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PubMed2003

Influence of microstructure and chemistry on the fracture toughness of dental ceramics.

OBJECTIVES: the primary aim of this research was to measure fracture toughness for several groups of dental ceramics, and determine how this property is affected by chemistry and microstructure. METHODS: Fracture toughness (KIc) values were obtained using Single Edge Precracked Beam (SEPB) and Single Edge V-Notch Beam (SEVNB) methods. Dynamic Young's modulus, which often scales with strength and has been used in explaining the microstructure/toughness relationship on a theoretical basis, was also obtained for the three groups of materials comprising this study. The first group, consisting of micaceous glass ceramics, included model materials that varied systematically in microstructure but not in chemistry. The second group, the feldspathic porcelains, varied significantly in microstructure, but little in chemistry. The ceramics comprising the third group were significantly different in both chemistry and microstructure. RESULTS: Upper toughness limits for the micaceous glass-ceramics and feldspathic porcelains were significantly raised compared to the base glasses, but remained under 2 MPa m(1/2). The highest toughnesses were associated with high percent crystallinity, large grains and high aspect ratios. The third group KIc values were 2.8 MPa m(1/2) for a lithium disilicate glass-ceramic, 3.1 MPa m(1/2) for a glass-infused alumina, and 4.9 MPa m(1/2) for zirconia. SIGNIFICANCE: the correlations between microstructural characteristics and measured properties supports theoretical predictions in the literature. From a practical standpoint, microstructural effects were found to be important, but only within a limited range; the chemistry apparently defined a band of achievable property values. This suggests very large increases in fracture toughness are unlikely to be attained by changes in microstructure alone. A functional relationship determined for the micaceous glass-ceramics enables quantitative predictions of fracture toughness based on the microstructure.

Aluminum Oxide↗
PubMed2001

Melting and stone production using MSW incinerated ash.

Most of the municipal solid waste (MSW) in Japan is incinerated and the generated ash is landfilled. However, environmental pollution problems have increased and Japan has decreased final disposal sites for landfills. With the application of a melting system, the volume of incinerated ash can be reduced and the effective use of melted slag is being developed for use in civil engineering works. However, the low strength of melted slag as a vitreous structure has limited its effective use. As a solution for this deficiency, a technology to crystallize melted slag into higher strength produced stones was developed. With the joint cooperation of Chiba Prefecture and Kamagaya City, a demonstration plant for melting and stone production with a capacity of 4.8 tons of incinerator ash per day was constructed. The demonstration test was conducted from May 1998 to June 1999 with satisfactory results stated below. Long-term stable operation and performance of the plant have been confirmed and effective applications of produced stones have been demonstrated on a commercial scale. The results are as follows. 1. A stable, continuous operation and good quality produced stones have been confirmed by treating more than 750 tons of MSW incinerated ash. 2. More than 99.9% of dioxins contained in the incinerated ash were decomposed, and the concentration of dioxins in produced stones were less than the detection limit set by Japanese environmental standards. 3. Leaching values of hazardous heavy metals of produced stones sufficiently met the environmental standard on soil pollution of the Environment Agency with superior leaching behavior for the vitreous slag, thus confirming their safe applications. 4. The effective application of produced stones for aggregate was tested based on Japanese Industrial Standards and every figure of test results met the Japanese standard values. The use of produced stones as raw materials for permeable pavement blocks has been confirmed in commercial construction for a park in Chiba Prefecture. Asphalt use was also demonstrated by paving a commercial roadway in Kamagaya City.

Aluminum Oxide↗
PubMed2002

Gamma irradiation alters fatigue-crack behavior and fracture toughness in 1900H and GUR 1050 UHMWPE.

Pitting and delamination remain causative factors of polyethylene failure in total knee replacement. Gamma irradiation induces cross linking in ultra-high-molecular-weight polyethylene, which has been shown to improve wear resistance. Irradiation may reduce fracture toughness and fatigue strength, however, and the effects of irradiation are dependent upon the resin, processing technique, and radiation dose. The effects of varying levels of gamma irradiation (0, 33, 66, and 100 kGy) on the fracture toughness and fatigue-crack resistance of UHMWPE, isostatically molded from 1900H and GUR 1050 resins, were examined. Paris law regressions were performed to quantify fatigue-crack propagation rates as functions of change in stress intensity, and J-integral methods were used to quantify the elastic-plastic fracture toughness. The results indicated that gamma irradiation reduced the resistance of both materials to fatigue-crack growth, and that the reductions were radiation dosage and resin dependent. Irradiation at any level was detrimental to the fracture toughness of the 1900H specimens. Irradiation at 33 kGy increased fracture toughness for the GUR 1050 specimens, and substantial reductions were observed only at the highest irradiation level. Scanning electron microscopy of the fracture surface revealed diamond-like fracture patterns of the nonirradiated specimens indicative of ductile, multilevel fracture. Pronounced striations were apparent on these fracture surfaces, oriented perpendicular to the direction of crack growth. The striations appeared as folds in surface layers of the GUR 1050 specimens. At the highest irradiation levels, the striations were nearly eliminated on the fracture surfaces of the 1900H specimens, and were markedly less severe for the GUR 1050. These results demonstrated that at higher irradiation levels the materials became more brittle in fatigue, with less ductile folding and tearing of the fracture surfaces.

Arthroplasty, Replacement, Knee↗
PubMed2005

Evaluation of a reinforced slot design for CEREC system to restore extensively compromised premolars.

OBJECTIVES: The structural stability and adhesive strength of a large-cavity premolar with a CEREC restoration is a frequent problem in long-term use. This study sought to determine whether an additional reinforced slot could increase tooth/ceramic retention using finite element (FE) analysis and fracture testing. METHODS: The cavity was designed in a typical MODL restoration failure shape when the lingual cusp has been lost. Two FE restored-tooth models with different cavity designs were created using image processing, contour stacking, and mesh generation. Interfacial (normal and shear) stresses were then calculated with and without the slot design for restored teeth under lateral and axial forces and different interfacial conditions (bonded and de-bonding). For validation, a fracture experiment was performed with and without reinforced slot designs for large ceramic CEREC restorations. RESULTS: The maximum stresses at the buccal wall increased when a lateral occlusal force acted on the restored tooth with a slot design. Conversely, the interfacial stresses decreased when the restored tooth received a uniform axial occlusal force. After de-bonding on the buccal tooth/ceramic interface, the stresses increased by an average factor of three over those obtained with a bonded interface. The fracture forces were consistent with the tendencies predicted in FE analyses. CONCLUSIONS: An additional reinforced slot for the CEREC restoration of a large cavity could increase retention when a restored tooth receives an axial occlusal load. However, the benefits of a slot seem to be doubtful for a premolar often subjected to a lateral load.

Analysis of Variance↗
PubMed2005

[Fractal analysis of trabecular architecture: with special reference to slice thickness and pixel size of the image].

Many analyses of bone microarchitecture using three-dimensional images of micro CT (microCT) have been reported recently. However, as extirpated bone is the subject of measurement on microCT, various kinds of information are not available clinically. Our aim is to evaluate usefulness of fractal dimension as an index of bone strength different from bone mineral density in in-vivo, to which microCT could not be applied. In this fundamental study, the relation between pixel size and the slice thickness of images was examined when fractal analysis was applied to clinical images. We examined 40 lumbar spine specimens extirpated from 16 male cadavers (30-88 years; mean age, 60.8 years). Three-dimensional images of the trabeculae of 150 slices were obtained by a microCT system under the following conditions: matrix size, 512 x 512; slice thickness, 23.2 em; and pixel size, 18.6 em. Based on images of 150 slices, images of four different matrix sizes and nine different slice thicknesses were made using public domain software (NIH Image). The threshold value for image binarization, and the relation between pixel size and the slice thickness of an image used for two-dimensional and three-dimensional fractal analyses were studied. In addition, the box counting method was used for fractal analysis. One hundred forty-five in box counting was most suitable as the threshold value for image binarization on the 256 gray levels. The correlation coefficients between two-dimensional fractal dimensions of processed images and three-dimensional fractal dimensions of original images were more than 0.9 for pixel sizes < or =148.8 microm at a slice thickness of 1 mm, and < or =74.4 microm at one of 2 mm. In terms of the relation between the three-dimensional fractal dimension of processed images and three-dimensional fractal dimension of original images, when pixel size was less than 74.4 microm, a correlation coefficient of more than 0.9 was obtained even for the maximal slice thickness (1.74 mm) examined in this study.

Adult↗
PubMed1996

Shear bond strength, microleakage and antimicrobial properties of AElitebond.

PURPOSE: To evaluate the shear bond strength (SBS) and microleakage (ML) to dentin as well as the antimicrobial action against five strains of oral bacteria of AElitebond single primer restorative system. MATERIALS AND METHODS: Fifteen molars were tested to failure for each of the four time periods: 15 minutes, 24 hours, 7 days and 30 days, after final cure. The test specimens were prepared on the dentin surfaces of the extracted molars ground on 600 grit SiC paper. The bonded cylinders were removed from the assembly apparatus after cure, stored in physiological saline at 37 degrees C for the four different time periods and subjected to a shear bond load at 0.5 mm/minute until fractured. For the microleakage determination, Class V cavity preparations were done on the facial surfaces of the roots of 15 canines below the cemento-enamel junction and the specimens thermocycled (500x) between 8 degrees C and 15 degrees C in 2% methylene blue. The teeth were cut into 6 mm thick sections and the sections which included the restorations were separately dissolved in acid. The color intensities of the dissolved sections were measured at a wavelength of 590 nm against a standard curve which was constructed from the dye. The modified model cavity method of Meryon & Johnson (1989) was used to assess the antimicrobial properties of the restorative system. RESULTS: The mean SBS values (in MPa) were found to be 10.3, 9.8, 11.47 and 9.9 after 15 minutes, 24 hours, 7 days, and 30 days, respectively. There was no significant increase (P < 5%) in the SBS after 15 minutes. The ML of 0.76 micrograms dye/ restoration was relatively low in comparison to the SBS values. The restorative system significantly (P < 5%) inhibited the growth of Actinomyces naeslundii with 88%, Streptococcus mutans with 42%, Streptococcus sanguis with 39% and Streptococcus oralis with 9%. However, the growth of Veillonella parvula was stimulated with 49%.

Actinomyces↗
PubMed1997

Specificity of resistance training responses in neck muscle size and strength.

This study examined hypertrophy after head extension resistance training to assess which muscles of the complicated cervical neuromuscular system were used in this activity. We also determined if conventional resistance exercises, which are likely to evoke isometric action of the neck, induce generalized hypertrophy of the cervical muscle. Twenty-two active college students were studied. [mean (SE) age, weight and height: 21 (1) years, 71 (4) kg and 173 (3) cm, respectively]. Subjects were assigned to one of three groups: RESX (head extension exercise and other resistance exercises), RES (resistance exercises without specific neck exercise), or CON (no training). Groups RESX (n = 8) and RES (n = 6) trained 3 days/week for 12 weeks with large-muscle mass exercises (squat, deadlift, push press, bent row and mid-thigh pull). Group RESX also performed three sets of ten repetitions of a head extension exercise 3 days/week with a load equal to the 3 x 10 repetition maximum (RM). Group CON (n = 8) was a control group. The cross-sectional area (CSA) of nine individual muscles or muscle groups was determined by magnetic resonance imaging (MRI) of the cervical region. The CSA data were averaged over four contiguous transaxial slices in which all muscles of interest were visible. The 3 x 10 RM for the head extension exercise increased for RESX after training [from 17.9 (1.0) to 23.9 (1.4) kg, P < 0.05] but not for RES [from 17.6 (1.4) to 17.7 (1.9) kg] or CON [from 10.1 (2.2) to 10.3 (2.1) kg]. RESX showed an increase in total neck muscle CSA after training [from 19.5 (3.0) to 22.0 (3.6) cm2, P < 0.05], but RES and CON did not [from 19.6 (2.9) to 19.7 (2.9) cm2 and 17.0 (2.5) to 17.0 (2.4) cm2, respectively]. This hypertrophy for RESX was due mainly to increases in CSA of 23.9 (3.2), 24.0 (5.8), and 24.9 (5.3)% for the splenius capitis, and semispinalis capitis and cervicis muscles, respectively. The lack of generalized neck muscle hypertrophy in RES was not due to insufficient training. For example, the CSA of their quadriceps femoris muscle group, as assessed by MRI, increased by 7 (1)% after this short-term training (P < 0.05). The results suggest that: (1) the splenius capitis, and semispinalis capitis and cervicis muscles are mainly responsible for head extension; (2) short-term resistance training does not provide a sufficient stimulus to evoke neck muscle hypertrophy unless specific neck exercises are performed; and (3) the postural role of head extensors provides modest loading in bipeds.

Adult↗
PubMed2002

The effect of ultrasonic vibration on the compaction characteristics of ibuprofen.

An ultrasonic (US) compaction rig has been developed, capable of providing compaction pressure together with high-power ultrasonic vibrations of 20 kHz to a powder or granular material in a die. The rig has been used to investigate the effect of ultrasound on the compaction properties of ibuprofen, a drug with poor compaction properties which produces tablets that are weak and frequently exhibit capping. It was found that coherent ibuprofen tablets could be prepared by ultrasound-assisted compaction at pressures as low as 20-30 MPa. Application of ultrasound before and after compaction was found not to be as effective as ultrasound applied during compaction. The breaking forces of the tablets produced with ultrasound applied during compaction were found to be consistently significantly higher than when compaction was performed conventionally, or with ultrasound applied before or after compaction. Application of ultrasound during compaction made it possible to increase tablet mechanical strength, typically by a factor of 2-5. It was concluded that pressure should be applied together with ultrasound in order to achieve a better acoustical contact, which is required to transmit vibrations from the horn to the material, and also to bond the surfaces of the particles. Ultrasound application during ibuprofen compaction also resulted in an increase in the apparent density, in relation to the apparent density of conventionally prepared tablets, of up to 14.4%. Ultrasound appears to improve particle rearrangement and provides energy for partial melting of particle asperities and subsequent fusion of particle surfaces, so as to increase interparticulate bonding. Solid bridge formation was thought to result in a reduction of void space, which in turn reduced the rate of water penetration into the compacts and consequently increased disintegration and dissolution times. It was found that the results of ultrasound-assisted compaction are influenced by formulation and US time. When ibuprofen was mixed with a second material, such as dibasic calcium phosphate dihydrate (DCP) or microcrystalline cellulose (MCC), stronger tablets were prepared by ultrasound-assisted compaction compared to the compacts containing no filler. Positive interactions were considered to have occurred due to ultrasound-induced bonding between the two materials. With an increase in DCP and MCC concentration in ibuprofen formulations, disintegration and drug dissolution rates of the tablets produced with ultrasound significantly increased. Using temperature-sensitive labels it was found that thermal changes occurred in powdered solids undergoing ultrasound-assisted compaction. Increases in the temperature of tablets were related to US amplitude and US time. With an increase in US amplitude from 5 to 13 microns, the temperature of the DCP tablet surface increased from 40 to 99 degrees C. With an increase in US time from 1 to 5 sec, the temperature of the surface of ibuprofen tablets increased from 43 to 60 degrees C. Increased tablet temperature was thought to be due to ultrasonic energy dissipation turned into heat. X-ray powder diffraction (XRD) studies of ibuprofen tablets prepared by ultrasound-assisted compaction at 32 MPa revealed that no changes in chemical or/and crystalline structure of the material occurred when ultrasound was applied for up to 5 sec (US amplitude 7 microns). An XRD study of DCP tablets produced by ultrasound-assisted compaction at 32 MPa with ultrasound of different amplitudes (5, 7, 13 microns) applied for 2 sec indicated that no material deterioration occurred in all the tested samples.

Compressive Strength↗
PubMed1997

Mechanical property of a TIM-barrel protein.

The mechanical response of a TIM-barrel protein to an applied pressure has been studied. We generated structures under an applied pressure by assuming the volume change to be a linear function of normal mode variables. By Delaunay tessellation, the space occupied by protein atoms is divided uniquely into tetrahedra, whose four vertices correspond to atomic positions. Based on the atoms that define them, the resulting Delaunay tetrahedra are classified as belonging to various secondary structures in the protein. The compressibility of various regions identified with respect to secondary structural elements in this protein is obtained from volume changes of respective regions in two structures with and without an applied pressure. We found that the beta barrel region located at the core of the protein is quite soft. The interior of the beta barrel, occupied by side chains of beta strands, is the softest. The helix, strand, and loop segments themselves are extremely rigid, while the regions existing between these secondary structural elements are soft. These results suggest that the regions between secondary structural elements play an important role in protein dynamics. Another aspect of tetrahedra, referred to as bond distance, is introduced to account for rigidities of the tetrahedra. Bond distance is a measure of separation of the atoms of a tetrahedron in terms of number of bonds along the polypeptide chain or side chains. Tetrahedra with longer bond distances are found to be softer on average. From this behavior, we derive a simple empirical equation, which well describes the compressibilities of various regions.

Compressive Strength↗
PubMed1997

Composition- and history-dependent radial compressive behavior of human atherosclerotic plaque.

Invasive procedures to revascularize occluded blood vessels rely on the mechanical response of the diseased tissue. Failure rates associated with such procedures show the need for improvement. to understand the associated mechanics, the material properties of atherosclerotic plaque should be known; yet data are scant. The purpose of this study was to investigate the different mechanical responses exhibited by plaques with different compositions, focusing specifically on radial compressive behavior. A custom-built experimental system was developed that was fully computer controlled with a broad range of loading capabilities. A temperature-controlled, physiologic specimen bath allowed testing at 37 degrees C. Monotonically loaded specimens showed that plaque behavior was nonlinear under finite deformations. A multiple cycle protocol, executed in two phases, distinguished three types of mechanical response of different plaques. The differences in behavior were associated with histologic differences in plaque composition, and mechanically characterized by different "repeatability" (the stabilization of the cyclic response) and "recoverability" (the second loading phase retracing the first loading phase behavior). Type 1 behavior was categorized by repeatability and recoverability. Type 2 behavior displayed repeatability but only partial recovery during the second loading phase. Recovery was absent in type 3 behavior. The histologic observations demonstrated that calcified tissue was present only in specimens displaying type 1 behavior. Fibrous tissue and part of a modified media (due to disease) were present in specimens displaying type 2 behavior. An atheroma, along with a relatively thin modified media, was present in specimens displaying type 3 behavior. The differences in the maximum stretches attained at the end of phase I loading, the stretch offset from the first to the 15th cycle of phase I loading, and the hysteresis in the first and 15th cycles of phase I loading distinguished the specimen behaviors with statistical significance. These compression data showed that plaques exhibit composition- and history-dependent nonlinear and inelastic responses under finite deformations.

Aged↗
PubMed1998

Compressive creep characteristics of extruded ultrahigh-molecular-weight polyethylene.

The static compressive creep behavior of ultrahigh-molecular-weight polyethylene (UHMWPE) was studied under physiologic conditions. Specimens were machined from the center and periphery of extruded GUR 4150HP rod stock and were subjected to constant pressures of 2, 4, or 8 MPa for intervals as long as 10(4) min. The creep strain (creep divided by initial thickness) was compared to the pressure and duration of loading by using analysis of variance and linear regression analysis. The amount of creep strain increased rapidly in the early period of testing and was followed by a reduced rate of creep, which reached a steady state after approximately 4000 min. The amount and rate of creep strain increased linearly with pressure. Surprisingly, the rate of creep strain varied with the radial position in the rod stock: specimens obtained from the periphery had 8-19% larger creep strain rates than did specimens obtained from the center (p = 0.1 to p < 0.001). These results advance the characterization of creep's contribution to the in vivo penetration of the metallic component into the UHMWPE component, thereby facilitating the measurement of true in vivo wear. These data also help explain the azimuthally nonuniform deformation observed in retrieved acetabular cups.

Compressive Strength↗
PubMed1998

Viscoelastic properties of demineralized human dentin measured in water with atomic force microscope (AFM)-based indentation.

Using an atomic force microscope (AFM) with an attachment specifically designed for indentation, we measured the mechanical properties of demineralized human dentin under three conditions: in water, in air after desiccation, and in water after rehydration. The static elastic modulus (E(h)r = 134 kPa) and viscoelastic responses (tau(epsilon) = 5.1 s and tau(sigma) = 6.6 s) of the hydrated, demineralized collagen scaffolding were determined from the standard linear solid model of viscoelasticity. No significant variation of these properties was observed with location. On desiccation, the samples showed considerably larger elastic moduli (2 GPa), and a hardness value of 0.2 GPa was measured. Upon rehydration the elastic modulus decreased but did not fully recover to the value prior to dehydration (381 kPa).

Analysis of Variance↗
PubMed1999

Study of fatigue resistance of chemical and radiation crosslinked medical grade ultrahigh molecular weight polyethylene.

The aim of this work is to understand the role of chemical and radiation induced crosslinking on the fatigue crack propagation resistance of medical grade ultrahigh molecular weight polyethylene (UHMWPE). In recent years, the need to improve the tribological performance of UHMWPE used in total joint replacements has resulted in the widespread utilization of crosslinking as a method to improve wear resistance. Although crosslinking has been shown to drastically improve the wear resistance of the polymer, the potential trade-off in fatigue properties has yet to be addressed. Fatigue crack propagation resistance is a concern in tibial inserts where large cyclic stresses are sufficient to drive the growth of subsurface cracks that potentially contribute to delamination wear mechanisms. For clinical relevance, the combined effects of sterilization and aging are examined in two commercially available crosslinked resins. Nonsterile and unaged resins serve as a control. To evaluate the effect of crosslinking, a comparison is made to uncrosslinked resins. Scanning electron microscopy is used to provide an understanding of fatigue fracture mechanisms in the crosslinked polymers. The results of this study show that the current level of crosslinking used in orthopedic resins for enhanced wear resistance is not beneficial for fatigue crack propagation resistance.

Biocompatible Materials↗
PubMed2000

Production of porous hydroxyapatite by the gel-casting of foams and cytotoxic evaluation.

This study presents the manufacture of highly porous hydroxyapatite by a novel technique that employs the foaming of suspensions prior to the in situ polymerization of organic monomers contained in the compositions. This method produces strong gelled bodies with up to 90% porosity that can withstand machining in the green state. Complex-shaped components can be obtained if the process comprises casting in one of the processing steps. The organic additives are eliminated at temperatures above 300 degrees C, and sintering is carried out for consolidation of the ceramic matrix. Spherical interconnected cells with sizes ranging from 20 to 1000 micrometer characterize the porous structure, depending on the specimen density. Cytotoxicity tests were conducted on extracts from sintered HA foams based on a quantitative method of cell colony formation and the determination of cell death after indirect contact of the porous material with mammalian cells. This in vitro test of biological evaluation revealed that the original purity of the biomedical-grade hydroxyapatite powder was affected neither through processing nor by the employed reagents.

Animals↗
PubMed2000

Localized drug delivery using crosslinked gelatin gels containing liposomes: factors influencing liposome stability and drug release.

We describe a drug-delivery vehicle that combines the sustained release properties of liposomes with the structural advantages of crosslinked gelatin gels that can be implanted directly or coated onto medical devices. Liposome inclusion in gelatin gels does not compromise thermal stability nor does it interfere with the resiliency of gels to tensile force. However, electron spin resonance analysis of sequestered DPPC liposomes revealed a slight depression (ca. 1.0 degrees C) of the gel-to-fluid phase transition relative to liposomes in suspension. The level of liposome release from gels was determined by liposome concentration, liposome size, and the presence of poly(ethylene oxide) chains in the gel matrix or in the liposome membrane. Both neutral and charged liposomes displayed relatively high affinities for poly(ethylene glycol)gelatin gels, with only 10-15% release of initially sequestered liposomes while liposomes in which poly(ethylene glycol) was included within the membrane were not as well retained (approximately 65% release). The in vitro efflux of ciprofloxacin from liposomal gels immersed in serum was nearly complete after 24 h compared to 38% release of liposomal chlorhexidine after 6 days. The serum-induced destabilization of liposomal ciprofloxacin depended on the accessibility of serum components to gels as partly immersed gels retained approximately 50% of their load of drug after 24 h. In vivo experiments using a catheterized rabbit model of urinary tract infection revealed the absence of viable Escherichia coli on coated catheter surfaces in seven out of nine cases while all untreated catheter surfaces examined (n = 7) were contaminated.

1,2-Dipalmitoylphosphatidylcholine↗
PubMed1998

Compressive loading on bone surfaces from muscular contraction: an in vivo study in the miniature pig, Sus scrofa.

Several authors have speculated that muscles contracting adjacent to bony surfaces may cause compressive loads against the bone and thus influence skull development. This study was undertaken to evaluate the premise of this argument. A flat, semiconductor pressure transducer was surgically placed on bony surfaces beneath muscle attachments. Pressures were recorded during normal mastication (n = 7) and while overlying muscles were stimulated in anesthetized pigs (n = 15). The transducer was highly specific; no pressure was recorded in quiescent or passively stretched muscles or when other muscles were stimulated. Contraction of the overlying muscles exerted high normal loads on the bone, always exceeding systolic blood pressure (16 kPa). Temporal fossa pressure during mastication followed temporalis electromyographic (EMG) signals with a lag period approximating the twitch contraction time. When three different sites were compared in anesthetized animals, compressive load was highest on the temporal fossa (111.4 +/- 56.5 kPa, n = 15), intermediate on the mandibular angle (58.4 +/- 28.3 kPa, n = 4), and lowest on the medial side of the zygomatic arch (37.2 +/- 19.7 kPa, n = 15). Pressure amplitudes were not related to body size or relative muscle size. Muscle complexity and compartmental constraints did appear to influence pressure. Disruption of the external aponeurosis of the masseter decreased pressure on the mandibular angle by 45%, confirming the importance of tendinous constraint in determining pressure production. Thus, contracting muscles exert substantial but site-specific compressive loads on adjacent bone surfaces.

Animals↗
PubMed2000

Energy/temperature diagram and compression behavior of the polymorphs of D-mannitol.

Three modifications of D-mannitol were produced and investigated: mod. I (mp 166.5 degrees C, heat of fusion 53.5 kJ mol(-1)), mod. II (mp 166 degrees C, heat of fusion 52.1 kJ mol(-1)), and mod. III (mp incongruent 150-158 degrees C, heat of transition, III to I 0.2 kJ mol(-1)). The measured densities are 1.490 +/- 0.000 g cm(-3) [95% confidence interval (CI)] for mod. I, 1.468 +/- 0.002 g cm(-3) (95% CI) for mod. II, and 1.499 +/- 0.004 g cm(-3) (95% CI) for mod. III. It was possible to relate the different modifications given in the literature to one of the three pure crystal forms or to mixtures of two or all three modifications. The thermodynamic relationship among the crystal forms is represented in a semi-schematic energy/temperature diagram. From these data we can conclude that mod. III is thermodynamically stable at absolute zero. It is enantiotropically related to mod. I and mod. II. FTIR and Raman spectra, differential scanning calorimetry curves, and X-ray powder patterns of these crystal forms are depicted for doubtless assignment in the future. The water uptake of the three modifications at 92% relative humidity and 25 degrees C is less than 1%. The differences of the heat capacities and the heats of solution between mod. II and III are not significant, whereas mod. I shows small significant differences compared with the other modifications. In addition, compaction studies of these crystal forms were performed by means of an instrumented hydraulic press. The results show that mod. III should have the best tableting behavior under these conditions.

Calorimetry, Differential Scanning↗
PubMed2001

Compressive stress-relaxation of human atherosclerotic plaque.

Knowledge of the mechanical properties of human atherosclerotic plaque is fundamental to understanding atherosclerosis and its treatment. Data are scant, however, particularly with respect to the time-dependent nature of plaque behavior. Previous experiments in our lab showed that human plaques do not exhibit the traditional preconditioning behavior common to most soft tissues. In particular, the behaviors of three classes of plaques differed fundamentally in response to multiple, successive, cyclic compression protocols. In this report, we demonstrate that plaques exhibit different responses to successive relaxation tests in uniaxial compression. Not only is there significant relaxation, but there are composition-dependent differences in the general character of the relaxation responses. Such information on the time-dependent behavior is important for the design of clinical protocols such as stenting or angioplasty wherein the atherosclerotic vessel is subjected to persistent or multiple short duration loadings. This study presents a step toward a better understanding of the biomechanical behavior of atherosclerotic plaques; however, the need for much more data remains.

Angioplasty↗