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Results for “Merkel Cells”

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PubMed2004

Summer skin check.

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Carcinoma, Merkel Cell↗
PubMed2006

Use of negative-pressure dressings to manage a difficult surgical neck wound.

We used negative-pressure dressings to treat a poorly healing cervical rotation flap following radical neck dissection in an elderly man. The wound had failed to heal properly after 2 weeks of conservative management. Following application of the negative-pressure dressings, the wound granulated quickly and healed well by secondary intention.

Aged↗
PubMedDate not supplied

[Neuroendocrine carcinoma of the skin].

The neuroendocrine carcinoma of the skin (NCS) is an uncommon disease, having been described about 400 cases in world literature. Two cases of NCS in a 52-year-old woman and in a 44-year-old man are reported; their histogenesis is still uncertain. It is advisable a wide cutaneous excision of the neoplasm extending 2-3 cm. over its macroscopic borders, in order to decrease the incidence of local recurrences, reaching 33% in some reports; when regional nodes are involved a lymphadenectomy is recommended. The authors also recommend a prophylactic radiotherapy of locoregional node chains, because of the high radiosensitivity of these tumors.

Buttocks↗
PubMedDate not supplied

[A case of Merkel carcinoma with facial localization].

A case of Merkel carcinoma is reported. It concerns a 40-year-old lady, who had first noticed the lesion one year before she came to our observation. The authors point out the rarity of this tumour, whose not distinctive gross appearance (firm, sessile tumour with well circumscribed margins; hyperhemic overlaying skin; slowly increasing volume) may suggest other macroscopic diagnoses such as intradermal nevus or nodular basalioma. The authors also point out the usefulness of a prompt correct clinical diagnosis of this lesion, whose clinical behaviour may be highly aggressive.

Adult↗
PubMed1983

[Cutaneous apudoma. Apropos of a case and review of the literature].

It has been suggested that Merkel Ranvier cells, generally considered as belonging to the Apud system, may be the origin of extremely rare skin tumors. The authors analyse the characteristics of an apudoma in connexion with a case, and compare their findings with those of 58 other cases reported in the literature. With light microscopy techniques, the differential diagnosis is essentially one of a non-differentiated primary or secondary carcinoma, or of a lymphosarcoma. Detection by electron microscopy of neurosecretory granules in the cell cytoplasm, the neuron-specific enolase activity, when this is detectable, the possibility of ectopic polypeptide secretions, and the evolution potential of the tumor, are all features warranting inclusion of this type of tumor in the category of apudomas.

APUD Cells↗
PubMed1981

Multiple fibrofolliculomas with trichodiscomas and acrochordons.

The syndrome of multiple fibrofolliculomas with trichodiscomas and acrochordons clinically is characterized by asymptomatic dome-shaped papules primarily involving the head, neck, chest, back, and arms. These tumors represent benign proliferations of the mesodermal and ectodermal components of the pilar apparatus. Substantial overlap between each of these lesions exists. Individual patients also exhibit a disease spectrum in which various tumors preponderate. The stimulus for this proliferation may be genetically determined, but the cause remains unknown. Merkel's cells were not identified in an electron microscopic study of a single trichodiscoma, but banded structures similar to those described in the closely related lesions of perifollicular fibroma and fibrous papule were seen.

Adult↗
PubMed1995

[Primary cutaneous neuroendocrine carcinoma (Merkel tumor). Clinical and therapeutic update apropos of 4 cases].

The clinical and pathological features of 4 cases of cutaneous neuroendocrine carcinoma are reported. There are unusual malignancies mostly observed in elderly, the prognosis is poor by loco-regional aggressivity and disseminated metastases. They are diagnosed by a pathologist: ultrastructural studies and immunohistochemistry support the diagnosis. A combination of a wild local excision, node dissection and post-operative radiation is recommended.

Aged↗
PubMed1993

Adnexal carcinomas of the skin.

Adnexal carcinomas of the skin are a rare, highly malignant, and extremely diverse group of neoplasms. This article reviews skin adnexal tumors of nervous, vascular, and fibrous tissue of the head and neck. These tumors pose a significant diagnostic and therapeutic challenge, requiring close cooperation between the head and neck surgeon and the dermatopathologist.

Carcinoma, Merkel Cell↗
PubMed1996

[Regeneration of free nerve endings and sensory corpuscles after implantation of nerve into the denervated skin in the monkey].

Two rhesus monkeys were used. Their fingers were denervated first and then the nerve was implanted into the denervated skin. The results showed that: (1) the process of regeneration of nerve fibers was similar to that of previous experiments in rabbits; (2) regeneration of nervous tissue included 2 kinds of sensory receptors with capsule-Meissner corpuscles and Merkel cell-dendrite complex; (3) the regenerative rate of Meissner corpuscles increased progressively and their morphology and structure became matured with elapse of time; (4) no regeneration of pacinian corpuscle was found in 6 months after nerve implantation; (5) Meissner corpuscles also regenerated in the transplanted glabrous skin.

Animals↗
PubMed1996

Morphological differences among nerve fiber endings in the rat oral mucosa as revealed by methylene blue staining.

The nerve fiber distribution in the oral mucosa of the soft palate and palatoglossal arch of the rat was studied by means of methylene blue supravital staining. It was focused primarily on the dye uptake of intraepithelial nerve fibers. Differences in the morphology of nerve fiber terminations were found between these regions of the oral mucosa. In the soft palate, local accumulations of intraepithelial nerve fibers which branched and showed terminal enlargements were detected. Intra- and perigemmal nerve fibers of chemosensory corpuscles could be stained. In the palatoglossal arch, numerous elongated papillae were seen containing nerve fiber plexus showing a complicated arborization pattern. In part, the collaterals penetrated the epithelium. The soft palate contained only a small number of lower but broader papillae which were covered by a more expanded intraepithelial nerve fiber plexus. In both regions, anastomoses between the branches of single nerve fibers were sometimes seen. Solitary delicate nerve fiber endings were loosely distributed throughout the epithelia. In addition, intrapapillar nerve endings, which were enclosed by a slightly stained capsule, were intensely stained; they showed characteristic lateral protuberances. The Merkel's discs were visualized as the components of a terminal network of nerve fiber branches. The observed differences in the shape and locations of the nerve terminations suggest different functions of these nerve fibers. Due to the low costs of the staining procedure and its ease in handling, it is well-suited for a mapping of the innervation pattern of the whole oral mucosa.

Animals↗
PubMed1995

Comparison of labeled MIBG and somatostatin analogs in imaging neuroendocrine tumors.

In 10 patients with histologically proven neuroendocrine tumors (4 carcinoids, 4 pheochromocytomas, 1 medullary thyroid cancer and 1 Merkel tumor) the results of radiolabeled metaiodobenzylguanidine (MIBG) and somatostatin analogs were compared. A total of 24 tumor lesions was detected on standard imaging studies. MIBG scintigraphy correctly localized 12 (50%) of these lesions which were observed in 5 patients (4 with pheochromocytoma and 1 with carcinoid tumor). Scintigraphy using labeled somatostatin analogs correctly localized 21 (87%) lesions which occurred in 8 patients (4 with carcinoid, 2 with pheochromocytoma, 1 with medullary thyroid cancer and 1 with Merkel tumor). Concordant scintigraphic results were obtained in 1 patient with carcinoid and 2 with pheochromocytoma. In conclusion, although this series was limited, our results suggest that MIBG is more accurate than somatostatin analogs in imaging pheochromocytoma. Conversely, somatostatin analogs are more accurate than MIBG in detecting other neuroendocrine tumors such as carcinoids.

3-Iodobenzylguanidine↗
PubMed1996

[Uncommon tumor and pseudotumor lesions of the submandibular fossa].

The histological examination of the salivary gland tumors is a very important step in the diagnostic approach of the lesions, on which depends the success of therapeutic outcome. Some surprises may occur; four examples were reported. In one case the lesion was not a tumor but a tuberculous lymphadenitis; another showed a Destombes Rosai Dorfman syndrome. Two other cases were found to be unusual tumors: a carcinosarcoma of the submandibular gland and a metastasis of a Merkel carcinoma in the submandibular gland.

Adult↗