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PubMed2001

Spatial learning induces neurotrophin receptor and synapsin I in the hippocampus.

We report that rats learning a spatial memory task in the Morris water maze show elevated expression of the signal transduction receptor for BDNF and the synaptic associated protein synapsin I in the hippocampus. Nuclease protection assays showed maximal levels of TrkB and synapsin I mRNAs in the hippocampus by the time that asymptotic learning performance had been reached (Day 6). Increases in synapsin I mRNA were matched by changes in synapsin I protein as revealed by western blot analysis. Synapsin I is a downstream effector for the BDNF tyrosine kinase cascade pathway which has important roles in synaptic remodeling and function. Therefore, parallel changes in TrkB and synapsin I mRNAs suggest a role of the BDNF system in synaptic function or adaptation. Levels of TrkB mRNA in the hippocampus were attenuated after learning acquisition (Day 20), but synapsin I mRNA was still elevated, suggesting that the BDNF system may participate in events secondary to learning, such as strengthening of neural circuits. TrkB and synapsin I mRNAs showed an increasing trend in the cerebellum of learning rats and no changes were observed in the caudal cerebral cortex. The selectivity of the changes in trkB and synapsin I, affecting the hippocampus, is in agreement with the role of this structure in processing of spatial information. Behavioral regulation of neurotrophins may provide a molecular basis for the enhanced cognitive function associated with active lifestyles, and guide development of strategies to promote neural healing after CNS injury or disease.

Animals↗
PubMed1996

Apoptotic morphology of dentate gyrus granule cells following experimental cortical impact injury in rats: possible role in spatial memory deficits.

Loss of hippocampal neurons as a result of traumatic brain injury (TBI) is thought to contribute to the observed spatial memory deficits. Using a rodent model of experimental brain injury, we have examined the nature of hippocampal cell death following TBI. Light microscope examination of stained sections showed the presence of a large number of hyperchromatic and dystrophic neurons in the dentate gyrus of the hippocampus. These cells appeared to be undergoing nuclear condensation. Electron microscope examination demonstrated the presence of cell shrinkage, condensed chromatin, nuclear segmentation, and cytoplasmic vacuolization. Detection of a DNA ladder and in situ labeling (TUNEL) were also consistent with the process of apoptosis. However, in some dystrophic neurons these morphologies were also accompanied by the presence of swollen mitochondria and a lack of distinctive rough endoplasmic reticulum which are typically associated with necrosis. These findings show that cortical impact injury produces cell death in the hippocampus which has both apoptotic and necrotic features.

Animals↗
PubMed1997

Evidence for recovery of spatial learning following entorhinal cortex lesions in mice.

The influence of entorhinal cortex lesions on behaviour and concommitant changes in synaptophysin immunoreactivity (IR) in the denervated dentate gyrus was assessed. Male, C57/B6 mice received either bilateral (BI), unilateral (UNI), or no lesion (SHAM) to the entorhinal cortex. At various stages post-lesion the animals were evaluated in tests to examine neurological and cognitive (spatial and cued learning, Morris water maze) function. UNI lesioned animals from 6-36 days post-lesion showed no neurological nor marked cued learning deficit, yet a profound spatial learning deficit. However by 70 days post-lesion, spatial learning ability was clearly evident. In contrast, BI lesioned animals showed severe spatial learning deficits throughout the test period (6-70 days), cued learning was also impaired. In parallel groups of UNI lesioned mice, 6-36 days post-lesion there was a marked reduction (-40%) in synaptophysin IR in the dentate gyrus molecular layer. However by 70 days post-lesion a clear increase in this measure was noted. Changes in the expression of the growth associated protein, GAP43, were also noted over this period. Taken together, the present results suggest some recovery of spatial learning following unilateral entorhinal cortex lesions in mice. This behavioural recovery of a hippocampally dependant task may be associated with a recovery of function related to the synaptic remodelling and elevation of synapse number in the denervated hippocampus, as evidenced by changes in synaptophysin and GAP43 IR.

Animals↗
PubMed1997

Hippocampally dependent and independent chronic spatial navigational deficits following parasagittal fluid percussion brain injury in the rat.

Previous reports have documented spatial navigational deficits following experimental traumatic brain injury (TBI), although the majority of the work to date has involved assessment at acute intervals following TBI, and has focused on tasks sensitive to hippocampal dysfunction. The present experiments were designed to investigate the chronic consequences of TBI, and the possible contribution of extrahippocampal dysfunction to TBI-induced spatial navigational deficits, in a moderate parasagittal fluid percussion TBI model. In Experiment 1, animals were pre-trained in a water maze, subjected to TBI or sham procedures, and re-evaluated in the water maze 48 h following the insult. Six to 8 weeks following TBI, the same animals were required to navigate to a different platform location. TBI animals exhibited significant deficits in retention of previously learned spatial information at the 48 h interval, and marginally impaired acquisition of a novel platform location during the chronic test sessions. In Experiment 2, animals were required to navigate to novel spatial locations using cued (to evaluate extrahippocampal function) as well as non-cued variants of the water maze task during the 8 week period following the insult. Injured animals exhibited deficits in both tasks which gradually diminished over the course of testing. The results of these experiments indicate that moderate TBI is accompanied by both retention and acquisition deficits, and that some of the navigational deficits observed in the water maze can be attributed to extrahippocampal damage. The possible recovery of spatial navigational ability following parasagittal TBI at moderate intensities is also discussed.

Acute Disease↗
PubMed1997

The decrease of serotonin release induced by a tryptophan-free amino acid diet does not affect spatial and passive avoidance learning.

We assessed whether consumption of a diet lacking in tryptophan (TRP) resulted in alteration in learning and memory performance and hippocampal 5-HT release in rats. Two hours after the acute administration of TRP-free (T) and balanced (B) diet rats were trained in a one-trial passive avoidance task. The two groups of rats showed no significant difference in retention latencies. Two other groups of rats, fed with the above diets during the acquisition of a radial-arm maze task, showed no difference in baseline performance. The acute ingestion of the T diet produced a significant and long lasting decrease of hippocampal and cortical 5-HT release in rats when compared to the B diet, while the 12th day of the T diet, 5-HT was not detectable in the dialysate. These data indicate that the diminished brain release of 5-HT induced by a T diet is not sufficient to impair cognitive processes.

Animals↗
PubMed1997

The GABA(B) receptor antagonist CGP36742 attenuates the baclofen- and scopolamine-induced deficit in Morris water maze task in rats.

Effects of CGP36742 (3-aminopropyl-n-butylphosphinic acid), an orally active GABA(B) receptor antagonist, on the baclofen- and scopolamine-induced deficit of place learning in the Morris water maze task were examined in rats. Rats were given four training trials per day with the submerged platform at a fixed location in the maze for 4 days. On day 4, the rats were required to swim in the pool without the platform after the fourth training trial (probe test). Intraperitoneal injection of baclofen (4 mg/kg) or scopolamine (0.3 mg/kg) significantly increased the escape latency to reach the platform and decreased the duration in the quadrant where the platform had been originally located. Increased latency in the training trials and decreased duration in the probe test induced by baclofen or scopolamine were significantly attenuated by oral administration of CGP36742 at doses of 10 and 30 mg/kg. In the rotarod test, CGP36742 at a dose of 100 mg/kg but not at doses of 10 or 30 mg/kg antagonized the baclofen-induced motor incoordination. Thus, there was dissociation between the effective doses of CGP36742 in the learning task and those in the sensory motor test. These results suggest the possible involvement of cholinergic systems as well as GABA(B) receptor systems in the CGP36742 action.

Animals↗
PubMed1998

Recordings of postsubiculum head direction cells following lesions of the laterodorsal thalamic nucleus.

Areas of the rodent limbic system are important for solving spatial tasks and accurate navigation. Previous studies have identified cells in the postsubiculum (PoS) and the lateral dorsal thalamus (LDN) which discharge as a function of the animal's head direction in the horizontal plane. These two brain areas are reciprocally connected with one another. To determine the contribution of the LDN to the functioning of PoS head direction cells, we lesioned the LDN and recorded single units in the PoS. We report here that lesions of the LDN had little effect upon the firing properties of PoS HD cells. In addition, HD cells from lesioned animals showed normal responses to two environmental manipulations: (1) when the salient visual cue was rotated the preferred firing directions of PoS HD cells shifted a similar amount and (2) cells frequently ceased firing, or had reductions in their peak firing rate, when the animal was restrained and passively rotated through the preferred firing direction. These results indicate that the LDN does not play a substantive role in either the generation or the stability of the HD cell signal in the PoS.

Action Potentials↗
PubMed1998

Place field dynamics and directionality in a spatial memory task.

In previous studies place fields have been shown to be governed by one or more polarizing stimuli such that rotation of the stimuli caused concomitant rotation of the fields. Place fields have also been observed to persist after removal of stimulus cues. In the present study we confirm the previous findings and report two new responses. Hippocampal place fields were observed to decrease or cease place specific firing after the removal of the polarizing cues. Others increased or initiated place specific firing after cue removal. Thus in these instances place field location was dependent on the orientation of the polarizing cues but place field magnitude was governed by their presence or absence. A subset of the place fields recorded in the present study were found to display directionality. Place field directionality was found to be governed by the polarizing cues such that cue rotation produced concomitant rotation in the direction of maximal firing. However directionally specific firing was unaffected by cue removal. These results suggest that place field directionality is initially set up by the polarizing cues but is subsequently independent of them.

Action Potentials↗
PubMed1998

Acute blockade of hippocampal glucocorticoid receptors facilitates spatial learning in rats.

Corticosteroids can facilitate or impair learning and memory processes. We found that the glucocorticoid receptor antagonist RU38486 injected locally into the dorsal hippocampus dose-dependently improved the performance of male Wistar rats in the water maze 24 h after treatment. This observation suggests a discrete specificity of hippocampal glucocorticoid receptors in facilitation of memory.

Animals↗
PubMed1998

Differential rearing affects corpus callosum size and cognitive function of rhesus monkeys.

This study investigated the effects of different rearing conditions on neural and cognitive development of male rhesus monkeys (Macaca mulatta). Infants raised individually in a nursery from 2 to 12 months of age (NURSERY, n=9) were compared to age-matched infants raised in a semi-naturalistic, social environment (CONTROL, n=11). Various brain regions were measured by MRI. Although overall brain volumes did not differ between NURSERY and CONTROL animals, corpus callosum (CC) size, measured in mid-sagittal sections, was significantly decreased in the NURSERY group. Group differences were most evident in the posterior aspects of the corpus callosum and appeared to result from changes in the number of cross-hemispheric projections rather than from a decrease in cortical gray matter volume. The decrease in corpus callosum size in the NURSERY animals persisted after 6 months of social housing in a peer-group. Rearing group differences were not found in other structures analyzed, including the hippocampus, cerebellum and anterior commissure. In cognitive testing, NURSERY animals had more difficulty acquiring the delayed non-matching to sample (DNMS) task, but showed no deficits in subsequent memory performance when a 2 or 10 min delay was imposed. The NURSERY infant monkeys were also impaired in object, but not in spatial, reversal learning, although there were no differences in a simple object discrimination task. The cognitive deficits exhibited by the NURSERY animals were significantly correlated with the alterations found in the CC. In summary, rearing environment was associated with sustained differences in cross-hemispheric projections, white matter volume and cognitive performance.

Animals↗
PubMed1999

The promnesic neurosteroid pregnenolone sulfate increases paradoxical sleep in rats.

The effect of systemic administration of the neurosteroid pregnenolone sulfate (PREG-S) on sleep-wakefulness cycle and on spatial memory performances was investigated in male Sprague-Dawley rats. In the first experiment, the effect of PREG-S administration (saline, 4.75, 47.5 mg/kg, i.p.) on 24 h EEG recording was evaluated. In the second experiment, spatial memory performance in a two-trial memory task was evaluated after post-acquisition administration of similar doses of PREG-S as in the first experiment. Results show that PREG-S increases paradoxical sleep and improves the performance on the memory task yielding similar dose response curves. Starting 4 h after administration of 47.5 mg/kg PREG-S, paradoxical sleep is increased for 10 h. The PREG-S effect on spatial memory lasts for at least 24 h after injection. These results suggest that an enhancement of paradoxical sleep may be involved in the promnesic effects of this neurosteroid.

Animals↗
PubMed2000

Pregnenolone sulfate increases hippocampal acetylcholine release and spatial recognition.

The pregnenolone sulfate is a neurosteroid with promnesic properties. Recently, a correlation between endogenous levels of pregnenolone sulfate in the hippocampus and performance in a spatial memory task has been reported in aged rats. Cholinergic transmission is known to modulate memory processes and to be altered with age. In the present experiment we investigated the effect of increasing doses of pregnenolone sulfate on hippocampal acetylcholine release. Our results show that intracerebroventricular administrations of this neurosteroid induced a dose-dependent increase in acetylcholine release. Administration of 12 and 48 nmol of pregnenolone sulfate induced a short lasting (20 min) enhancement of acetylcholine output with a maximum around 120% over baseline and the administration of 96 and 192 nmol doses induced a long-lasting (80 min) increase that peaked around 300% over baseline. In a second experiment we have observed that the 12 nmol dose enhanced spatial memory performance, whereas the 192 nmol dose was inefficient. These results are consistent with previous work suggesting that, a modest increase in acetylcholine release facilitates memory processes, while elevation beyond an optimal level is ineffective. Nevertheless, neurosteroids may be of value for reinforcing depressed cholinergic transmission in certain age-related memory disorders.

Acetylcholine↗
PubMed2000

Linguistic and non-linguistic spatial categorization.

Three experiments examine the relation between linguistic and non-linguistic categorization of spatial relations. We compare linguistic and non-linguistic responses to the same spatial stimuli. Contrary to earlier claims in the literature (Hayward, W. G. & Tarr, M. J. (1995). Spatial language and spatial representation. Cognition, 55, 39-84), we find that linguistic and non-linguistic spatial categories do not correspond. Rather, they appear to have an inverse relation such that the prototypes of linguistic categories, such as 'above', are boundaries in non-linguistic spatial categorization. Evidence for this inverse relation comes from linguistic acceptability judgments and the pattern of bias in participants' reproductions of location. Our findings suggest that while linguistic and non-linguistic spatial organization rely on a common underlying structure, that structure may play different roles in the two organizational systems.

Cognition↗
PubMed1997

Body-centered representations for visually-guided action emerge during early infancy.

The nature of the spatial representations that underlie simple visually guided actions early in life were investigated through the application of a 'double-step' saccade paradigm to 3- and 7-month-old infants. Saccades in the older infants, like those observed in adults, were executed within body-centered spatial coordinates that take into account the effects of intervening eye movements. In contrast, younger infants tended to respond according to the targets' retinocentric locations and did not incorporate the effects of displacements caused by previous saccades. These results indicate that contrary to prevailing views, body-centered representations for action are not present from birth but emerge, probably through experience, over the first few months of life.

Body Image↗
PubMed2003

Representation and perception of scenic layout.

This paper presents a cognitive approach to on-line spatial perception within scenes. A theoretical framework is developed, based on the idea that experience with a scene can activate a complex representation of layout that facilitates subsequent processing of spatial relations within the scene. The representations integrate significant, relevant scenic information and are substantial in amount or extent. The representations are active across short periods of time and across changes in the retinal position of the image. These claims were supported in a series of experiments in which pictures of scenes (primes) facilitated subsequent spatial relations processing within the scenes. The prime-induced representations integrated object identity and layout, were broad in scope, involved both foreground and background information, and were effective across changes in image position.

Cognition↗
PubMed2004

Hermann Zingerle's "Impaired perception of the own body due to organic brain disorders". 1913. An introductory comment, and an abridged translation.

In the late 1970's Edoardo Bisiach and his coworkers provided definitive evidence that spatial unilateral neglect involves a disorder of the internal representation of extra-personal space. A few years later Bisiach and Berti (1987) revived the so far neglected contribution of an Austrian neurologist, Hermann Zingerle (1913). Ninety years ago Zingerle had described the symptom-complex of two right-brain-damaged patients, who showed left hemisomatoagnosia, unawareness of left hemiplegia, and left motor neglect. In addition to the detailed case reports, Zingerle had put forward a unitary interpretation of these deficits in terms of a disordered representation of one side of the body (dyschiria). A unitary representational account of these unilateral impairments was conspicuously absent in the contemporary neurological literature (Anton, Pick, Babinski), and attracted Bisiach's interest. An abridged translation of Zingerle's paper is provided. The clinical case reports and Zingerle's conclusions are discussed, with reference both to Bisiach's views, and to present knowledge of unilateral spatial neglect.

Body Image↗
PubMed2004

Cognition in dyschiria: Edoardo Bisiach's theory of spatial disorders and consciousness.

An overview of Bisiach's theory of mental representations and consciousness is presented. Neuropsychological observations on space disorders led Bisiach to consider analogical representations (and not only symbolic representations) as truly 'cognitive', insofar as they are necessary for the normal functioning of linguistic processes. Bisiach's approach to the scientific study of consciousness, conceived both as the private aspect of phenomenal experience and as a monitoring process, is also discussed.

Body Image↗