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At least 1,729 records · Page 96Linked to original sources
PubMed1979

Arterial PCO2 response to intravenous CO2 in awake dogs unencumbered by external breathing apparatus.

The steady-state arterial CO2 tension (PaCO2) was examined during control and intravenous CO2 loading in awake dogs unencumbered by any breathing apparatus. The dogs inhaled air while undergoing intravenous CO2 loading, and we estimated the gain, delta VA/delta PACO2. CO2 was introduced into the systemic venous blood via a membrane gas exchanger in a femoral arteriovenous shunt circuit, and the extracorporeal blood flow was maintained constant at 0.5 l/min. A total of 11 experiments were performed in 3 dogs comprising 93 control observations and 83 CO2 loading observations. Intravenous CO2 produced a significant increase in the steady state PaCO2, a finding consistent with our previous study in tracheostomized awake dogs. We conclude that intravenous CO2 produces hypercapnia in the awake dog with an intact airway unencumbered by external respiratory apparatus.

Acidosis, Respiratory↗
PubMed1989

Mixed acid-base disorders.

Mixed acid-base disturbances are combinations of two or more primary acid-base disturbances. Mixed acid-base disturbances may be suspected on the basis of findings obtained from the medical history, physical examination, serum electrolytes and chemistries, and anion gap. The history, physical examination, and serum biochemical profile may reveal disease processes commonly associated with acid-base disturbances. Changes in serum total CO2, serum potassium and chloride concentrations, or increased anion gap may provide clues to the existence of acid-base disorders. Blood gas analysis is usually required to confirm mixed acid-base disorders. To identify mixed acid-base disorders, blood gas analysis is used to identify primary acid-base disturbance and determine if an appropriate compensatory response has developed. Inappropriate compensatory responses (inadequate or excessive) are evidence of a mixed respiratory and metabolic disorder. The anion gap is also of value in detecting mixed acid-base disturbances. In high anion gap metabolic acidosis, the change in the anion gap should approximate the change in serum bicarbonate. Absence of this relationship should prompt consideration of a mixed metabolic acid-base disorder. Finding an elevated anion gap, regardless of serum bicarbonate concentration, suggests metabolic acidosis. In some instances, elevated anion gap is the only evidence of metabolic acidosis. In patients with hyperchloremic metabolic acidosis, increases in the serum chloride concentration should approximate the reduction in the serum bicarbonate concentration. Significant alterations from this relationship also indicate that a mixed metabolic disorder may be present. In treatment of mixed acid-base disorders, careful consideration should be given to the potential impact of therapeutically altering one acid-base disorder without correcting others.

Acid-Base Equilibrium↗
PubMedDate not supplied

Heliox inhalation in status asthmaticus and respiratory acidemia: a brief report.

A 28-year-old woman in status asthmaticus and respiratory acidemia refused orotracheal intubation and mechanical ventilation in the emergency department. In view of this situation, a mixture of helium-oxygen gas (heliox) was initiated with a nonrebreathing oxygen mask. Within 2 hours of treatment, the patient's respiratory acidemia had been corrected, and heliox inhalation therapy was discontinued without further incident.

Acidosis, Respiratory↗
PubMed1975

Alfathesin for anaesthetic induction at caesarean section.

Anaesthesia was induced with Alfathesin (60 - 70 mul/kg) in 50 healthy mothers undergoing elective Caesarean section. Anaesthesia was maintained with nitrous oxide, oxygen, muscle relaxants and controlled ventilation. The mothers were tilted laterally throughout the operation. Blood gas studies done on the mothers before induction and at delivery, revealed a mild respiratory alkalosis associated with a moderate degree of metabolic acidosis, which appeared to increase during anaesthesia. Umbilical cord blood gas analyses indicated a mild degree of fetal respiratory acidosis (mean pCO2 Uv 45,3

Acidosis↗
PubMed1984

[Changes in the extracellular pH value and its effect on the intracellular pH value of tissues].

The behavior of intracellular pH in different tissues during variation of plasma pH by respiratory and metabolic changes was studied in nephrectomized, unrestrained male Sprague-Dawley rats. The following conclusions can be made: pHi is influenced by respiratory and non-respiratory disturbances of the extracellular acid-base status. pHi is different in different tissues at specified pHe. Skeletal muscle is well protected against slight acidosis because pHi remains constant in a certain range. Our further investigations referred to: Influence of a carbonic anhydrase inhibitor (Diamox) on intracellular tissue pH in vitro and in vivo; Intra-/extracellular tris distribution in tissues at different extracellular pH in vivo; Influence of tris and bicarbonate infusion on intracellular bicarbonate of the whole animal and on intracellular tissue pH in vivo. All these results show that bicarbonate is the more effective substance for correction of metabolic acidosis and should be preferred in clinical practice.

Acid-Base Equilibrium↗