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Acute spondylolytic spondylolisthesis. Risk of progression and neurological complications.

Acute spondylolytic spondylolisthesis was diagnosed after major trauma in five patients. The level of injury was between the third and fourth lumbar vertebrae in one patient and between the fifth lumbar and first sacral vertebrae in four. The initial spondylolisthesis was grade I in four patients and grade III in one. Four of the patients were initially managed non-operatively. The deformity did not progress in a five-year-old boy with grade-I spondylolisthesis who had been managed with immobilization in a body cast. The deformity progressed in two of the adolescents who had been managed non-operatively; the progression was from grade I to grade III in one of these patients and from grade III to grade V (spondyloptosis) in the other, in whom a cauda equina syndrome also developed. The latter patient was subsequently managed with posterior reduction and arthrodesis followed by an anterior arthrodesis, and the neurological deficits resolved. The deformity also progressed, from grade I to grade II over three years, in a fifty-seven-year-old woman who had been managed non-operatively. One patient who had a grade-I deformity was managed with immediate operative stabilization followed by immobilization in a thoracolumbosacral orthosis; the deformity did not progress. Although minor or repetitive trauma is often associated with spondylolysis, high-energy trauma may produce a more severe form of spondylolysis with spondylolisthesis. These deformities are more unstable, with instability similar to that of a fracture-dislocation, and they have a greater propensity to progress than the usual form of spondylolytic spondylolisthesis.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗

[Electrophysiological study on lumbosacral compression radiculopathy].

Using an electrophysiological approach, a functional diagnosis was attempted to evaluate lumbosacral compression radiculopathy. The cauda equina action potential (root-CEAP) and the somatosensory evoked potential (root-SEP) were measured by stimulating a single nerve root. The mixed nerve root action potential (MRAP) and the CEAP (P-CEAP) were recorded by stimulating a peripheral nerve. When a root was stimulated, reproduction of pain was also investigated. Seventy-four patients with lumbago and sciatica were examined. Nerve roots involved with neurological signs showed some abnormal conductivity in the order of P-CEAP, MRAP, root-SEP and root-CEAP. Subclinical involvement was also observed. It seems to be that the relationship between neurological signs and classification of root-SEP and root-CEAP are rather close. Pain was reproduced by stimulating the root in all cases of disc herniations irrespective of the neurological deficit. The above mentioned electrophysiological tests make it possible to identify and judge the extent of root involvement.

Action Potentials↗

Local anesthetic distribution in a spinal model: a possible mechanism of neurologic injury after continuous spinal anesthesia.

BACKGROUND AND OBJECTIVES: Cauda equina syndrome has been reported recently in patients receiving continuous spinal anesthesia using newly developed microcatheters (28 gauge). Failure of microcatheters to allow adequate mixing of local anesthetic was studied as a possible mechanism of the neurologic injury reported with these catheters. METHODS: A spinal canal model was developed and the distribution of hyperbaric lidocaine was measured after injection through catheters typically used for continuous spinal anesthesia (i.e., 20, 28, and 32 gauge). RESULTS: Lidocaine distribution was less uniform and lidocaine concentration and osmolarity in the dependent portions of the model were significantly higher after injection through microcatheters compared to the 20-gauge catheter. CONCLUSIONS: Dependent drug concentrations were greater than those reported in the literature, capable of producing permanent neurologic injury. Directing the catheter tip in the nondependent direction and injecting lidocaine rapidly or through catheters with multiple end holes improved mixing and decreased dependent drug concentration.

Anesthesia, Spinal↗

Comparison of different outlier criteria in quantitative anal sphincter electromyography.

OBJECTIVE: Analysis based on 'outliers' has been demonstrated to be a useful adjunct to mean value analysis in quantitative needle electromyography (EMG). However, the outlier criteria applied have been arbitrarily chosen. The aim of the present study was to determine the most useful outlier criteria in motor unit potential (MUP) analysis. METHODS: The external anal sphincter (EAS) muscles were examined by multi-MUP analysis. From 115 muscles of 64 normative subjects, the 0/100, 5/95, 10/90, 15/85, 20/80, and 25/75 percentile MUP parameter values were grouped individually. From these, the 5/95, 2.5/97.5, 1/99 and 0/100% confidence limits were determined. Thus, 24 sets of outlier limits were formed. To calculate sensitivity and specificity, data from 79 patients with cauda equina lesions (189 muscles), and from 77 controls (119 muscles) were compared to normative outlier limits. RESULTS: Sensitivities were highest with outlier limits formed from the 10-90 percentile ranges, followed by the 5-95 and 15-85 percentile ranges, while specificity was highest using the 15-85, followed by the 20-80, and 25-75 percentile ranges. On direct head-to-head comparison the 10-90 percentile ranges were more sensitive and 5-95 were more specific. CONCLUSIONS: The study demonstrated considerable differences in the sensitivity and specificity of outlier limits calculated from different percentile ranges, with outlier criteria calculated from the 10-90 and from the 5-95 percentile ranges appearing to be the most useful for detection of neuropathy in the EAS muscle. SIGNIFICANCE: In future EAS muscle EMG I propose that outlier criteria calculated from the 10-90 percentile ranges be used.

Adolescent↗

Operative spinal endoscopy: stereotopography and surgical possibilities.

The polyprojective microstereotopography of spinal canal structures at the cerebello-spinal, cervical, thoracic, lumbosacral and cauda equina levels on 20 fresh cadavers is presented using flexiscopes 3.7-3.9 mm diameter. This is possible due to the space between spinal cord-vertebral canal which is about 10 mm at all levels. This also allows one to insert the endoscopic tube by posterior or interradicular approach. The subdural and subarachnoid endoscopic examinations have been performed through small foraminotomic openings with resection of the base of the spinous process. The anterior and posterior roots, the spinal cord, dural root sleeves, cerebellar tonsils, orifice of the IV ventricle, vertebral artery and its lower branches can be visualised. On the stereotopographic basis the first operations in patients with severe spinal cord injury (detection of multilevel cord compression, removal of massive subarachnoid bleeding), syringomyelia and haemorrhage into the IV ventricle (clot removal by the ascending cervical route) were undertaken. More than 10 real and probable indications for operative spinal endofiberoscopy are discussed.

Adult↗

Infarction of the conus medullaris.

We describe 5 patients who presented with an acute cauda equina syndrome, which we believe was due to infarction of the conus medullaris. In 3 patients, the onset was spontaneous, and in 2 patients it was secondary to temporary occlusion of the distal aorta during medical manipulation. Pain in the buttocks and posterior thighs was a prominent initial symptom in the 3 patients with unprovoked attacks. The main clinical features were profound impairment of bowel and bladder function and of perianal and perineal sensation (S3 to S5 segments). There was sensory and motor impairment in the legs of variable extent, most marked in the S1 and S2 segments, but extending as high as L4 in 2 patients. In 1 patient, ischemic changes in the conus medullaris were confirmed post mortem. Ischemia confined to the caudal tip of the spinal cord is rare, and an underlying anomaly of the pattern of arterial supply is a likely predisposing factor. Four patients had partial return of function over a period of weeks.

Aged↗

Multiple spinal "miliary" hemangioblastomas in von Hippel-Lindau (vHL) disease without cerebellar involvement. A case report and review of the literature.

We report on a 57-year-old male presenting with radicular pain in the nerve roots of L5 and S1 on the right side and dysuria. Magnetic resonance imaging (MRI) of the lumbar spine showed multiple (up to 20) small, intradural enhancing nodules attached to the cauda equina down to the sacrum, the largest 1 cm in diameter at the level Th12/L1 compressing the conus. Additionally, small nodules in the cervico-thoracal region adjacent to the cord, but no cerebellar or cerebral abnormalities, were detected in a consecutive MRI of the remaining neuroaxis. The histology of a resected lesion at Th12/L1 revealed hemangioblastoma of the reticular type. Together with a history of left eye enucleation performed 17 years ago for angiomatosis of the retina and the immunohistochemical detection of von Hippel-Lindau (vHL) protein within the removed spinal hemangioblastoma, a diagnosis of vHL disease was established. Family history and screening for visceral manifestations of vHL disease were negative. In contrast to cerebellar or solitary spinal hemangioblastomas, multiple spinal hemangioblastomas without cerebellar involvement in vHL represent unusual manifestations. Unlike the case for solitary lesions in non-syndromic patients, a surgical cure does not seem feasible in this case. The role of treatment modalities is discussed.

Biomarkers, Tumor↗

Immune responses in experimental allergic neuritis.

The antibody and cell mediated immune responses were investigated in inbred Lewis rats with experimental allergic neuritis (EAN) induced by either P2, a protein purified from the bovine cauda equina nerve roots, or whole bovine nerve root myelin. In the P2 immunised animals both antibodies to P2 detected by radioimmunoassay and cell-mediated immunity to P2 assayed by skin testing appeared before the onset of EAN and persisted during and after the disease. In the myelin immunised animals the antibody titres were lower and somewhat delayed and the skin tests became negative at the height of the disease. Complement-fixing antibodies to galactocerebroside, which have been implicated in the production of demyelination under some circumstances, could not be detected in the serum after immunisation with either P2 or myelin. EAN was transferred passively with lymph node cells from rats immunised with either P2 or myelin although anti-P2 antibodies could not be detected in the serum of recipients with EAN. The results favour a cell-mediated immune response to P2 as the most important pathogenetic mechanism in EAN induced wtih whole myelin in the rat.

Animals↗

Effects of magnitude and duration of compression on spinal nerve root conduction.

Spinal nerve root compression occurs commonly in conditions such as herniated nucleus pulposus, spinal stenosis, and trauma. However, the pathophysiology of the symptoms and signs related to spinal nerve root compression is poorly understood. The purpose of the present study was to assess and compare effects of various pressures and durations of acute compression on spinal nerve root conduction in the pig cauda equina. Efferent conduction (compound motor action potentials) and afferent conduction (compound nerve action potentials) were monitored during compression for 2 or 4 hours with compression pressures of 0 (sham), 50, 100, or 200 mm Hg. Recovery from compression was monitored for 1.5 hours. No significant deficits in spinal nerve root conduction were observed with 0 or 50 mm Hg compression, compared to significant conduction deficits induced by 100 and 200 mm Hg compression. Three-way analysis of variance demonstrated significant effects of compression pressure and duration on conduction at the end of compression and recovery, with a significant difference between efferent and afferent conduction at the end of the recovery period. These observations suggest an interaction between biomechanical and microvascular mechanisms in the production of nerve root conduction deficits. Such information may relate to the motor and sensory dysfunction in clinical conditions associated with spinal nerve root compression.

Action Potentials↗

Lumbar synovial or ganglion cysts.

Most reports regarding synovial cysts of the spinal canal have been presentations identifying an unusual pathological entity that is to be included in the differential diagnosis of cauda equina compression syndromes. Most of the 26 cases reported represent isolated examples of this pathological process. We present five cases of lumbar synovial cysts encountered in our practice in the past 8 years. Patients with lumbar synovial cysts do not demonstrate any predictable clinical picture. They may present with a unilateral sciatica or neurogenic claudication. Lumbar extension is usually restricted, whereas flexion is full. Mechanical signs of nerve root entrapment or lumbosacral plexus irritation are unimpressive. Neurological deficits are usually mild, if present. Radiological findings include degenerative spondylosis, spondylolisthesis, and a rounded posterolateral extradural mass of low attenuation value adjacent to a facet shown on computed tomographic scan. The etiology of lumbar synovial cysts is not known. Histological findings of myxoid degeneration, microcystic change, calcification, and hemosiderin deposits suggest that chronic microtrauma with occasional focal hemorrhage may play a major role in the etiology of the cysts. With resection of the cyst, the postoperative course is usually uneventful. Recurrences have not yet been encountered in our patients.

Adult↗

A rapid transport route between the epidural space and the intraneural capillaries of the nerve roots.

STUDY DESIGN: The possibility of epidurally applied substances reaching the intraneural capillaries of the spinal nerve roots and cauda equina was assessed in the pig sacrococcygeal spine. METHODS: The presence of Evans blue-labelled albumin in intraneural capillaries after epidural application for 1, 10, or 30 minutes was studied with fluorescence microscopy. Ink angiography was used to determine whether there were any direct communicating vessels between the epidural vein plexus and the intraneural capillaries. RESULTS: Evans blue-labelled albumin was present in the intraneural capillaries 1 minute after epidural application. Microangiography demonstrated small venules that connected the epidural vein plexus and the intraneural capillaries. CONCLUSIONS: The results of this study demonstrated a rapid transport route between the epidural space and the intraneural capillaries. The results suggest that nucleus pulposus material, as well as epidurally applied substances, such as local anesthetic drugs or epidurally injected corticosteroids, may have a rapid, direct transport route to the axons of the spinal nerve roots. The demonstrated transport route also may be related to the mechanisms behind epidural anesthesia and spinal nerve root infiltration.

Albumins↗

[Neurotoxicity of intrathecal lidocaine].

Lidocaine is a local anesthetic belonging to the amide group and has been administered intrathecally for over 40 years. Although no serious complications had been attributed to lidocaine before the 1990s, subarachnoid administration is now the subject of controversy following its implication in numerous cases of neurological complication. The clinical pictures described in the literature are cauda equina syndrome, which is mainly associated with continuous subarachnoid anesthesia through microcatheters, and transitory neurological symptoms, also termed radicular irritation syndrome and associated with single injections. The literature reveals a clearly higher incidence of transitory neurological symptoms with lidocaine than with other local anesthetics. Although the underlying mechanism remains unclear, the main hypotheses being the neurotoxicity of lidocaine itself or the malpositioning of the paravertebral musculature due to extreme relaxation. The various factors that can lead to neuropathy have been widely described in the many articles reporting complications. Arthroscopy and lithotomy positions are significantly related to the appearance of symptoms, as are early ambulation or the use of small-gauge needles or pencil-point needles. Further clinical studies should be undertaken. No consensus on subarachnoid administration of lidocaine has emerged, yet no alternative has been demonstrated to be safe and to offer similar pharmacological features (short latency, short duration of action and good muscle relaxation). Prilocaine, mepivacaine, articaine and bupivacaine at low doses have been suggested as alternatives.

Anesthesia, Spinal↗

Radiologic imaging of symptomatic ligamentum flavum thickening with and without ossification.

Thickening of the ligamenta flava with and without ossification in the thoracic and lumbar regions is a frequent finding on CT scanning; however, it is not widely appreciated as a possible primary cause of compressive cord, cauda equina, and nerve-root symptoms. We present observations from a series of seven patients whose symptoms were caused exclusively or largely by thickened ligamenta flava in the thoracic and lumbar regions. The findings were best demonstrated on myelography. One of our cases had been missed on previous MR, as would be expected with the null signal of calcification. CT scanning necessitates an extended window to ensure discrimination of an ossified ligament from thecal metrizamide. Thickened ligamenta flava are often found in conjunction with degenerative disease and spinal stenosis at multiple levels and should not be ignored as a possible major contributing factor to the patient's symptoms. In addition, those patients with a secondary block from a thickened ligamentum flavum should be studied from above with C1-C2 puncture to rule out other levels of clinically significant disease. Attention to the particular findings of thickened ligamenta flava is important since surgical intervention must involve removal of the entire offending ligament(s); otherwise clinical symptoms may not be relieved.

Adult↗

Cervical spinal epidural haematoma: the double jeopardy.

Spontaneous spinal epidural haematoma is an unusual but well recognized cause of compressive myelopathy or cauda equina syndrome. Radicular pain is one of the earliest symptoms and a hallmark of spontaneous spinal epidural haematoma, as in the case of cervical spondylosis and disc prolapse. Should an epidural haematoma be located in the cervical spine, the resultant cervical radicular pain may sometimes be erroneously attributed to a cardiac cause, especially in the setting of pre-existing cardiac disease. The error in diagnosis can lead to another pitfall, the addition of heparin. If the etiology of the pain is a cervical epidural haematoma this can have grave consequences. Moreover, patients with cardiac ischemia who are treated with anticoagulants may rarely develop a cervical epidural haematoma. The resulting radicular pain can overlap with cardiac pain and escape recognition. Symptoms of neck and upper extremity pain with bilateral signs of myelopathy with a sensory level should lead to a suspicion of acute cervical cord compression. The addition of heparin can only compound the disastrous consequence of a rapidly expanding spinal epidural haematoma. The following cases illustrate this diagnostic and therapeutic conundrum.

Aged↗

Influence of halothane, enflurane, and isoflurane on motor evoked potentials.

The influence of the inhalational anesthetics halothane, enflurane, and isoflurane on motor evoked potentials was studied in a total of 10 rabbits. Motor evoked potentials were recorded from the extremity muscles as well as from the epidural space of the spinal cord and cauda equina in response to electrical stimulation of the motor cortex at baseline conditions and equianesthetic concentrations (0.25 to 1.5 minimal alveolar concentration). Our results show a dose-dependent suppression of the electromyographic responses, which was similar with all anesthetics. Beyond 0.5 minimal alveolar concentration of any of the agents, electromyographic responses were absent. In contrast, spinal evoked responses representing neural activity were only slightly affected by the anesthetics. We hypothesize that the descending impulse elicited by the electrical stimulation of the motor cortex is mainly inhibited at the level of the spinal interneuronal or motoneuronal systems, because 1) electromyographic responses evoked by the stimulation of the cervical and lumbar nerve roots were only minimally affected by 1.5 minimal alveolar concentration halothane; and 2) spinal evoked responses were stable several minutes after cardiac arrest, indicating a subcortical action site of the electrical impulse. In conclusion, intraoperative monitoring of descending pathways by means of motor evoked potentials during anesthesia with the inhalational agents halothane, enflurane and isoflurane is only feasible when neural activity is evaluated.

Afferent Pathways↗

Characterization of sulfated glucuronic acid containing glycolipids reacting with IgM M-proteins in patients with neuropathy.

In some patients with neuropathy and plasma cell dyscrasia, the serum IgM M-proteins are known to bind to the myelin associated glycoprotein and to peripheral nerve glycolipids. We have isolated two acidic glycolipids which bind to the M-protein from human cauda equina by DEAE-Sephadex, Iatrobeads, and high performance liquid column chromatographies. The major acidic glycolipid migrated between GM1 and GD1a and the minor acidic glycolipid migrated between GD1a and GD1b. Their structures were elucidated by sugar analysis, enzymatic digestion, mild acid hydrolysis, permethylation, fast atom bombardment mass spectrometry, and NMR studies. Their core structure was confirmed to be paragloboside by high performance thin-layer chromatography-immunostaining using anti-paragloboside monoclonal antibody. Both acidic glycolipids lacked sialic acid but contained sulfated glucuronic acid as their acidic moiety. The sulfate group in the glucuronic acid was established by periodate oxidation and permethylation studies to be attached to the 3 position. The structures of the two acidic glycolipids are therefore consistent with the following: IV3GlcUA(3-sulfate)nLcOse4Cer and VI3GlcUA(3-sulfate)nLcOse6Cer. Additionally, the free carboxyl group on the glucuronic acid residue was shown to be necessary to bind the IgM M-proteins from neuropathy patients.

Antibodies, Monoclonal↗

Statistics: can we prove an association for a rare complication?

BACKGROUND AND OBJECTIVES: Microcatheters for continuous spinal anesthesia were withdrawn from the market after an apparent increase in the incidence of cauda equina syndrome (CES) associated with spinal anesthesia after introduction of these catheters. The objective of this review is to evaluate the historical data on CES after spinal anesthesia and to compare the result to the recent data. METHODS: The literature on the use of statistics and on complications associated with spinal anesthesia was reviewed. Poisson probabilities were calculated to assess the probability of seeing the recent cases of CES, given the historical data. The sample size required for a prospective study was calculated. RESULTS: Statistics cannot "prove" an hypothesis but can only support or fail to support it. Use and interpretation of the p value are discussed, as are possible problems with interpretation of the p value. The difference between causal and statistical inference is discussed. Probabilities for the occurrence of CES after microcatheter use were calculated. The sample size for a prospective study of this problem was calculated; a large sample is required. CONCLUSIONS: Statistics alone cannot support an association of microcatheters with CES after spinal anesthesia. Additional considerations suggest a possible association, but further study is required.

Anesthesia, Spinal↗

Schwannoma with rhabdomyoblastic differentiation: a unique variant of malignant triton tumor.

A 54-year-old woman presented with intractable perianal, bilateral buttock, and radiating thigh/calf pain. An MRI scan showed an intradural, contrast-enhancing, ovoid mass in the cauda equina region at L1-L2. At laminectomy, the ovoid mass arose from a nerve root and, intact, was gross totally resected. Histologically, the dominant pattern was that of schwannoma. One year thereafter, the symptoms recurred. An MRI scan demonstrated an irregular, heterogeneously enhancing tumor recurrence. A repeat laminectomy disclosed a large fleshy tumor involving multiple nerve roots. The lesion was subtotally resected and showed pluridirectional differentiation toward embryonal rhabdomyosarcoma, primitive neuroectodermal tumor, and rare malignant epithelial cells. Review of the original tumor disclosed only foci of embryonal rhabdomyosarcoma and primitive neuroectodermal tumor. Based upon available data regarding divergent differentiation in peripheral nerve sheath tumors, this is a unique, previously undescribed tumor demonstrating rhabdomyosarcomatous, primitive neuroectodermal tumor and scant epithelial differentiation in a schwannoma. In essence, it is a variant of malignant Triton tumor because of its origin in a tumor consisting of well-differentiated Schwann cells. It supports the contention that the Schwann cell is the source of a variety of heterologous elements in nerve sheath tumors.

Cauda Equina↗