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PubMed1996

Laparoscopic Approach for Severe Pelvic Vault Prolapse

Laparoscopic repair of grade 1 to 4 pelvic vault prolapse was performed in 103 patients. All women filled in quality of life questionnaires, and had standing vault examination, transperineal ultrasound examination, and cough stress test. Laparoscopic Burch, paravaginal repair, central pubovesical repair, culdoplasty, sacral colpopexy, and posterior vaginal repair were performed after the type and extent of the prolapse were determined. The majority of the procedures were done as day surgery. Almost all women were able to void spontaneously. At 6 weeks all patients had repeat questionnaires, vault examination, transperineal ultrasound, and cough stress test. No recurrences of vault prolapse or of genuine stress incontinence (GSI) were found at that time. Eighty-nine women were reexamined at 1 one year with the questionnaires, ultrasound vault examination, cough stress, and urodynamics. Of the 89 with GSI, 83 (93%) were objectively dry. Five (6%) of the 89 had recurrent vault prolapse. The laparoscopic cure rate of GSI is comparable with that of open repairs.

Journal Article↗
PubMed1988

Vaginal neoplasms in infancy: the combined role of chemotherapy and conservative surgical resection.

This retrospective review of nine infants treated for vaginal tumors between 1964 and 1986 identifies the spectrum of lesions and examines the trend toward more conservative surgical therapy. Our patients' ages ranged from 1 to 30 months. Symptoms of vaginal bleeding or protruding tissue prompted examination under general anesthesia in all cases. Two children had benign protruding polypoid masses treated by simple excision. Seven had malignant tumors, two with endodermal sinus lesions and five with embryonal rhabdomyosarcoma. Early in this series, surgical therapy for embryonal rhabdomyosarcoma consisted of either anterior or complete pelvic exenteration, with adjuvant chemotherapy given in two of the three patients. One patient was operated on prior to the development of effective chemotherapy, and died of recurrent tumor 14 months after surgery. A second patient died from cardiac failure secondary to adriamycin toxicity 6 years after initial therapy. A third patient underwent total pelvic exenteration followed by successful reanastomosis of the colon to the anal verge. This patient, a female, is the oldest survivor and is free of disease 14 years after therapy. The most recent therapeutic approach used in two patients with embryonal rhabdomyosarcoma consisted of local tumor excision followed by postoperative chemotherapy. Both patients are alive and disease-free 9 and 11 years after therapy. Two patients with endodermal sinus tumor were treated with chemotherapy after simple excisional biopsy. They were then followed with serial vaginal biopsies at 3-month intervals. One required a partial vaginectomy for local recurrence 21 months after initial presentation. Both patients are alive and disease-free 18 months and 4 years after surgery.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

Screening for cancer of uterine cervix and approaches adopted in India.

Cervical cancer is the leading malignancy among Indian women. It has been estimated that in the absence of any control programme, the incident number of cervical cancer cases in the country would rise to 140 thousand by the turn of this century. Cytology screening remains the main stay for the control of cervix cancer. In the present communication the evidence available for screening for cancer of cervix has been presented. Difficulties in organising cervical cancer screening programmes in India and the alternative approach have been discussed.

Cervix Uteri↗
PubMed1995

A combined abdominoperineal approach for the resection of a large giant cell tumor of the sacrum.

We describe the case of a 24-year-old woman with a giant cell tumor originating from the distal part of the sacrum, which was almost completely filling the pelvis and extending to the umbilicus. At laparotomy, the tumor was separated from all of the pelvic structures including the ureters. The sigmoid colon was transected and the tumor was dissected down to the pelvic floor. A separate perineal incision was made, the rectovaginal septum was entered, and the posterior vaginal wall was bisected to give better access. It was possible to mobilize the tumor completely after dividing the rectum 5 cm from the anus. All macroscopic tumor was removed in continuity with the sigmoid colon. The ovaries were transposed to the paracolic gutter to avoid artificial menopause following radiation therapy. A sigmoid colostomy was formed. Because histology could not provide definite evidence of complete removal of the tumor, radiation therapy to the sacrum was given. Forty-two months after her surgery, the woman remains free of disease. The abdominoperineal approach should be considered for patients with a large tumor which is fixed to the sacrum.

Abdomen↗
PubMed1995

Laparoscopy-assisted vaginal hysterectomy: cost analysis and review of initial experience in a community hospital.

During the past 2 years, an increasing number of gynecologic surgeons have performed laparoscopy-assisted vaginal hysterectomy (LAVH) and laparoscopic hysterectomy (LH). Although these procedures have become more common, they are still considered controversial. Many gynecologists question their cost, safety, efficacy, and indications. We reviewed and analyzed the perioperative and postoperative course of ten patients as well as the total cost. The patients who underwent these procedures were compared with ten matched patients who underwent abdominal hysterectomy for similar indications. Compared with control subjects, patients in the laparoscopic group had a shorter hospitalization stay (2.2 days vs 4.2 days), shorter recovery (2 weeks vs 5 weeks), and 28% fewer complications. Although the LAVH took significantly longer than TAH (3.28 hours vs 1.75 hours), the total hospital costs and charges for both procedures were similar. As technology advances and techniques are modified, the laparoscopic approach should reduce hospital costs and charges significantly. The current results suggest that LAVH may eventually be preferred to the TAH approach by physicians and their patients.

Adult↗
PubMed2005

Ultrasound and urodynamic comparison between caudocranial and craniocaudal tension-free vaginal tape for stress urinary incontinence.

OBJECTIVES: To compare the efficacy and safety of the conventional caudocranial tension-free vaginal tape (TVT) procedure and craniocaudal TVT procedure for the treatment of primary stress urinary incontinence. METHODS: Ninety patients with urodynamic stress incontinence and without prolapse underwent a caudocranial TVT (45 women) or craniocaudal TVT (45 women) procedure. The two patient groups were comparable in terms of age, parity, body weight, previous pelvic surgery, and menopausal status. Both methods were performed under local anesthesia with adequate sedation. Introital ultrasound evaluation on the mid-urethra TVT tapes and urodynamic evaluation was performed before and after surgery. RESULTS: The average follow-up period for caudocranial TVT and craniocaudal TVT was 1.9 years and 1.4 years, respectively. Objective evaluations were performed at similar times at 1 year postoperatively. No significant differences were found in the cure rate at 88.9% (40 of 45 women) after caudocranial TVT and 91.1% (41 of 45 women) after craniocaudal TVT (P = 1.000). The intraoperative complications were minor. No patient had long-term voiding difficulty or required long-term catheterization. Both groups had the vaginal tape implanted at the mid-urethra, with a urethral knee angle observed during maximal straining. A more proximal tape position, less elasticity of the tape, and more obstruction by the sling were found using the craniocaudal approach. Postoperative dysfunctional voiding was minor. CONCLUSIONS: The caudocranial and craniocaudal TVT procedures are highly effective, minimally invasive, and safe procedures in the treatment of urinary stress incontinence. The variations in implanted tape position and postoperative sling obstruction were most likely caused by the mode of insertion.

Female↗
PubMed2000

Establishing a new technique of laparoscopic pelvic and para-aortic lymphadenectomy.

OBJECTIVE: To assess the number of operations necessary to develop and standardize a laparoscopic approach to pelvic and para-aortic lymphadenectomy, with radicality and number of complications as quality markers. METHODS: Over 4 years, 108 women had complete laparoscopic pelvic and para-aortic lymphadenectomies combined with laparoscopy-assisted radical vaginal hysterectomies for primary therapy of cervical cancer. Complete data and videotapes were available for 99 women. Operating time and radicality for specific anatomic subareas were measured by review of video documentation and histologic lymph node counts. Intra- and postoperative complications were recorded prospectively. To analyze the progress of surgery, we compared two groups of women, one operated on at the beginning of our study (early group, subjects 6-35) and one operated on in the final period of the study (late group, subjects 79-108). RESULTS: The operating time for pelvic and para-aortic lymphadenectomy increased constantly. Comparing the early and late groups for para-aortic lymphadenectomy, there was an increase in mean operating time (34.8 versus 73.2 minutes; P < .001) and mean histologic lymph node yield (5.1 versus 10.6; P < .001). For pelvic lymphadenectomy, mean operating time increased slightly (60.7 versus 69.7 minutes; not significant) but mean histologic lymph node count decreased over time (24.3 versus 21.0; not significant). Retrospective evaluation of videotapes showed that the radicality of lymphadenectomy improved continuously in all evaluated subareas. CONCLUSION: Establishment of a protocol for para-aortic and pelvic lymphadenectomy took 100 operations. Video documentation was a more reliable indicator of progress in technical performance than were histologic lymph node counts.

Adult↗
PubMed2002

Biology of female sexual function.

Although the psychosocial and relationship aspects of female sexuality have been extensively investigated, studies concerning the anatomy, physiology and pathophysiology of female sexual function and dysfunction are limited. The paucity of biologic data may be attributed to a lack of reliable experimental models and tools for investigating female sexual function and to limited funding, which is critical for developing experimental approaches. Research efforts by several investigators in different laboratories have been establishing experimental models needed for investigating the physiologic mechanisms involved in the genital arousal response of sexual function. These experimental models have permitted assessment of genital hemodynamics, vaginal lubrication, regulation of genital smooth muscle contractility and signaling pathways, providing preliminary information about the role of neurotransmitters and sex steroid hormones in sexual function. Further research is needed to define the neurotransmitters responsible for vaginal smooth muscle relaxation and the role of sex steroid hormones and their receptors in modulating genital hemodynamics, smooth muscle contractility, and neurotransmitter receptor expression. Finally, a global and integral understanding of the biologic aspects of female sexual function requires investigation of the vascular, neurologic (central and peripheral), and structural components of this extremely complex physiologic process.

Animals↗
PubMed1998

An anatomical classification--a new paradigm for management of female lower urinary tract dysfunction.

A new anatomical classification specifies anatomical defects in the anterior, middle and posterior zones of the vagina as the cause of female lower urinary tract dysfunction. An external musculoelastic mechanism stretches the vagina to open and close the outflow tract. The same pelvic floor muscles provide a peripheral control mechanism for micturition. The stretched vagina prevents the filling bladder from activating the stretch receptors in the bladder neck. Vaginal laxity may weaken transmission of muscle forces, interfering with urethral opening and closure, a mechanical process. Laxity may also destabilize the peripheral control mechanism, a neurological process, causing bladder control to swing between the open and closed modes urodynamically interpreted as bladder instability. Specific symptoms, signs, and urodynamic tests can be arranged into a pictorial algorithm. This acts as a practical guide for locating the three zones of anatomical defects. It has been possible to reinterpret almost all the definitions and descriptions of the International Continence Society (ICS) in terms of this classification, and to explain how vaginal laxity may cause premature activation of the micturition reflex (detrusor instability), stress incontinence and abnormal emptying (dribble, overflow). This convergence in anatomical and urodynamic (ICS) concepts explains many previously unexplained phenomena, and potentially opens up a new approach to management, nonsurgical strengthening of specific ligaments, or surgical reinforcement thereof with ambulatory "microinvasive" methods which do not require catheterization.

Biomechanical Phenomena↗
PubMed1977

Rise of plasma corticosterone concentrations in rats immediately before and after birth and in fetal rats after the ligation of maternal uterine blood vessels or of the umbilical cord.

Just before normal vaginal delivery the plasma corticosterone concentration (PCC) in fetal rats increased markedly compared with that on day 22 of gestation. The PCC was elevated 2 h after birth and then declined until 12 h after birth, when it approached the level found on day 22 of gestation. Similarly, in premature newborn rats obtained by cesarean delivery on days 21 and 22 of gestation, the PCC increased 2 to 4 h after delivery and then declined. The PCC in 22-day-old fetal rats, 30 min after ligation of the maternal blood vessels running along a uterine horn, rose markedly compared with that in fetuses in the contralateral intact horn. A similar increase in PCC was not observed in either decapitated or encephalectomized fetuses, but observed in fetuses whose umbilical cords were ligated. The rise in fetal PCC after ligation of uterine blood vessels and of umbilical cords was considerably higher than that observed after various stresses reported by other investigators and also higher than that found 60 min after maternal adrenalectomy. The rise in PCC just before and just after birth and after the ligation should not be considered as the result of stress, parturition or ligation, but may be a result of the response to other factors.

Animals↗
PubMed2005

Pregnancy outcomes in women with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

OBJECTIVE: Despite earlier detection, treatment, and surgical advances, fertility prognosis in women with classical 21-hydroxylase deficiency (21-OHD) is still low, especially in the salt-wasting (SW) form. PATIENTS AND METHODS: We analysed the course and outcome of four pregnancies in two simple virilizing (SV) and one SW patient. RESULTS: The evaluation of carrier status indicated that all three fathers had two normal CYP21 genes. During the pregnancy, the dose of prednisolone was increased in one of the SV patients and the SW patient. In the SW patient who developed pre-eclampsia, the dose of fludrocortisone was also increased. Three patients gave birth to a total of four healthy girls who were heterozygotes for 21-OHD with normal genitalia (one by vaginal delivery and three by Caesarean section). Family studies revealed that the mother of the SW patient has nonclassical 21-OHD. CONCLUSION: Improving a low birth rate in females with SW 21-OHD remains a problem and new approaches are required. If the mother has 21-OHD (even nonclassical 21-OHD), pre-conception counselling and paternal genotyping are advisable and prenatal dexamethasone therapy should be considered.

Adrenal Hyperplasia, Congenital↗
PubMed1990

Easy method of upper-pole heminephroureterectomy in duplex systems in children.

An easy method of upper-pole heminephroureterectomy is described in which a finger is inserted into the dilated upper collecting system, and the upper pole is removed by dissecting directly against the collecting system using finger guidance. This approach prevents entry into the lower-pole collecting system, minimizes blood loss, and maximizes preservation of normal renal tissue. Easy access to the lower ureter through the same incision is facilitated by the use of the Sims vaginal retractor.

Child↗
PubMed1981

[The value of estimating the levels of amniotic insulin which come from the fetus in looking after diabetic pregnancies in the last trimester (author's transl)].

The authors carried out 49 estimations of amniotic fluid levels of insulin in 41 patients. 25 of these patients were non-diabetic and they were a control group, and 16 patients were diabetic (24 estimations). The liquor was collected by amniocentesis between the 32nd and the 42nd week of amenorrhoea. The mean of the control levels was 3.17 micro-units per ml. The mean of the values in diabetic pregnancies was 9.97 micro-units per ml. The difference between the two groups is statistically significant. We have studied this insulinaemia in relationship to the duration of the diabetes, the maternal weight increase, the levels of insulin used therapeutically, the blood glucose level, the rise in arterial blood pressure, the weight of the infant, the date of delivery, the presence of fetal distress and the control of blood sugar. There is a statistically significant difference between the insulinaemia of patients in whom the diabetes is well controlled (mean level of 7.08 micro-units per ml) and the patients in whom the diabetes is badly controlled (31.7 micro-units per ml). This new parameter for supervision of the third trimester of pregnancy in diabetics gives rise to the possibilities of a better approach to materno-fetal blood sugar regulation and to an adjustment of the therapeutic doses of insulin that are given which will result in lengthening of the duration of pregnancy, with the aim of achieving a spontaneous vaginal delivery at term.

Amniocentesis↗
PubMed1997

[The surgical correction of anterior rectocele. Our experience].

Rectocele, or namely the protrusion of the anterior wall of the rectum into the vaginal lumen following the collapse of the rectovaginal septum, is the most common anatomic alteration observed in patients suffering from defecation disorders. The surgical treatment of this pathology is still controversial, particularly in the choice of the surgical approach. From 1992 to 1994 10 patients suffering from low type, symptomatic anterior rectocele associated with intrarectal intussusception underwent muscular plastic surgery of the rectocele and anterior mucosectomy. The aim of this study was to evaluate whether surgical muscular plastic of the rectocele using a transanal approach associated with anterior mucosectomy represents in selected symptomatic patients, a rational and elective therapeutic option. In spite of the small number of patients and the short postoperative follow-up, the authors state that, on the basis of the results obtained, the surgical technique used in this clinical series significantly improves symptoms with a lower incidence of complications compared to the transvaginal approach.

Adult↗
PubMedDate not supplied

[Introduction of the anterior sagittal trans-ano-rectal approach (ASTRA) as a technical variation of the Passerini-Glazel clitoro-vaginoplasty: preliminary results].

A variant technique to the 1-stage clitorovaginoplasty in severely masculinized female pseudohermaphrodites is presented. The new variant consist of an anterior sagittal trans-ano-rectal approach (A.S.T.R.A.) with the patient placed in the prone position after that a clitoroplasty was performed by the Paserini-Glazel procedure. A.S.T.R.A. permit to perform the dissection between the vagina and the urethra, the suture of the vaginal stump and the anastomosis between the neo-introitus vaginalis and the vagina under direct vision. A.S.T.R.A. with a protective colostomy was performed in two patients with normal rectum. The anorectal sphinteric mechanism was divided in the anterior midline, and the rectum was opened just in the anterior rectal wall. This provided excellent exposure to urogenital sinus. The vagina was then easily and fully separated from the urogenital sinus, the vaginal stump sutured and the anastomosis between the mucocutaneous cylinder (neo-introitus vaginalis) and the vagina performed. The rectum, perineal body and the anterior sphinteric mechanism were reconstructed. The postoperative course was uneventful. The patients had normal fecal control after the colostomy closure. No urinary incontinence was encountered. An anterior sagittal midline incision provides excellent exposure to the urogenital sinus and assure the preservation of the anorectal innervation and the sphinteric mechanism.

Adrenal Hyperplasia, Congenital↗
PubMed2001

Monochorionic monoamnionic twins: vaginal delivery.

Monochorionic monoamnionic pregnancies are rare and have a poor obstetric prognosis. A single amniotic sac promotes cord knotting and entanglement with a high risk of fetal anoxia. The response to this risk has been obstetric management consisting of routine cesarean section at 32 weeks of gestation or when pulmonary maturity is attained. This approach is called into question by the series of seven monochorionic monoamnionic pregnancies we present here. Such pregnancies do indeed require increased surveillance to term, but we think it is possible to apply the usual obstetric management of twin pregnancies.

Adult↗
PubMed1999

Pediatric retroperitoneoscopic nephrectomy using 2 mm. instrumentation.

PURPOSE: We describe several modifications of the retroperitoneoscopic approach to nephrectomy for benign renal disease, including the use of 2 mm. instrumentation and prone patient positioning. MATERIALS AND METHODS: A total of 14 children underwent retroperitoneoscopic nephrectomy in the prone position. An inflatable dissecting device was inserted into the retroperitoneum after a small muscle splitting incision was made at the lateral border of the sacrospinalis muscle approximately 1 cm. below the costovertebral angle. After inflation the dissecting device was replaced with a 5 mm. cannula and pneumoretroperitoneum was maintained with carbon dioxide insufflation. Two 2 mm. trocars were then placed under endoscopic guidance. Dissection was performed using 2 mm. instrumentation and the specimen was retrieved through the largest port site. RESULTS: Nephrectomy was performed in 9 girls and 5 boys 3 months to 9.8 years old. The preoperative diagnosis included chronic pyelonephritis with minimal renal function, reflux with a nonfunctioning kidney, multicystic dysplastic kidney, an upper pole dysplastic moiety with an associated ureterocele and a dysplastic kidney with a vaginal ectopic ureter. Mean operative time for retroperitoneoscopic nephrectomy was 142 minutes with an estimated blood loss of less than 15 ml. Contralateral ureteral reimplantation was performed after retroperitoneoscopic dissection in 5 patients. Overall average hospital stay was 2 days and there were no complications. CONCLUSIONS: Several modifications of the retroperitoneal approach, including the use of prone patient positioning and 2 mm. instrumentation for visualization and dissection, may improve the safety and efficacy of this technique in children.

Child↗