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Memory and attention make smart word learning: an alternative account of Akhtar, Carpenter, and Tomasello.

Two general types of accounts have been offered to explain the smartness of young children's word learning. One account postulates that children enter the word-learning task with specific knowledge about how words link to categories. The second account puts the source of children's smart word learning in knowledge about the pragmatics of communication and social interactions. The present experiment tested a third idea: that children's seemingly smart word learning derives from general, indeed mundane, cognitive processes. Forty-eight children from 18 to 28 months of age participated in a task designed to test our alternative explanation as applied to Akhtar, Carpenter, and Tomasello's (1996) finding that children use knowledge of the communicative intents of others to interpret a novel noun. Specifically, we suggest that children's attention to the proper referent was guided by the general effects of a contextual shift on memory and attention. The procedure in the present study was identical to that of Akhtar et al. except that we differentiated the target through a nonsocial context shift. Findings similar to that of Akhtar et al. emerged under the present procedures. These results strongly suggest that general attentional and memorial processes, and not knowledge about the communicative intents of others, may guide young children's word learning. These findings provide one demonstration of how smart word learning may emerge from more ordinary (and dumb) cognitive processes.

Attention↗

Model estimates of CSF and skull influences on scalp-recorded ERPs.

Dipole source localization promises to enhance knowledge about the structural and functional processes underlying differences in scalp-recorded ERPs observed between normal and patient populations. In this paper the Cuffin and Cohen (1) four-compartment model of volume conduction is used to examine the effects of variations in size of different compartments on scalp-recorded potentials. Using single discrete current dipoles located various distances from the center of the head, the effect of varying the thickness of the superficial extra-sulcal subarachnoid layer of CSF and the thickness of the skull are examined. Changing the thickness of the CSF layer alters amplitude recorded at the scalp and also alters the topographic distribution of the potential; these effects are more pronounced the closer the dipole source is to the surface. Changes in skull thickness have similar, but even greater effects.

Cerebrospinal Fluid↗

Chemical ecology: a view from the pharmaceutical industry.

Biological diversity reflects an underlying molecular diversity. The molecules found in nature may be regarded as solutions to challenges that have been confronted and overcome during molecular evolution. As our understanding of these solutions deepens, the efficiency with which we can discover and/or design new treatments for human disease grows. Nature assists our drug discovery efforts in a variety of ways. Some compounds synthesized by microorganisms and plants are used directly as drugs. Human genetic variations that predispose to (or protect against) certain diseases may point to important drug targets. Organisms that manipulate molecules within us to their benefit also may help us to recognize key biochemical control points. Drug design efforts are expedited by knowledge of the biochemistry of a target. To supplement this knowledge, we screen compounds from sources selected to maximize molecular diversity. Organisms known to manipulate biochemical pathways of other organisms can be sources of particular interest. By using high throughput assays, pharmaceutical companies can rapidly scan the contents of tens of thousands of extracts of microorganisms, plants, and insects. A screen may be designed to search for compounds that affect the activity of an individual targeted human receptor, enzyme, or ion channel, or the screen might be designed to capture compounds that affect any step in a targeted metabolic or biochemical signaling pathway. While a natural product discovered by such a screen will itself only rarely become a drug (its potency, selectivity, bioavailability, and/or stability may be inadequate), it may suggest a type of structure that would interact with the target, serving as a point of departure for a medicinal chemistry effort--i.e., it may be a "lead." It is still beyond our capability to design, routinely, such lead structures, based simply upon knowledge of the structure of our target. However, if a drug discovery target contains regions of structure homologous to that in other proteins, structures known to interact with those proteins may prove useful as leads for a medicinal chemistry effort. The specificity of a lead for a target may be optimized by directing structural variation to specificity-determining sites and away from those sites required for interaction with conserved features of the targeted protein structure. Strategies that facilitate recognition and exploration of sites at which variation is most likely to generate a novel function increase the efficiency with which useful molecules can be created.

Animals↗

Advances in how clinical nurses can evaluate and improve quality of life for individuals with cancer.

PURPOSE/OBJECTIVES: To describe advances in the ways that clinical nurses understand, assess, and work to improve quality of life (QOL) for individuals with cancer since the 1995 Oncology Nursing Society's State-of-the-Knowledge Conference on QOL. DATA SOURCES: Published research and clinical articles. DATA SYNTHESIS: The number of QOL assessment tools and methods for understanding QOL results has increased. However, scant literature has focused on how clinical oncology nurses evaluate QOL and the methods they use to affect QOL for individuals with cancer. CONCLUSIONS: Based on the nurse-patient relationship, clinical nurses are able to assess QOL in individuals with cancer and intervene appropriately to improve QOL. IMPLICATIONS FOR NURSING: Clinical nurses can involve individuals with cancer in rating their QOL to assist in providing high-quality care that is directed at positively affecting QOL.

Attitude of Health Personnel↗

Predictors and outcome of early- versus late-onset major bacterial infections in liver transplant recipients receiving tacrolimus (FK506) as primary immunosuppression.

Major bacterial infections and the predictors of early (within 100 days of transplantation) versus late onset (after 100 days post-transplant) bacterial infections were prospectively assessed in 130 consecutive liver transplant recipients receiving tacrolimus (FK506) as primary immunosuppression. The median follow-up period was 38 months. Overall, 35% (45/130) of the patients developed 67 episodes of major bacterial infections (0.52 episodes/patient). Sixty-three percent of the major bacterial infections occurred early, and 37% occurred in the late post-transplant period. Eighty-four percent of the abdominal infections occurred early, whereas 38% of the cases of pneumonia, 60% of the cases of primary bacteremia, and 50% of the biliary infections occurred late. By logistic regression analysis, portal vein thrombosis was the most significant independent risk factor for early-onset major bacterial infection (odds ratio 4.1; 95% CI 1.4-12.2), and recurrent hepatitis C was the most significant independent predictor of late-onset major bacterial infections (odds ratio 6.21; 95% CI 1.9-20.2). Thus, sources and risk factors differ for early versus late-onset bacterial infections after liver transplantation. Knowledge of the differences in the potential sources, the pathogens, and the predictors of early versus late-onset bacterial infections can be valuable in the evaluation and empiric treatment of liver transplant recipients with bacterial infections.

Adult↗

Stem cell therapy for retinal degeneration: retinal neurons from heterologous sources.

Over the past few years a great deal of interest has been generated in using stem cells/progenitors to treat degenerative diseases that afflict different tissues, including retina. This interest is due to the defining properties of stem cells/progenitors, the ability of these cells to self-renew and generate all the basic cell types of the particular tissue to which they belong. In addition, the recent reports of plasticity of the adult tissue-specific stem cells/progenitors and directed differentiation of the embryonic cells (ES) has fueled the hope for cell and gene therapy using stem cells from heterologous sources. Will this approach work for treating retinal degeneration? Here, we review the current state of knowledge about obtaining retinal cells from heterologous sources, including ES cells.

Animals↗

[Information in the fight against HIV infection and AIDS: results of a knowledge survey among general practice physicians, journalists, and users of the AIDS Green Line].

This work presents the outcomes of the study "Evaluation of the role of social communication in the fight against HIV infection and AIDS" carried out by some researchers of the Istituto Superiore di Sanità (ISS) and financed within the 2nd Social Research Project on AIDS. Through an accurate survey, the study aimed to evaluate the standard of knowledge on HIV/AIDS in two most important sources of information frequently contacted by citizens: general practitioners and journalists. It also sounded out the knowledge in a random sample of users of the AIDS Help-Line of the ISS. We could find out a generally low standard of knowledge of HIV/AIDS among journalists. As far as general practitioners are concerned, the differences found in the standard of knowledge are inversely proportioned to age and number of patients. A fairly good standard of knowledge is found out among the users the AIDS Help-Line. Of course, the same outcomes cannot be valid also for the general population; on the contrary, the outcomes concerning general practitioners and journalists could be generalized. Information gathered from data collection could make easier the planning of more specific interventions and the drawing up of appropriate guidelines.

Acquired Immunodeficiency Syndrome↗

What do general practice patients know about their prescription medications?

AIM: To explore the knowledge that general practice patients have about their prescription medications and identify demographic predictors of poor medication knowledge. METHODS: This is a questionnaire survey of a large New Zealand urban general practice serving a range of socioeconomic groups. Patients attending this practice completed a questionnaire about their prescription medications. Their responses were validated using practice records and pharmaceutical reference manuals. RESULTS: Seven hundred and forty five medication questionnaires were submitted by 344 patients. The medication name was correct in 85% of these questionnaires; therapeutic action was correct in 79% of responses; indication for medication was correct in 87% of responses; while dosage was correctly recalled in 83% of responses. Age and household income were associated with accurate recall of medication names (p = 0.006 and p = 0.002 respectively), and income was associated with accurate knowledge of the therapeutic action of medication (p = 0.04). General practitioners and specialists were patients primary source of information about medications. CONCLUSIONS: Patient knowledge about their medications was much higher than in previous studies conducted in hospital settings. Our findings reinforce the educational role of the general practitioner and specialist when prescribing. This is particularly important when prescribing for patients who are elderly, retired and have a low income.

Adolescent↗

Using a capture-recapture method to assess the frequency of adverse drug reactions in a French university hospital.

AIMS: There is evidence that different methods used to identify and quantify adverse drug reactions (ADR) in hospitals are not exhaustive (spontaneous reporting or computerized medical databases). The combination of these different sources of data could improve knowledge about ADR frequency in hospitals. The aim of this study was to estimate the incidence of serious ADRs handled in medical wards of a French university hospital using data from the Programme de Medicalization des Systemes d'Information (PMSI) and spontaneous reports recorded in the French Pharmacovigilance Database. METHODS: The study period was the first semester of 2001. RESULTS: From PMSI, all hospitalization summaries including an ICD-10th code related to a potential ADR were selected. From the French Pharmacovigilance Database, all serious ADRs which occurred during the study period and were reported by physicians working in the University Hospital were collected. After identification of common cases, the capture-recapture method was applied in order to estimate the real number of ADRs occurring during the first semester of 2001. From PMSI, we identified 274 different hospital stays related to an ADR. Out of 241 reports selected from the French Pharmacovigilance Database, we retained 151 ADRs for analysis. Fifty-two ADRs were common in the two databases, giving an estimated number of serious ADRs of 796 [95% confidence interval (CI) 638, 954], corresponding to 2.9% of inpatients (95% CI 2.3, 3.5). CONCLUSIONS: This study shows the lack of exhaustiveness of ADR reporting whatever the sources of data and underlines the interest of merging data from different databases to identify fully the real impact of ADR in hospitals.

Adolescent↗

Promoting oral health in South Africa: public perceptions of water fluoridation.

Public knowledge of water fluoridation (WF), sources of information, purpose of WF and the level of support for the implementation of WF was assessed in South Africa. Of the 2229 respondents interviewed, 23 per cent had heard or read about WF. Almost a third said they obtained their information from schools or community networks while 60 per cent mentioned either radio, newspapers/magazines, or television. About 25 per cent correctly recognized the protection of teeth as the purpose of fluoridation, while two-fifths believed the purpose of WF is to purify water. More than sixty per cent of respondents were in favour of WF, with almost a quarter of the sample feeling uncertain. This study demonstrates that a considerable amount of educational and political action is required for water fluoridation to be implemented in South Africa.

Adolescent↗

The middle mesenteric artery: an unusual source for colonic hemorrhage.

To the authors' knowledge, colonic hemorrhage from anomalous ventral aortic mesenteric arteries has not been described previously. They report a case in which a middle mesenteric artery with unusual vascular distribution supplied a splenic flexure hemorrhage in a 62-year-old man. Although this is a rare anomaly, a thorough understanding of the middle mesenteric artery may have important diagnostic and therapeutic implications.

Colon↗

Vegetable-transmitted parasites among inhabitants of El-Prince, Alexandria and its relation to housewives' knowledge and practices.

In the present study, stool samples were obtained from 575 individuals from El-Prince, a suburban village of Alexandria, Egypt to detect helminthic eggs and protozoan cysts. The results showed that, 35.7% of the sample had at least one vegetable-transmitted parasite, the highest percentage (46.4%) was in the age group of 6 to less than 15 years. The nematode Ascaris lumbricoides was the most prevalent in 18.4%, followed by the protozoan Giardia lamblia in 10.4%. Fasciola eggs were found in 2.4% of samples. Knowledge and practices of housewives concerning Fasciola and its source of transmission and methods of washing leafy vegetables was obtained through house-to-house interviews with 303 housewives. Knowledge that leafy vegetables were a source of Fasciola infection was indirectly proportional with better in younger housewives and those of secondary or higher education. More than half of the interviewed housewives (57.7%) washed leafy vegetables under running tap water and 32.7% soaked them in tap water. Only 9.6% soaked them in water mixed with a substance as vinegar, lemon juice or common salt. Only 5% of those who were infected with vegetable transmitted parasites washed vegetables by soaking in water with an added substance compared to 19.6% of parasite free housewives. Most of those adding a substance to soaking water (89.7%) used vinegar. Results of the study revealed that a serious and consistent effort through public health activities is essential to educate housewives about vegetable-transmitted parasites, their transmission and ways of prevention.

Adult↗

[Evaluation of information sources and the effectiveness of health education in the North Bohemian Region, as indicated by knowledge of risk factors for cardiovascular diseases].

In May 1988 in the North Bohemian region an anonymous enquiry was made among a representative group of 3,767 respondents which was focused among others on problems of health education. The respondents consider the most important source of health education in 60.37% a talk with their doctor, in 37.67% television and in 17.67% lectures. Newspaper articles, pamphlets and films are rated roughly equally (cca 5% of the respondents). Posters are negligible as a source of health education. Health education is most appreciated by the oldest age group and least by respondents aged 16-30 years. It is necessary to prefer the most appreciated forms of health education and to seek contents and forms attractive for the youngest group of patients. Part of the enquiry was focused on knowledge of risk factors of cardiovascular diseases. Smoking is considered generally most harmful, less than half know about the harmfulness of stress, few respondents know that diabetes is a risk factor (26.3%). The most frequently incorrectly mentioned factor was alcohol.

Adult↗

The discipline of innovation. 1985.

How much of innovation is inspiration, and how much is hard work? The answer lies somewhere in the middle, says management thinker Peter Drucker. In this HBR classic from 1985, he argues that innovation is real work that can and should be managed like any other corporate function. Success is more likely to result from the systematic pursuit of opportunities than from a flash of genius. Indeed, most innovative business ideas arise through the methodical analysis of seven areas of opportunity. Within a company or industry, opportunities can be found in unexpected occurrences, incongruities of various kinds, process needs, or changes in an industry or market. Outside a company, opportunities arise from demographic changes, changes in perception, or new knowledge. There is some overlap among the sources, and the potential for innovation may well lie in more than one area at a time. Innovations based on new knowledge tend to have the greatest effect on the marketplace, but it often takes decades before the ideas are translated into actual products, processes, or services. The other sources of innovation are easier and simpler to handle, yet they still require managers to look beyond established practices, Drucker explains. The author emphasizes that innovators need to look for simple, focused solutions to real problems. The greatest praise an innovation can receive is for people to say, "That's so obvious!" Grandiose ideas designed to revolutionize an industry rarely work. Innovation, like any other endeavor, takes talent, ingenuity, and knowledge. But Drucker cautions that if diligence, persistence, and commitment are lacking, companies are unlikely to succeed at the business of innovation.

Commerce↗

Factors that influence the elderly to use traditional or nontraditional nutrition information sources.

This study analyzed sociodemographic variables, access to medical care, health status-related variables, and nutrition status-related variables to determine their ability to predict an orientation toward traditional or nontraditional nutrition information sources among aged subjects in Eugene, OR. Data were collected from 165 randomly selected subjects by trained interviewers using face-to-face interviews. Nutritionist orientation was measured by a Traditional/Nontraditional Index (TNT Index) developed for the study. Nutrition knowledge and misinformation, supplement use, and sources of nutrition information were also investigated. Predictors of nontraditional nutritionist orientation were acceptance of nutrition misinformation and male sex (adjusted R2 = .09). For women, predictors of a similar orientation were acceptance of nutrition misinformation, low knowledge of general nutrition information, and low functional health status (adjusted R2 = .19). Mean nutrition knowledge scores were high, with a mean of 4.7 (standard deviation [SD] = 0.8) on a scale ranging from 4 (high) to 8 (low). However, many of the subjects did not list dairy foods (28%) and grains (27%) as necessary in the diet. In addition, belief in certain nutrition myths was widespread. More than 58% were taking one or more supplements (mean = 1.4 supplements per day, SD = 1.98). Physicians were mentioned as most likely sources of nutrition information, with dietitians and health food store personnel mentioned second, indicating the importance of marketing efforts for registered dietitians.

Aged↗

Sources, transport and alterations of metal compounds: an overview. I. Arsenic, beryllium, cadmium, chromium, and nickel.

An overview is presented of the current state of knowledge of the salient aspects of the sources, transport, and alterations of arsenic, beryllium, cadmium, chromium, and nickel. This information is considered vital for a better assessment of the scope of potential human hazard to these ubiquitous toxicants and their compounds. Stress is focused on both natural and industrial activities, particularly on the latter's projected trends. Increasing use patterns per se of most of these metals, as well as aspects of waste disposal and the anticipated increased combustion of fossil fuels for power generation and space heating (particularly in the United States), are major causes of potential health concern. Additionally, attention is drawn to the need for increased research to fill the gaps in our knowledge in these vital areas, all in the hope of permitting a more facile identification and quantification of the potential hazard to exposure to these agents.

Air Pollutants↗

Medico-legal knowledge of general practitioners: disjunctions, errors and uncertainties.

This article discusses a survey of Victorian general practitioners which investigated doctors' legal knowledge, the impact of law on clinical practice, doctors' current medico-legal information sources and their legal education needs and preferences. Knowledge of legal standards was investigated in relation to three areas: disclosure of risk; ownership of, and access to, medical records; and proxy decision-making. Additionally, the impact of statutory reform in relation to proxy decision-making was explored. Further, doctors' past experience of medico-legal education, current sources of medico-legal information and preferences concerning future medico-legal information were explored. Results indicated that overall, respondents had a very inadequate understanding of relevant law and that relevant statutory standards have had little impact on clinical practice. Professional bulletins and journals were identified as major current legal information sources, whilst printed materials, seminars and conferences were preferred sources of legal information. The authors conclude that there is a significant disjunction between legal standards and doctors' awareness of those standards, thereby creating a significant source of liability for doctors. Results highlight an urgent need to develop legal education programs for general practitioners based on doctors' identified needs and preferences.

Adult↗

Implementing effectiveness research and improving care for schizophrenia in real-world settings.

OBJECTIVE: To review recent advances in medication practices and standards of care in the treatment of schizophrenia and examine the disparity between the knowledge base and clinical practice. DATA SOURCES: Key literature on medication practices, novel pharmacotherapies, and the evolution of practice guidelines for schizophrenia were reviewed. DISCUSSION: Emerging data demonstrate a lack of consistent application of current knowledge and best practices, in part due to major structural inconsistencies in the public mental health system. Implementation of results from effectiveness research as well as the incorporation of practice guidelines may help bridge this gap. CONCLUSION: As standards of care for schizophrenia are developed, the following issues will need particular attention: coordination with the criminal justice system, comprehensive treatment of comorbid illnesses, outcomes based on symptoms in all domains, and continuous and integrated collection of data to produce rational cost justification.

Antipsychotic Agents↗