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Testing and evaluation for astronaut extravehicular activity (EVA) operability.

Because it is the human component that defines space mission success, careful planning is required to ensure that hardware can be operated and maintained by crews on-orbit. Several methods exist to allow researchers and designers to better predict how hardware designs will behave under the harsh environment of low Earth orbit, and whether designs incorporate the necessary features for Extra Vehicular Activity (EVA) operability. Testing under conditions of simulated microgravity can occur during the design concept phase when verifying design operability, during mission training, or concurrently with on-orbit mission operations. The bulk of testing is focused on normal operations, but also includes evaluation of credible mission contingencies or "what would happen if" planning. The astronauts and cosmonauts who fly these space missions are well prepared and trained to survive and be productive in Earth's orbit. The engineers, designers, and training crews involved in space missions subject themselves to Earth based simulation techniques that also expose them to extreme environments. Aircraft falling ten thousand feet, alternating g-loads, underwater testing at 45 foot depth, enclosure in a vacuum chamber and subject to thermal extremes, each carries with it inherent risks to the humans preparing for space missions.

Astronauts↗

Is there an effect of weightlessness on mental rotation of three-dimensional objects?

We studied the performance of eight cosmonauts in a mental rotation paradigm with simultaneously presented perspective views of three-dimensional objects. The cosmonauts were tested successively on earth, in microgravity aboard the Russian MIR station and again on earth. Their performance was compared to performance of a control group of five subjects tested on earth on the same dates. We particularly tried to disambiguate the effect of microgravity, procedural bias and practice. Our results show that the microgravity did not alter the mental rotation process. The performance of cosmonauts increased with practice, similarly to the performance of control group's subjects suggesting that the weightlessness did not impair implicit learning as well. Finally, we propose an explanation of previous contradictory results.

Adult↗

[Effect of a 7-day space flight on the structure and function of the human locomotor apparatus].

The goal of the joint USSR-Cuba experiment Support was to study the support properties of the foot arch in weightlessness-induced motor changes and their prevention with the help of the Cupula Sand-501 device. Comparison of the responses of the crewmembers shows that support simulation diminished the level of many of the adverse effects of zero-g in the Cuban pilot who used the prophylactic device. It is suggested that the efficiency of the device is due to its activation of the system of support reactions. The mechanisms of the effects of weightlessness on the structure and function of the bones and joints in humans are discussed.

Biomechanical Phenomena↗

Decreased femoral arterial flow during simulated microgravity in the rat.

To determine whether the blood supply to the hindlimbs of rats is altered by the tail-suspension model of weightlessness, rats were chronically instrumented for the measurement of femoral artery flow. Ultrasonic transit-time flow probes were implanted into 8-wk-old Wistar-Furth rats under ketamine-xylazine anesthesia, and, after 24 h of recovery, flow was measured in the normal ambulatory posture. Next, rats were suspended and flow was measured immediately and then daily over the next 4-7 days. Rats were subsequently returned to normal posture, and flow was monitored daily for 1-3 days. Mean arterial flow decreased immediately on the rats being suspended and continued to decrease until a new steady state of approximately 60% of control values was attained at 5 days. On the rats returning to normal posture, flow increased to levels observed before suspension. Quantile-quantile plots of blood flow data revealed a decrease in flow during both systole and diastole. The observed decrease in hindlimb blood flow during suspension suggests a possible role in the etiology of muscular atrophy and bone loss in microgravity.

Adaptation, Physiological↗

Skill maintenance in extended spaceflight: a human factors analysis of space and analogue work environments.

This paper discusses the implications of increasing mission lengths of manned spaceflight for the design of future space systems from a human factors point of view. It is argued that the increase in mission duration has brought about a number of new problems, which have not been sufficiently addressed in space research. Therefore, a review of analogue work environments is carried out to make up for the paucity of space research found in the area of human performance in long-duration spaceflight. This resulted in an evaluation of seven analogue environments concerning their similarity to space with industrial process control and nuclear submarines coming out as the closest match on the technical dimension. Finally, some recommendations are given from the lessons learned in spaceflight, simulation studies and appropriate analogue environments.

Aerospace Medicine↗

The strategic role of exercise devices in manned spaceflight.

Exercise appears in various contexts during spaceflight. It serves as a key countermeasure against adverse physiological adaptation processes; it also plays a role in life sciences research as reference state or stimulus. Further aspects concern human factors, recreational activities, health monitoring and training for emergency egress and extra-vehicular activities. Current approaches rely on conventional ergometers, they add rather than integrate training programs, and they tend to disregard applications other than "countermeasures". Two major consequences are an appreciable impact on available crew-time and an unsolved problem: Exercise countermeasures use extrapolations of 1g-physiology in order to eliminate what physiologists would like to study: adaptation to weightlessness. New concepts and devices are required to reconcile such conflicting demands and to reduce time consumption for physical training. Key elements are an improved simulation of terrestrial locomotion and a recombination of work and physical exercise. The GRASIM device will be presented as an example for a new generation of multi-purpose "exercisers".

Adaptation, Physiological↗

[Orthostatic circulatory instability: role of deconditioning of resistance vessels].

One of the effects of weightlessness on the circulatory system, i.e. reduction of the tension distending resistance vessels due to the loss of hydrostatic pressure, was simulated. For this purpose the abdominal aorta of rats was constricted by a wire spiral. As a result, the arterial pressure in the posterior body decreased by 30-50%. Beginning with postoperation day 7 the hydraulic resistance of resistance vessels of hindlimbs was decreased progressively and the myogenic regulation of their lumen was inhibited. The response to the stimulation of vasoconstrictive fibers of the sciatic nerve that was reduced 7-14 days after operation returned to normal 90 days later. An examination of the tail arteries demonstrated that the ability of their muscular layer to withstand the distending effect of the physiologically normal pressure was impaired. The magnitude of the constrictor reactions to norepinephrine (particularly to its moderate concentrations) was lowered. These changes may play an important role in the orthostatic disorders of circulation that occur after exposure to weightlessness.

Animals↗

Three dimensional spatial memory and learning in real and virtual environments.

Human orientation and spatial cognition partly depends on our ability to remember sets of visual landmarks and imagine their relationship to us from a different viewpoint. We normally make large body rotations only about a single axis which is aligned with gravity. However, astronauts who try to recognize environments rotated in 3 dimensions report that their terrestrial ability to imagine the relative orientation of remembered landmarks does not easily generalize. The ability of human subjects to learn to mentally rotate a simple array of six objects around them was studied in 1-G laboratory experiments. Subjects were tested in a cubic chamber (n = 73) and a equivalent virtual environment (n = 24), analogous to the interior of a space station node module. A picture of an object was presented at the center of each wall. Subjects had to memorize the spatial relationships among the six objects and learn to predict the direction to a specific object if their body were in a specified 3D orientation. Percent correct learning curves and response times were measured. Most subjects achieved high accuracy from a given viewpoint within 20 trials, regardless of roll orientation, and learned a second view direction with equal or greater ease. Performance of the subject group that used a head mounted display/head tracker was qualitatively similar to that of the second group tested in a physical node simulator. Body position with respect to gravity had a significant but minor effect on performance of each group, suggesting that results may also apply to weightless situations. A correlation was found between task performance measures and conventional paper-and-pencil tests of field independence and 2&3 dimensional figure rotation ability.

Adolescent↗

The use of micro-worlds for human factors research in extended spaceflight.

This article provides an analysis of the utility of micro-worlds for human factors research in extended spaceflight. It outlines potential areas of application of the micro-world research paradigm in the context of spaceflight. While the research literature provides several examples of micro-worlds that simulate different work environments of high complexity, little work has been done with this tool in the operational environment of spaceflight. The author presents a micro-world, called CAMS, that has been especially developed for use in space-related research. The results from a research programme (comprising seven studies using CAMS) are presented. Based on a comparative analysis of the benefits and limitations of micro-worlds compared to other simulation types, the author argues that micro-worlds can be a very effective tool, provided their inherent limitations are taken into consideration.

Astronauts↗

A conceptual framework for designing micro-worlds for complex work domains: a case study of the Cabin Air Management System.

A conceptual framework for the design of micro-worlds is presented in this paper. This is illustrated by a micro-world, called Cabin Air Management System (CAMS), that has been used in a research program to investigate human behavior during work with complex systems. Although CAMS is based on the operational context of spaceflight, its underlying principles correspond to a process control task. The authors propose a theoretical framework for micro-world design, which was used to guide the development of the CAMS micro-world. This may provide a helpful guideline for researchers wishing to develop a micro-world by using a more structured approach. A detailed technical description of CAMS is given to demonstrate the kind of real-world scenarios that may be simulated with this task environment. Finally, general aspects of the utility of micro-world research are discussed.

Air Conditioning↗

[Genesis of vestibulo-autonomic disorders in space flight].

Some considerations on the mechanisms of vestibulo-vegetative disturbance in space flight are given on the basis of clinical observations, experience of otoneurological clinic, simulation experiments and examinations of cosmonauts. The starting point in these disturbances was a significant fact of blood redistribution in weightlessness and subsequent changes in hemodynamics, metabolism, etc. The body reactions to weightlessness seem to prepare pronounced vestibulo-vegetative reflexes to threshold and subthreshold vestibular stimuli induced by head and body movements in flight. Some aspects of the vestibular selection and training of cosmonauts are discussed from this point of view.

Autonomic Nervous System↗

Centrifuges and inertial shear forces.

Centrifuges are often used in biological studies for 1 x g control samples in space flight microgravity experiments as well as in ground based research. Using centrifugation as a tool to generate an Earth like acceleration introduces unwanted inertial shear forces to the sample. Depending on the centrifuge and the geometry of the experiment hardware used these shear forces may contribute as much as 99% to the total force acting on the cells or tissues. The inertial shear force artifact should be dealt with for future experiment hardware development for Shuttle and the International Space Station (ISS) as well as for the interpretation of previous spaceflight and on-ground research data.

Cell Adhesion↗

[Water-salt homeostasis in rats during space flight].

The paper generalized the results of s series of experiments aimed at studying liquid and electrolytes contents in various organs and tissues of rats following 3-week space flights (SF). The results ascertain high reliability of the water-salt homeostasis maintaining system which ensures stable water and electrolytes amounts in the majority of animal tissues in SF. The following alterations appear to be of greatest significance: deduced potassium levels in the heart ventricle tissues in male rats after short-duration (7-9 d) exposure in SF, zero-g-induced degradation of the body ability to bind potassium at injection of isotonic solution KCl into the stomach; redistribution of potassium ions between mother and developing fetuses in space experiments with pregnant animals. Simulated experiments showed that similar shifting of potassium ions in the mother-fetus system may be due not to weightlessness exclusively but other impacts, i.e. they are not specific.

Animals↗

Reversal of weightlessness-induced musculoskeletal losses with androgens: quantification by MRI.

Microgravity causes rapid decrement in musculoskeletal mass is associated with a marked decrease in circulatory testosterone levels, as we reported in hindlimb-suspended (HLS) rats. In this model which simulates microgravity, we hypothesized that testosterone supplementation should prevent these losses, and we tested this in two studies. Muscle volumes and bone masses were quantitated by using magnetic resonance imaging (MRI) on day 12. In the first study, 12-wk-old Sprague-Dawley rats that were HLS for 12 days lost 28.5% of muscle volume (53.3 +/- 4.8 vs. 74.5 +/- 3.6 cm3 in the ground control rats; P < 0.001) and had a 5% decrease in bone mineral density (BMD) (P < 0.05). In the second study, 30 male 12-wk-old Wistar rats were HLS and were administered either a vehicle (control), testosterone, or nandrolone decanoate (ND). An additional 20 rats were used as ground controls, one-half of which received testosterone. HLS rats had a significant reduction in muscle volume (42.9 +/- 3.0 vs. 56 +/- 1.8 cm3 in ground control rats; P < 0.01). Both testosterone and ND treatments prevented this muscle loss (51.5 +/- 2 and 51.6 +/- 1.2 cm3, respectively; a 63% improvement; P < 0. 05). There were no statistical differences between the two active treatment groups nor with the ground controls. Similarly, there was an 85% improvement in BMD in the testosterone group (1.15 +/- 0.04 vs. 1.04 +/- 0.04 density units in vehicle controls; P < 0.05) and a 76% improvement in the ND group (1.13 +/- 0.07 density units), whereas ground control rats had a BMD of 1.17 +/- 0.03 density units. Because serum testosterone levels are markedly reduced in this model of simulated microgravity, androgen replacement seems to be a rational countermeasure to prevent microgravity-induced musculoskeletal losses.

Anabolic Agents↗

[Biological research in space].

The paper presents the results of investigations carried out during the last two decades on various biological objects--microorganisms, plant seeds, insects, higher and lower plants, fish and amphibians--in real and simulation space flights. The paper discusses the current knowledge of the biological role of gravity and possible mechanisms of adaptation to weightlessness as well as the suitability of different biological objects for further space studies. Most experiments conducted in real space flights have lent support to the theoretical studies of the level and limits of weightlessness effects upon biological systems. Analysis of the data obtained in space and ground-bound experiments suggests that molecular processes are indifferent to an altered gravity and that energy metabolism plays an important role in adaptation of biological systems to zero-g.

Adaptation, Physiological↗

Physiologic mechanisms effecting circulatory and body fluid losses in weightlessness as shown by mathematical modeling.

The mechanisms causing large body water losses in weightlessness are not clear. It has long been considered that a central volume expansion drives the physiologic adaptation to a reduced total blood volume, with normal blood composition eventually regained. However, inflight venous pressure measures suggest that central volume expansion in weightlessness may be very transient, or that considerable cardiovascular adaptation to fluid shifts occurs on the ground while astronauts wait in the semi-supine pre-launch position. If a central volume stimulus does not persist, other mechanisms must drive the adaptation of circulation to a reduced blood volume and account for body fluid losses. Recent results from the SLS-1 mission suggest that body fluid volumes do not simply decline to new equilibria but that they decrease to a low point, then undergo some recovery. Similar "under-shoots" of body fluid volumes have also been shown in computer simulations, providing confidence in the validity of the model. The purpose of this study was to examine the mechanisms which could explain the loss of body fluids in weightlessness and how a cardiovascular preadaptation countermeasure we previously tested ameliorated body fluid losses. It is assumed that the physiology of head down tilt (HDT) provides a reasonably accurate analog of weightless exposure.

Blood Viscosity↗

Engineering and simulation of life sciences Spacelab experiments.

The third in a series of Spacelab Mission Development tests was conducted at the Johnson (correction of Johnston) Space Center as a part of the development of Life Sciences experiments for the Space Shuttle era. The latest test was a joint effort of the Ames Research and Johnson Space Centers and utilized animals and men for study. The basic objective of this test was to evaluate the operational concepts planned for the Space Shuttle life science payloads program. A three-man crew (Mission Specialist and two Payload Specialists) conducted 26 experiments and 12 operational tests, which were selected for this 7-day mission simulation. The crew lived on board a simulated Orbiter/Spacelab mockup 24 hr a day. The Orbiter section contained the mid deck crew quarters area, complete with sleeping, galley and waste management provisions. The Spacelab was identical in geometry to the European Space Agency Spacelab design, complete with removable rack sections and stowage provisions. Communications between the crewmen and support personnel were configured and controlled as currently planned for operational shuttle flights. For this test a Science Operations Remote Center was manned at the Ames Research Center and was managed by simulated Mission Control and Payload Operation Control Centers at the Johnson Space Center. This paper presents the test objectives, description of the facilities and test program, and the results of this test.

Animals↗

Doppler evaluation of cardiac filling and ejection properties in humans during parabolic flight.

The cardiac filling and ejection properties of seven normal human subjects were examined during microgravity created on a National Aeronautics and Space Administration aircraft during parabolic flight. Doppler echocardiography was used to measure intracardiac velocities in sitting and supine subjects during three phases of flight: hypergravity (phase I), early microgravity (phase III), and late microgravity (phase IV). Heart rate declined 6% (P < 0.001) and right ventricular inflow velocities rose (46%, early; 26%, mean; P < 0.01) between phase I and phases III or IV in the sitting position only. Peak left ventricular outflow velocities rose 12% and inflow velocities rose (13%, early; 20%, mean) between phases I and IV while subjects were in the supine position (P < 0.05). A 14% rise in early velocities alone was seen between phases I and IV while subjects were in the sitting position (P < 0.05). In subjects entering microgravity while sitting, right heart chambers can accept additional venous return. When microgravity was entered while subjects were supine, however, venous augmentation was not observed. Left heart filling was more prominently enhanced when microgravity was entered while subjects were supine, suggesting a shift of fluid within the pulmonary vasculature.

Adult↗