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PubMed1975

[The language of the unconscious].

The concept of consciousness, separate from that of vigilance, can be defined as the immediate knowledge of motor-perceptual activities on the cognitive assimilation of the real duration. The linguistic theories distinguish in the language first of all linguistic competence, it is grouping of signs or linguistic knowledge of the group, which one can compare to phenomenon of automatism, and secondly the spoken language or linguistic performance, a creative individual and voluntary act. The observation of aphasics and of a certain partial temporal epileptics permits to dissociate these two forms of language. That of the consciousness linked to the immediate observation of the self by ones' self could only be the creative word. The unconscious listener, separated from real time, without real creative ability, could only be the "-echo-souvenir" of the conscient person.

Aged↗
PubMed2002

Utility of preoperative functional magnetic resonance imaging for identifying language cortices in patients with vascular malformations.

OBJECT: The goal of this study was to evaluate the utility of preoperative functional magnetic resonance (fMR) imaging in the prediction of whether a given cortical area would be deemed essential for language processing by electrocortical stimulation mapping (ESM). METHODS: The authors studied patients with vascular malformations, specifically arteriovenous malformations (AVMs) and cavernous angiomas, in whom blood-flow patterns are not normal and in whom a perfusion-dependent mapping signal may be questionable. Ten patients were studied (seven harboring AVMs and three with cavernous angiomas). The authors used a battery of linguistic tasks, including visual object naming, word generation, auditory responsive naming, visual responsive naming, and sentence comprehension, to identify brain regions that were consistently activated across expression and comprehension linguistic tasks. In a comparison of ESM and fMR imaging activations, the authors varied the matching criteria (overlapping activations, adjacent activations, and deep activations) and the radii of influence of ESM (2.5, 5, and 10 mm) to determine the effects of these factors on the sensitivity and specificity of fMR imaging. The sensitivity and specificity of fMR imaging were dependent on the task, lobe, and matching criterion. For the population studied, the sensitivity and specificity of fMR imaging activations during expressive linguistic tasks were found to be up to 100 and 66.7%, respectively, in the frontal lobe, and during comprehension linguistic tasks up to 96.2 and 69.8%, respectively, in the temporal and parietal lobes. The sensitivity and specificity of each disease population (patients with AVMs and those with cavernous angiomas) and of individuals were consistent with those values reported for the entire population studied. CONCLUSIONS: The authors conclude that preoperative fMR imaging is a highly sensitive preoperative planning tool for the identification of which cortical areas are essential for language and that this imaging modality may play a future role in presurgical planning for patients with vascular malformations.

Cerebral Cortex↗
PubMed1992

Cultural barriers associated with large gene frequency differences among Italian populations.

Analysis of geographic variation for eight red cell markers in Italy shows significant spatial structure for most alleles. Effective population sizes estimated from FST values at these loci are much smaller than those predicted from data on consanguineous marriage, suggesting the presence of factors (presumably barriers) that have reduced gene flow and enhanced the evolutionary weight of genetic drift. Most regions of sharp gene frequency change correspond to geographic and linguistic barriers. Two allele frequencies are significantly correlated with measures of linguistic differentiation but not with indexes describing broad religious and social attitudes. The similarity between patterns of genetic and linguistic variation in Italy, also observed in a previous study, suggests that in specific areas linguistic diversity has acted as a biological barrier constraining mating, dispersal, or both. There is no evidence for a similar role of other extent cultural barriers.

Communication Barriers↗
PubMed2006

Caring for diverse populations: do academic family medicine practices have CLAS?

BACKGROUND AND OBJECTIVES: The Future of Family Medicine Final Report calls for greater emphasis on training physicians to provide culturally proficient and effective quality care to an increasingly diverse population. It remains unclear, however, how prepared academic family medicine practices are to address this need. METHODS: We carried out a qualitative sub-study (as part of a larger research study) using depth and focus group interviews at two urban family medicine centers to understand the challenges and opportunities involved in meeting the Department of Health and Human Services Office of Minority Health's National Standards for Culturally and Linguistically Appropriate Services (CLAS) in Health Care. The Lewin Group's Organizational Cultural Competence Assessment Profile was used to analyze the qualitative interview data. RESULTS: The main themes that emerged from interviews with faculty physicians, administrators, staff, and patients were: (1) the need for more linguistically appropriate services, (2) lack of communication among those involved in care delivery, and (3) interest in education about cultural and linguistic competence. CONCLUSIONS: The academic family medicine practices studied are frustrated and challenged to integrate cultural and linguistic competence into patient care. Organizational pressures, multiple competing demands, and resource constraints inhibit preparedness to address the CLAS standards and important new national requirements and guidelines.

Clinical Competence↗
PubMed2006

[Alienation and adaptation in English translation of traditional Chinese medicinal literature].

Alienation and adaptation are two of the principles and methods in translation, each possessing their own values. Alienation should be applied in translating linguistic content in order to transfer the imbedded cultural messages trustfully; while the principle of adaptation should be followed in linguistic structure translation due to the different thinking patterns between Chinese and English which results in a great linguistic structure difference. Therefore, the translator must express the original meaning trustfully, on the other hand, to make the Chinese version more smooth, linguistic structure should be transformed to conform to the thinking habit of the readers. In brief,alienation and adaptation should complement each other in translation to make it a bridge connecting the different cultures.

Medicine, Chinese Traditional↗
PubMed1986

Characteristics of verbal impairment in closed head injured patients.

One hundred twenty-five closed head injured postcoma patients in a rehabilitation medicine center underwent standardized aphasia tests to determine the presence and nature of verbal deficits. Mean time since injury for the group was 45 weeks. All patients evidenced linguistic impairment which was only apparent on testing, not in conversation. The population fell into three relatively equally sized groups: classic aphasia, dysarthria accompanied by linguistic deficits, and "subclinical" aphasic deficits. No patient with a history of coma after closed head injury was spared defective performance on selected language tasks. The patient groups reflected a severity continuum ranging from aphasia, the most severely impaired group, to the least impaired, the subclinical aphasia group. Further, closed head injured patients with a history of coma who manifest motor speech impairment (dysarthria) also manifest linguistic processing deficits. The study results suggest that linguistic functions are particularly vulnerable in severe head injury.

Adolescent↗
PubMed1988

Language and speech defects.

A review of recent research conducted at the Rusk Institute of Rehabilitation Medicine in New York City concerning speech and language deficits in closed head injured patients (CHI). One hundred and twenty-five consecutive admissions of 125 closed head injured post coma patients were administered standardized aphasia tests to determine the presence and nature of verbal deficits. Mean time since injury for the group was 45 weeks. All patients, without exception, evidenced linguistic impairment. The population fell into three relatively equally sized groups: classic aphasia, dysarthria accompanied by linguistic deficits, and "subclinical" aphasic deficits. The study results suggest that linguistic functions are particularly vulnerable in severe head injury. A second study compared aphasia secondary to CVA and CHI. When age and time since onset were controlled, aphasic CHI and CVA patients are more similar than different in linguistic task performance and overall functional communication effectiveness. The results suggest that the therapeutic approaches traditionally implemented with CVA aphasic patients are appropriate for the management of CHI aphasic patients as well.

Adolescent↗
PubMed1981

Sign and symbol in children's processing of familiar auditory stimuli.

The perceptual-linguistic stimulus distinction for auditory stimuli was examined. In Study 1, stimulus recognition was tested, and serial recall was tested in Study 2. Stimuli were sounds (perceptual condition) and the corresponding words (linguistic condition) for 49 familiar events, in within-subjects designs. Subjects were 3- through 5-year-old nonretarded children and moderately and severely mentally retarded public-school students. Results revealed a strong main effect of developmental age for both stimulus conditions and IQ. Retarded and nonretarded students performed similarly on auditory-perceptual stimuli. Nonretarded students performed significantly better than did retarded students on auditory-linguistic stimuli. The assumption of a developmental relationship in which younger children would perform better on perceptual and older children on linguistic stimuli was not confirmed. Limitations of the recall-test procedure were discussed. A hypothesis for the relationship of auditory-perceptual stimulus recognition to language learning of retarded people was presented. The importance of studying retarded persons' cognitive processes in mediation systems other than the verbal was emphasized.

Adolescent↗
PubMed1982

[Crossed aphasia in right-handed patients. II. Neuropsychological and neurolinguistic study of a case. Evolution over a 2 year period].

We present an unusual case of crossed aphasia in a doctor who is totally right handed, following an infarction which almost completely destroyed his right hemisphere. The observations--linguistic and extra linguistic--during a study over two years are presented. The aphasia evolved in three stages, taking semiological and evolutive aspects not commonly met with. In speech and writing there were: 1. an oral agrammatism and a written dyssyntaxia in the initial stage; 2. the evolution of a non-fluent speech typically agrammatic leading to a jargonaphasia; 3. a dissociation between oral and written language, characterised by phonemic paraphasias in speech and dyssyntaxia in writing. Comprehension was good except for a verbal class called "empty signs" of language, in which the lexic which refers to the notion of space and time has a primary role. On an extra linguistic level some of the usual signs of right hemisphere lesions were present indicating disturbances of a spatial type. The patient could no longer grasp the concept of numerical value and showed severe difficulties in relation to time. On a linguistic level, the discussion is first considered from a typological point of view; this allows to compare our patient's disorders with a Broca's then with a conduction aphasia, Secondly, the discussion is considered from a semiological point of view, taking into consideration the 10 selected cases in the literature and adding our own; a semiological formula of crossed aphasia is given: agrammatism and/or dyssyntaxia + phonemic paraphasia and/or dysorthographia. A suggestion concerning the role of each hemisphere in the language of our patient is proposed: the possible role played by a congenital deafness in the right ear (discovered in the patient at the age of 8) to explain this abnormal hemispherical functional specialisation is discussed. Original comprehension difficulties concerning the time-space lexic are replaced by a perspective of a cognitive type. We conclude that in our patient, there was a "breakdown" of time and space which comes close to the "indifferenciation" of spatial order and time which Piaget has described in children.

Aphasia↗
PubMed1994

Mountains and genes: population history of the Pyrenees.

The Pyrenees Mountains rise between France and Spain. At their western end live the Basques, one of the oldest populations in Europe. All the available genetic information (gene frequencies of blood groups, serum proteins, red cell enzymes, and HLA antigens) on Pyrenean populations has been gathered and subjected to two kinds of analysis: a discrete approach, in which eight separate populations have been defined according to linguistic and geographic criteria to compute genetic distances between them; and a continuous principal components analysis on gene frequencies interpolated to a regular grid. In the first approach the Pyrenean samples have also been compared to other Western European populations. Our results show that the Basque population is most genetically differentiated with respect to other Pyrenean and Western European populations. There is a strong genetic gradient along the mountain range (i.e., in an east-west direction); thus the mountains have not acted as barriers to gene flow. A Catalan-speaking sample, the Cerdanya, is slightly detached from its neighbors and seems closer to other European populations. This genetic picture together with linguistic, paleoanthropological, and archeological data points to a Mesolithic (or older) differentiation of the Cantabrian ancestors of the Basques. Moreover, the Basque genetic features are found in the northern slope of the Pyrenees far beyond the present Basque linguistic boundaries, in accordance with the most recent hypotheses on Pyrenean historical linguistics. The genetic consequences of the arrival of the first Indo-European-speaking peoples in the Iberian Peninsula are also studied; no clear genetic trace has been left of that population movement, except perhaps for the Cerdanya, an eastern valley that affords a passage between north and south.

Algorithms↗
PubMed1995

[Are we really talking about psychic symptoms?].

To conceive psychic symptoms as a linguistic sign stemmed from binding a form (the significant) with a meaning (the signified) assumes that rules binding signs of mental illnesses are identical to rules binding linguistic signs, but above all, that those rules are extant. The author exposes that they are not, no rules permitting to associate a linguistic form to a meaning are extant. Consequently the interpretation of psychic symptoms based on the equivalence with linguistic scheme is built on a twisted argument.

Humans↗
PubMed1976

The sociology of language in Johann David Michaelis's dissertation of 1760.

In 1759 Johann David Michaelis won a prize from the Prussian Royal Academy for his essay Beantwortung der Frage von dem Einfluss der Meinungen in die Sprache, und der sprache in die Meinungen. The essay was published in the following year and translated into French in 1762, into English in 1769, and into Dutch in 1771. The work has two major themes--linguistic relativity and language change--with ancillary discussions of language in general and of homonymy. Its most significant contribution to the theory of language is its discussion of linguistic relativity, especially in its manifestations in the influence of language on thought. Given the intellectual milieu of the work where inquiry was centered on the origin of language and language universals, it stands as one of the few discussions of this topic and it is also one of the most fruitful discussions of linguistic relativity for any period of history.

Germany↗
PubMed1975

Taxonomic congruence in Eskimoid populations.

The study compares distance relationships in Eskimoid populations based on metric and attribute data with linguistic relationships based on structural and lexicostatistical data. Taxonomic congruence and the non-specificity hypothesis are investigated by matrix correlations and by a clustering procedure. The matrix correlation approaches employed are the Pearson product-moment correlation coefficient and the Spearman rank-order correlation coefficient. An unweighted pair-group clustering procedure provides a visual comparison of biological and linguistic relationships. Data consist of 74 craniometric measurements and 28 cranial observations taken on 12 Eskimoid populations. Mahalanobis' D2 and Balakrishnan and Sanghvi's B2 were used to compute the metric and attribute distances, respectively. The results indicate that a strict adherence to the non-specificity hypothesis is untenable. Also, there is better concordance between the sexes for metric distances than for attribute distances, and the metric data are more concordant with linguistic relationships than are the attribute data.

Cephalometry↗
PubMed1994

Altitude, language, and class I HLA allele frequencies in Papua New Guinea.

Class I HLA gene frequencies show considerable variation over short geographical distances in Papua New Guinea. Hypothesis to account for this invoke natural selection, population structure, the pattern of population movement, or past demographic changes. To determine the role of the various factors in shaping this distribution, we have studied correlations between HLA-based genetic distances, geographical distances, altitude, and linguistic differences in Papua New Guinea. Linguistic differences at the family or stock level within the Trans-New Guinea Phylum generally correspond to genetic differences. However, on the basis of their HLA gene frequencies, speakers of Austronesian (AN) languages do not form a distinct group of populations. Linguistic variation and spatial autocorrelation do not fully account for the altitudinal cline differences noted in gene frequencies, particularly at the HLA-A locus. We propose that the distribution of HLA gene frequencies in Papua New Guinea is partially under the control of selection operating differentially along the altitude gradient.

Alleles↗
PubMed1994

[Reflexions on the usage of information theory in biology].

For living beings, information is as fundamental as matter or energy. In this paper we show: a) inadequacies of quantitative theories of information, b) how a qualitative analysis leads to a classification of information systems and to a modelling of intercellular communication. From a quantitative point of view, the application in biology of information theories borrowed from communication techniques proved to be disappointing. These theories ignore deliberately the significance of messages, and do not give any definition of information. They refer to quantities, based upon arbitrarily defined probabilistic events. Probability is subjective. The receiver of the message needs to have 'meta-knowledge' of the events. The quantity of information depends on language, coding, and arbitrary definition of disorder. The suggested objectivity is fallacious. In common language, the word 'information' is synonymous with knowledge of order. Following common sense a message (letters, coded signals, etc.) is information just in case it is interpretable, i.e. if it fits to a previously acquired meaning (the words of an available language, etc.). The consequence is that calculation of quantities in the sense of Shannon can be used for transmissions, but it is itself meaningless (has no significance). In linguistics and semantics, information is composed of a 'signifier', a physical medium (letters, coded signals, etc.), and a 'signified' or significance. The nature of information is complex. The laws of linguistics and semantics are valid not only at the human, organismic level, but also at the cellular and molecular level. The physiology of sensations gives us many examples for application of a concept of information An electromagnetic wave of 0.7% give us the sensation of a red colour. Sensations have no physical reality. They are purely subjective. At the cellular level communication operates by means of chemical messengers (first messengers), which generally do not penetrate the plasmic membrane. Specific captors operate as transductors: external factors are converted into secondary messengers (cyclic AMP, Ca ion, etc.). Sometimes, electric signals (like depolarization waves) may also play a part in the intercellular communication. Such processes are characterized by changes in a sequence of different molecules carried by a physical signal. What is transmitted is the meaning of the message (significance) which can be memorized by the cell, providing a possible following use. At the molecular level one can find also the processes of linguistic nature. We know that the significance of a word is changed with changing the order of letters (ADD-->DAD, etc.).(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed2005

Neural organization for recognition of grammatical and emotional facial expressions in deaf ASL signers and hearing nonsigners.

Recognition of emotional facial expressions is universal for all humans, but signed language users must also recognize certain non-affective facial expressions as linguistic markers. fMRI was used to investigate the neural systems underlying recognition of these functionally distinct expressions, comparing deaf ASL signers and hearing nonsigners. Within the superior temporal sulcus (STS), activation for emotional expressions was right lateralized for the hearing group and bilateral for the deaf group. In contrast, activation within STS for linguistic facial expressions was left lateralized only for signers and only when linguistic facial expressions co-occurred with verbs. Within the fusiform gyrus (FG), activation was left lateralized for ASL signers for both expression types, whereas activation was bilateral for both expression types for nonsigners. We propose that left lateralization in FG may be due to continuous analysis of local facial features during on-line sign language processing. The results indicate that function in part drives the lateralization of neural systems that process human facial expressions.

Adult↗
PubMed2004

HLA-DP polymorphism in Venezuelan Amerindians.

Three different Venezuelan Amerindian tribes were studied for human leukocyte antigen (HLA)-DPA1 and DPB1 allelic variability using polymerase chain reaction-sequence-specific oligonucleotide probes (PCR-SSOP) and sequence-based typing in a selected group of samples. These tribes are geographically (two from the Perija Mountain range and one from the Orinoco Delta) and linguistically distinct: the Bari (from Campo Rosario and Saymaidoyi villages) and the Warao have been classified within the Chibcha linguistic family, whereas the Yucpa (from the Aroy, Marewa, and Peraya villages) are Carib speaking. Venezuelan Indians, like other Native American tribes, show a markedly reduced number of different HLA-DP alleles (range, 2-7) and haplotypes (range, 4-11) in comparison with neighboring Venezuelan mestizo and other non-Indian populations. Some HLA-DPB1 (*0402 and *1401) alleles characteristic for all Amerindian tribes are present also in these populations. Despite general similarities, each tribe and, in some cases, some subtribes show their own pattern of allele and haplotype distribution apparently more as a result of linguistic than to geographic variation.

Alleles↗
PubMed2005

Towards new information resources for public health--from WordNet to MedicalWordNet.

In the last two decades, WordNet has evolved as the most comprehensive computational lexicon of general English. In this article, we discuss its potential for supporting the creation of an entirely new kind of information resource for public health, viz. MedicalWordNet. This resource is not to be conceived merely as a lexical extension of the original WordNet to medical terminology; indeed, there is already a considerable degree of overlap between WordNet and the vocabulary of medicine. Instead, we propose a new type of repository, consisting of three large collections of (1) medically relevant word forms, structured along the lines of the existing Princeton WordNet; (2) medically validated propositions, referred to here as medical facts, which will constitute what we shall call MedicalFactNet; and (3) propositions reflecting laypersons' medical beliefs, which will constitute what we shall call the MedicalBeliefNet. We introduce a methodology for setting up the MedicalWordNet. We then turn to the discussion of research challenges that have to be met to build this new type of information resource. We build a database of sentences relevant to the medical domain. The sentences are generated from WordNet via its relations as well as from medical statements broken down into elementary propositions. Two subcorpora of sentences are distinguished, MedicalBeliefNet and MedicalFactNet. The former is rated for assent by laypersons; the latter for correctness by medical experts. The sentence corpora will be valuable for a variety of applications in information retrieval as well as in research in linguistics and psychology with respect to the study of expert and non-expert beliefs and their linguistic expressions. Our work has to meet several considerable challenges. These include accounting for the distinction between medical experts and laypersons, the social issues of expert-layperson communication in different media, the linguistic aspects of encoding medical knowledge, and the reliability, volume, and emergence of medical knowledge. The work described here has been tested in a small pilot experiment and awaits large-scale implementation.

Computational Biology↗