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At least 1,711 records · Page 95Linked to original sources
PubMed1990

Verapamil inhibits proliferation but not steroidogenesis of regenerating rat adrenal cortex.

The effect of verapamil, a calcium channel antagonist, on proliferation and steroidogenesis was investigated in regenerating rat adrenal cortex. Verapamil was given subcutaneously in two doses (1 and 5 mg/kg) to male Wistar rats subjected to adrenal enucleation combined with contralateral adrenalectomy. It was found that verapamil inhibited the mitotic activity of adrenocortical cells on the 4th and 8th day after surgery in a dose-dependent manner. However, no changes in corticosterone secretion were observed.

Adrenal Cortex↗
PubMed1987

Stereologic studies on the adrenal cortex of 4-APP (4-amino-pyrazolopyrimidine)-induced lipoprotein-deficient rats.

The effect of 4-APP (4-aminopyrazolopyrimidine), the compound reducing hepatic release of lipoproteins, on the rat adrenal cortex was studied by means of stereological methods. Within 3 days 4-APP resulted in a marked increase in the absolute and relative adrenal weights and markedly lowered plasma and adrenal total cholesterol concentration. 4-APP did not change the relative volume of individual adrenocortical zones, however significantly increased the volume in mm3 of the zona fasciculata (ZF) and reticularis (ZR) and of the entire cortex. The average volume of the ZF and ZR cells of 4-APP treated rats was markedly higher than in control rats while no difference was found in the zona glomerulosa (ZG) cell. In lipoprotein-deficient rats the number of adrenocortical cells within the entire cortex was similar to that observed in control rats. A marked increase in the number of mitoses in both, adrenocortical and endothelial cells suggests inhibitory action of 4-APP on the proliferative activity of these cells. The present study shows that 4-APP-induced changes in the rat adrenal cortex mainly depends upon the stimulatory action of that compound on ACTH secretion, however this adenine analogue also exerts a direct action on the adrenocortical cells.

Adenine↗
PubMed1984

Regional distribution of free and sulfoconjugated catecholamines in the bovine adrenal cortex and medulla.

The intraadrenal distribution of free and sulfoconjugated catecholamines and the activity of the catecholamine sulfoconjugating enzyme phenolsulfotransferase in the bovine adrenal gland are described. In the adrenal cortex all three free catecholamines, epinephrine, norepinephrine, and dopamine, were detected in various concentrations. In the adrenal medulla, the relative proportion of the main adrenal catecholamines, free epinephrine and free norepinephrine, was found to be higher in the medullary sections derived from the subcortical areas where the ratio of epinephrine to norepinephrine was 8:1 than in the centre of the organ where norepinephrine levels reached those of epinephrine. Free dopamine, representing about 1.0% of the total catecholamine content was distributed in the same pattern as epinephrine or the sum of epinephrine and norepinephrine, revealing a significant positive correlation between regional dopamine and epinephrine plus norepinephrine (r = 0.97) as well as between dopamine and epinephrine (r = 0.96). Phenolsulfotransferase activity was present in both medulla and cortex. Dopamine sulfate was detected in relatively small concentration in all cortical and medullary layers, but norepinephrine sulfate and epinephrine sulfate were not present. The meaning of this distribution of individual catecholamines and phenolsulfotransferase activity in both cortex and medulla is discussed.

Adrenal Cortex↗