Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Recognition memory”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,711 records · Page 95Linked to original sources
PubMed2001

Semantic dementia: relevance to connectionist models of long-term memory.

Semantic dementia is a recently documented syndrome associated with non-Alzheimer degenerative pathology of the polar and inferolateral temporal neocortex, with relative sparing (at least in the early stages) of the hippocampal complex. Patients typically show a progressive deterioration in their semantic knowledge about people, objects, facts and the meanings of words. Yet, at least clinically, they seem to possess relatively preserved day-to-day (episodic) memory. Neuropsychological investigations of semantic dementia provide, therefore, a unique opportunity to investigate the organization of human long-term memory and, more specifically, to determine the relationship between semantic memory and other cognitive systems, such as episodic memory. In this review, we summarize recent empirical findings from patients with semantic dementia and discuss whether the neuropsychological phenomena of the disease are consistent with current cognitive and computational models of human long-term memory and amnesia. Six specific issues are addressed: (i) the relative preservation of category-level (superordinate) compared with fine-graded (subordinate) semantic knowledge as the disease progresses; (ii) the better recall of recent autobiographical and semantic memories compared with those in the distant past; (iii) the preservation of new learning, as measured by recognition memory, early in the disease; (iv) the interaction between autobiographical experience and semantic knowledge in the current, but not the distant, time-period; (v) increased long-term forgetting of newly learned material; and (vi) impaired implicit memory. It is concluded that recent findings from semantic dementia offer strong support for the view that memory consolidation in humans is dependent upon interactions between the hippocampal complex and neocortex. Furthermore, these investigations have provided computational modellers of human memory with a novel set of neuropsychological data to be simulated and tested.

Amnesia↗
PubMed2001

A neuropsychological-neuropathological case study of variant Creutzfeldt-Jakob disease.

We report the first neuropsychological-neuropathological case study of a patient with variant Creutzfeldt-Jakob disease (vCJD) who was seen at the early stages of the disease, and whose cognitive functioning was monitored in the following months until his death. At presentation, his neuropsychological profile included impaired ability to retain new episodic information, deficits on tests of retrieval from semantic memory, and impairments on tests of memory for public knowledge, such as famous personalities. Tests of executive function were also performed poorly. Picture recognition memory and autobiographical memory were relatively spared, as was performance on tests of face perception and complex copying ability. Neuropsychological testing may be useful in monitoring the progression of vCJD, and we provide evidence to show a steady rate of decline in perceptual and naming tasks over a 4-month period. Post-mortem findings showed neuronal loss in the caudate, putamen, dorsal thalamus, cerebellum and occipital cortex. Spongiform changes were found throughout the brain, including the entorhinal cortex and anterior thalamus. Prion protein accumulation was noted in the hippocampus. We hypothesize that primary subcortical damage to structures in the thalamus and neostriatum, together with secondary frontal lobe dysfunction, combine to yield the pattern of neuropsychological impairment and neuropsychological sparing that was found.

Adult↗
PubMed1999

Neuropsychological correlates of domestic violence.

Neuropsychological functioning was assessed in 39 males who had committed domestic violence (batterers) and compared to 63 nonviolent (both maritally discordant and satisfied) subjects recruited by advertisement. Subjects were subsequently divided into two groups (head injured, nonhead injured) and these groups were also contrasted as a function of batterer status. Tests were administered to assess for cognitive and behavioral functions, including executive dysfunction, hypothesized to be a factor contributing to propensity for violence. Questionnaires and structured clinical interviews were used to assess marital discord, emotional distress, and violent behaviors. Batterers differed from nonbatterers across several cognitive domains: executive, learning, memory, and verbal functioning. Batterers were reliably discriminated from nonbatterers based on three neuropsychological tasks: Digit Symbol, Recognition Memory Test-Words, Wisconsin Card Sorting Test. Neuropsychological performance was the strongest correlate of domestic violence of all clinical variables measured. However, the inclusion of two other variables, severity of emotional distress and history of head injury, together with the neuropsychological indices provided the strongest correlation with batterers status. Among batterers, neuropsychological performance did not vary as a function of head injury status, indicating that while prior head injury was correlated with batterer status, it was not the sole basis for their impairments. The findings suggest that current cognitive status, prior brain injury, childhood academic problems, as well as psychosocial influences, contribute along with coexisting emotional distress to a propensity for domestic violence.

Achievement↗
PubMed2002

Toward a unified account of spacing effects in explicit cued-memory tasks.

Memory for repeated items improves when presentations are spaced during study. This effect is found in memory tasks using different types of material, paradigms, and participant populations. Although several explanations have been proposed, none explains the presence of spacing effects in cued-memory tasks for unfamiliar stimuli. Two experiments assessed the spacing effect on a yes-no recognition-memory task using nonwords and words as targets. The main results showed that changing the font between repeated occurrences of targets at study removed the spacing effect for nonwords only. A 3rd experiment using lexical decision showed that the font manipulation reduced repetition priming of nonwords when items were repeated at Lag 0. These results suggest that short-term perceptual priming supports spacing effects in cued-memory tasks for unfamiliar stimuli.

Analysis of Variance↗
PubMed1981

Modality memory and frequency of occurrence memory for young and middle-aged adults.

Young and middle-aged subjects, matched for scores on a figural relations test, did not differ in memory for either word content or the case format in which study list words had been presented, suggesting that age deficits for modality memory are restricted to late adulthood. Scores on the figural relations test, as a measure of fluid intelligence, correlated positively with case recognition scores, but significantly so only for the young subjects. In addition case recognition memory was more proficient under intentional conditions than under incidental conditions for both age groups, implying that case encoding is a cognitively effortful activity. In agreement with this position, case recognition scores showed an absence of correlation with scores on a frequency judgment task, a task commonly assumed to involve an automatic encoding process.

Adolescent↗
PubMed2005

The ubiquity of memory retrieval deficits in patients with frontal-striatal dysfunction.

OBJECTIVE AND BACKGROUND: Previous studies have shown that patients with frontal-striatal dysfunction demonstrate improved performance on tests of recognition memory relative to free recall memory, suggesting deficits in retrieval processes. Not all studies, however, have indicated that all patients with frontal-striatal dysfunction display this profile. In this study, we examined the ubiquity of this "retrieval deficit" profile in a relatively large sample of patients with Parkinson disease (PD) or Huntington disease (HD). METHODS: Participants included 150 patients with PD and 65 patients with HD. Patients were classified as demonstrating a retrieval deficit or not based on a comparison of their standardized performances on the Recognition Discriminability and Long-Delay Free Recall indices from the California Verbal Learning Test. RESULTS: Results indicated that 1) a retrieval deficit was more prevalent in patients with HD than PD, 2) this group difference emerged only in patients with at least a mild level of global cognitive impairment, and 3) even when the profile did emerge more frequently in patients with HD, it was present in only 44% of the patients. CONCLUSIONS: These findings suggest that not all patient groups with frontal-striatal dysfunction display a retrieval deficit profile, but in groups that do (ie, patients with HD), it is more likely to appear in individuals with greater cognitive impairment.

Aged↗
PubMed2005

Wistar rats show episodic-like memory for unique experiences.

Human episodic memory refers to the recollection of an unique past experience in terms of its details, its locale, and temporal occurrence. Episodic memory, even in principle, has been difficult to demonstrate in non-verbal mammals. Previously, we provided evidence that mice are able to form an integrated memory for "what," "where," and "when" aspects of single experiences by combining different versions of the novelty-preference paradigm, i.e., object recognition memory, the memory for locations in which objects were explored, and the temporal order memory for objects presented at distinct time points. In the present series of experiments we evaluated whether this paradigm, with minor modifications, also works with rats. We found that rats spent more time exploring an "old familiar" object relative to a "recent familiar" object, suggesting that they recognized objects previously explored during separate trials and remembered their order of presentation. Concurrently, the rats responded differentially to spatial object displacement dependent on whether an "old familiar" or "recent familiar" object was shifted to a location, where it was not encountered previously. These results provide strong evidence that the rats established an integrated memory for "what," "where," and "when." We also found that acute stress impaired the animal's performance in the episodic-like memory task, which, however, could be partially reversed by the N-Methyl-D-aspartate-receptors agonist D-cycloserine.

Animals↗
PubMed1991

Contribution of perceptual fluency to recognition judgments.

Following a shallow (count vowels) or deep (read) study task, old and new words were tested for both fluency of perception and recognition memory. Subjects first identified a test word as it came gradually into view and then judged it as old or new. Old words were identified faster than new words, indicating implicit, perceptual memory for old words. Independently of this effect, words judged old were identified faster than words judged new, especially after shallow study. Eight experiments examined the possible causal relationship between perceptual fluency and recognition judgements. Experiments 1 to 4 showed that fast identifications per se do not promote old judgments. Accelerating the identification of test items by semantically priming them or making them come more quickly into view did not affect recognition judgments. Experiment 5 showed that the usual association of fast identifications with old judgments is not an artifact of item selection because the association disappeared when the identifications and judgements were segregated into different phases of the test task. Experiments 6 and 7 showed tha the likelihood of old judgments increases directly with the pretested perceptibility of test words, but only after shallow study. Experiment 8 showed that the dependency of recognition judgments on perceptual fluency continues to hold when the requirement to identify the words before judging them is eliminated. We conclude that fluency of perception contributes to recognition judgments, but only when the fluency is produced naturally (e.g., through perceptual memory) and explicit memory is minimal.

Adult↗
PubMed2005

Music, memory, and Alzheimer's disease: is music recognition spared in dementia, and how can it be assessed?

Despite intriguing and suggestive clinical observations, no formal research has assessed the possible sparing of musical recognition and memory in Alzheimer's dementia (AD). A case study is presented of an 84-year old woman with severe cognitive impairment implicating AD, but for whom music recognition and memory, according to her caregivers, appeared to be spared. The hypotheses addressed were, first, that memory for familiar music may be spared in dementia, and second, that musical recognition and memory may be reliably assessed with existing tests if behavioral observation is employed to overcome the problem of verbal or written communication. Our hypotheses were stimulated by the patient EN, for whom diagnosis of AD became probable in 2000. With severe problems in memory, language, and cognition, she now has a mini-mental status score of 8 (out of 30) and is unable to understand or recall standard instructions. In order to assess her music recognition abilities, three tests from the previous literature were adapted for behavioral observation. Two tests involved the discrimination of familiar melodies from unfamiliar melodies. The third involved the detection of distortions ("wrong" notes) in familiar melodies and discrimination of distorted melodies from melodies correctly reproduced. Test melodies were presented to EN on a CD player and her responses were observed by two test administrators. EN responded to familiar melodies by singing along, usually with the words, and often continuing to sing after the stimulus had stopped. She never responded to the unfamiliar melodies. She responded to distorted melodies with facial expressions - surprise, laughter, a frown, or an exclamation, "Oh, dear!"; she never responded in this way to the undistorted melodies. Allowing these responses as indicators of detection, the results for EN were in the normal or near normal range of scores for elderly controls. As well, lyrics to familiar melodies, spoken in a conversational voice without rhythmic or pitch clues, often prompted EN to sing the tune that correctly accompanied the lyrics. EN's results provide encouraging support for our hypotheses that sparing of musical memory may be a feature of some forms of dementia and that it may be reliably and quantitatively assessed through behavioral observation. The contrast between EN's response to music and her mini-mental status is dramatic. The article concludes with several considerations why music may be preserved in dementia and suggestions to guide future research.

Aged↗
PubMed1982

Memory for pictograms, pictures, and words separately and all mixed up.

Pictograms were created in which the outline of a work denoting an object was shaped to be the same as the object itself. A number of objects were presented, some drawn as pictograms, some as outline shapes, and some as normally printed words. The experiment was designed to test if recognition memory was superior for the pictograms as compared to outline pictures or words, and if this would be true whether the subjects were asked to attend to the form or only the content of the stimuli. One group of subjects was trained to respond OLD only if the test item was the same object in the same form, and NEW only to objects never before shown in any form. Recognition accuracy (a signal detection analysis) was greatest for the pictograms, and poorest for the words in both groups. Though the subjects could disregard form, they were most accurate when probed with the same form as presented. But in all comparisons subjects were most accurate when forced to recall both the form and the content. These and other results were taken to be mildly supportive of a dual coding hypothesis, and of the utility of these new stimuli.

Concept Formation↗
PubMed2006

Memory for choices in Alzheimer's disease.

Despite their cognitive impairment, patients with mild Alzheimer's disease (AD) often make important life choices. When making choices, people frequently attempt to directly compare the features of different options, rather than evaluating each option separately. Not every feature has an analogous (or alignable) feature in the other option, however. In 2005, Mather's group found that both younger and older adults filled in such gaps when remembering, creating features in the other option to contrast with existing features. In the present study, such effects of alignability on recognition memory were not found in patients with mild AD. This finding suggests that patients with mild AD are less likely to engage in feature-by-feature comparison processes across choice options, a change that may lead them to make qualitatively different choices than healthy older adults.

Aged↗
PubMed1997

The role of the temporal lobes in recognizing visuospatial materials: remembering versus knowing.

Recognition memory for abstract visuospatial designs was assessed in unilateral temporal lobe epilepsy (TLE) patients and normal controls using a remember/know recognition paradigm. Subjects assigned "remember" judgments to recognized items for which they could recall the study presentation, and "know" judgments to items recognized on the basis of familiarity without conscious recollection of the study episode. In Experiment 1 normal controls and left TLE patients gave more "know" than "remember" recognition judgments for visuospatial materials. Right TLE subjects, however, showed the opposite response pattern. Experiment 1a demonstrated that this dissociation between left and right temporal patients occurred in both presurgery and postsurgery patients. In Experiment 2 recognition was assessed following encoding conditions in which subjects answered questions about either the number of lines in the designs or the appropriateness of verbal labels for presented stimuli. The previous pattern of "know" and "remember" responses was replicated for all groups in the line count condition, but was reversed for normal controls in the label condition. These results are interpreted within a theoretical framework in which "remember" responses are based on the contribution of distinctiveness of individual items to recognition whereas "know" judgements reflect perceptual fluency.

Adult↗
PubMed2002

Cognitive enhancing effects of modafinil in healthy volunteers.

RATIONALE: Modafinil, a novel wake-promoting agent, has been shown to have a similar clinical profile to that of conventional stimulants such as methylphenidate. We were therefore interested in assessing whether modafinil, with its unique pharmacological mode of action, might offer similar potential as a cognitive enhancer, without the side effects commonly experienced with amphetamine-like drugs. OBJECTIVES: The main aim of this study was to evaluate the cognitive enhancing potential of this novel agent using a comprehensive battery of neuropsychological tests. METHODS: Sixty healthy young adult male volunteers received either a single oral dose of placebo, or 100 mg or 200 mg modafinil prior to performing a variety of tasks designed to test memory and attention. A randomised double-blind, between-subjects design was used. RESULTS: Modafinil significantly enhanced performance on tests of digit span, visual pattern recognition memory, spatial planning and stop-signal reaction time. These performance improvements were complemented by a slowing in latency on three tests: delayed matching to sample, a decision-making task and the spatial planning task. Subjects reported feeling more alert, attentive and energetic on drug. The effects were not clearly dose dependent, except for those seen with the stop-signal paradigm. In contrast to previous findings with methylphenidate, there were no significant effects of drug on spatial memory span, spatial working memory, rapid visual information processing or attentional set-shifting. Additionally, no effects on paired associates learning were identified. CONCLUSIONS: These data indicate that modafinil selectively improves neuropsychological task performance. This improvement may be attributable to an enhanced ability to inhibit pre-potent responses. This effect appears to reduce impulsive responding, suggesting that modafinil may be of benefit in the treatment of attention deficit hyperactivity disorder.

Adult↗
PubMed2004

Differential age-related change of prose memory in older Hong Kong Chinese of higher and lower education.

BACKGROUND: Memory difficulty is one of the most common complaints of older people, with or without psychiatric conditions. It is therefore of utmost important to understand how normal ageing process impacts upon prose memory so as to gain insight into ways to differentiate pathological vs normal age-related changes of the recall of prose observed among older people. OBJECTIVES: To understand the differential age-related change of prose memory in older Hong Kong Chinese of higher and lower education. METHOD: Forty-eight normal, healthy Cantonese-speaking Chinese were recruited. Seventeen of them were younger, highly educated participants. Among the 31 older people recruited, 19 of them received education comparable with the younger participants and 12 were older people of low education. A prose passage was constructed to measure the different processes of prose memory, including learning efficiency, rate of forgetting, recall accuracy, accuracy of temporal sequence of information recalled, distortions, and recognition memory. RESULTS: As expected, ageing affected all the processes of prose memory measured, except the rate of forgetting. Apart from learning efficiency and rate of forgetting, education was observed to modify the effect of ageing on all the processes studied. CONCLUSIONS: Changes of prose memory associated with ageing and the differential effect of education on prose recall among older people were discussed. The findings seem to suggest that prose memory is a multifaceted construct.

Adult↗
PubMed2003

Comparison of computational models of familiarity discrimination in the perirhinal cortex.

This study compares the efficiency and plausibility of published computational models of familiarity discrimination in the perirhinal cortex. Substantial evidence indicates that the perirhinal cortex is involved in both the familiarity discrimination aspect of recognition memory and in perceptual functions involved with representations of complete stimuli (i.e., object identification). Published models of how the perirhinal cortex may perform familiarity discrimination can be divided into two groups. The first group assumes that a proportion of perirhinal neurons form a network specialised just for familiarity discrimination (these models may be based on Hebbian or anti-Hebbian synaptic plasticity). In contrast, the second group assumes that both familiarity discrimination and learning representations of complete stimuli are performed within a single combined network. This study establishes that when the responses of neurons that provide input to the familiarity discrimination network are correlated (as indicated by experimental data), specialised networks based on anti-Hebbian learning may recognise the previous occurrence of many more stimuli (i.e., have a capacity up to thousands of times larger) than specialised networks based on Hebbian learning. The currently published combined models do not learn an optimal stimulus representation (they do not fully extract statistically independent features), and hence their capacities are even lower than those of the specialised models based on Hebbian learning. Hence, the combined models published thus far are critically less efficient than the specialised models based on anti-Hebbian learning. This study also compares the consistency of the models with experimental observations concerning what is known of synaptic plasticity in the perirhinal cortex and the responses of its neurons. Many theoretically important parameters remain undetermined, and experiments are suggested to provide information critical for refining and distinguishing between the various models. However, the above theoretical arguments and currently published data favour the existence of a separate network specialised for familiarity discrimination.

Animals↗
PubMed1995

Postnatal development of CA3 pyramidal neurons and their afferents in the Ammon's horn of rhesus monkeys.

Previous studies described the postnatal development of CA3 pyramidal neurons and their afferents in the rat. However, the postnatal development of the primate hippocampus was not previously studied. Thus, pyramidal neurons of the CA3 area of the monkey hippocampus were analyzed postnatally in the present study. At birth, a few thorny excrescences, the complex spines postsynaptic to mossy fibers, were found on the proximal segments of both apical and basal dendrites, whereas distal dendrites displayed pedunculate spines. Thorny excrescences increased in number until the third month. A continuous increase in the number of spines per unit length along the distal dendrites was observed during the first 12 months. The ultrastructural features of somata and dendrites of pyramidal cells in newborn monkeys were similar to those of adults. The analysis of the afferents to the CA3 pyramidal neurons was limited to the development of mossy fibers, the axons of granule cells, and myelinated axons in the alveus, stratum oriens, and stratum lacunosum-moleculare. At birth, most mossy fiber terminals were densely packed with synaptic vesicles and formed mainly axospinous synapses with CA3 pyramidal cells. By 1 month of age, the number of mitochondria and embedded spines increased to mature amounts. In the first postnatal month, degenerating axons and axon terminals were frequently observed in the mossy fiber bundles in stratum lucidum. The proportion of myelinated axons increased simultaneously in all three examined layers. At birth most axons were unmyelinated, whereas at 7 months of age the proportion of myelinated axons was similar to that found in adults. The present study indicates that most pyramidal neurons of the CA3 region in monkeys are in an advanced stage of development at the time of birth. Thus, mossy fibers from granule cells in the dentate gyrus have established mature-looking synapses, and the thorny excrescences of pyramidal cells that are postsynaptic to mossy fibers are also adult-like. Nevertheless, several of the adult features, such as the spine density of distal dendrites of pyramidal neurons and the myelination of afferent axons, develop during an extended period of time in the first year. The significance of this early anatomical maturation in a brain region involved in memory function is consistent with recent behavioral data that show a rapid postnatal maturation of limbic-dependent recognition memory in rhesus monkeys.

Afferent Pathways↗
PubMed2005

The primate hippocampus: ontogeny, early insult and memory.

Recent evidence suggests that in primates, as in rodents, the hippocampus shows a developmental continuum that affects memory abilities from infancy to adulthood. In primates relatively few hippocampal-dependent abilities (e.g. some aspects of recognition memory) are present in early infancy, whereas others (e.g. relational memory) begin to show adult-like characteristics around 2 years of age in monkeys and 5-7 years in humans. Profound and persistent memory loss resulting from insult to the hippocampus in infancy becomes evident in everyday behavior only later in childhood. This pattern of results suggests a maturational gradient within the medial temporal lobe memory system, with most abilities crucially dependent upon the hippocampus emerging in later stages of development, supporting a model of hierarchical organization of memory within the medial temporal lobe.

Animals↗
PubMed1998

Recovery of function processes in human amnesia: evidence from transient global amnesia.

There are few clues as to the processes that underlie recovery of function from human amnesia. Evidence is offered from the perspective of a study of recovery of function during an episode of transient global amnesia (TGA) that occurred as a complication of a cerebral angiographic procedure being carried out in a neurosciences centre, and where there was therefore a unique opportunity to examine acute changes in memory function. This allowed us to conduct the first quantitative study where shrinkage of anterograde and retrograde memory loss was plotted at four separate intervals throughout the acute recovery process, and also 24 hr later. Recovery of retrograde amnesia preceded recovery from anterograde amnesia. Resolution of a naming deficit more closely paralleled recovery from retrograde amnesia rather than anterograde amnesia. Within retrograde amnesia for public events, there was a temporal gradient of memory loss, with more recent events affected to a greater degree than earlier events. Within anterograde amnesia, picture recognition memory preceded recovery of story recall memory. On the basis of these findings, and related observations in the published literature, it is proposed that recovery from some types of human amnesia, such as that associated with TGA, follows a 'lateral-to-medial' rule--lateral inferotemporal areas that play a major role in retrograde amnesia recover first from hypometabolism related to the TGA attack, followed by 'interface' areas such as the rhinal and parahippocampal cortices that are considered to have a role in both anterograde and retrograde memory functioning, with the last areas to recover physiological integrity being discrete limbic-diencephalic structures such as the hippocampus.

Adult↗