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[The recognition of the facial expression of emotions by patients with endogenous depression (clinico-psychophysiological research)].

The recognition of facial emotional expression in depressed patients with major depressive disorder (MDD) and slow progressive schizophrenia (SPS) in acute state and in remission was studied in comparison with healthy persons. All the subjects were right-handed. The drawings of sad, neutral and happy faces followed by masking stimulus were displayed in the center field and in the left or right hemifield of vision on the computer screen for 80 ms. All the depressed patients revealed marked impairment of facial emotion recognition, especially for negative on, and disturbances of hemisphere asymmetry. There were some differences between MDD and SPS patients. The MDD patients showed more significant impairment of emotion recognition and right hemisphere disfunction. The SPS patients were less impaired and revealed mild worsening in the left hemisphere only. In remission MDD patients showed a significant improvement of emotion recognition contrary to SPS patients who failed to recover this function. The revealed emotion recognition disturbances in MDD patients are supposed to be dynamic, whereas in depressed patients with SPS it is considered to be a trait feature.

Adult↗

Cost-effective screening of schoolchildren for refractive errors.

Uncorrected refractive errors are the main cause of severely impaired vision in India. This in itself indicates that there is a shortage of basic eye care services and spectacles, and too little public awareness of the need for them. A simple method for screening schoolchildren for refractive errors is described and the results are analysed. Evaluation of the materials used and the accuracy of the screening shows that this method can be used successfully by teachers.

Adolescent↗

Comparison of computer-photoscreening with non-cycloplegic retinoscopy for amblyopiogenic risk factors in children.

OBJECTIVE: To determine the sensitivity and specificity of using a computer-photoscreener and non-cycloplegic retinoscopy in the detection of amblyopiogenic factors in nine to fifty months old infants and children. METHODS: Three hundred children, nine to fifty months old, were screened with the computer-photoscreener and non-cycloplegic retinoscopy. With a blinded standardized clinical assessment as the standard, an overall comparison of the sensitivity of and specificity results obtained with the two techniques was made. Photoscreen images on the computer monitor screen were reviewed and analyzed immediately by two independent observers for indicators of amblyopiogenic risk factors. Simultaneously, the results were compared to the findings of a full ophthalmologic examination. RESULTS: The computer-photoscreener revealed a sensitivity of 94.6% and specificity of 90.1%, and the non-cycloplegic retinocopy revealed a sensitivity of 85.7% and specificity of 81.0% for the detection of amblyopiogenic risk factors, including hyperopia (+2.75 D or more), myopia (-1.50 D or more), astigmatism (1.75 D or more), anisometropia (2.00 D or more), ocular misalignment (5 degrees or more), and media opacity (1.5 mm or more). CONCLUSIONS: The computer-photoscreener offers an opportunity to identify problems that limit vision, and could provide a feasible and sufficiently reliable screening technique in infants and preschool children to be screened successfully for amblyopiogenic risk factors.

Amblyopia↗

Telemedicine screening of glaucoma.

OBJECTIVES: Glaucoma is a major cause of blindness. More than 80,000 Americans suffer permanent vision loss from the disease. Widespread screening is fundamental in limiting the incidence of glaucoma-associated blindness. This pilot study explored the use of stereo digital images taken at a primary care center for telemedicine review by an off-site specialist as a means of screening for glaucoma. MATERIALS AND METHODS: Thirty-two diabetic patients were screened at a family medicine clinic. None had previously been diagnosed with glaucoma. A senior optometry student took stereoscopic digital and 35-mm optic disc photographs with a nonmydriatic retinal camera. The digital images were forwarded to a remote ophthalmologist for review. The conventional color stereo slide pairs of the same eyes were subsequently reviewed for comparison. Agreement on signs of glaucomatous disc changes between the two imaging systems was analyzed. RESULTS: Twenty-six of 32 eyes' digital and 35-mm photographs were analyzed. Six of 32 eyes (18.8%) could not be compared due to lack of matching 35-mm slides or digital images. Out of 26 eyes, lamina cribosa visibility was undeterminable in 8 eyes' digital images and 3 other eyes' 35-mm slides. Agreement among digital images and 35-mm slides of the remaining eyes was: 100%-vertical elongation, barring of vessels, bayoneting of vessels, and drance hemorrhage; 96.2%-focus notching of rim and rim pallor; 93.3%-lamina cribosa visability; 92. 3%-overpass cupping; 88.5%-focal enlargement; 84.6%-parapapillary halo; 80%-nerve fiber visibility; 65.4%-parapapillary atrophy. Parapapillary halo (p = 0.046) and nerve fiber layer visibility (p = 0.18) were detected on some 35-mm slides but not seen on matching digital views. CONCLUSION: Evaluations of cup-to-disc ratio (C/D) using both methods were in general agreement. However, some digital images were noted as too dark for assessing fine glaucomatous disc changes. Stereo digital images taken with a nonmydriatic camera by nonophthalmic photographers is a promising alternative for glaucoma screening in primary care settings. Telemedicine offers efficient communications with off-site glaucoma specialists. A larger study population is necessary to determine the overall effectiveness of using stereo digital imagery and teleophthalmology for glaucoma screening.

Adult↗

[Work with visual demands. Assumption of responsibility for optical correction by the employer].

Comparison of visual demands of work in a traditional office to those of work in an office equiped with a screen. Description of problems of vision when focusing the eye to various distances and fixing it in various directions. Range of possibilities for optical correction for work with a screen (monofocal, bifocal, progressive or for reading), specifying among the optical corrections those which are exclusively reserved for this activity and should become the employer's responsibility.

Aging↗

Sensitivity, specificity, and predictive values of screening tests for eye conditions in a clinic-based population.

PURPOSE: To assess four commonly available visual function tests to detect visually disabling or vision-threatening eye conditions among new patients of a large, urban, public, general ophthalmology clinic. METHODS: Three hundred seventeen patients were tested for contrast sensitivity, Amsler grid abnormalities, and visual acuity at near and at distance. A complete eye evaluation found the prevalence of serious eye diseases, allowing determination of the sensitivity (Sn), specificity (Sp), likelihood ratio (LR), and other characteristics of each test. RESULTS: Of 317 patients, most were Hispanic (77%), women (60%), and middle-aged (44 +/- 17 years). Normal findings were reported in 18%; refractive error in 43%; cataracts in 16%; glaucoma in 7.3%; and macular degeneration in 4.1%. Near visual acuity of 20/40 or worse (Sn = 0.75; Sp = 0.74; LR = 2.8); and distance visual acuity testing of 20/30 or worse (Sn = 0.74; Sp = 0.73; LR = 2.7) correlated significantly with ocular disease, whereas contrast sensitivity testing (Sn = 0.62; Sp = 0.41; LR = 1.1) and Amsler grid test (Sn = 0.19; Sp = 0.92; LR = 2.4) did not. Test performance decreased when refractive errors were excluded and among those younger than 40 years of age relative to those 40 years of age or older. CONCLUSION: Of the four screening tests studied, distance and near threshold visual acuities as defined above were judged to have the best correlations of an abnormal result with ocular disease, both including or excluding refractive error. Different combinations of tests did not result in more accurate detection of ocular disease. More efficient screening tools for detecting ocular disease need to be developed.

Adolescent↗

Amblyopia screening in kindergartens with tno stereotest.

One hundred and fifty children between 3 and 6 years old were screened for amblyopia with TNO stereotest in their kindergartens. Thirty screening positive children were found of whom 3 were amblyopic with strabismus and no stereopsis. Re-testing showed that 19 children were false screening positive. Three children with refractive errors and equally impaired vision in both eyes were not detected. The test was found suitable for screening of monocular amblyopia in kindergartens, as it was easy to administrate and indicated all children with monocular amblyopia.

Amblyopia↗

The design of diagnostic tests for defective colour vision.

Pseudoisochromatic plates are among the most popular tests for defective colour vision. They are particularly good for screening but are less good in assessing the degree and type of the colour vision defect. To select colours for use in diagnostic plates a large number of colour defective subjects have made colour matches with the Lovibond Tintometer and the isochromatic data collected. Pseudoisochromatic plates have been printed using pairs of colours only and incorporating both a random dot and a regular dot format. These plates have proved effective in a clinical trial. Not only must pairs of inks be carefully selected to lie upon appropriate isochromatic lines but the luminance contrast between the two colours must be kept within 5%. Failure to control luminance contrast is as much a source of error in currently available pseudoischromatic tests as the inappropriate use of colour.

Color Perception Tests↗

Risk, causes, and outcomes of visual impairment after loss of vision in the non-amblyopic eye: a population-based study.

BACKGROUND: Screening for amblyopia in early childhood is done in many countries to ensure that affected children are detected and treated within the critical period, and achieve a level of vision in their amblyopic eye that would be useful should they lose vision in their non-amblyopic eye later in life. We aimed to investigate the risk, causes, and outcomes of visual impairment attributable to loss of vision in the non-amblyopic eye. METHODS: For 24 months from July, 1997, national surveillance was done to identify all individuals in the UK with unilateral amblyopia (acuity worse than 6/12) who had newly acquired vision loss in the non-amblyopic eye, resulting in acuity of worse than 6/12 or visual-field restriction precluding driving. Information about participants was obtained at presentation and 1 year later. Participants were categorised as having socially significant visual impairment, or visual impairment, severe visual impairment, or blindness, in accordance with WHO taxonomy. FINDINGS: Of 370 eligible individuals, at presentation 104 (28%) had socially significant visual impairment, 180 (49%) visual impairment, and 86 (23%) severe visual impairment or blindness. The minimum risk of permanent visual impairment by age 95 years was 32.9 (95% CI 29.1-36.9) per 100,000 total population. The projected lifetime risk of vision loss for an individual with amblyopia was at least 1.2% (95% CI 1.1-1.4). Only 36 (35%) of 102 people previously in paid employment were able to continue. INTERPRETATION: In the UK, where screening for amblyopia is under review, risk of serious vision loss affecting the non-amblyopic eye and its results are greater than that previously assumed. Thus, in addition to the benefits of improved vision in the amblyopic eye, treatment of amblyopia during childhood is a potentially valuable strategy to prevent incapacitating vision loss later in life.

Adolescent↗

Health screening in older women.

Health screening is an important aspect of health promotion and disease prevention in women over 65 years of age. Screening efforts should address conditions that cause significant morbidity and mortality in this age group. In addition to screening for cardiovascular disease, cerebrovascular disease and cancer, primary care physicians should identify risk factors unique to an aging population. These factors include hearing and vision loss, dysmobility or functional impairment, osteoporosis, cognitive and affective disorders, urinary incontinence and domestic violence. Although screening for many conditions cannot be proved to merit an "A" recommendation (indicating conclusive proof of benefit), special attention to these factors can decrease morbidity and improve quality of life in aging women.

Activities of Daily Living↗

VISION USA--optometry's national charity program.

BACKGROUND: There are an estimated 18 million uninsured working Americans and their families who are unable to afford the cost of eye care. These individuals often fall between the cracks of government and private health care assistance. Members of the American Optometric Association have developed the VISION USA program to provide free eye care to those who might otherwise not receive it. METHODS: Nearly 8,000 doctors of optometry nationwide have volunteered to provide free eye examinations in their offices for VISION USA patients. Patients are screened for eligibility and matched to the nearest available participating doctor using a computerized ZIP code matching system. Examinations are usually provided each year during March in observance of Save Your Vision Week. RESULTS: In the first three years of the program, services have been provided to over 115,000 individuals. For over 21 percent of the patients seen, this was their first eye examination ever. More than 86 percent of the patients had one or more vision problems. More than 70 percent were given new or updated prescriptions. CONCLUSION: The VISION USA program is helping to meet a significant unmet need for eye care which exists within a segment of the American population. The program is an outstanding example of the willingness of doctors of optometry to give back to their communities, and to those in need, some of what they have gained from the practice of their profession.

Adolescent↗

The association between vision quality of life and academics as measured by the College of Optometrists in Vision Development Quality of Life questionnaire.

BACKGROUND: Undetected visual problems are one of the causes of academic difficulties in the classroom. An easily administered screening device that identifies children who are likely to do poorly in school because of vision problems would be a valuable tool. The screening should be able to be performed by a classroom teacher or aide. The objective of this study was to determine if there was an association between vision-related quality-of-life factors (19-item College of Optometrists in Vision Development Quality of Life [COVD-QOL] questionnaire checklist) and academic performance. A secondary objective was to determine whether student and parent responses to the questionnaire would be similar. METHODS: Ninety-one parents or guardians and their children, attending the third, fifth, and seventh grades in a public school participated in this study. Both the parent or guardian and student independently completed the checklist. The scores of both groups were compared with the Stanford IX test scores for total reading, total math, total spelling, and total battery scores of the Stanford IX. The parent or guardian and student scores were compared to evaluate the agreement (intergroup reliability). RESULTS: Parent or guardian and student checklist scores were compared. The Wilcoxon Signed Rank test showed that the mean scores for the parent or guardian were significantly lower than for third grade students and also for the total sample. Visual symptoms were found to be inversely correlated to academic performance; the lower the academic score, the more symptoms were reported. Symptoms reported by third grade students and their parents tended to be more highly correlated with academic scores. In general, symptoms reported by the parent were more highly correlated with academic score than the symptoms reported by the student. CONCLUSION: The COVD-QOL questionnaire is a cost-effective, quick, and easy tool that may be used in school screening to identify possible visual symptoms that are correlated to academic performance.

Child↗

Behavioral genetic approaches to visual system development and function in zebrafish.

The zebrafish is a recent vertebrate model system that shows great potential for a genetic analysis of behavior. Early development is extraordinarily rapid, so that larvae already display a range of behaviors 5 days after fertilization. In particular the visual system develops precociously, supporting a number of visually mediated behaviors in the larva. This provides the opportunity to use these visually mediated behaviors to screen chemically mutagenized strains for defects in vision. Larval optokinetic and optomotor responses have already been successfully employed to screen for mutant strains with defects in the visual system. In the adult zebrafish a visually mediated escape response has proved useful for screening for dominant mutations of the visual system. Here, I summarize visually mediated behaviors of both larval and adult zebrafish and their applicability for genetic screens, and present, the approaches and results of visual behavior carried out to date.

Animals↗