Isolation of an habituational position effect in paired-associate learning.
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Adult↗
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PAVLOV: an information retrieval program for the analysis of learning data.
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Computers↗
Affect and meaningfulness as variables in mediate association.
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Affect↗
Differences between essential and reactive alcoholics on tests of neuropsychological functioning and affect.
This study tested the hypothesis that Essential Alcoholics (n = 15) develop a more severe form of alcoholism than Reactive Alcoholics (n = 12). VA alcoholic patients were classified as Essential or Reactive Alcoholics, using the Rudie-McGaughran questionnaire, and tested on four neuropsychological tests, the Neuropsychological Impairment Scale, the Beck Depression Inventory, Tarter's Hyperactivity/Minimal Brain Dysfunction questionnaire, and Latcham's Measure of Antisocial Behavior. While the two groups did not differ in age, education, or Family History of alcoholism. Essential Alcoholics had an earlier age of onset and a longer chronicity of alcoholism. After analysis of covariance was used to control for group differences in age of onset and chronicity, Essential Alcoholics were still significantly higher on depression and significantly more impaired on five subtests of the Neuropsychological Impairment Scale: global measure, total items, general, learning-verbal, and frustration. Nonsignificant group differences, in the expected direction, were found for the Shipley Mental Age and Tarter's questionnaire. These results suggest that Essential Alcoholics have higher depression scores and greater impairments in neuropsychological functioning than Reactive Alcoholics.
Adult↗
Correlations of memory and learning with vision in aged patients before and after a cataract operation.
The connection between memory and learning with vision was investigated by studying 100 cataract operation patients, aged 71 to 76 years, 25 of them being men and 75 women. The cataract operation restored sufficient acuity of vision for reading (minimum E-test value 0.40) to 79% of the subjects. Short-term memory was studied with series of numbers, homogenic and heterogenic inhibition, and long sentences. Learning was tested with paired-associate learning and word learning. Psychological symptoms were measured on the Brief Psychiatric Rating Scale and personality on the Mini-Mult MMPI. Memory and learning improved significantly when vision was normalized after the cataract operation. Poor memory and learning scores correlated with monocular vision before the operation and with defects in the field of vision, due to glaucoma and exceeding 20%, postsurgery. Monocular vision and defects in the visual field caused a continuous sense of abnormalness, which impaired old people's ability to concentrate on tasks of memory and learning. Cerebrovascular disturbances, beginning dementia, and moderate psychological symptoms obstructed memory and learning on both test rounds. Depression was the most important psychological symptom contributing to poor memory and learning scores after the cataract operation. The memory and learning defects mainly reflected disturbances in memorizing.
Aged↗
Cognitive, social, and economic costs of allergic rhinitis.
Allergic rhinitis is a highly prevalent, chronic condition. In addition to physical discomfort, rhinitis symptoms have been associated with detrimental effects on the psychological and social aspects of patients' lives. In allergy-specific questionnaires, subjects with allergic rhinitis consistently report lower quality of life than nonallergic controls. Untreated patients are embarrassed and frustrated by their allergy symptoms. Atopic individuals consistently exhibit significant declines in cognitive processing, psychomotor speed, verbal learning, and memory during allergy season. The discomfort, cognitive impairment, and absenteeism associated with allergic rhinitis exact a significant economic toll on U.S. businesses through decreased productivity. When combined with direct medical expenditures, the economic burden of allergic rhinitis is considerable. The effect of treatment on the economics of allergic rhinitis is highly variable: relatively inexpensive medications (lower direct costs) have central nervous system side effects that can cause somnolence and impair learning, memory, and performance (higher indirect costs). Health outcomes data on the effects of allergic rhinitis and its treatments can help establish, monitor, and improve standards of care; as well as inform priority setting, direct resource allocation, and eliminate unnecessary practices.
Chronic Disease↗
Predicting community integration after traumatic brain injury with neuropsychological measures.
A neuropsychological test battery was administered to 23 subjects with traumatic brain injury during initial inpatient rehabilitation who were participating in the national Traumatic Brain Injury Model Systems study. Trails B and the Rey Auditory Verbal Learning Test total scores obtained during inpatient rehabilitation were significantly correlated with the Community Integration Questionnaire total score that was administered at one year postinjury. These findings suggest that performances on tests of cognitive speed and flexibility, complex attention, and memory during the acute phase of recovery may be useful for the later prediction of "real world" behavior and psychosocial outcome after one year postinjury.
Adolescent↗
Memory abilities during normal aging.
One hundred and five normal subjects from 20 to 89 years old, and with a minimum of six years of formal education were selected. Subjects were divided into seven age ranges, with 15 subjects in each group. The following tests were individually administered: (1) Wechsler Memory Scale (WMS) (Wechsler, 1945); (2) Serial Verbal Learning (Ardila, Rosselli & Puente, 1994; Ardila & Ostrosky, 1991); (3) The Rey-Osterrieth Complex Figure (ROCF) (Osterrieth, 1944) (copy, immediate, and delayed reproduction); (4) Corsi's blocks (Milner, 1971) (forwards and backwards); and (5) Rivermead Behavioural Memory Test (Wilson, Cockburn, & Baddeley, 1985). This last test may be considered as a functional or ecological memory test. All test scores declined across ages between 4.1% and 76.6%. In all the tests, excepting Digits, standard deviations increased with age. It was observed that the youngest subjects could retain about three-fourths of the information presented, whereas the oldest retained around one-third of this information. About half of the test significantly correlated with the Rivermead Behavioral Memory Test. A factor analysis revealed four different factors accounting for 63.3% of the variance. A single nonverbal memory factor accounted for over 40% of the variance.
Adult↗
Neuropsychological evaluation of patients with inoperable non-small cell lung cancer treated with combination chemotherapy or radiotherapy.
Neuropsychological tests were used to evaluate possible central nervous system dysfunction in patients treated with chemotherapy. Ninety-five patients with non-small cell lung cancer limited disease were randomized to either radiotherapy (2.8 Gy x 15) or combination chemotherapy with cisplatin and etoposide. In order to evaluate cognitive functions three neuropsychological tests were applied: Trail Making, Benton Visual Retention Test and Verbal Learning. Changes in the patients' test scores before and after treatment were compared. The chemotherapy patients showed reduced performance on some of the neuropsychological tests compared to the radiotherapy group. This indicates a treatment related effect on the central nervous system, possibly caused by the combination chemotherapy.
Adult↗
A hidden client group? Communication impairment in hospice patients.
Retrospective research has identified communication impairment in over a quarter of hospice patients (Jackson et al. 1996) but this field has not been investigated using speech and language therapy assessments. The present study assessed a sample of 12 hospice patients using tests of verbal learning and recall, word-finding, sentence comprehension and motor speech. Eleven patients experienced difficulties in one or more areas of assessment. Possible reasons are discussed, including the effects of patients' illness and treatment and changes in mood or cognitive functioning. A role for speech and language therapy is proposed, in terms of assessment, advice and training. Further research is suggested to help establish the extent of impairment and define a role for speech and language therapy.
Aged↗
Cognitive rehabilitation therapy of brain-injured students in a public high school setting.
Cognitive rehabilitation therapy is a systematic effort to assist brain damaged individuals in developing ways to compensate for cognitive deficits. Although this treatment is considered standard in a field of rehabilitation, access to services is limited by the availability of specialists. A model for bringing cognitive rehabilitation techniques to children with acquired brain injury within their own school setting is presented. A convenience sample of 10 public high school students with acquired brain injury received biweekly cognitive rehabilitation sessions for 20 weeks. Treatment was based on a developmental model of brain functioning. Treatments were provided by trained school teachers under the supervision of psychologists specializing in cognitive rehabilitation. Students were evaluated pre- and post-treatment using neuropsychological tests. After treatment, the students demonstrated a significant increase in general memory ability (p < 0.05). These gains were due mostly to increases in verbal learning ability. Integration of cognitive rehabilitation therapy with public school services is a significant step in providing this valuable treatment to a wider range of children with acquired brain injury.
Adolescent↗
[Memory function in aging and Parkinson's disease--an event-related potential study].
The N400 of event-related potentials (ERPs) was recorded in 17 healthy young subjects (mean age 24.4 years), 14 healthy old subjects (healthy control subjects, mean age 62.7 years), and 21 patients with nondemented Parkinson's disease (PD, mean age, 63.8 years) as they listened to words or nonwords. Some words were repeated immediately after the initial presentation (2 sec), while others were repeated after 5 intervening words (12 sec) or after 2 to 4 minutes. The subjects were required to respond to occasional nonwords. Rey's auditory verbal learning test(AVLT) was also performed. The mean N400 amplitude was smaller in patients with PD than in either healthy group, but there was no difference between the two healthy groups. In the young subjects, N400 was attenuated for repeated words, and the attenuation was more pronounced for immediate than for delayed repetitions. N400 attenuation in the old subjects was more markedly reduced as the interval between the 1st and 2nd presentation increased than in the young subjects. In PD patients, attenuation was noted only for immediate repetition. Free recall by the old subjects was impaired relative to the young subjects throughout the AVLT trials, and was even more impaired in patients with PD. In addition, the number of free recalls increased less with the number of trials in patients with PD than in the old subjects. These results may indicate that episodic memory declines with advancing age, and declines even more in patients with PD. In addition, the ability to transform information form short-term memory to long-term memory appear to be impaired in patients with PD.
Adult↗
[Neuropsychological comparison between corticobasal degeneration and progressive supranuclear palsy].
We conducted a neuropsychological comparison among cases with corticobasal degeneration (CBD; n = 8), those with progressive supranuclear palsy (PSP; n = 5) and healthy control subjects (n = 12) using an extensive neuropsychological battery assessing memory and executive functions. There were no significant differences among three groups for age, education, scores on the Mini-Mental State Examination and Zung's self-rating depression scale. Both patient groups showed retrieval impairment without recognition difficulties, and a dysexecutive syndrome. Along with those similarities, we observed some differences between CBD and PSP patients. Memory impairments in CBD patients were more marked than PSP patients in Rey's complex figure test, while they were less prominent in Rey's auditory verbal learning test. Perseverative errors of Nelson in Wisconsin card sorting test (Keio version) were more marked in CBD patients than in PSP patients. These two diseases showed memory and executive dysfunctions probably due to subcortico-frontal dysfunction. Some neuropsychological differences may help to distinguish CBD clinically from PSP.
Aged↗
[Memory function in patients with Parkinson's disease: in relation to neuropsychological tests and cerebral blood flow].
We conducted a neuropsychological comparison between Parkinson's disease (PD; n = 24) and healthy control subjects (n = 12) using Rey's auditory-verbal learning test (RAVLT) and the Rey-Osterrieth complex figure test (RCFT) assessing memory function. In addition, to determine the function of cortical and subcortical areas, we measured the regional cerebral blood flow (rCBF) using N-isopropyl-p[123I]-iodoamhetamine (123I-IMP) and single photon emission computed tomography (SPECT) and analyzed the relationships between brain regions and memory function. On the RAVLT, significant group differences in recall words were found on all learning trials between patients with PD and control subjects, whereas recognition, learning rate and forgetting rate were basically the same. In addition, the primacy/recency effect was statistically equal for both groups. Results suggest faulty retrieval mechanisms in PD, whereas encoding and retention procesess did not prove to be affected. There were significant correlations between perfusion of the prefrontal and parietal cortices and total number of free recall in five trials. On the RCFT, recalls after 30 sec and 30 min were impaired in patients with PD although no significant difference in accuracy scores obtained in copy was noted. A percent recall score calculated using the formula 100 x [1 - (copy-recall)/copy] was also decreased in patients with PD. There were significant correlations between perfusion of the occipital and parietal cortices and percent recall score. Our data suggest that auditory memory deficits based on the RAVLT in PD may be mainly related to frontal and parietal cortical dysfunction, while visual recall deficits based on the RCFT may be related to the parieto-occipital cortical dysfunction.
Aged↗
Neurobehavioral functioning and magnetic resonance imaging findings in young boxers.
In a prospective investigation of neurobehavioral functioning in young boxers, 13 pugilists and 13 matched control subjects underwent tests of attention, information-processing rate, memory, and visuomotor coordination and speed. The results disclosed more proficient verbal learning in the control subjects, whereas delayed recall and other measurements of memory did not differ between the two groups. Reaction time was faster in the boxers than in the control subjects, but no other differences were significant. Ten subjects in each group were retested 6 months later and exhibited improvement in their neuropsychological performance as compared to baseline measurements. However, there were no differences in scores between the boxers and the control subjects at the follow-up examination or in the magnitude of improvement from baseline values. Magnetic resonance imaging, which was performed in nine of the boxers, disclosed normal findings.
Adult↗
Cognitive functioning in long-term survivors of high-grade glioma.
In a pilot study, two groups of patients with malignant glioma underwent sequential neuropsychological evaluations after successful tumor treatment. Group 1 included nine patients treated from 1981 to 1985; all patients received irradiation and eight underwent chemotherapy. The baseline neuropsychological assessment was performed 1 to 63 months after tumor diagnosis, with follow-up evaluations at irregular intervals over the next 3 to 7 years. Six patients in Group 1 exhibited impairment on most measures at baseline; subsequently, two patients developed profound cognitive impairment. Initially, three patients functioned in the average range on most tasks; thereafter, two deteriorated on one measure each. Group 2 was ascertained prospectively and included 16 patients treated from 1985 to 1987, all of whom received irradiation and chemotherapy. The first evaluation was performed 18 months after diagnosis, then every 6 months for 2 years, and then yearly. Compared to a control group, those in Group 2 had significant cognitive impairment at baseline. Cognitive performance did not change over the next 12 months in 10 patients who remained free of tumor, but within 2 years of baseline testing, deterioration on specific tasks was evident in two of seven disease-free survivors. When last tested, five of six disease-free survivors had deteriorated on one or more measures. Unlike Group 1, severe global cognitive impairment was not seen, perhaps because Group 2 was followed for a shorter time. Verbal and nonverbal composite scores derived from intelligence quotient (IQ) tests showed less impairment at baseline than did other measures and were more likely to remain stable subsequently. Verbal memory and sustained attention were the most impaired at baseline, and verbal learning and flexibility in thinking showed the greatest tendency to decline over time. Cognitive functioning in survivors of high-grade glioma is best measured and monitored by tests that probe a broader spectrum of abilities than IQ. Neuropsychological measures used in this analysis lacked sensitivity at the lower end of the impaired range. Future studies should use tests better able to discern cognitive differences at low performance levels. Based on this experience, the authors conclude that most long-term survivors of high-grade glioma will have significant cognitive difficulties, usually evident by the first assessment; some patients will develop profound impairment years later, and few are capable of fully independent living.
Adult↗
Phonological similarity neighborhoods and children's short-term memory: typical development and dyslexia.
In this article, we explore whether structural characteristics of the phonological lexicon affect serial recall in typically developing and dyslexic children. Recent work has emphasized the importance of long-term phonological representations in supporting short-term memory performance. This occurs via redintegration (reconstruction) processes, which show significant neighborhood density effects in adults. We assessed whether serial recall in children was affected by neighborhood density in word and nonword tasks. Furthermore, we compared dyslexic children with typically developing children of the same age or reading level. Dyslexic children are held to have impaired phonological representations of lexical items. These impaired representations may impair or prevent the use of long-term phonological representations to redintegrate short-term memory traces. We report significant rime neighborhood density effects for serial recall of both words and nonwords, for both dyslexic and typically developing children.
Attention↗
The list strength effect: a contextual competition account.
Research on the list strength effect (LSE) has shown that learning some words on a list more strongly than others impairs memory for the weakly learned words when tested with a recall task. Norman (2002) demonstrated that the LSE also occurs within the recollection process of a recognition test. In this study, a mechanistic dual-process account of the LSE was tested that simultaneously makes predictions concerning additional sources of context in interference effects. In two experiments, we attempted to replicate Norman's (2002) findings and provide the basis for our modeling efforts. We found evidence for a recollection LSE in raw measures of responding, with memory performance also benefiting from reinstatement of perceptual characteristics at test. However, large differences in the hits between the lists were accompanied by small differences in false alarms, such that when d' is calculated, differences between the lists are not significant. We propose an account of the LSE whereby the actual effect of competition between items on the list is small, although present, and difficult to distinguish from large effects of bias due to the strength manipulations. We argue that our findings provide support for a mechanistic explanation of LSE that is based on competition of source activation and changes in the thresholds for responses.
Attention↗