARY OF BACKGROUND DATA: Using single-rod anterior instrumentation for thoracolumbar and lumbar scoliosis, an unacceptable incidence of loss of correction, segmental kyphosis, and pseudarthrosis has been reported. Inadequate construct stiffness due to early postoperative bone-screw interface failure, especially at cephalad and caudal-end vertebrae, has been implicated as the cause of these complications. METHODS: Thirty calf spines were instrumented over 5 segments with: (1) single-rod augmented with rod-plate implants, (2) dual-rod construct, and (3) single-rod with titanium mesh cages. Stiffness in flexion-extension and lateral bending modes was determined initially and post-cyclical loading by measuring segmental range of motion (ROM). Post-fatigue screw pullout tests were also performed. RESULTS: In lateral bending, the caudal-end segmental ROM for rod-plate construct was 54% less than single-rod with cages construct (P < 0.05), with no difference between rod-plate and dual-rod constructs. In flexion-extension, the rod-plate construct showed 45% to 91% (initial test) and 84% to 90% (post-fatigue) less ROM than the single-rod with cages construct (P < 0.001). Again, there was no difference between rod-plate and dual-rod constructs at the cephalad and caudal-end segments. Post-fatigue screw pullout strengths of the rod-plate construct were significantly greater than those of the dual-rod and single-rod with cages constructs (P < 0.05). CONCLUSIONS: The rod-plate construct was significantly stiffer and provided greater stability of bone-screw interface than the single-rod with cages construct. It achieved similar stiffness and improved bone-screw interface stability compared to dual-rod construct.

Animals↗
PubMed2004

A tale of two brothers: ultra-long-term follow-up of juvenile idiopathic scoliosis.

OBJECTIVE: The aim of this work was to demonstrate the life-saving benefit of spine fusion for progressive juvenile idiopathic scoliosis. A follow-up of this duration (73 years) has never been previously reported. RESULTS: The properly treated patient is alive and well 73 years after surgery, but the brother whose curve was ignored died of cor pulmonale at age 45. CONCLUSIONS: Properly done spine fusion can save the life of children with progressive juvenile idiopathic scoliosis.

Aged↗
PubMed2004

Radiographic predictors of outcome after long fusion to L5 in adult scoliosis.

Radiographic factors that correlate with outcome following long posterior fusion to L5 for adult scoliosis were investigated. Measurement of thoracic, lumbar, and fractional lumbosacral curves, L5 obliquity, lumbar and L5-S1 lordosis, coronal balance, sagittal balance, and L5-S1 disc height were performed on preoperative, postoperative, and follow-up 36-in posteroanterior/lateral radiographs. Of 16 patients, 14 were female (88%) and 2 male (12%). Average follow-up was 32 months (8-78 months). Scoliotic curves demonstrated stable corrections; however, lumbar and L5-S1 lordosis decreased and sagittal decompensation worsened. Ten patients (62%) had no evidence of transitional degeneration. Six patients (38%) had radiographic evidence of L5-S1 degeneration, and three (19%) underwent revision. Patients with good preoperative sagittal balance, preserved lumbar lordosis, good postoperative fractional curve correction, and L5-S1 disc height preservation are most likely to benefit from posterior fusion to L5, avoiding sacral fusion, for adult scoliosis.

Adult↗
PubMed2005

Allograft bone in spinal fusion for adolescent idiopathic scoliosis.

OBJECTIVE: The purpose of this long-term study was to determine the efficacy of allograft bone for spinal fusion for adolescent idiopathic scoliosis. Prior studies comparing allograft and autograft have been short term. METHODS: This multicenter retrospective study was carried out on 111 patients with 132 total curves fused for adolescent idiopathic scoliosis. Minimum follow-up was 5 years (average 72 months). A variety of segmental instrumentation was used, with most being dual-rod, multiple-hook constructs. RESULTS: Average preoperative curve was 59 degrees with immediate correction to 29 degrees (51%) and final follow-up of 32.24 degrees (45.4%). Average loss of correction was 3.5 degrees (5.9%). There were three pseudarthroses, one infection, and no rod breakage. CONCLUSION: Pseudarthrosis rate of 2.7% and loss of correction of 5.9% are comparable with or better than those in previous reports using autogenous bone graft and either segmental or nonsegmental instrumentation.

Adolescent↗
PubMed2005

Reliability analysis for digital adolescent idiopathic scoliosis measurements.

OBJECTIVE: Analysis of adolescent idiopathic scoliosis (AIS) requires a thorough clinical and radiographic evaluation to completely assess the three-dimensional deformity. Recently, these radiographic parameters have been analyzed for reliability and reproducibility following manual measurements; however, most of these parameters have not been analyzed with regard to digital measurements. The purpose of this study is to determine the intra- and interobserver reliability of common scoliosis radiographic parameters using a digital software measurement program. METHODS: Thirty sets of preoperative (posteroanterior [PA], lateral, and side-bending [SB]) and postoperative (PA and lateral) radiographs were analyzed by three independent observers on two separate occasions using a software measurement program (PhDx, Albuquerque, NM). Coronal measures included main thoracic (MT) and thoracolumbar-lumbar (TL/L) Cobb, SB MT Cobb, MT and TL/L apical vertical translation (AVT), C7 to center sacral vertical line (CSVL), T1 tilt, LIV tilt, disk below lowest instrumented vertebra (LIV), coronal balance, and Risser, whereas sagittal measures included T2-T5, T5-T12, T2-T12, T10-L2, T12-S1, and sagittal balance. Analysis of variance for repeated measures or Cohen three-way kappa correlation coefficient analysis was performed as appropriate to calculate the intra- and interobserver reliability for each parameter. RESULTS: The majority of the radiographic parameters assessed demonstrated good or excellent intra- and interobserver reliability. The relationship of the LIV to the CSVL (intraobserver kappaa = 0.48-0.78, fair to excellent; interobserver kappaa = 0.34-0.41, fair to poor), interobserver measurement of AVT (rho = 0.49-0.73, low to good), Risser grade (intraobserver rho = 0.41-0.97, low to excellent; interobserver rho = 0.60-0.70, fair to good), intraobserver measurement of the angulation of the disk inferior to the LIV (rho = 0.53-0.88, fair to good), apical Nash-Moe vertebral rotation (intraobserver rho = 0.50-0.85, fair to good; interobserver rho = 0.53-0.59, fair), and especially regional thoracic kyphosis from T2 to T5 (intraobserver rho = 0.22-0.65, poor to fair; interobserver rho = 0.33-0.47, low) demonstrated lesser reliability. In general, preoperative measures demonstrated greater reliability than postoperative measures, and coronal angular measures were more reliable than sagittal measures. CONCLUSIONS: Most common radiographic parameters for AIS assessment demonstrated good or excellent reliability for digital measurement and can be recommended for routine clinical and academic use. Preoperative assessments and coronal measures may be more reliable than postoperative and sagittal measurements. The reliability of digital measurements will be increasingly important as digital radiographic viewing becomes commonplace.

Adolescent↗
PubMed2005

Vertebral rotation and thoracic torsion in adolescent idiopathic scoliosis: what is the best radiographic correlate?

BACKGROUND: As a result of the increased appreciation of the three-dimensional nature of scoliosis and modern spinal instrumentation's improved corrective capabilities, there has been renewed interest in the correction and measurement of vertebral rotation. Computed tomography (CT), the gold standard for accuracy, is limited in its clinical utility owing to cost, radiation exposure, and the effects of postural changes on scoliosis curves and vertebral rotation. Consequently, the Perdriolle and Nash-Moe techniques remain the standard measurements for providing a reasonable estimate of pre- and postoperative vertebral rotation because of their simplicity. However, these techniques have considerable interobserver variability, and pedicle screw instrumentation obscures the landmarks necessary for utilizing these techniques for postoperative vertebral rotation assessment. The purpose of the present study was to assess the utility of alternate radiographic measures to assess vertebral rotation and thoracic torsion when compared with conventional measures on pre- and postoperative radiographs and CT evaluation. METHODS: We reviewed the preoperative, immediate postoperative, and final follow-up radiographs, as well as the pre- and postoperative CT scans, of 19 patients (average age 15 years, 6 months) with Lenke 1 curves (average 55 degrees , range 47-66 degrees ), all treated with anterior spinal fusion. Coronal and sagittal Cobb angles as well as vertebral rotation (Perdriolle and Nash-Moe) at the superior uninstrumented, superior instrumented, apical, inferior instrumented, and inferior uninstrumented vertebrae were measured on all films, and vertebral rotation was assessed on the CT scans by a previously described method. Additionally, several measures of thoracic torsion (as a proxy for vertebral rotation and overall deformity improvement) were assessed. These included the rib-vertebral angle difference (RVAD), apical rib hump prominence (RH), apical vertebral body-rib ratio (AVB-R), and apical rib spread difference (ARSD). RESULTS: The postoperative main thoracic curve averaged 26 degrees (range 16-39 degrees , 52% correction) and 29 degrees (range 22-40 degrees , 47% correction) at final follow-up. For apical derotation, the postoperative CT improved from -11.5 degrees to -6.6 degrees and correlated significantly with the Cobb main thoracic curves (42% correction, r = 0.48, P = 0.003). There was weakly positive, but statistically significant, correlation between the pre- and postoperative CT scans and the corresponding Perdriolle and Nash-Moe measures of segmental rotation (r = 0.32-0.40, all P < 0.0001). The RVAD demonstrated poor correlation with the main thoracic curve values and correction, Perdriolle rotation and correction, and CT rotation and correction (r = -0.22-0.37, all P > 0.20). The apical RH demonstrated good correlation with the main thoracic curve (r = 0.65, P < 0.0001), apical Perdriolle rotation (r = 0.57, P < 0.0001), and CT apical rotation (r = 0.53, P = 0.002). We also found moderate correlation between the AVB-R and the main thoracic Cobb, apical Perdriolle, and CT (r = 0.57, 0.59, and 0.49, respectively; all P < 0.005). Similar relationships were found with the ARSD (r = 0.51, 0.47, and 0.43, respectively; all P < 0.02). CONCLUSIONS: The RH, AVB-R, and the ARSD-measures of thoracic torsion-demonstrated moderate to good overall correlation with the main thoracic curve Cobb angles, apical Perdriolle rotation, and apical CT rotation. These should be useful as clinical measures for assessing three-dimensional deformity correction on plane radiographs, especially for the intraoperative evaluation of vertebral derotation and thoracic symmetry restoration.

Adolescent↗
PubMed2005

Pedicle anatomy in a patient with severe early-onset scoliosis: can pedicle screws be safely inserted?

OBJECTIVE: With the rapid increase in the use of pedicle screws in the thoracic spine for various pathologies, knowledge of the pedicle anatomy is critical. Previous authors, in discussing pedicle morphology, have usually reported their findings in nondeformed adult specimens. More recently, the use of pedicle screws in adolescent idiopathic scoliosis has been reported. METHODS: The authors studied the pedicle diameters in the spine of a patient with infantile idiopathic scoliosis who died at age 28 of cor pulmonale. The concave pedicles from T6 to L3 were measured both directly and with thin-section computed tomography (CT) scanning (the curve apex was T8-T11). RESULTS: By direct measurement, the concave pedicle width at its narrowest point (the isthmus) ranged from 2.9 (T9) to 6.7 (L1, L3) mm. Three apical concave pedicles (T8, T9, T10) had no cancellous cavity. By CT scan measurement, the four apical concave pedicles measured 3.4 (T8), 2.8 (T9), 2.6 (T10), and 3.4 (T11) mm, respectively. CONCLUSIONS: In conclusion, the authors confirm others' findings that the concave pedicles can be so small that pedicle screw insertion is impossible. We also found that these findings can be confirmed preoperatively with thin-section CT scanning. In such situations, extrapedicular screw placement should be considered.

Adult↗