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PubMed2001

Optical and biometric relationships of the isolated pig crystalline lens.

AIM: To investigate the interrelationships between optical and biometric properties of the porcine crystalline lens, to compare these findings with similar relationships found for the human lens and to attempt to fit this data to a geometric model of the optical and biometric properties of the pig lens. METHODS: Weight, focal length, spherical aberration, surface curvatures, thickness and diameters of 20 isolated pig lenses were measured and equivalent refractive index was calculated. These parameters were compared and used to geometrically model the pig lens. RESULTS: Linear relationships were identified between many of the lens biometric and optical properties. The existence of these relationships allowed a simple geometrical model of the pig lens to be calculated which offers predictions of the optical properties. CONCLUSIONS: The linear relationships found and the agreement observed between measured and modeled results suggest that the pig lens confirms to a predictable, preset developmental pattern and that the optical and biometric properties are predictably interrelated.

Animals↗
PubMed2001

Detection of uveal melanoma by optometrists in the United Kingdom.

In the United Kingdom, most uveal melanomas are detected by optometrists. Prospectively collected data on patients with uveal melanoma presenting to optometrists were analysed retrospectively to determine: (a) the proportion of patients who were asymptomatic at the time of tumour detection, (b) the proportion of symptomatic patients reporting that their tumour was missed at their initial presentation and (c) the clinical features related to immediate tumour detection. The 223 patients had a mean age of 59.7 years, a mean tumour diameter of 11.3 mm and a mean tumour thickness of 4.6 mm. Symptoms were present in 122 patients (55%) and were associated with large tumour size (p < 0.0001) and male gender (p = 0.003), with more males tending to have a large tumour (p = 0.004). Seventy-nine percent of symptomatic patients reported that their tumour was detected at their first visit. Failure of tumour detection in symptomatic patients was associated with absence of tumour extension posterior to equator (p < 0.0001).

Adult↗
PubMed2001

Methods for measuring the proximity-fixation-disparity curve.

The reliability and validity of new tests of fixation disparity were investigated as a function of viewing distance (100, 60, 40, and 30 cm). The 'nonius offset card' presents a set of paired dichoptic nonius (vernier) lines with different offset simultaneously: the subject has to indicate the coinciding lines. The 'computer test' uses a psychophysical procedure that presents one pair of nonius lines sequentially with varying offset; the effect of the number of short-term nonius test trials is investigated. As a reference, the Mallett unit and the Sheedy disparometer were used. Despite different group means, the methods had significant test-retest correlations and inter-correlations, as tested at 40 cm. All methods showed an increase in exo fixation disparity as the viewing distance was shortened; the slope of this proximity-fixation-disparity curve, however, was different between the nonius offset card and the computer test.

Computer Graphics↗
PubMed2001

Improving the description of the retinal vasculature and patient history taking for monitoring systemic hypertension.

Systemic hypertension is an important public health concern. If optometrists are to perform a more active role in the detection and monitoring of high blood pressure (BP), there is a need to improve the consistency of describing the retinal vasculature and to assess patient's ability to correctly report the diagnosis of hypertension, its control and medication. One hundred and one patients aged > 40 years were dilated and had fundus photography performed. BP was measured and a self-reported history of general health and current medication was compared with the records of their general practitioner (GP). The status of the retinal vasculature was quantified using a numeric scale by five clinicians and this was compared to the same evaluation performed with the aid of a basic pictorial grading scale. Image analysis was used to objectively measure the artery-to-vein (A/V) ratio and arterial reflex. Arteriolar tortuosity and calibre changes were found to be the most sensitive retinal signs of high BP. Using the grading scale to describe the retinal vasculature significantly improved inter- and intra-observer repeatability. Almost half the patients examined were on medication for high BP or cardiovascular disease. Patients' ability to give their complete medical history was poor, as was their ability to recall what medication they had been prescribed. GPs indicated it was useful to receive details of their patient's BP when it was > 140/90 mmHg. The use of improved description of the retinal vasculature and stronger links between optometrists and GPs may enhance future patient care.

Adult↗
PubMed2001

Ocular signs of systemic hypertension: a review.

Cardiovascular disease and stroke continue to be the chief causes of death in developed countries and one of the leading causes of visual impairment. The individual with systemic hypertension may remain asymptomatic for many years. Systemic mortality and morbidity are markedly higher for hypertensives than normotensives, but can be significantly reduced by early diagnosis and then efficient management. However, the ability of Optometrists to detect and appropriately refer systemic hypertensives remains generally poor. This review examines the disease, its effects and detection by observation of the retinal signs, particularly those considered to be pre-malignant. Previous methods of classifying retinal hypertensive signs are discussed along with more recent image analysis techniques. The role of the optometrist in detecting, monitoring and appropriate referral of systemic hypertensives is discussed in relation to current research.

Adult↗
PubMed2002

Paediatric community vision screening with combined optometric and orthoptic care: a 64-month review.

We report a new model of community-based secondary vision screening and demonstrate that a high proportion of children can be effectively managed in such a clinic without referral to the hospital eye service (HES). We performed a 64-month retrospective study of a secondary vision screening clinic providing the combined skills of an optometrist and orthoptist in a community setting. Particular attention was given to the diagnosis and management of children not referred to the HES. During this period, 1755 children were sent appointments and 74% (1300) attended the clinic. The community orthoptist and school nurses referred 53% of the patients and health visitors, general practitioners and community medical officers made 32% of the clinic referrals. Spectacles were prescribed for 41% of the children and 8% were prescribed patching. Sixteen per cent of the children were referred on to the HES. This model of care using the combined expertise of the orthoptist and optometrist is able to diagnose and manage the majority of children who have failed primary vision screening and avoids unnecessary referrals to the HES.

Ambulatory Care↗
PubMed2002

Randomised controlled trial of the effect of coloured overlays on the rate of reading of people with specific learning difficulties.

A randomised controlled trial has demonstrated that, for selected children with reading difficulties, individually prescribed coloured filters reduce symptoms of asthenopia. In the present study, we investigate the effect of individually prescribed coloured overlays on the rate of reading. Subjects were 33 children and adults who: had consulted a specific learning difficulties clinic; had received treatment to normalise any conventional optometric and orthoptic anomalies; and subsequently reported symptomatic relief from coloured filters. These subjects carried out the Wilkins Rate of Reading Test (which assesses visual rather than linguistic factors) under two conditions: with their chosen coloured overlay and with a control filter. Steps were taken to ensure that a strong placebo effect was associated with the control overlay and, when asked which they preferred, subjects were not significantly more likely to prefer their coloured overlay than the control filter (p=0.11). Nonetheless, the rate of reading was significantly faster with the coloured overlay than with the control (p=0.0019). Further analyses support the conclusion that individually prescribed coloured filters can improve reading performance for reasons that cannot be solely attributed to conventional optometric factors or to placebo effects.

Adult↗
PubMed2002

Coloured overlays in schools: orthoptic and optometric findings.

In two studies, the first in a school in Peterborough and the second in a school in Norwich, more than 233 children aged 8-12 years received either an orthoptic examination, or an optometric examination, together with an examination using coloured overlays and a test of reading fluency. In both studies more than one-third of the children reported visual symptoms. More than one-third of the children chose to use an overlay, and they read more quickly with it than without. The colour of the overlay chosen was weakly related to the binocular amplitude of accommodation: overlays reflecting greater energy at long wavelengths were chosen more frequently by children with a higher amplitude of accommodation. Although the visual symptoms were strongly related to the use of an overlay, in neither study was the benefit from an overlay strongly related to the orthoptic or optometric findings. Nevertheless, children who used an overlay had slightly, but significantly, reduced mean binocular amplitude of accommodation and fusional reserves. On average, children with 'sensory' or 'motor' instability of the nonius strips of the Mallett unit read more slowly than others, as did those with poor stereopsis. However, 60% of those demonstrating sustained overlay use gave a normal response on the Mallett aligning prism test, compared with 80% of those who did not use an overlay for a sustained period. Another indicator of decompensated heterophoria, Sheard's criterion, did not differentiate subjects who used overlays from those who did not. Although binocular and accommodative anomalies do not appear to be the underlying mechanism for the benefit from coloured filters in most cases, there may be some individuals who respond to coloured filters and in whom these ocular motor factors require treatment. Children with visually precipitated symptoms and/or reading difficulties need both a careful evaluation of their accommodative and binocular status, and an investigation of the effect of coloured filters.

Accommodation, Ocular↗
PubMed2002

Gender-related optical aspects of the onset of presbyopia.

Evidence is presented which substantiates the frequent clinical impression that female optometric patients require their first reading prescription at a slightly earlier age than males. Furthermore newly presbyopic females require an initial add of slightly greater magnitude than age-matched males. A high (>+1.50 D) first add requirement is revealed as a predominantly male characteristic, an outcome attributable essentially to their often relatively later age of presentation for an initial presbyopic refractive examination.

Age of Onset↗
PubMed2002

Effects of viewing distance on accommodative and pupillary responses following a three-dimensional task.

We have investigated accommodation and pupil responses after viewing stereoscopic images related to the resting position of accommodation. After a 10-min visual task viewing stereoscopic three-dimensional images, measurements of dynamic accommodation and pupil response were made using an infrared optometer and a pupil analyser. Four conditions were given for the viewing distance: 0.4 m (closer than the subjects' resting position), 1 m (approximating to their resting state), and 1.5 and 3 m (farther than the resting position). For the 0.4- and 1-m groups, a delay in the accommodation response for near-to-far movement was shown after the task, from 817 to 1120 ms and from 830 to 898 ms, respectively, but there was no change in the pupillary response. In the 1.5- and 3-m groups, on the other hand, a significant delay in the accommodation response for far-to-near movement was shown, from 827 to 912 ms and from 857 to 1150 ms, respectively, and greater miosis was found, from 7.2 to 9.2 mm2 and from 8.0 to 10.4 mm2. The data reveal that there are different after-effects on accommodation and pupillary functions when subjects perform the task within their accommodative resting position, than when the task is performed outside the resting position.

Accommodation, Ocular↗
PubMed2002

Are there age differences in the accommodative response curve between 3 and 14 years of age?

The monocular ocular accommodative responses of 118 emmetropic children, aged from 3 to 14 years, were measured at five different stimulus distances (0, 1, 2, 3, 4 D) from the principal plane of the eye with a Canon Autoref R-1. The change in the accommodative response curve in emmetropic children between 3 and 14 years old was found to be negligible.

Accommodation, Ocular↗
PubMed2002

Image quality in wearers of a centre distance concentric design bifocal contact lens.

The optical performance of eyes wearing bifocal concentric contact lens was studied using the double-pass technique. Retinal image quality was measured for four subjects wearing CIBA Bisoft contact lenses presenting the central zone for correcting distance vision. Lenses with two different central optic zone diameter (COZD), 3.2 and 3.8 mm, were studied and the influence of pupil diameter and viewing distance were analysed. Results show that the best optical performance is obtained for far vision conditions when no lens is worn even if the pupil coverage by the COZD is complete. For near vision conditions, the optical performance when the lens is worn is, in general, better than when no lens is worn. When the lens is worn the best optical performance corresponds to a pupil diameter of 3 mm and far vision conditions. For this pupil diameter, variations in the situations analysed can be explained by changes in the percentage of pupil coverage corresponding to the far or the near vision zone of the lens. For a pupil diameter of 5 mm, the retinal image quality is more similar in all situations studied and pupil coverage alone cannot explain the results obtained and the influence of other parameters related to the design or contact lens fitting characteristics must be considered.

Adult↗
PubMed2002

MEM and Nott dynamic retinoscopy in patients with disorders of vergence and accommodation.

The accommodative response in 34 patients with accommodative and binocular disorders was assessed with two different techniques of dynamic retinoscopy used in clinical practice: monocular estimate method (MEM) and Nott retinoscopy. The data obtained by both techniques were compared, evaluating the correlation and agreement between them. Results showed that there were statistically significant differences between the techniques with MEM values being more plus than Nott ones. There was a high correlation between the two techniques (0.90) and the regression analysis indicated that a linear relationship existed between MEM and Nott dynamic retinoscopy, so that accommodative lag value for Nott dynamic retinoscopy would be calculated by dividing the MEM result by 2. However, although both retinoscopies were related, there was a lack of agreement between them (+/-0.53 D) indicating that the two methods are not interchangeable for clinical purposes.

Accommodation, Ocular↗
PubMed2002

Optometrists' examination and referral practices for patients presenting with flashes and floaters.

INTRODUCTION: Patients experiencing flashes and floaters commonly present to their optometrist. Some of these patients may have significant pathology, yet there is a great deal of variability with regard to examination technique and referral practice. METHODS: A questionnaire survey was undertaken to determine the current management of patients presenting to their optometrist with flashes and floaters. All practising community optometrists within Southern Derbyshire received a questionnaire and 74 (56.9%) completed replies were received. RESULTS: Optometrists estimated that an average of 14 patients per month per optometrist presented with symptoms of flashes and/or floaters. Mydriasis was utilised routinely for examination in approximately half of the patients. Mean relative confidence was 2.0 at identifying a vitreous haemorrhage and 6.5 for vitreous pigment (complete confidence = 0, complete lack of confidence = 10). Eight percent of responders were unfamiliar with the clinical sign of vitreous pigment, and 17% identifying this sign did not refer all such patients to the hospital services. CONCLUSIONS: Patients presenting to their optometrists with flashes and/or floaters make up a sizeable part of the community optometrist's workload and the management of these patients is highly variable. A large proportion of these patients are examined without mydriasis, even in the presence of various risk factors for retinal detachment. There is a relative lack of confidence amongst optometrists with regards the detection of vitreous pigment and the prognostic implications of this finding. Educational measures such as study days may help the level of understanding and heighten the appreciation of the implications of flashes and floaters and the various clinical signs encountered.

Clinical Competence↗
PubMed2002

Validation of computer morphs for grading contact lens complications.

Abstract An alternative to the use of printed grading scales for assessing the severity of contact lens-induced ocular pathology is to use computer-generated grading morphs. This technique involves manipulation of a continuously variable movie sequence until this matches the severity of the condition being observed. To validate the use of computer morphs, nine experienced optometrists were each invited to grade - to the nearest 0.1 increment - an image of each of 16 contact lens complications, using printed scales (Efron Grading Scales for Contact Lens Complications) and computer morphs (Efron Grading Morphs). This entire procedure was repeated approximately 2 weeks later, yielding a total data base comprising of 576 individual grading estimates. Good accuracy was achieved using computer morphs, as evidenced by the similarity between the mean of the test and retest grading estimates for the printed scales (2.8 +/- 0.7) and the computer morphs (2.6 +/- 0.8) (F1,8 = 2.7, p = 0.14). There was no difference in median reliability between the printed scales (+/- 0.41) and the computer morphs (+/- 0.43) (Z = 0.1, p = 0.95). Computer morphs are thus considered to have been validated in view of their accuracy and reliability compared with printed scales. In addition, computer morphs offer considerable utility in terms of computer-based clinical record keeping, teaching and learning, and clinical research.

Computer Graphics↗
PubMed2002

A multi-centre study of lapsed contact lens wearers.

PURPOSE: Discontinuation from contact lens wear has been identified as a contributing factor in the lack of growth of contact lens use in Europe. The purpose of this study was to determine the proportion of lapsed contact lens wearers that can be refitted successfully with contact lenses and to evaluate the reasons for discontinuation from contact lens wear. METHODS: This was a multi-site clinical study involving 15 UK investigators and 236 lapsed contact lens wearers who had previously tried contact lenses and discontinued. The reasons for discontinuation were assessed by subjects, who were then refitted with contact lenses. Investigators subsequently evaluated factors associated with their initial discontinuation. Short-term success was defined as the successful completion of 1 month of contact lens wear with absence of complications that would prevent further wear. Subjects were interviewed by telephone 6 months after being refitted to determine whether they were still wearing contact lenses. Those who were not wearing lenses were questioned about the reasons for discontinuation and their likelihood of resuming lens wear. RESULTS: A majority of subjects (51%) cited discomfort as the principal reason for having previously given up contact lens wear. Problems with vision were the second most common reason (13%), either with reading (6%) or general vision (7%). The most common type of discomfort was dryness (40%). In almost all cases (97%), the investigator's assessment of the reasons for discontinuation agreed with the subject's own assessment but investigators also cited product-related and practitioner-related factors as contributing to previous failure. The short-term success rate for refitting lapsed wearers was found to be 77% (Cl: 70-82%). The highest short-term success rates were for 2-weekly/monthly soft spherical lenses (91%) and daily disposable lenses (89%). Lower success rates were found for soft toric (69%) and soft bifocal (53%) lenses. At the 6-month stage, 73% of those who continued in lenses after the 1-month visit were still wearing contact lenses and a further 18% indicated that they were either 'very likely' or 'likely' to resume lens wear. CONCLUSIONS: A high proportion of lapsed contact lens wearers can be successfully refitted with contact lenses. The prime reason for previous discontinuation from contact lenses is discomfort and, in particular, dryness-related discomfort. In many cases, previous contact lens failure is product or practitioner-related rather than because of patient-specific problems. Once refitted with contact lenses, lapsed wearers cite vision problems rather than discomfort as the most common reason for discontinuing. This finding suggests that recent advances in contact lens material, design, replacement frequencies and care systems have improved the prospects for avoiding lens-related discomfort and for continuing contact lens wear.

Adolescent↗
PubMed2002

Intra-observer and inter-observer repeatability of anterior eye segment analysis system (EAS-1000) in anterior chamber configuration.

BACKGROUND: Anterior chamber configuration can be assessed via optical or ultrasonic techniques. Scheimpflug photography is a non-invasive method measuring the anterior segment. The Anterior Eye Segment analysis system, EAS-1000, utilises the Scheimpflug principle and was found to have good repeatability. Previous repeatability studies, however, have had limitations in their design. The current study investigated the intra-observer and interobserver repeatability of the EAS-1000. METHODS: Twenty-five healthy young subjects were recruited. The anterior chamber angles in different quadrants were measured by two examiners for interobserver analysis. The first examiner repeated the measurement at another session for intra-observer analysis. The 95% limits of agreement and intra-class correlation coefficient (ICC) were calculated. The anterior chamber depth was also measured and compared with ultrasound biometry. RESULTS: The anterior chamber angle assessment demonstrated good intra-observer (ICC ranging from 0.77 to 0.90 for different quadrants) and interobserver (ICC ranging from 0.68 to 0.81 for different quadrants) repeatability. The 95% intra-observer limits of agreement were within +/-5 degrees. The 95% interobserver limits of agreement were within +/-6 degrees. There was no significant difference between male and female subjects or among angles at different quadrants. The anterior chamber depth was found to be repeatable (ICC > 0.90) with 95% limits of agreement +/-0.1 mm. The anterior chamber depth was shallower than that obtained from ultrasound biometry. CONCLUSIONS: The EAS-100 is a non-invasive instrument which is repeatable for measuring the anterior chamber angle and depth. It provides quick results and is good for screening purposes. There is an under-estimation of anterior chamber depth, as previously reported.

Adolescent↗