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[Aarno Snellman, the pioneer of modern neurosurgery in Finland and the founder of the Neurosurgical Clinic of Helsinki University Hospital].

Aarno Snellman, M.D., (1893-1964) was the pioneer of modern neurosurgery in Finland and the founder of the Neurosurgical Clinic of Helsinki University Hospital. In 1932, at the initiative of Marshal Mannerheim, the Finnish Red Cross Hospital started functioning at Helsinki, with trauma as its focus of activity. From the outset, the main task of the hospital was to treat the brain injuries caused by traffic accidents in the capital and its environment. With a view to improving the prognosis of the patients, the medical staff took an active interest in the achievements of foreign neurosurgeons. Assistant Surgeon Aarno Snellman had been working at Prof. Herbert Olivecrona's Neurosurgical Clinic in Stockholm. After his return in 1935, he was the first to perform a craniotomy in Helsinki. When the war began in 1939, the development of neurosurgery was delayed by the lack of staff. On the other hand, the war provided a strong incentive for the development of independent neurosurgery. The military authorities favoured the Finnish Red Cross Hospital, all wounds to the brain, spinal cord and peripheral nervous system being referred to its wards, which were superintended by Snellman. After the conclusion of peace, these wards were gradually transformed into an independent neurosurgical clinic led by Snellman. He was appointed Personal Professor of Neurosurgery at the University of Helsinki in 1947. He retired from his post as Head of the clinic in 1961. Aarno Snellman's abundant achievements include the organization of treatment and after-care of the brain-injured war veterans in Finland.

Finland↗

[Modern aspects of diagnosis and treatment of acute pancreatitis].

Problems of pathophysiology, diagnosis and main principles of treatment of an acute pancreatitis were considered. An early accurate diagnosis, taking into account form of the disease, prognostication of his course, application of modern intensive therapy, obligatory prophylaxis and treatment of systemic inflammatory reaction and the early (noninfectional) and late (infectional) syndrome of polyorganic dysfunction, conduction of endoscopic intervention in systemic-toxic phase of the disease, adequate choice of operative method in presence of pancreatic infection are promoting the reduction of the disease course severity and the mortality lowering.

Acute Disease↗

Prognosis--the dilemma of modern periodontics.

As periodontics has progressed towards an understanding of the influences of risk factors such as genetics, smoking and stress in the occurrence and severity of periodontal disease, the question of prognosis, so essential to treatment planning, has become even more perplexing to the clinician. A survey of long term clinical practice gives insight into the outcome of therapy relative to initial severity, and modern concepts of bacteria versus host relationships provide directions for greater predictability. However, it is only with observation over time that a more accurate assessment of prognosis can be made, as response to initial therapeutic measures can be determined.

Bacteria↗

The application of polyvinyl alcohol in the technology of modern drug form.

The following presentation is a review of literature related to application of nonionic polymer, polyvinyl alcohol, in the technology of modern drug form. The review contains the description of physical-chemical properties of this polymer, such as hydrolysis degree, solubility, swelling capacity. Each characteristic is followed by the description of its application as a therapeutical substance carrier in the pharmacy.

Administration, Cutaneous↗

[Modern illnesses from the critical viewpoint].

Psychosomatic illness as "modern diseases" are of increasing interest to the public. Environmental illnesses, for example assumed intoxication with organic solvents, multiple chemical sensitivity, sick building syndrome, chronic fatigue syndrome, fibromyalgia, the influence of amalgam or of electromagnetic waves and ozone are often causes of anxiety. There are many hypotheses about the origin of these diseases. Some scientists emphasize an organic basis; however, this is not generally accepted. Very often with good reason a psychological cause is supposed. Objective diagnostic criteria are not available, therefore these diagnoses may only be applied after sufficient exclusion of other known organic diseases. Mostly a psychological treatment is refused by the person affected, and a scientifically based somatic concept for the therapy does not exist. The medicolegal problems are important and often the reason for prolonged forensic confrontations.

Chronic Disease↗

[Modern principles of treating bronchial obstruction in pulmonary tuberculosis patients].

The efficiency of bronchodilating therapy described in the Federal Program for patients with chronic obstructive pulmonary diseases was evaluated in patients with lung tuberculosis with bronchial obstruction, treated in accordance with the Federal Program. Obvious advantages of modern inhalation therapy in comparison with the traditional methods were demonstrated: respiratory symptoms decreased and bronchial patency improved. These results recommend the therapy presented in the Federal Program for wide practical use.

Adult↗

A comparison of inclusive and restrictive strategies in modern missing data procedures.

Two classes of modern missing data procedures, maximum likelihood (ML) and multiple imputation (MI), tend to yield similar results when implemented in comparable ways. In either approach, it is possible to include auxiliary variables solely for the purpose of improving the missing data procedure. A simulation was presented to assess the potential costs and benefits of a restrictive strategy, which makes minimal use of auxiliary variables, versus an inclusive strategy, which makes liberal use of such variables. The simulation showed that the inclusive strategy is to be greatly preferred. With an inclusive strategy not only is there a reduced chance of inadvertently omitting an important cause of missingness, there is also the possibility of noticeable gains in terms of increased efficiency and reduced bias, with only minor costs. As implemented in currently available software, the ML approach tends to encourage the use of a restrictive strategy, whereas the MI approach makes it relatively simple to use an inclusive strategy.

Confidence Intervals↗

[Modern methods of treatment of diabetic foot syndrome].

Method of complex treatment of the diabetic foot syndrome (DFS), which included combined application of intravascular laser irradiation of blood, ultraviolet irradiation of blood, indirect electrochemical detoxication of organism, endolymphatic therapy, abacterial environment, modern methods of physical antisepsis was elaborated and introduced in practice.

Diabetic Foot↗

[Modern histological classification of renal neoplasms].

The review presents current literary information on basic forms of kidney cancer (clear cell carcinoma, chromophil or papillary cancer, chromophobe renal cell carcinoma, oncocytoma, Bellini carcinoma, sarcomatoid carcinoma and neuroendocrine carcinoma), their morphological characteristics and principles of classification. Modern histological classification of renal cancer is based on immunohistochemical evidence on markers of various nephron segments, this allowing to specify histogenesis of separate forms of renal cell carcinoma. In addition, cytogenetic studies of renal carcinoma reveal correlations between genetic changes in cancer cells and tumor phenotype found at light microscopy. Thus, current classification of renal carcinoma characterizes biology of these neoplasms. This should be taken into account in prognostication and design of new treatment methods.

Humans↗

[Progress of pediatrical physio - pathological theory in modern TCM].

Progress was made in significance of pediatrical physio pathology in modern TCM, including the elaboration on the role of dry dampness as etiological factor in pediatrics; the elaboration of renovation of theory of fetal - toxicity from an eugenic viewpoint; the popularization of variolation and its immunological mechanism, and its verification conclusion in TCM; combination of traditional wind syndrome - like western physiopathology in cerebral - neurology.

China↗

[Modern western medical education in Fujian].

The modem western medical education in Fujian mainly stemmed from three aspects: medical schools established by Missionary, western schools managed by government and western medical education in the Soviet District of Western Fujian. These three educational modalities promoted the development of modern western medical education in Fujian.

China↗

[Frostbite in modern fighting pathology].

In modern war 1-2% in the structure of fighting surgical pathology constitute the frostbites. In cold time of year their frequency increases up to 10%. Late admission of the injured to the stages of medical evacuation, their different and often limited diagnostic and therapeutic potentials influence on the outcomes of frostbites' treatment. The role of rational operative treatment with the use of surgical dermato-plastic methods rises. The analysis of periods, outcomes of treatment, restoration of working capacity and fitness for military service after the frostbites of different degrees and levels of injury permits to propose the military-and-medical classification of this trauma type. Slight, moderate and severe frostbites were selected. The places of final treatment of the injured with reference to the classical scheme of treatment- and evacuation support under conditions of the local armed conflict were determined.

Frostbite↗

[Modern magic and medicine].

In a paper presented on the occasion of the 5th Congress of gynecology in the GDR the author discusses in details the phenomenon of modern occultism and quackery. Preferably he examines the so called parapsychology and declares that this is a field without any scientific value. Therefore the course of action of parapsychologists is not to be accepted without resolute reply.

Ethics, Medical↗

W. D. Miller. The pioneer who laid the foundation for modern dental research.

Toothache has been the most ubiquitous ailment to plague mankind from time immemorial. Until the late 1700s, it was thought that the cause of this torment was the wriggling, in a carious tooth, of a worm. And early attempts at treatment were focused on driving the "worm" out. It was one of the world's greatest scientists, the dentist W. D. Miller, who, after extensive research, in 1891 published his epochal work, The Microorganisms of the Human Mouth, which set forth a new theory regarding the cause of dental caries. His postulating a "chemico-parasitic" origin of caries laid the basis for all the modern research in dentistry aimed at wiping this scourge out. Contemporary research has proven the worth of Miller's groundbreaking theory.

Bacteriology↗

[Bezoars: from ancient talismans to modern disease].

Bezoars are concretions of foreign materials that are created in the intestinal tract of various animals and humans. They have been known to western medicine since ancient times, when they were used for countering and preventing poisoning. In modern times bezoars were described as an unusual cause for various gastrointestinal symptoms. Trichobezoars are an infrequent form of bezoar, formed from ingested hair. We present a case of a trichobezoar, which appeared as a large abdominal mass, with gastric bleeding, ulceration and perforation. As in most previously reported cases, the diagnosis was not made on clinical grounds prior to imaging studies.

Adolescent↗

[A study of the organizing process of the modern midwifery system in Yamagata Prefecture focusing on the enactment of "Midwifery Regulation" in the 32th year of Meiji].

The Japanese modern midwifery system was provided at the start by the "Medical regulation" in the 7th year of Meiji and was organized to national unity by the Imperial Ordinance "Midwifery Regulation" in the 32th year of Meiji (1899). During these twenty-five years, Hokkaido and each of the prefectures enacted their own "Midwifery Regulation" to conform with the "Midwifery Regulation," and they organized the original midwifery system. This study focuses on the Yamagata Prefecture and midwifery system in the Tohoku district, and considers the organizing process of the system. Because the Yamagata district continued the Edo Period custom of infanticide, the Yamagata prefectual administration maintained strict control of that custom. At the same time it repeatedly enacted and revised the "Mid-wifery Regulation" to adjust it to the conditions of farm and mountain villages. Finally, it established the original "Registered Midwife System" in the 22th year of Meiji. That organizing process was classified into four stages. The present study shows that the system was not contradictory to the Imperial Ordinance "Midwifery Regulation" enacted in the 32th year of Meiji, which was amended to the unified national midwife system.

History, 19th Century↗

[Measuring the functional status of patients in clinical trials using modern clinimetric methods].

In clinical medicine numerous measurement instruments have been developed to assess the functional outcome of patients in clinical trials. The majority are questionnaires with multiple-choice items. The responses of the patients are used to calculate a sum score. However, there are some disadvantages associated with the use of sum scores. Modern clinimetric methods, based on item response theory (IRT) in combination with a calibrated item bank, can overcome these problems. When using this measurement technique, it is possible to arrange both the item difficulty and the patient's ability on a single, hierarchical linear scale. This allows the user to obtain a sufficiently detailed clinical picture using a small number of items. In addition to being efficient, this method makes it possible to present different sets of items to different groups of patients. Since all of the items are calibrated, the measurements remain comparable. The application of this innovative method of measuring is being studied in the ongoing 'Amsterdam linear disability score' (ALDS) project.

Clinical Trials as Topic↗