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PubMed2005

Microsystem technology as a road from macro to nanoworld.

Tremendous progress of microelectronic technology observed within last 40 years is closely related to even more remarkable progress of technological tools. It is important to note however, that these new tools may be used for fabrication of diverse multifunctional structures as well. Such devices, called MEMS (Micro-Electro-Mechanical-System) and MOEMS (Micro-Electro-Opto-Mechanical-System) integrate microelectronic and micromechanical structures in one system enabling interdisciplinary application, with most interesting and prospective being bio-medical investigations. Development of these applications requires however cooperation of multidisciplinary team of specialists, covering broad range of physics, (bio) chemistry and electronics, not mentioning medical doctors and other medical specialists. Thus, dissemination, of knowledge about existing processing capabilities is of key importance. In this paper, examples of various applications of microelectronic technology for fabrication of Microsystems which may be used for medicine and chemistry, will be presented. Besides, information concerning a design and technology potential available in poland and new, emerging opportunities will be given.

Microchemistry↗

PubMed2004

Bauplan of urmetazoa: basis for genetic complexity of metazoa.

Sponges were first grouped to the animal-plants or plant-animals then to the Zoophyta or Mesozoa and finally to the Parazoa. Only after the application of molecular biological techniques was it possible to place the Porifera monophyletically with the other metazoan phyla, justifying a unification of all multicellular animals to only one kingdom, the Metazoa. The first strong support came from the discovery that cell-cell and cell-matrix adhesion molecules that were cloned from sponges and were subsequently expressed share a high DNA sequence and protein function similarity with the corresponding molecules of other metazoans. Besides these evolutionary novelties for Metazoa, sponges also have morphogens and transcription factors in common with other metazoan phyla. Surprisingly, even those elements exist in Porifera, which are characteristic for pattern and axis formation. Recent studies showed that epithelial layers of sponges are sealed against the extracellular milieu through tight-junction proteins. The cell culture system from sponges, the primmorphs, was suitable for understanding morphogenetic events. Finally, stem cell marker genes were isolated, which underscored that sponge cells have the capacity to differentiate. In the relatively short period of time, approximately 200 million years, the basic pathways had to be established that allowed the transition for multicellular organisms to a colonial system through the formation of adhesion molecules; based on the development of a complex immune system and the apoptotic machinery of an integrated system, the Urmetazoa, which evolved approximately 800 million years ago, could be reached. Hence, the Bauplan of the hypothetical Urmetazoa can now be constructed according to genomic regulatory systems similar to those found in higher Metazoa. These data caused a paradigmatic change; the Porifera are complex and simple but by far not primitive.

Animals↗

PubMed2026

Copper-Containing Surface Engineering for Soft-Tissue Biomedical Devices: Structure-Function Relationships and Ion Release-Driven Biological Performance, A Systematic Review.

Copper and copper-based materials have gained increasing attention for the functional modification of implantable medical devices intended for prolonged soft-tissue contact, including vascular stents, catheters, and intrauterine devices. Owing to their broad-spectrum antimicrobial activity, redox reactivity, and involvement in angiogenesis and cellular signaling, copper-based systems offer significant potential for multifunctional surface engineering. However, achieving a balance between antibacterial efficacy, corrosion behavior, controlled ion release, and cytocompatibility remains a critical challenge. This PRISMA-compliant systematic review analyzes copper-containing materials and surface modification strategies for soft-tissue biomedical applications. A structured search of Scopus, Web of Science, and PubMed (2015-2025) identified 65 eligible studies. The review encompasses bulk copper-containing alloys, electrochemical and chemical surface modification techniques, physical vapor deposition approaches, and advanced hybrid systems integrating copper with polymers, hydrogels, or metal-phenolic networks. Across the reviewed literature, antibacterial performance was strongly dependent on copper concentration, microstructural distribution, and spatiotemporal ion release profiles. Moderate, well-controlled copper incorporation frequently improved antibacterial efficacy while maintaining acceptable hemocompatibility and cytocompatibility, particularly in vascular and blood-contacting devices. In contrast, excessive copper loading often accelerated corrosion and induced adverse cellular responses. Emerging multifunctional architectures demonstrated improved regulation of biological interactions, enabling simultaneous antibacterial, antithrombotic, and proendothelial effects. Overall, copper-based surface technologies represent a versatile platform for soft-tissue implant modification. Future translational progress will require precise control of copper release kinetics and comprehensive long-term in vivo validation to ensure safety and sustained therapeutic performance. From the authors' perspective, the most promising future direction involves multifunctional copper-based hybrid coatings capable of dynamically regulating ion release, host tissue integration, and antibacterial performance simultaneously. Strategies integrating hierarchical architectures, stimulus-responsive release systems, and clinically scalable fabrication methods are expected to play a key role in translating copper-containing surfaces from experimental concepts toward commercially viable soft-tissue biomedical devices.

Copper↗

PubMed1995

Coherence and congruence: two aspects of personality integration.

Coherence and congruence-based measures of personality integration were related to a variety of healthy personality characteristics. Functional coherence was defined as occurring when participants' "personal strivings" (R.A. Emmons, 1986) help bring about each other or help bring about higher level goals. Organismic congruence was defined as occurring when participants strive for self-determined reasons or when strivings help bring about intrinsic rather than extrinsic higher level goals. Study 1 found the integration measures were related to each other and to inventory measures of health and well-being. Study 2 showed that these goal integration measures were also related to role system integration and were prospective predictors of daily mood, vitality, and engagement in meaningful as opposed to distracting activities.

Adult↗

PubMed2005

Systems biology: will it work?

Systems biology describes the collection of a set of measurements on a system, integrated with a mathematical model of that system. The model and the measurements must be made together and refined iteratively, requiring close collaboration between biologists and modellers. A complete cell is probably too large and complicated to model yet, but simplified subsystems will probably produce valuable results. I consider various ways of simplifying the system and conclude that the biggest challenge is to get everyone working together productively.

Models, Biological↗

PubMed1997

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.

CLUSTAL X is a new windows interface for the widely-used progressive multiple sequence alignment program CLUSTAL W. The new system is easy to use, providing an integrated system for performing multiple sequence and profile alignments and analysing the results. CLUSTAL X displays the sequence alignment in a window on the screen. A versatile sequence colouring scheme allows the user to highlight conserved features in the alignment. Pull-down menus provide all the options required for traditional multiple sequence and profile alignment. New features include: the ability to cut-and-paste sequences to change the order of the alignment, selection of a subset of the sequences to be realigned, and selection of a sub-range of the alignment to be realigned and inserted back into the original alignment. Alignment quality analysis can be performed and low-scoring segments or exceptional residues can be highlighted. Quality analysis and realignment of selected residue ranges provide the user with a powerful tool to improve and refine difficult alignments and to trap errors in input sequences. CLUSTAL X has been compiled on SUN Solaris, IRIX5.3 on Silicon Graphics, Digital UNIX on DECstations, Microsoft Windows (32 bit) for PCs, Linux ELF for x86 PCs, and Macintosh PowerMac.

Algorithms↗

PubMed1980

Quantitation of uterine activity: clinical evaluation of a new method of data presentation.

An on-line, automated system, voltage-controlled oscillator (VCO), with digital print-out of uterine activity units (UAU) at designated intervals, has been used in clinical studies and appears reliable. A comparison was made between the VCO system and a microprocessor-controlled digital integrator system (MCDI), which displays UAUs as a bar graph every 10 minutes on the uterine activity channel of the clinical fetal monitor.

Data Display↗

PubMed2001

A new approach to determine the total airborne N input into the soil/plant system using 15N isotope dilution (ITNI): results for agricultural areas in Central Germany.

The atmospheric deposition of nitrogen (N) in the environment is of great concern due to its impact on natural ecosystems including affecting vegetation, reducing biodiversity, increasing tree growth in forests, and the eutrophication of aquatic systems. Taking into account the average annual N emission into the atmosphere in Germany of about 2 million t N (ammonia/ammonium, NOx), and assuming homogeneous distribution throughout Germany, an average N deposition of 45 kg/ha x year can be calculated. Such high atmospheric N deposition could be confirmed by N balances from long-term field experiments in Central Germany (e.g., the Static Fertilization Experiment in Bad Lauchstdt). By contrast, estimates by standard methods indicate a deposition of only about 30 kg N/ha x year. This is because the standard methods are using wet-only or bulk collectors, which fail to take into account gaseous deposition and the direct uptake of atmospheric N by aerial plant parts. Therefore, a new system was developed using 15N isotope dilution methodology to measure the actual total atmospheric N input into a soil/plant system (Integrated Total Nitrogen Input, ITNI). A soil/plant system is labeled with [15N]ammonium-[15N]nitrate and the total input of airborne N is calculated from the dilution of this tracer by N from the atmosphere. An average annual deposition of 64 +/- 11 kg/ha x year from 1994-2000 was measured with the ITNI system at the Bad Lauchstdt research farm in the dry belt of Central Germany. Measurements in 1999/2000 at three other sites in Central Germany produced deposition rates of about 60 kg/ha x year. These data clearly show that the total atmospheric N deposition into the soil/plant system determined by the newly developed ITNI system significantly exceeds that obtained from standard wet-only and bulk collectors. The higher atmospheric N depositions found closely match those postulated from the N balances of long-term agricultural field experiments.

Chemistry Techniques, Analytical↗

PubMed2006

Glycomics approach to structure-function relationships of glycosaminoglycans.

Extracellular modulation of phenotype is an emerging paradigm in this current postgenomics age of molecular and cell biology. Glycosaminoglycans (GAGs) are primary components of the cell surface and the cell-extracellular matrix (ECM) interface. Advances in the technology to analyze GAGs and in whole-organism genetics have led to a dramatic increase in the known important biological role of these complex polysaccharides. Owing to their ubiquitous distribution at the cell-ECM interface, GAGs interact with numerous proteins and modulate their activity, thus impinging on fundamental biological processes such as cell growth and development. Many recent reviews have captured important aspects of GAG structure and biosynthesis, GAG-protein interactions, and GAG biology. GAG research is currently at a stage where there is a need for an integrated systems or glycomics approach, which involves an integration of all of the above concepts to define their structure-function relationships. Focusing on heparin/heparan (HSGAGs) and chondroitin/dermatan sulfate (CSGAGs), this review highlights the important aspects of GAGs and summarizes these aspects in the context of taking a glycomics approach that integrates the different technologies to define structure-function relationships of GAGs.

Animals↗

PubMed1998

Interactive MR imaging-guided biopsy and aspiration with a modified clinical C-arm system.

OBJECTIVE: This investigation was performed to test the hypotheses that interactive guidance of MR image acquisition during needle-directed procedures using a clinical 0.2-T C-arm open MR imaging system integrated with a frameless optically linked stereotaxy system is feasible, and that procedure times can be sufficiently short to be well tolerated by the patient. SUBJECTS AND METHODS: One hundred six MR-guided procedures were performed in 86 patients (ranging in age from 5 months to 88 years) using a clinical C-arm imaging system supplemented with an in-room RF-shielded liquid crystal display monitor, a frameless stereotaxy system, rapid gradient-echo sequences for needle guidance, and MR-compatible monitoring and surgical lighting equipment. We performed 50 biopsies and aspirations of the head and neck in 37 patients, 23 biopsies of musculoskeletal lesions in 22 patients, 16 biopsies of abdominal sites in 10 patients, six biopsies of the thoracolumbar spine or sacrum in six patients, and 11 shoulder joint injections for MR arthrography in 11 patients, in addition to 38 MR arthrographic injections on the same imaging system described in a previous report. Tissue sampling included fine-needle aspiration (n = 90) and cutting needle core biopsy (n = 41). Thirty-five patients underwent both procedures. Procedures were evaluated for success of needle placement, procedure time, and complications. RESULTS: Needle placement was successful in all cases, and no complications occurred. Tissue was sufficient for pathologic diagnosis for all but eight patients. Passes per patient averaged 2.1. For fine-needle aspiration, instrument time averaged 7 min 42 sec per pass, cutting needle core biopsy averaged 6 min 24 sec, and shoulder injection averaged 8 min. CONCLUSION: MR imaging guidance for needle procedures on a clinical 0.2-T C-arm system with supplemental interventional accessories is feasible, with relatively rapid needle placement.

Abdomen↗

PubMed1998

Mathematical modeling of immunological reactions.

The immune system is a highly regulated, complex and integrated system which has evolved to provide the organism with substantial defenses against pathogenic organisms. Over the last several decades there has been an explosion of experimental data in this area, and new techniques in molecular and cellular biology have been crucial in deepening our understanding of immune processes. Most of these new techniques have allowed the isolation of the process or cell under study so that the results can be readily interpretable. At the present time, however, there is an emerging need to understand the system as it functions as a whole and the language of mathematics is the one best suited for this purpose. This review, written from the perspective of an experimental immunologist, describes some of the recent advances in the development of mathematical models of the immune system. Particular emphasis is placed on the rapidly growing field of modeling in HIV infection and T cell activation. Immunology as a whole will benefit from the introduction of the language of mathematics in much the same way as neuroscience has done in the last decade.

Animals↗

PubMed1990

Neuropsychological systems deficits and the isomorphism of control.

The papers that follow are based on a symposium presented at the Twelfth European Conference of the International Neuropsychological Society held in Antwerp, Belgium between 5-8th July 1989. The symposium, using closed head injury as a vehicle, attempted to overview approaches to the study of systems function and dysfunction. Rather than concentrate on skill and subtest deficit, the papers addressed diffuse, systemic, subcortical effects and disruption of lower integration centers. They addressed the utility of neural network models to develop theory to explain deficits in behavioral integrating systems; the role of systems approaches in better understanding the overlapping clinical subsets of migraine and seizure disorders; the provision of visual examples of lateralized systemic changes associated with closed head injury through infrared thermology and the presentation of an application of biomathematical systems modeling with potent applications for diagnosis and rehabilitation. Finally the papers were discussed in terms of the clinical and philosophical issues.

Brain↗

PubMedDate not supplied

Medical image informatics infrastructure design and applications.

Picture archiving and communication systems (PACS) is a system integration of multimodality images and health information systems designed for improving the operation of a radiology department. As it evolves, PACS becomes a hospital image document management system with a voluminous image and related data file repository. A medical image informatics infrastructure can be designed to take advantage of existing data, providing PACS with add-on value for health care service, research, and education. A medical image informatics infrastructure (MIII) consists of the following components: medical images and associated data (including PACS database), image processing, data/knowledge base management, visualization, graphic user interface, communication networking, and application oriented software. This paper describes these components and their logical connection, and illustrates some applications based on the concept of the MIII.

Age Determination by Skeleton↗

PubMed1996

An in vivo battery for identifying endocrine modulators that are estrogenic or dopamine regulators.

We have combined several endpoints into a single 5-day in vivo screening procedure to identify estrogenic compounds and dopaminergic modulators, both of which play important roles in enhancing mammary tumorigenesis in rodents. The endpoints evaluated as markers of estrogenicity included increases in uterine fluid and vaginal cornification incidence, serum prolactin levels, uterine weight, uterine epithelial cell height, uterine stromal cell proliferation, and uterine progesterone receptor (PR) number and decreases in uterine estrogen receptor (ER) number. The endpoints evaluated for changes in dopamine regulation included increases in prolactin and decreases in growth hormone levels. The estrogen agonist estradiol (E2) and estriol (E3), the mixed estrogen agonist/ antagonist tamoxifen (TAM), the full antiestrogen ICI-182, 780 (ICI),and the dopamine modulators haloperidol (HAL) and reserpine (RES) were tested using a three-time/day (8-hr intervals) intraperitoneal dosing regimen in sexually mature ovariectomized female Crl:CD BR rats. All compounds were evaluated over a range of concentrations. This in vivo battery was used to evaluate the effects of different classes of endocrine modulators on the selected endpoints. For example, the estrogen receptor agonists E2 and E3 display a unique profile based on changes in the uterotrophic endpoints (estrus conversion, uterine fluid imbibition, increases in uterine weight, and uterine endometrial cell proliferation) where full and partial agonists can be distinguished by the magnitude of these responses. Both the estrogen receptor antagonist ICI and the dopamine modulators HAL and RES lack these uterotrophic responses. Dopamine modulators can be distinguished from estrogen receptor agonists by the profile of increased prolactin levels with no uterotrophic changes. Estrogen receptor antagonists can be distinguished from agonists by comparing their effects on ER, PR, and uterotrophic responses. For instance, the full estrogen receptor antagonist ICI decreased ER (to almost 0) and PR levels, but has no uterotrophic effects, while TAM decreases ER (to almost 0) and increases PR with uterotrophic effects. The most useful endpoints for distinguishing estrogen agonists and dopamine modulators were uterine fluid imbibition, uterine weight, uterine stromal cell proliferation, and serum prolactin levels. In order to distinguish an estrogen agonist from an antagonist, other endpoints, such as receptor levels, are necessary. The advantage of an in vivo screen is that it utilizes a metabolically and physiologically defined system which is especially important with highly integrative system such as the endocrine system. This battery can be used as a screening tool to identify potential endocrine modulators as well as to identify mode of action following adverse findings in toxicology studies. Last, additional endpoints may be added to identify other classes of endocrine modulators.

Animals↗

PubMed1985

Anatomical considerations in the design of a long-term implantable human left ventricle assist system.

A permanently implantable left ventricle assist system (LVAS) is being developed and is planned to be implanted in the left chest cavity against the chest wall with the electrohydraulic energy converter placed in a resected rib space. The inflow and outflow pump ports are connected to the left ventricle (LV) apex and to the descending aorta, respectively. Three additional major components of this system consist of the transcutaneous energy transmission system (TETS) (Thermedics), the variable volume device (VVD), and the internal battery. To finalize the design of this integrated system, key anatomical information was obtained by a special radiographic and angiographic study of 31 adult men with a varying degree of coronary artery disease and myocardial dysfunction. These data were combined with the previous computed tomography study by using a standard vertical reference system. The resultant integrated data, which consist of the three-dimensional chest model, the LV apex and axis orientation, rib orientation, chest wall thickness, and the descending aorta location, were used to define the design and anatomical locations of the inflow and outflow pump ports, the VVD, the pump and energy converter orientation, the TETS, and the internal battery. The most critical component for the design was found to be the inflow system. With regard to the average coronary disease patient, an anatomically practical configuration was demonstrated to exist for the presently proposed LVAS. Design flexibility was allowed for some of the critical components in order to fit the system in a large number of patients regardless of the stage and type of the underlying disease.

Adult↗

PubMed2003

Integrating air pollution modelling with scenario testing in road transport planning: the TRAEMS approach.

Transport add-on environmental modelling system (TRAEMS) is a GIS-based environmental modelling system designed to evaluate the environmental consequences of road traffic in urban areas. Its development has been underpinned by the premises that the evaluation of road traffic impacts is best undertaken during the early planning stages of road networks, and that this can utilise much of the data generated by the transport planners themselves as they apply their travel demand models as to planning of road networks. The system integrates information about traffic-usually from travel-forecasting models-with information about land use, to provide the input data to a range of commonly used models that estimate pollution from a road traffic system, and the energy consumption of that system. TRAEMS facilitates this integration and allows land use, transport and environmental planners to have rapid feedback on the environmental effects of road transport network scenarios that are being developed and tested. Its purpose is to aid in the selection of environmentally-preferred road networks and to highlight where management of pollution levels on future road networks will be required. TRAEMS has a modular structure. This paper describes the main features of the air pollution and fuel consumption modules of the system and illustrates the system's utility through case studies at both metropolitan-wide- and local-area scales.

Air Pollution↗

PubMed2002

Surface integration of velocity vectors from 3D digital colour Doppler: an angle independent method for laminar flow measurements.

BACKGROUND: The study was designed to test the angle independence of a dynamic three-dimensional digital colour Doppler method for laminar flow measurement. The technique acquired three-dimensional data by rotational acquisition and used surface integration of Doppler vector velocities and flow areas in time and space for flow computation. METHOD: A series of pulsatile flows (peak flow 55-180 ml/s) through a curved tube were studied with reference flow rates obtained using an ultrasonic flow meter. Colour Doppler imaging was performed at three angles to the direction of flow (20 degrees, 30 degrees, 40 degrees), using a multiplane transoesophageal probe controlled by an ATL HDI5000 system. Integration of digital velocity vectors over a curved three-dimensional surface across the tube for each of the 11 flow rates at each angle was performed off-line to compute peak flow. RESULTS: Peak flow rates correlated closely (r=0.99) with the flow meter with the mean difference from the reference being -0.8+/-2 x 4 ml/s, 0.9+/-2.6 ml/s, 1.0+/-2 x 3 ml/s for 20 degrees, 30 degrees and 40 degrees respectively. Comparison of the three angle groups showed no significant differences (P=0.15, ANOVA). When sampled obliquely, the flow area on the curved surface increased while the velocities measured decreased. CONCLUSION: Surface integration of velocity vectors to compute three-dimensional Doppler flow data is less angle dependent than conventional Doppler methods.

Blood Flow Velocity↗

PubMed2005

Performance of a static-anode/flat-panel x-ray fluoroscopy system in a diagnostic strength magnetic field: a truly hybrid x-ray/MR imaging system.

Minimally invasive procedures are increasing in variety and frequency, facilitated by advances in imaging technology. Our hybrid imaging system (GE Apollo flat panel, custom Brand x-ray static anode x-ray tube, GE Lunar high-frequency power supply and 0.5 T Signa SP) provides both x-ray and MR imaging capability to guide complex procedures without requiring motion of the patient between two distant gantries. The performance of the x-ray tube in this closely integrated system was evaluated by modeling and measuring both the response of the filament to an externally applied field and the behavior of the electron beam for field strengths and geometries of interest. The performance of the detector was assessed by measuring the slanted-edge modulation transfer function (MTF) and when placed at zero field and at 0.5 T. Measured resonant frequencies of filaments can be approximated using a modified vibrating beam model, and were at frequencies well below the 25 kHz frequency of our generator for our filament geometry. The amplitude of vibration was not sufficient to cause shorting of the filament during operation within the magnetic field. A simple model of electrons in uniform electric and magnetic fields can be used to estimate the deflection of the electron beam on the anode for the fields of interest between 0.2 and 0.5 T. The MTF measured at the detector and the DQE showed no significant difference inside and outside of the magnetic field. With the proper modifications, an x-ray system can be fully integrated with a MR system, with minimal loss of image quality. Any x-ray tube can be assessed for compatibility when placed at a particular location within the field using the models. We have also concluded that a-Si electronics are robust against magnetic fields. Detailed knowledge of the x-ray system installation is required to provide estimates of system operation.

Electromagnetic Fields↗