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At least 1,711 records · Page 95Linked to original sources
PubMed1982

The Euglena paraflagellar rod: structure, relationship to other flagellar components and preliminary biochemical characterization.

Demembranated flagella from Euglena gracilis consisted of three distinct components: a 9 + 2 axoneme of microtubules, an extensive surface coating of long and short mastigonemes and a lattice-like axial fibre known as the paraflagellar rod. Negatively stained preparations of isolated paraflagellar rods showed the major structural unit to be a 22 nm filament oriented at approximately 45 degrees to the long axis of the rod in a 7-start left-handed helical arrangement. Attachment of the paraflagellar rod to the flagellar axoneme was via a series of goblet-shaped projections, which anchored the rod to a single outer doublet microtubule. Comparisons of axonemes from E. gracilis bearing the paraflagellar rod with those of Chlamydomonas reinhardtii, in which it is absent, by polyacrylamide gel electrophoresis revealed the presence of two prominent additional peptides with molecular weights of 80,000 and 69,000. Exposure of Euglena axonemes to trypsin selectively solubilized the paraflagellar rod and also removed both proteins, which were therefore tentatively identified as the major subunit proteins of the rod and designed PFR 1 and 2, respectively. In addition to these details of the structure and composition of the paraflagellar rod, the mode of attachment of the axoneme of both long and short mastigonemes was also identified.

Animals↗
PubMed2003

Storytelling that moves people. A conversation with screenwriting coach Robert McKee.

When executives need to persuade an audience, most try to build a case with facts, statistics, and some quotes from authorities. In other words, they resort to "companyspeak," the tools of rhetoric they have been trained to use. In this conversation with HBR, Robert McKee, the world's best-known screenwriting lecturer, argues that executives can engage people in a much deeper--and ultimately more convincing--way if they toss out their Power-Point slides and memos and learn to tell good stories. As human beings, we make sense of our experiences through stories. But becoming a good storyteller is hard. It requires imagination and an understanding of what makes a story worth telling. All great stories deal with the conflict between subjective expectations and an uncooperative objective reality. They show a protagonist wrestling with antagonizing forces, not a rosy picture of results meeting expectations--which no one ends up believing. Consider the CEO of a biotech start-up that has discovered a chemical compound to prevent heart attacks. He could make a pitch to investors by offering up market projections, the business plan, and upbeat, hypothetical scenarios. Or he could captivate them by telling the story of his father, who died of a heart attack, and of the CEO's subsequent struggle against various antagonists--nature, the FDA, potential rivals--to bring to market the effective, low-cost test that might have prevented his father's death. Good storytellers are not necessarily good leaders, but they do share certain traits. Both are self-aware, and both are skeptics who realize that all people--and institutions--wear masks. Compelling stories can be found behind those masks.

Administrative Personnel↗
PubMed2005

[Odontology in Spain: towards the integration to the European high education space].

The European Higher Education Space (EHES) is a project to harmonize all the European University systems in order that all of them will posses a homogeneous structure of undergraduate, graduate and post graduate studies. The time period established to implement this project is year 2010. The present paper describes the establishment of a new career degree model in Spain, the degree in Dentistry that started twenty years ago. Also it has been stated the number of the present Departments and Schools, the access system to Public University Schools of Spain, the evaluation system, and which are the new mechanisms incorporated in the Spanish University system to implement this integration to the EHEE. This is the moment to design the new master guidelines to obtain homogeneous career degrees that may imply more accessibility and mobility of students and professionals.

Curriculum↗
PubMed1996

The central venous catheter for young patients: an "umbilical cord" fantasy.

Central Venous Catheter (CVC) allows the administration of drugs, parenteral nutrition and blood sample taking for laboratory tests, avoiding continuous damage to the peripheral veins. Most of the psychological traumas caused by crude treatments also decrease and therefore CVC may initially be experienced as the end of continuous physical injuries. Nevertheless, it often happens that other sorts of psychological trauma, due to fantasies and fears elicited by the CVC, arise in children and their families. The CVC is often felt as a dangerous and invasive "foreign body". Moreover after it has been used for a long time it may create a psychological state of dependency and it frequently becomes the only means of salvation. This makes removal particularly difficult and it is felt as a "cutting" of the CVC at the end of the therapy. Young patients elaborate complex fantasies about the starting point, the route and the end point of the catheter. Their parents are often unknowing accomplices of these fears, partially because they project their own experience and also because they are conditioned by the way they have elaborated the information provided by the assistance staff. Since the handling of CVC is under the parent's responsibility when the child is not in Hospital, we should be able to help the patients and their families to cope with this experience in the most suitable way. This makes it possible to avoid both excessive worries and the tendency to underestimate the risk of infection. This is why we consider that submitting children and their family members to interviews, surveys and spontaneous drawing is wise in order to evaluate the existence, nature and extent of the fantasies. This helps to modify possible distortions both of perception and behavior.

Adolescent↗
PubMed1984

Evaluation of screening for breast cancer in a non-randomised study (the DOM project) by means of a case-control study.

In 1974 a non-randomised study of the effect of mass screening by physical examination and xeromammography on mortality from breast cancer was started. Of the 20 555 eligible women in the city of Utrecht born between 1911 and 1925 (aged 50-64 at the start of the study), 14 796 attended for screening. Four rounds of screening were carried out. The relative risk of dying from breast cancer among women ever screened compared with women never screened was 0.30 (95% confidence interval 0.13-0.70).

Adult↗
PubMed1989

National project on the prevention of mother-to-infant infection by hepatitis B virus in Japan.

In Japan, a nationwide prevention program against mother-to-infant infection by hepatitis B virus (HBV) started in 1985. This program consists of double screenings of pregnant women and prophylactic treatment to the infants born to both hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) positive mothers. These infants are treated with two injections of hepatitis B immune globulin (HBIG) and at least three injections of plasma derived hepatitis B vaccine. We sent questionnaires about the numbers of each procedure or examination during nine months of investigation period to each local government in 1986 and 1987. 93.4% pregnant women had the chance to be examined for HBsAg, and the positive rate was 1.4 to 1.5%. The HBeAg positive rate in HBsAg positive was 23 to 26%. The HBsAg positive rate in neonates and in infants before two months were 3% and 2% respectively. Some problems may arise, because 27 to 30% of infants need the fourth vaccination in some restricted areas.

Carrier State↗
PubMed2005

High performance workflow implementation for protein surface characterization using grid technology.

BACKGROUND: This study concerns the development of a high performance workflow that, using grid technology, correlates different kinds of Bioinformatics data, starting from the base pairs of the nucleotide sequence to the exposed residues of the protein surface. The implementation of this workflow is based on the Italian Grid.it project infrastructure, that is a network of several computational resources and storage facilities distributed at different grid sites. METHODS: Workflows are very common in Bioinformatics because they allow to process large quantities of data by delegating the management of resources to the information streaming. Grid technology optimizes the computational load during the different workflow steps, dividing the more expensive tasks into a set of small jobs. RESULTS: Grid technology allows efficient database management, a crucial problem for obtaining good results in Bioinformatics applications. The proposed workflow is implemented to integrate huge amounts of data and the results themselves must be stored into a relational database, which results as the added value to the global knowledge. CONCLUSION: A web interface has been developed to make this technology accessible to grid users. Once the workflow has started, by means of the simplified interface, it is possible to follow all the different steps throughout the data processing. Eventually, when the workflow has been terminated, the different features of the protein, like the amino acids exposed on the protein surface, can be compared with the data present in the output database.

Automation↗
PubMedDate not supplied

The Diabetic Foot Project of Flanders, the northern part of Belgium: implementation of the St Vincent consensus. Sensibilisation and registration in diabetes centres.

As a result of the St Vincent declaration, a Belgian "task force" was installed in 1992 and consequently 16 working groups were formed. They presented their objectives in 1995. The working group "prevention and treatment of diabetic foot lesions" started the implementation of a screening program to obtain an overview of the presentation of diabetic foot lesions, the amputation rate and the prevalence of patients with a foot at risk. This study reports the results from 43 out of 73 Flemish diabetes centres. 1653 patients were enrolled in this study (53% women, 47% men, median age 61). 34.6% were type 1 and, 65.4% type 2. One or more arterial pedal pulses were absent in 28%, 30.5% had an abnormal monofilament test, 35% skin lesions and 28% malformations. Still 19% smoked, 15.8% had visual problems and 11% had already developed an ulcer previously. Ulcers were reported in 8.7% of which almost 2/3 belonged to Wagner class I. 69 (3.87%) of the patients had had amputations. According to the four-risk categories-scale 46.3% of the patients belonged to the highest one; peripheral vascular disease, previous amputations, previous ulcers, and Charcot joints. In our region we didn't have previous data on the prevalence and morbidity of the amputation rate with diabetes patients. We observed 3.87% amputations, which is rather high in comparison with international data (0.44% - 2.4%). The general follow-up of diabetic foot problems can be organised in co-operation with other care providers. A national program therefore is going to start in the next months. We all have to be aware of the size of the problem to offer the best possible prevention. As we have seen, the use of inlay soles and podiatrist-made ortheses for example is very low. We hope that all care providers will participate in this important project, so that they will acquire a specific attitude towards these patients. In daily clinical practice there are some key-roles to be respected by all health care providers. In our opinion the next are of the utmost importance: take off your diabetic patient's shoes when they visit you; give specific education if your patient has a foot at risk; if an ulcer is present, carefully follow-up is mandatory and if no good evolution of the ulcer is seen, an early referral to a diabetic foot clinic is obvious. Together we can lower down the amputation rate of diabetic foot lesions. And that would be a marvelous implementation of the St Vincent declaration in Belgium.

Aged↗
PubMed2002

Reproducibility of the ventricular synchronization parameters assessed by multiharmonic phase analysis of radionuclide angiography in the normal heart.

Radionuclide angiography (RNA) permits analysis of contractility and conduction abnormalities. We determined the parameters of normal ventricular synchronization, assessed the reproducibility of the technique, and compared first harmonic (1H) and third harmonic (3H) analysis. Forty-four normal subjects (28 men and 16 women) were studied. RNA was performed in left anterior oblique (LAO) and left lateral (LL) projections. The onset (To), mean time (Tm), total contraction time (Tt) for right ventricle (RV) and left ventricle (LV), interventricular time (T(RV-LV) = Tm(LV - Tm(RV)) in LAO, and the apex-to-base time (T(a-b)) in LL were measured on the histograms of the time-activity curve. Reproducibility (R) was tested by studying 26 consecutive patients with two successive RNAs. RV starts contracting 25 ms before LV (To(RV) = 29 +/- 37 ms; To(LV) = 54 +/- 39 ms; mean +/- SD) with a 37 ms longer total contraction time. T(RV-LV) is 3 +/- 16 ms. In LL projection, apex and base contract synchronously: T(a-b) = 2 +/- 16 ms. 3H analysis enlarges all duration parameters (To, Tm and Tt), but does not alter synchronization (deltaT(a-b) and deltaT(RV-LV) between 1H and 3H <1%, p = NS). Reproducibility of the duration (T(tLV) and T(tRv)) and synchronization parameters (T(a-b) and T(RV-LV)) is high (R < or = 2.2%). In conclusion, the simultaneous contraction of right and left ventricles and of apex and base can be quantified by RNA phase analysis with high reproducibility. These results, consistent with published electrophysiological data, provide the basis for further non-invasive investigations of ventricular resynchronization in patients with basal electrical or mechanical asynchrony.

Female↗
PubMed1989

Dorsal medullary inspiratory neurons: effects of superior laryngeal afferent stimulation.

In decerebrate paralyzed cats ventilated with a cycle-triggered pump, we examined the responses of inspiratory (I) neurons in the region of the ventrolateral nucleus tractus solitarius (NTS) to single electrical stimuli delivered to the ipsilateral superior laryngeal nerve (SLN). Sixty-five I neurons were classified as: I(-), I(0), I(+, early), I(+, late) or I(other) on the basis of responses to lung inflation, and as I(bulbophrenic) or I(non-bulbophrenic) on the basis of evidence of an excitatory projection to the contralateral phrenic motoneuron pool. The peristimulus histograms of contralateral phrenic activity showed an early peak of excitation with average latency of 4.9 +/- 0.1 ms (mean +/- S.E.M.), followed by depression at 7.3 +/- 0.2 ms, start of recovery from depression at 22.7 +/- 1.0 ms, and recovery to control levels at 28.4 +/- 1.1 ms. The peristimulus histograms of ipsilateral I unit activity showed an initial excitation (latency 2.9 +/- 0.3 ms), followed by spiking silence (latency 6.0 +/- 0.6 ms) and recovery to control discharge frequency at 38.8 +/- 3.6 ms. This time of inhibition was significantly longer than the time of phrenic depression, suggesting that other bulbophrenic excitatory projections are able to rapidly compensate for decreased NTS output. Subgroups of I neurons, as classified by lung inflation tests, did not differ significantly with respect to these timing variables. In contrast, latencies of excitation for I(bulbophrenic) neurons were significantly less than for I(non-bulbophrenic) neurons.

Action Potentials↗
PubMed2001

Pursuing perfection: RWJF, IHI announce project to improve health care performance.

Achieving quality health care--by stamping out mediocrity while supporting superior performances in all care processes--may seem to many in the health care industry a far-off realization. But, this area may be getting a kick-start soon with a new initiative, "Pursuing Perfection: Raising the Bar for Health Care Performance," funded by the Robert Wood Johnson Foundation of Princeton, N.J., and managed by the Boston-based Institute for Healthcare Improvement. With the program, six health care organizations will be given opportunities to improve patient outcomes by "pursuing perfection across all their care processes."

Academies and Institutes↗
PubMed1996

Development of the time coding pathways in the auditory brainstem of the barn owl.

The barn owl's head grows after hatching, causing interaural distances to more than double in the first 3 weeks posthatch. These changes expose the bird to a constantly increasing range of interaural time cues. We have used Golgi and ultrastructural techniques to analyze the development of the connections and cell types of the nucleus magnocellularis (NM) and the nucleus laminaris (NL) with reference to the growth of the head. The time coding circuit is formed but immature at the time of hatching. In the month posthatch, the auditory nerve projection to the NM matures, and appears adult-like by posthatch day (P)21. NM neurons show a late growth of permanent dendrites starting at P6. Over the first month, these dendrites change in length and number, depending upon rostrocaudal position, to establish the adult pattern in which high best frequency neurons have few or no dendrites. These changes are not complete by P21, when NM neurons still have more dendrites than in the adult owl. The neurons of NL have many short dendrites before hatching. Their number is greatly reduced by P6, and then does not change during later development. Like NM neurons, NL neurons and dendrites grow in the first month posthatch, and at P21, NL dendrites are longer than those in the adult owl. Thus, the auditory brainstem circuits grow in the first month after hatching, but are not yet mature at the time the head reaches its adult size.

Animals↗
PubMed1993

The impact of population growth on the standard of living: demo-economic scenarios for the Netherlands.

"The core of the article can be comprised in the question: Will population ageing become a threat to [the] standard of living [in the Netherlands]?... In order to explore a broad range of possibilities two strongly contrasting...scenarios serve as the starting-points of the analyses.... The question of whether the ageing process will jeopardize the standard of living, is, for each of the demographic projections, answered by comparing them with three economic targets.... The most important conclusion is that in the long run neither of the scenarios developed will generate an economic growth comparable with that of the 1960s and 1970s." (SUMMARY IN FRE)

Demography↗
PubMed2006

Neurofilament content is correlated with branch length in developing collateral branches of Xenopus spinal cord neurons.

During development, axons form interstitial collateral branches, which are initially dynamic but gradually stabilize as the projection sharpens. The initial outgrowth of collaterals is characterized by transitions in growth dynamics that occur at different lengths. Below 10 microm, collateral branches start out as unstable, thin filopodia. Above 30 microm, the branches stabilize. Although the relationship between branch length and the presence of microfilaments and microtubules has been well characterized, relatively less is known about the development of the neurofilament cytoskeleton in collateral branches. In the main axon, successive stages of outgrowth are accompanied by changes in the polypeptide composition of neurofilaments (NFs), which shifts from being rich in Type III neuronal intermediate filament proteins (nIFs) to progressively favoring Type IV subunits. To characterize the NF composition of developing collateral branches, antibodies to peripherin (a Type III nIF) and NF-M (a Type IV nIF) were used to stain newly differentiating embryonic Xenopus laevis spinal cord neurons in culture. In contrast to what happens in the main axon, staining for both subunits coincided in collaterals. Branches shorter than 10 microm seldom had NFs, whereas all branches longer than 30 microm did. In branches that had NFs staining either extended all the way to branch tip or terminated approximately 10mum from it. These lengths correspond remarkably well with lengths associated with branch stabilization. Given that NFs are the most stable of the cytoskeletal polymers, we speculate that they may contribute to this stabilization.

Animals↗
PubMed1998

Characterising ultrasonic physiotherapy systems by performance and safety now internationally agreed.

The IEC 1689 standard specifies: methods of measurement, characterisation of the output performance, requirements for safety due to the ultrasonic field generated, characteristics to be declared by manufacturers and acceptance criteria for aspects of performance. For the characterisation, reference as well as routine testing methods are described. Important parameters such as effective radiating area (AER), beam nonuniformity ratio (RBN) (characterising 'hot-spots': potentially harmful to patients) and beam type have been re-defined. The quality, reproducibility and accuracy of measurements of AER are significantly improved compared to those in IEC 150 (which is now replaced) and the FDA 1050.10 (USA) standards. As a result, values of effective intensity are shown to be significantly higher than those obtained using the FDA 1050.10 (USA) definitions. As it may be expected that the new standard will be implemented worldwide, this problem is just a matter of time. The standard discussed above specifies the need for acoustic power measurement with an accuracy of more than 15%. However, several investigations carried out over the last ten years show a lack of proper facilities to calibrate the acoustic output power at physiotherapy levels. A project to investigate the complications and to produce definitive guidance for therapy-level power measurements is funded by the EC and has been started recently. Future activities will be undertaken to estimate the expected temperature rise in tissue due to the ultrasonic field. Such a figure may result in an improved judgement of the ultrasonic safety aspects of physiotherapy systems.

Acoustics↗
PubMedDate not supplied

Protocols for bridging the peptide to nonpeptide gap in topological similarity searches.

Similarity searches based on chemical descriptors have proven extremely useful in aiding large-scale drug screening. Typically an investigator starts with a "probe", a drug-like molecule with an interesting biological activity, and searches a database to find similar compounds. In some projects, however, the only known actives are peptides, and the investigator needs to identify drug-like actives. 3D similarity methods are able to help in this endeavor but suffer from the necessity of having to specify the active conformation of the probe, something that is not always possible at the beginning of a project. Also, 3D methods are slow and are complicated by the need to generate low-energy conformations. In contrast, topological methods are relatively rapid and do not depend on conformation. However, unmodified topological similarity methods, given a peptide probe, will preferentially select other peptides from a database. In this paper we show some simple protocols that, if used with a standard topological similarity search method, are sufficient to select nonpeptide actives given a peptide probe. We demonstrate these protocols by using 10 peptide-like probes to select appropriate nonpeptide actives from the MDDR database.

Computer Simulation↗
PubMed1998

Codes and morals: is there a missing link? (The Nuremberg Code revisited).

Codes are a well known and popular but weak form of ethical regulation in medical practice. There is, however, a lack of research on the relations between moral judgments and ethical Codes, or on the possibility of morally justifying these Codes. Our analysis begins by showing, given the Nuremberg Code, how a typical reference to natural law has historically served as moral justification. We then indicate, following the analyses of H. T. Engelhardt, Jr., and A. MacIntyre, why such general moral justifications of codes must necessarily fail in a society of "moral strangers." Going beyond Engelhardt we argue, that after the genealogical suspicion in morals raised by Nietzsche, not even Engelhardt's "principle of permission" can be rationally justified in a strong sense--a problem of transcendental argumentation in morals already realized by I. Kant. Therefore, we propose to abandon the project of providing general justifications for moral judgements and to replace it with a hermeneutical analysis of ethical meanings in real-world situations, starting with the archetypal ethical situation, the encounter with the Other (E. Levinas).

Codes of Ethics↗
PubMed1980

Chemotherapy of advanced malignant teratomas.

Between 1977 and November 1979 we have treated 53 patients with malignant teratomas (43 males, 10 females). Thirty (70%) out of the 43 male patients had advanced and bulky disease at the time of presentation. Using different drug combinations in a sequential manner as described below, results are as follows: of the initial 33 male patients, 22 (67%) have discontinued treatment (mean 9.5 months). Nineteen have responded completely and 3 have static computed tomography (CT) nodules. Life-table analysis projects a survival of 66% (analysis at 1 December 1979). Nine out of 10 ovarian teratoma patients are alive. Adverse prognostic factors at the start of treatment were recognized in 9/10 male patients and the 1 female patient who have died. Although the survival of patients with malignant teratomas has improved dramatically, there are still problems with drug resistance in patients with very advanced disease. Patients with these tumours should continue to be treated in centres specializing in managing what has now become a potentially curable disease in most cases.

Adolescent↗