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PubMed1972

R factors in hospital infection.

In order to assess the clinical importance of R factors 524 "coliform" infections were studied in a general hospital. Of these, 95 were caused by Pseudomonas aeruginosa. Among the remaining 429, 43% were caused by drug-resistant enterobacteria; resistance was frequently multiple and determined by transmissible R factors. Choice of therapy was thus limited but in every case at least one antibiotic, effective in vitro, was still available.

Anti-Bacterial Agents↗
PubMed1968

DNA repair.

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Bacteriophages↗
PubMed1992

Repression of the E. coli lactose operon by cooperation between two individually unproductive "half-operator" sites.

Two remote and weak lac regressor binding sites can be used jointly to repress the synthesis of beta-galactosidase in E. coli, while they cannot separately. When this result is discussed in reference to the various modes of cooperation between the sites, it supports with a new approach a model implying the simultaneous binding of lac repressor to both sites with the formation of a DNA loop. In connection with this point, we present a new strategy to detect cooperative interactions in vivo, based on the asymmetry of the DNA binding site, formally equivalent here to a half-site, heterodimerization of the protein, and influence of orientation of the sites on repression at short and long distance.

DNA, Bacterial↗
PubMed1992

[Control of homologous recombination by mismatch base repair system in bacteria: implications concerning the chromosome stability and the evolution of species].

The generalized mismatch repair system controls, in bacteria, the homologous recombination between diverged (homologous) DNA. It thus constitute, together with the sequence divergence, a barrier to recombination between bacteria of different species as we have shown for E. coli and S. typhimurium. It is moreover, by preventing the recombination between diverged repeated sequences, a key component of the chromosome stability.

Biological Evolution↗