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At least 1,729 records · Page 96Linked to original sources
PubMed1980

[Relationships between clinico-therapeutic parameters and immunological status in patients with lung cancer].

150 patients with lung cancer have been studied from the immunological point of view: the two years that elapsed between the study and processing of the data permitted an evaluation of the prognosis in terms of immunology also. This study has been carried out in vivo by means of skin tests (BCG, PPD, Candida, Varidase, CCB, Mumps, BNCB) and in vitro with lymphocyte blastization in the presence of PHA and dependent antibody cytotoxicity. Serum factors which can interfere with lymphocyte cytotoxicity have also been studied. Peri- and intra-tumour lymphocyte infiltration and the lymph node activation stage have been analyzed in patients who underwent surgery. A real depression of the cell mediated immunity observed in the negative response to skin tests has been found. The study of in vitro parameters showed a deficient blast response in 86% of the cases examined, decreased cytotoxicity in 62% and the presence of inhibiting serum factors in 53%. No correlation was observed between positivity to skin tests, normal response to PHA, normal concentration of inhibiting serum factors on the one hand and survival on the other. The only finding which seems to be correlated with survival is lymphocyte infiltration; its peri- and intrastromal presence on the neoplasia may be associated with a significantly better prognosis.

Antigens↗
PubMed1980

A radioisotopic leukocyte adherence test.

A modification of the leukocyte adherence inhibition method is described which utilizes 51Cr-labeled blood mononuclear cells placed in microwells. The test is reproducible, objective, employs approximately 2,000 cells per well, and allows multiple replicates of several antigens. With the two antigens tested, SK-SD and PPD, both increases and decreases of leukocyte adherence are observed. Serum proteins are important in the medium and inactivated AB serum gave the best results. A good correlation was observed between this leukocyte adherence test and positivity of skin testing,

Chromium Radioisotopes↗
PubMed1981

Age dependence of subpopulations and functions of human peripheral lymphocytes.

The eventual dependency of a series of immune parameters on age has been studied in a material of 288 normal persons, divided into 2 sexes and with 16 persons in each 5-year age interval between 5 and 95 years, using a cryobiological freezing and storage system for lymphocytes with subsequent testing in large series. Lymphocyte transformation responses were studied after stimulation with a series of mitogens and specific antigens (PHA, PWM, PPD, Con A, SA, EC, CA and SK/SD), as well as with allogene cells in mixed lymphocyte culture. Values were found to decrease with increasing age. No age-dependency could be demonstrated for T and B lymphocytes using rosette formation tests. There was no difference between the two sexes. Thus, increasing age does not change the distribution between T and B lymphocytes, but does lead to a decrease in the function of the cell-mediated response.

Adolescent↗
PubMed1982

Stimulation of NK-like CMC by skin test antigens in vitro is depressed in patients with SLE.

Peripheral blood mononuclear cells isolated from patients with systemic lupus erythematosus (SLE) developed lower levels of skin test antigen stimulated natural killer cell like cell-mediated cytolysis (NK-like CMC) than did similar cells from age and sex matched non-SLE volunteers. When the subjects were grouped according to disease activity the cells from the patients with mild disease activity developed lower levels of NK-like CMC than did those from the non-SLE control subjects. The cells isolated from SLE patients who had moderate to severely active disease developed little if any NK-like CMC after exposure to various skin test antigens. Greatly decreased skin test antigen stimulation of NK-like CMC in the cells from the SLE patients with more active disease did not appear to be due to therapy with corticosteroids or to a suppressor effect on this response by monocytes present in the peripheral blood mononuclear cell populations.

Adult↗
PubMed1981

[Adhesion prophylaxis in surgical gynecology].

In operations near the internal genitalia it is important to prevent adhesions if fertility is to be preserved. As animal experiments and clinical experience have shown a fibrinolysin can be use for prevention of adhesions. In operations on the tube for restoring fertility and during chromolaparoscopy one should use a fibrinolysin, or example Varidase, and a cortisone derivative.

Anti-Bacterial Agents↗
PubMed1981

Lymphocyte transformation and the number of antigen-responsive cells in humans.

The lymphocyte transformation response of normal human subjects to the antigen streptokinase/streptodornase (SK/SD) was analyzed by quantitating antigen-responsive cells (ARC), estimating the first generation lymphocyte response (FGLR), and performing standard lymphocyte transformation assays at different time points. Unlike the results obtained with the nonspecific mitogen phytohemagglutinin (PHA), the response to SK/SD appeared to depend almost entirely on the participation of progeny lymphocytes derived from a small number (mean of 21.3 +/- 5.8 per 100,000 mononuclear cells) of cells initially sensitive to the antigen. Similar peak lymphocyte transformation responses were obtained for the 2 stimuli, although those to SK/SD occurred later. Lymphocyte transformation data obtained after a shorter than optimal culture period (6 days) appeared to be a better estimate of ARC than the data obtained at the peak of the response of ARC than the data obtained at the peak of the responses did. However, ARC were best estimated by determining the FGLR or the number of days required for the lymphocyte transformation response to reach its peak.

Adult↗
PubMed1981

Abnormal immunologic measurements in asthmatic children and adults.

Several immunologic measurements were evaluated in 128 asthmatic patients (81 pediatric and 47 adults) in an effort to examine the question of altered cell-mediated immunity in asthmatics. Both pediatric and adult patients showed alterations in some but not all measurements. The results indicate that there are differences among subgroups of asthmatics and in some cases between pediatric and adult patients.

Adolescent↗
PubMed1981

Generation of a soluble immune response suppressor factor (IRSF) by unstimulated leukocytes of healthy subjects.

Supernatants derived from unstimulated cultures of mononuclear leucocytes obtained from healthy subjects contained a factor(s) which consistently suppressed lymphocyte proliferative responses to antigens and mitogens. This factor(s) is produced by a non-adherent cell and was generated in vitro after 4 hr of culture. Cells from almost all healthy subjects produced this substance(s). Cell number and viability were not affected by it. Kinetic studies suggested that interference with antigen presentation was not the mechanism of its action. The release of this immune response suppressor factor(s) (IRSF) was not blocked by indomethacin and its biological activity was unrelated to levels of prostaglandin E2. Experiments with low-specific-activity thymidine showed that suppression was not due to release of unlabelled nucleotide. Preliminary characterization of IRSF revealed that it is heat-stable and partially dialysable through membranes with an exclusion size of 12,000 daltons. IRSF differs from previously reported soluble suppressor substances and may play a role in immunoregulation in health.

Adult↗
PubMed1981

[Delayed skin reaction in a group of 400 hospital patients: control study (author's transl)].

Delayed hypersensitivity skin tests were carried out with 5 antigens - PPD, staphylococcus, streptokinase/streptodornase, candida and trichophytin-in 400 hospital patients without any known causes for diminished delayed hypersensitivity. The degree of reactivity to each antigen was: PPD. 69.50%; candida 49.75%; streptokinase/streptodornase 44.50%; trichophytin 42.00%; staphylococcus 14.25%. Reactivity to either PPD or candida occurred in 86.50% of all cases. Positive response to streptokinase/streptodornase was present in 7%; which brings the total cases with reactions to one or more of the 3 antigens to 93.50%. Those who responded to trichophytin or staphylococcus were 3% only, bringing the total response of all cases to at least one antigen, to 96.5%.

Adolescent↗
PubMed1977

Value of delayed hypersensitivity index in patients with malignancy.

A delayed hypersensitivity index can be obtained by standardized in vivo testing with available antigens. Recall antigens and DNCB to measure the afferent limb can be used to assess this important body function. The index is a valid indicator of cellular immunity, which is important as a dynamic indicator in many medical conditions and in treating patients with malignancy.

Candida↗
PubMed1978

An investigation into the antigen-specificity of transfer factor in its stimulatory action on lymphocyte transformation.

Dialysable transfer factor (TF) was prepared from the buffy-coat cells of donors with known cell-mediated reactivity to tuberculin (PPD), streptococcal protein (SKSD) and diphtheria toxoid (DT). The effect of such preparations on the transformation by these antigens of lymphocytes from tuberculin-negative donors was investigated. Transformation was determined as incorporation of tritiated thymidine. The concentrations of SKSD and DT were adjusted for different lymphocyte donors so as to give, in the absence of TF, a low index of transformation (less than 10-fold) comparable to that obtained with PPD. TF from tuberculin-positive donors stimulated antigen-induced transformation by on average approximately 2-fold whereas TF from tuberculin-negative donors generally had little effect. This was so not for PPD as antigen but also for SKSD and DT, and sensitivity of TF donor to SKSD of DT was not a determining factor. TF also frequently increased background transformation in the absence of antigen. Although a small effect, this ability tended to reflect the activity of TF in the presence of antigen. It is concluded that neither the whole nor any significant part of this enhancement of transformation can be ascribed to an antigen-specific factor. Tuberculin-positive donors apparently yield a higher level of non-specific factor and possible reasons for this are discussed. The factor active in transformation may be responsbile for the TF phenomenon in vivo.

Antigens, Bacterial↗