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Head movement properties during voluntary rapid jaw movement in humans.

The purpose of this study was to determine whether the start of the synchronized head movement during mandibular movement is evoked by the peripheral reflexes following mandibular movement (i.e. stretch or trigemino-neck reflexes), or, alternatively, is started by pre-programmed central command. Head movement accompanying voluntary rapid jaw opening movement was studied using accelerometers fixed to the upper and lower incisors, as well as electromyographs (EMGs) of the neck muscles. The direction of head acceleration at the upper incisor was towards head extension at the beginning of jaw opening movement in 89.2% of all trials, opposite to the direction of lower jaw acceleration. The onset of head acceleration was later than that of the lower jaw acceleration by averages of 6.2-10.7 ms, and the onset of electromyographic activities of the sternocleidomastoid (SCM) muscle preceded that of head acceleration by an average of 12.5-24.3 ms. These findings suggest that head movement during mandibular movement is not started by peripheral reflexes but by pre-programmed central commands. This may be relevant to muscular discomfort in the neck and shoulder regions of patients with stomatognathic disorders.

Acceleration↗

Who are the donors in organ donation? The family's perspective in mandated choice.

Evidence that families requested to permit organ donation refuse half the time has led to proposals for mandated choice. Under mandated choice, a person's donation wishes would be collected and retrieved at death, and requests to families would be avoided. There are both ethical and logistic problems with mandated choice. The view of the family should be respected in organ requests, even when patient wishes are known. Public sentiment against overriding family wishes could cause low rates of pro-donation registration. Caregivers have usually refused to take organs when families oppose donation. Logistic issues with mandated choice include the cost and complexity of maintaining a national database on donors and the enforcement of registration. No such database of adults currently exists, even for tax purposes. Two states that have mandated choice programs through departments of motor vehicles report relatively low number of pro-donation registrants compared with nondonors or undecided persons. Public education and voluntary donor identification hold more potential to increase donation.

Adult↗

Should smallpox vaccine be made available to the general public?

In June 2002, the Advisory Committee on Immunization Practices (ACIP) approved draft recommendations concerning preparation for potential biological terror attacks that utilize the smallpox virus. ACIP recommends against both mandatory and voluntary vaccination of the general public. The present paper examines the moral and political considerations both for and against each of the general public vaccination options considered by the ACIP in the context of the state's authority over vaccination for the purposes of protecting public health. Although it is clear that compulsory mass vaccination is not justified at this time, the issues surrounding voluntary vaccination are more complex. Should smallpox vaccination prior to an outbreak be made available to the general public? The paper concludes that the vaccine should not be made available at this time. This conclusion, however, is based upon contingent features of current circumstances, which would change once an outbreak occurred. In the even of a terror-related outbreak of smallpox, the general public's access to voluntary vaccination would become justified, even in areas beyond where the outbreak has occurred.

Advisory Committees↗

Operation Desert Shield and Storm: impact on undergraduate and graduate internal medicine education.

We evaluated the impact of mobilization during Operation Desert Shield and Storm on undergraduate and graduate internal medicine education. Surveys were sent to the 425 residency program directors and 128 chairs of departments of medicine of U.S. medical schools in February 1991. Among graduate programs (46% response), 1.6% of full-time faculty, 0.2% of voluntary faculty, and 0.1% of residents were mobilized. No full-time faculty, voluntary faculty, and residents were mobilized at 77%, 90%, and 93% of programs, respectively. Negative impact ranged from none (68%) to significant (2%). For undergraduate education (51% response), 1.2% of full-time faculty, 0.1% of voluntary faculty, and 0.3% of residents were activated. Sixty-three percent reported no full-time faculty, 97% no voluntary faculty, and 86% no residents activated. Negative impact ranged from none (53%) to significant (4%). The effect of mobilization was small, and program directors and chairs should feel comfortable supporting participation in reserve activities.

Education, Medical, Undergraduate↗

Description of a computerized adverse drug event monitor using a hospital information system.

To improve the detection and characterization of adverse drug events (ADEs) in hospitalized patients, a computerized adverse drug event monitor was developed. Computer programs were written to allow for voluntary as well as automated detection of adverse drug events using the HELP hospital information system, a large integrated hospital database containing computerized patient medical records and a knowledge base allowing for automated medical decisions. Programs were created to allow simple computer entry of potential adverse drug events by physicians, pharmacists, and nurses. Automated detection of potential adverse drug events relied on signals such as sudden medication stop orders, "antidote" orders, and selected abnormal laboratory values. Each day a list of all potential adverse drug events from these sources was generated and a pharmacist reviewed the medical records and interviewed healthcare personnel associated with patients identified as having potential adverse drug events. This process allowed for characterization of the event, causality assessment, and follow-up of the resulting clinical course by the pharmacist. The permanent storage of these results in the computerized patient medical record permits their future retrieval to prevent adverse drug events during subsequent hospital care. The authors conclude that fully integrated hospital systems will permit the further development and evaluation of computer-assisted methods for the detection of adverse drug events in hospitalized patients.

Adverse Drug Reaction Reporting Systems↗

Euthanasia policy in The Netherlands: the role of consultation-liaison psychiatrists.

The authors describe national guidelines introduced in the Netherlands in late 1990 for carrying out euthanasia requests by medically ill patients. In about 49,000 of the 130,000 annual deaths in that country, doctors make a decision that may influence the duration of life. In 2,300 cases doctors perform euthanasia. Thus euthanasia accounts for 1.8 percent of all deaths and 5 percent of the cases in which doctors' decisions play a role. The authors point out cultural differences between the U.S. and the Netherlands, such as in access to health care and in social tolerance and pragmatism, that should be considered by American policymakers who address the issue of euthanasia. The role of Dutch consultation-liaison psychiatrists in euthanasia was assessed by a survey of members of the Netherlands Consortium of Consultation/Liaison Psychiatry. Most felt that involvement of psychiatrists in such cases should not be mandatory and that their most important role was to assess patients' decision-making capacity. Half of the psychiatrists felt that their role was to support the decision-making process of the ward staff.

Aged↗

Access to office-based physicians under capitation reimbursement and Medicaid case management. Findings from the Children's Medicaid Program.

This study reports the effects of a voluntary Medicaid case-management demonstration on the primary care provided to young children by office-based physicians. The MDs who participated were reimbursed at rates higher than the regular Medicaid fee schedule, either through augmented fees for specific services or through monthly capitation payments. Using the Medicaid Management Information System (MMIS) claims data, we compared the rates at which children in the experimental program and children in the regular Medicaid program were seen by a physician during a one-year period. The majority of experimental children received regular and frequent care from primary care physicians during the demonstration. After controlling for race and prior utilization differences, we found that augmented fee-for-service children received more primary care from office-based physicians than children in the regular Medicaid program. Capitation children received at least the same amount of primary care as children in the regular Medicaid program. We interpret our data to mean that capitation payment, untied to the delivery of services, does not necessarily reduce access to primary care and that higher fees for physicians who treat children may, in fact, increase access.

Capitation Fee↗

AIDS, a social dilemma: detection of seropositives.

At present, we can observe an evolution in ideas about the detection of HIV seropositivity through a qualitative analysis of specialised literature on the ethical aspects of AIDS. In the case of this disease, systematic screening of the population does not correspond to epidemiological criteria: it is wasteful, troublesome and costly. Whether it is voluntary, and therefore biased, or compulsory, and therefore controversial, systematic screening seems an unlikely option. This situation has prompted many versions of target-group screening, which correspond to two options: systematic screening of known risk-groups, discriminatory, confidential and anonymous; target-group screening linked to particular circumstances: recognised as necessary by blood-donors and well-accepted by pregnant mothers. This method can be institutionalised and applied in the armed forces and in prisons,.... Lastly, we consider measures taken by different countries and organisations.

Acquired Immunodeficiency Syndrome↗

Women's Heart Advantage Program: the impact 3 years later.

Yale-New Haven Hospital, in partnership with Voluntary Hospital Association (VHA Inc), launched the Women's Heart Advantage program in March 2001. Major program components implemented include (1) a comprehensive initial and ongoing internal communication program; (2) a health promotion initiative including a 24-hour, 7-days-a-week women's heart line staffed by nurses and an Internet health question-and-answer forum; (3) significant ongoing communication with nurses and physicians; (4) a community outreach effort to educate poor and minority women; and (5) an aggressive effort to secure financial partners to underwrite the cost of the program. Before launching the program, a telephone survey of 300 randomly selected New Haven County women ages 40 to 70 years was initiated in January 2001 and repeated in January 2002, 2003, and 2004. Findings include (1) the percentage of women who recognize heart disease as the number-one killer of women their age increased from 26% in 2001 to 59% in 2004, (2) the percentage of women who would call 9-1-1 or go directly to a hospital emergency department increased from 63% in 2002 to 83% in 2004, and (3) the percentage of women aware of recent Women's Heart Advantage program promotion grew from 33% in 2002 to 50% in 2004. Perhaps most importantly, the number of women with heart problems admitted through the hospital's emergency department increased from 1528 per year in 2001 to 1870 per year in 2004 (7.5% annual increase), whereas the number of men with heart problems admitted through the emergency department during the same time period has been relatively low (0.8% annual increase). By linking clinical, public health, and marketing expertise along with finding ways to partner with other organizations, the Women's Heart Advantage program has contributed to remarkable changes in women's awareness, knowledge, and behaviors, suggesting a model for approaching similar health-related problems.

Adult↗

HIV infection and AIDS in the public health and health care systems: the role of law and litigation.

The AIDS Litigation Project has reviewed nearly 600 reported cases involving individuals with human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) in the federal and state courts in the United States between 1991 and 1997. Cases were identified through a federal and 50-state computer and library search. An important subset of litigation relates to HIV/AIDS in the public health and health care systems, since the law affects health care institutions and professionals, patients, and public health policy in America. This subset of HIV/AIDS litigation includes testing and reporting; privacy, the duty to warn, and the right to know; physician standards of care in prevention and treatment; and discrimination and access to health care. In broad terms, the review demonstrates a reliance on voluntary testing and protection of patient privacy through HIV-specific statutes and the common law. Negligence with potential civil and criminal liability has been alleged in cases of erroneous or missed diagnosis of HIV infection. In the first AIDS case to be considered by the Supreme Court, the Court will decide whether patients with asymptomatic HIV infection are protected under the Americans With Disabilities Act. Considerable progress has been made, both socially and legally, during the first 2 decades of the epidemic, but much still needs to be accomplished to protect privacy, prevent discrimination, and promote tolerance.

AIDS Serodiagnosis↗

Different cortical areas in man in organization of voluntary movements in extrapersonal space.

1. This paper reports regional cerebral blood flow (rCBF) measurements in 254 cortical regions with 133Xe injected into the internal carotid artery in 19 patients, none of whom had any major neurological defect. The purpose was to demonstrate the pattern of cortical activity, as revealed by rCBF increases, during two types of unilateral voluntary movement in extrapersonal space: a) the maze test, series of fast isolated movements in various directions in a frame, executed under verbal command; and b) the drawing of a spiral in the air. 2. Both types of movements were associated with increases of rCBF in the supplementary motor area (bilaterally), the convexity part of the premotor area (bilaterally), the primary sensorimotor hand and arm area (contralaterally), and in the superior and inferior parietal region (bilaterally). 3. During the maze test there were, in addition, bilateral focal increases of the blood flow in the auditory areas, the inferior frontal regions, and the frontal eye fields. 4. It is concluded that the supplementary motor areas, which are also active during programming and execution of movement sequences in intrapersonal space (33), elaborate programs for motor subroutines necessary in skilled voluntary motion. The convexity parts of the premotor areas are activated when a new motor program is established or a previously learned motor program is modulated. The primary motor area is the exclusive executive locus for voluntary movements of the hand and arm. 5. Voluntary movements in extrapersonal space only are associated with activation of the parietal regions. These areas are assumed to provide information to the motor programming neurons about the demanded direction of motion in extrapersonal space in relation to proprioceptive reference systems. 6. The increase of rCBF in the auditory areas, the inferior frontal regions, and the frontal eye fields during the maze test were ascribed to the processing of auditory information. 7. Both tests are accompanied by a diffuse increase of the hemispheric blood flow (approximately 10%), which is assumed to be a parallel to the commonly known desynchronization of the EEG during mental work.

Adolescent↗

HIV prevention and the two faces of partner notification.

In the cases of medical patients with sexually transmitted diseases (particularly those with the human immunodeficiency virus), two distinct approaches exist to notifying sexual and/or needle-sharing partners of possible risk. Each approach has its own history (including unique practical problems of implementation) and provokes its own ethical dilemmas. The first approach--the moral "duty to warn"--arose out of clinical situations in which a physician knew the identity of a person deemed to be at risk. The second approach--that of contact tracing--emerged from sexually transmitted disease control programs in which the clinician typically did not know the identity of those who might have been exposed. Confusion between the two approaches has led many to mistake processes that are fundamentally voluntary as mandatory and those that respect confidentiality as invasive of privacy. In the context of the AIDS epidemic and the vicissitudes of the two approaches, we describe the complex problems of partner notification and underscore the ethical and political contexts within which policy decisions have been made.

Confidentiality↗

Some influences on public participation in a genetic screening program.

To identify the psychosocial factors associated with voluntary cooperation in mass genetic testing, stratified random samples of 500 participants and 500 nonparticipants were drawn from an identified at-risk population for Tay-Sachs disease. Participants were relatively younger and better educated, reported higher levels of perceived susceptibility to being a carrier, and also stated more often that the impact of learning of being a carrier would be low. Participants were also more likely to indicate they would not alter plans for future progeny. Recommendations are made for enhancing participation in future genetic screening programs of this type.

Adolescent↗

Medial vs lateral frontal lobe lesions and differential impairment of central-gaze fixation maintenance in man.

The ability to maintain central-gaze fixation was studied in 35 patients with unilateral frontal lobe lesions. The stability of central-gaze fixation was tested in 2 oculomotor tasks requiring the suppression of reflexive saccades triggered by the sudden appearance of novel, peripheral visual stimuli. In the first task ('Instructed'), maintenance of gaze fixation was based on verbal instruction, whereas, in the second task ('Non-instructed'), it was based upon a foveating mechanism maintained by sensory stimulation during the performance of a categorization task. Patients with frontal lobe lesions were classified into 3 groups: a ventrolateral (n = 18), a dorsolateral (n = 10) and a medial (n = 7) group. The control group consisted of 20 healthy subjects. In the Non-instructed task, no group differences were found in the rate of reflexive saccades. Thus, lesions of the frontal lobe did not affect reactivity to extraneous stimuli per se. The only exception to this rule was the group of patients with ventrolateral lesions in the left frontal lobe, in which a higher number of reflexive saccades directed to the contralateral hemifield was observed. In the Instructed task, 2 different patterns of deficit in suppression of reflexive saccades were found. First, a bidirectional deficit was noted in the ventrolateral group, which might be attributed to an impairment in either maintaining a selected program of behaviour 'on-line' or suppressing inappropriate alternatives interfering with that program. Second, a unidirectional deficit in voluntary suppression of reflexive saccades triggered from within the contralateral hemifield was observed in the medial group. It is suggested that this type of deficit may reflect malfunctioning of the supplementary motor area--anterior cingulate system involved in the suppression of externally triggered interfering programs. Finally, no significant impairment was found in the dorsolateral group.

Adult↗