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PubMed1990

Multiple parameter assessment of vulvar irritant contact dermatitis.

Transepidermal water loss (TEWL), capacitance, pH, blood flow and color reflectance were evaluated for quantifying the irritant response of vulvar and forearm skin to 3% sodium lauryl sulfate in 9 healthy premenopausal women. TEWL, capacitance, pH, blood flow, and all parameters of color reflectance changed significantly in forearm irritant dermatitis. In vulvar irritant dermatitis, however, significant changes were observed only for blood flow and the color reflectance parameters a* and b*. Using the combination of TEWL, capacitance and blood flow, forearm irritant dermatitis was detected with a sensitivity of 84% and a specificity of 100%. In this study, the best combination of parameters to detect vulvar irritant dermatitis was pH, blood flow, a* and b*, which had a sensitivity of 78% and a specificity of 75%. It is concluded that available bioengineering techniques are less suitable to quantify irritant dermatitis in the vulva than in the forearm.

Adult↗
PubMed1990

Allergic contact dermatitis from gardenia fruit.

A 41-year-old man, with severe itchy dermatitis on the left leg, had treated a bruise on the left knee with a topical folk remedy called Sokujikoh, which contains about 16% powdered gardenia fruit. After 4 days, an exacerbation of symptoms appeared, with edema, erythema, and vesicles on the treated area. Patch testing indicated sensitivity to the seeds of gardenia fruit and, to a lesser extent, the pericarp (fruit wall). The allergens could be extracted into ethanol and, less readily, into water.

Adult↗