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[Clinical manifestations of Lyme disease].

Lyme disease can be divided into three phases; (1) a primary phase where the inconstant erythema migrans predominates; (2) a secondary phase, sometimes revealing the disease, with isolated or associated cutaneous and cardiac signs and articular or neurological manifestations responding to antibiotics, and (3) a tertiary phase with cutaneous, articular and above all neurological signs which are chronic and sometimes severe. A better knowledge of this infection has enabled some rheumatological or neurological manifestations to be explained. Clinicians should be aware of this, since these disorders are amenable to antibiotic therapy. Conversely, multivisceral symptoms should not be ascribed to Lyme disease without strong positive arguments.

Acrodermatitis↗

Papulovesicular acrolocalized syndrome.

A 1-year-old boy with a cutaneous eruption compatible with papulovesicular acrolocalized syndrome is described. This unusual but benign entity of early childhood can be differentiated both by its clinical presentation and appropriate laboratory testing from the two morphologically similar eruptions: Gianotti-Crosti syndrome and infection with Coxsackie virus A-16.

Acrodermatitis↗

Intestinal mucosal enzymes in the diagnosis of gastrointestinal metabolic disease.

The small intestinal mucosa is an actively metabolizing, rapidly proliferating, absorptive epithelium with nutritional and homeostatic functions. A metabolic dysfunction of this organ might, therefore, be expected to cause not only gastrointestinal dysfunction, but also systemic symptoms. Several diseases characterized by primary or secondary gastrointestinal metabolic alterations are discussed.

Acrodermatitis↗