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At least 1,729 records · Page 96Linked to original sources
PubMed1991

Effect of age on the radiation-induced repopulation in mouse lip mucosa.

The acute macroscopic radiation reactions in mouse lip mucosa were used as a biological model to evaluate the influence of aging on the radiosensitivity and more specifically on the repopulation capacity after irradiation of rapidly proliferating epithelial tissues. No difference in the mucosa response after single dose irradiations was observed for animals ranging between one and twelve months of age. There was a trend for decreased radiosensitivity of the lip mucosa comparing 18 months old (early-senescence) with young adult mice. The repopulation experiments involved two equal sized radiation doses delivered with an interval of ten days. Again, in all age-groups, not only was the 50% incidence-dose for mucosa desquamation similar, but also the full biphasic course of radiation reactions. These data therefore demonstrate that the capacity of the lip mucosa basal cells to restore the radiation damage was not modified by the phenomenon of aging.

Age Factors↗
PubMedDate not supplied

[The quantitative topographic characteristics of the minor salivary glands of the lips].

Secretory activity of labial minor salivary glands was examined in 20 normal caries-resistant subjects. The lower lip glands were found to dominate over the upper lip glands in the number of functioning glands, in the density of their location, and in secretion volume. Therefore, the labial mucosa and mandibular vestibular surface of the gingiva and teeth are washed by a higher amount of secretion than the upper lip mucosa and maxillary gingiva and teeth.

Dental Caries Susceptibility↗
PubMed1990

[Cephalometric analysis of morphological characteristics of the cranial base in cases with unilateral and bilateral clefts of the lip and palate].

Lateral cephalometric radiographs of 31 cases with unilateral clefts of the lip and palate, 31 cases with complete bilateral clefts of the lip and palate as well as 31 cases with skeletal class I relationship were used for this study. The following angular and linear measurements were analysed: NSBa, SBaN, BaSN, S-N, S-Ba and N-Ba. The groups were compared with each other for all measurements studied. There was no significant difference between these groups for NSBa and SBaN angles. The mean value of the BaSN angle was significantly lower in the group with complete unilateral clefts of the lip and palate than in the remaining two groups. The mean values for linear measurements investigated were significantly lower in the group with unilateral clefts than in the remaining two groups.

Cephalometry↗
PubMed1990

[Corrective surgery of cleft lip].

This paper presents a statistical review of corrective surgery for cleft lip, as performed at the Maxillofacial Surgery wards of the Pediatrics Hospital, National Medical Center, and the General Hospital, La Raza Medical Center, Institute of Social Security of Mexico. Frequency of occurrence, as well as most commonly used classifications, are described and correlated with results reaped from our study, which covered from March 1984 to March 1989, with surgeries performed on 116 patients suffering from unilateral and bilateral cleft lip; 120 plastic reconstructive maneuvers were performed by the Millard advance rotation technique or the modified Tennison Randall technique with triangular flaps, with Le Mesurier's square flaps approach for unilateral fissures and the Verdeja and Cronin techniques for bilateral clefts, thus defining criteria for treating children with cleft lip and cleft palate.

Cleft Lip↗
PubMed1989

[Electromyographic study of masticatory dysfunction in patients with unilateral cleft lip and palate and reversed occlusion].

UNLABELLED: Masticatory dysfunction in patients with unilateral cleft lip and palate was studied on the basis of electromyograms of the masticatory muscles. The purpose of the study was to elucidate the origin of the dysfunction by means of comparisons among electromyograms of masticatory muscles in cases of normal occlusion, reversed occlusion and reversed occlusion caused by unilateral cleft lip and palate. Subjects were 10 cases of normal occlusion (10y2m-11y10m), 10 cases of reversed occlusion (7y2m-11y2m) and 20 cases of unilateral cleft lip and palate (8y0m-14y3m). In each subject, electromyograms of the masseter and anterior venters of the temporal muscles at the isometric-contraction phase were recorded by means of the surface-electrode method with mandible loads of 1-5 kg. The electromyograms were analyzed quantitatively by means of an electromyographic device called a Turn Counter. Relations between loads and amplitude as well as numbers of turns were examined. At the same time maximum masticatory pressure and occlusal contact points were measured and then examined in comparison with electromyographic findings. RESULTS: 1. Correlation coefficients between loads and amplitudes as well as numbers of turns decreased among the groups in this order: normal occlusion, reversed occlusion and cleft-caused reversed occlusion. Significant differences were observed between the normal-occlusive group and the reversed and cleft-caused reversed-occlusive groups. 2. No. difference was observed between the normal-occlusive and reversed-occlusive groups in terms of correlation coefficients between total sums of amplitudes and turns of the 4 masseter muscles (right and left masseters and anterior venters of the temporal muscles) and loads. Correlation coefficients in the cleft group were significantly smaller than those in the other 2 groups. 3. Because of great differences in regression coefficient among individuals, no synergic contraction pattern of the 4 mastication muscles (right and left masseter and temporal muscles) could be specified. 4. The A/T ratio of masseters in the cleft group was significantly smaller than those in the normal- and reversed-occlusive groups. 5. Under maximum load, the activity ratio of the 4 masseter and temporal muscles was 1:1 in the normal- and reversed-occlusive groups, whereas temporal-muscle activity predominated over masseter-muscle activity in the cleft group. 6. Maximum masticatory pressure decreased in the order: normal-occlusive, reversed-occlusive, and cleft caused occlusive. No correlation with electromyographic findings was observed.(ABSTRACT TRUNCATED AT 400 WORDS)

Child↗
PubMed1989

[Case report of long-term treatment of a cleft lip and palate patient].

Cleft lip and palate patients have narrow maxillary arches and mesio-distal disharmony between the jaws caused by cicatricial contracture from cleft lip and palate surgeries. In such cases, early orthodontic treatment is required including improvement of the mesio-distal disharmony of the jaws. Following orthodontic treatment, prosthodontic treatment is required to improve the masticatory function and esthetic appearance in the cleft area. Thus, improving the occlusion of cleft lip and palate patients takes a long time. This case report concerns such a longterm handling of over 17 years from the initial treatment at 5 years 3 months till the final prosthodontic treatment for an under-developed maxilla with partial closure of the fistula to which ilium was later grafted following orthodontic treatment. Considerations are discussed about timing of the initiation of orthodontic treatment, closure of the oronasal fistula and the final prosthodontic restoration.

Child↗
PubMedDate not supplied

[Mathematic principles for lip reconstructions].

Anthropometric measurements of the orofacial region were performed in 240 probands of 6 different age groups. The mean width of the orifice of the mouth was approximately equal to the interpupillary distance. The normal length of the lip arch was 6.6 cm and increased by a factor of 1.5 (10 cm) with the lips stretched. From these measurements a mathematic equation was derived and represented as a diagram. Thus, the amount of tissue required for the reconstruction of lip defects can be readily assessed.

Humans↗
PubMedDate not supplied

[Basal cell epithelioma of the lip. Analysis of 42 cases].

Basal cell epithelioma of the lip. An analysis of 42 cases. The authors carried out a histopathological and epidemiological study of 42 basal cell epitheliomas of the lip. Both sexes were equally affected (male to female ratio 0.9:1) but the females were significantly older than the males (mean age: 70.7 years vs 62.3 years respectively). The incidence in the province of Trieste was 1.44%... for males and 1.46%... for females. More than 80% of the lesions (35 cases) consisted in solid forms, but there were also 4 cheratotic basal cell epitheliomas, 1 fibrosing epithelioma and 1 basosquamous epithelioma. In 2 of the males there was a recurrence a year after the surgical exeresis and in 6 cases another epithelioma was synchronous or metachronous to the lip epithelioma. Despite the fact that in 3 cases invasion of the muscular wall was noted and in another case the neoplasm had infiltrated and eroded the left nostril and the lower part of the septum, no patient died from the tumour nor were any metastasis observed.

Aged↗
PubMedDate not supplied

[Retrospective multicenter study on carcinomas of the lips and oral cavity. The role of multiple malignancies].

In a retrospective multicenter study the role of multiple cancer has been assessed in 2481 patients with carcinomas of the lips and oral cavity. In 3.2% of the cases the malignancies developed outside the maxillofacial area. In the majority of cases two malignant neoplasms were found. Most of them were histologically carcinomas. The bronchi and stomach were common localizations in patients with lip carcinomas, whereas patients with oral carcinomas exhibited mainly cancers of the breast, stomach and uterus. Sex-limited multiple cancers associated with oral carcinoma occurred predominantly in women. Surgery is the most common form of treatment. The prognosis for patients with lip carcinomas is significantly poorer when multiple cancers are present.

Adolescent↗
PubMed1989

[Tumors of the lip].

The AA report two cases of reconstruction of the lower lip (after removal of the growth) following the Bernard-Brown procedure. They discuss other technics for lip repair. In both instances the achieved results were good, both aesthetically and functionally, attaining the goals of this surgery: normal aspect of the lip borderline, good sensitivity, tonus of the muscles, and also suitable size of the mouth. All the objectives were accomplished in a single operation.

Aged↗
PubMed1989

Significance of mucosal vs salivary gland changes in lip biopsies in the diagnosis of chronic graft-vs-host disease.

Lip biopsy is frequently utilized to diagnose and stage chronic graft-vs-host disease (cGVHD). However, the significance of mucosal (MU) vs salivary gland (SG) involvement as well as the minimal histologic changes necessary for diagnosis remain unclear. We evaluated 68 lip and oral mucosa biopsy specimens using published diagnostic criteria. Thirty-four specimens contained both MU and SG tissue. Both MU and SG were definitely involved in 13 patients while apparent false-negatives for MU of 20% (2/10) and SG of 11% (1/9) were observed. No clinical differences were noted among the patients with both MU-alone-, or SG-alone-positive biopsy specimens. Patients with no evidence of cGVHD in either MU or SG showed significantly less other organ involvement than patients with positive evidence. Patients with minimal MU changes (rare dyskeratotic cells) were clinically indistinguishable from negative patients in terms of other organ involvement. However, 50% of the biopsy specimens with minimal MU involvement in which SG were present had definite GVHD in the SG. These data indicate that lip biopsy specimens must include both MU and SG tissue to rule out oral GVHD. Minimal MU changes are insufficient to diagnose oral cGVHD, although they do warrant close follow-up and a second biopsy if SG tissue is not present in the specimen.

Adolescent↗
PubMed1988

Polysomnographic indications for surgical intervention in Pierre Robin sequence: acute airway management and follow-up studies after repair and take-down of tongue-lip adhesion.

The major concern for neonates with Pierre Robin sequence is the stability of the airways. The accepted management has been close clinical observation followed by surgical intervention if the airway was felt to be unstable. Six newborns with this diagnosis were admitted for evaluation in a 7-month period. Each underwent transcutaneous oxygen and carbon dioxide monitoring in a resting state. Each infant then was evaluated with infant polysomnography to ascertain the presence of obstructive apnea. Pulse-oximetry was utilized to document the oxygen saturation of each child during the polysomnography. On the basis of these studies, four of the neonates required a tongue-lip adhesion to stabilize the airway. These four infants were reassessed with polysomnography postoperatively, prior to cleft palate repair, following palatoplasty, and after their tongue-lip adhesion was released. This method of evaluation allows early testing of the stability of the airway in a way that augments and confirms the clinical assessment of the infant, allowing appropriate surgical intervention when necessary. This method of evaluation also allows the safe prediction of airway stability following palatoplasty and release of the tongue-lip adhesion.

Blood Gas Monitoring, Transcutaneous↗
PubMed1988

Craniofacial growth in unilateral cleft lip and palate: skeletal growth from eight to eighteen years.

Sixteen individuals with complete unilateral cleft lip and palate (UCLP) were evaluated for determination of several craniofacial dimensional means and growth rates. Each had undergone primary lip and palatal closure and alveolar bone grafting. Serial cephalographs from ages 8 to 18 years, taken every 2 years, were utilized for determination of six cephalometric dimensions: anterior cranial base, upper and lower facial heights, posterior nasomaxillary height, maxillary horizontal length, and mandibular length. These were then compared to published cephalometric standards of a nonclefted group. All dimensions, except mandibular length, were smaller in the UCLP group. The horizontal maxillary length was the most diminished in mean length and growth rate; it appears to be most affected in UCLP. The remaining dimensions and growth rates are affected by UCLP, but to a lesser degree. These findings indicated that individuals with unilateral cleft lip and palate are primarily and adversely affected by clefting (and the surgery as described) in the horizontal maxilla, both in dimension and growth rate.

Adolescent↗
PubMed1988

The genetic basis of cleft lip and palate deformity.

The embryology of the normal lip and palate and the abnormal development of these structures causing cleft lip (CL) and cleft palate (CP) are discussed. As the development of the lip and palate is not dependent on a single factor but on many factors, it is understandable that CL and CP may occur as a result of abnormalities of genes of large mutant effect (i.e. Mendelian mutant genes), or due to chromosomal anomalies. However, these 2 causes are relatively uncommon and the commonest mode of production is dependent on both genetic and environmental factors. The mechanisms whereby these 3 groups may produce CL and CP will be discussed. Since the modes of inheritance differ in the 3 groups, it is important to discover which group a particular patient belongs to. The genetic load is high in the Mendelian group, is low usually in those due to chromosome disorders, and may be low or high in the last group depending on the polygenes as well as environmental factors. In this last group, empiric risk figures may be calculated for future offspring to be affected. The prenatal diagnosis of CL and CP is also discussed.

Chromosome Aberrations↗
PubMed1988

Bilateral cleft lip repair.

From 1970 to 1987 we treated 213 patients with bilateral cleft lip at Hokkaido University Hospital and its several branch hospitals. The patients were grouped into 3 types according to the shape of the clefting prolabium. Group 1: complete clefts bilaterally, group 2: incomplete clefts bilaterally, group 3: combination of complete and incomplete clefts. From 1974 to 1987 we treated 176 bilateral cleft lip patients by the Manchester method using several modifications. Presurgical oral orthopaedics, using head cap and orthodontic appliance devised by Dr Peat, was applied to 110 of the 176 cases. Surgical results were satisfactory and the Manchester method is our preferred procedure for bilateral cleft lip repair.

Child↗
PubMed1988

Seasonality, incidence, and sex distribution of cleft lip and palate births in Trent Region, 1973-1982.

The birth dates of 930 children born in the Trent Region 1973-1982 with a diagnosis corresponding to cleft palate, or cleft lip with or without cleft palate, was obtained from Hospital Activity Analysis. These data were analyzed to look at the incidence of clefting, sex distribution, and seasonal variation. The results obtained show a significant peak incidence of cleft palate births in August and September, with a low incidence in March to May. Cleft lip, with or without cleft palate, shows a different seasonal trend, with peak occurrence in December and January and a low frequency in May and June. These seasonal trends may act as a pointer to the environmental factors active in the multifactorial etiology of cleft lip and cleft palate.

Cleft Lip↗
PubMed1988

An intraoral appliance for management of the protrusive premaxilla in bilateral cleft lip.

Management of the protruding premaxilla and prolabium in bilateral cleft lip and palate can be a confounding problem. This report introduces an intraoral traction appliance that has been successfully used to move the premaxilla and prolabium to a more favorable position for surgical repair of the bilateral cleft lip. The appliance consists of a palatal baseplate for anchorage and a latex rubber traction strip looped over the prolabium to retract the premaxillary segment. The results in five cases are presented and compared to two cases where no presurgical management was performed and lip repair had been delayed for medical reasons. Advantages and disadvantages of the appliance are discussed.

Cleft Lip↗
PubMed1986

[Psychosocial studies of surgically treated adults with unilateral total lip-maxilla-palate clefts].

The psychological status of 51 adult subjects who had received surgery at the appropriate time for cleft lip-palate was investigated by questionnaire (Giessen test). In respect of social dominance this revealed a significant deviation towards social subordination among those with cleft lips and palates, which is explicable in terms of the lengthy and continuous treatment and appears to be of great importance as a defence and adaptation mechanism to those concerned. The inclusion of psychologists in the interdisciplinary care of cleft lip-palate patients is proposed.

Adult↗