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At least 1,693 records · Page 94Linked to original sources
PubMed2000

Responses to linear and logarithmic frequency-modulated sweeps in ferret primary auditory cortex.

Multi-unit responses to frequency-modulated (FM) sweeps were studied in the primary auditory cortex of ferrets using six different stimulation paradigms. In particular, the differences between the responses to linear FM sweeps (where frequency changes linearly with time) and logarithmic FM sweeps (where frequency changes exponentially with time) were emphasized. Some general features of the responses to FM sweeps are independent of the exact details of the frequency trajectory. Both for linear and for logarithmic FM sweeps, a short burst of spikes occurred when the sweep reached a triggering frequency close to the best frequency of the cluster. The neuronal preference for FM velocity was also independent of frequency trajectory. Thus, clusters that responded best to slow logarithmic FM also preferred slow linear FM and vice versa. Consequently, topographic distributions of velocity preference were roughly independent of the stimulation paradigm. Other characteristics of the responses, however, depended on the exact details of the frequency trajectory. A significant number of clusters showed large differences in directional sensitivity between linear and logarithmic FM sweeps; these differences depended on the velocity preference of the clusters in some paradigms but not in others. Consequently, topographic distributions of directional sensitivity differed between linear and logarithmic paradigms. In conclusion, some characteristics of cluster responses to FM sweeps depend on the exact details of the stimulation paradigm and are not 'invariants' of the cluster.

Acoustic Stimulation↗
PubMed2002

Response properties of neurons in the core of the central nucleus of the inferior colliculus of the barn owl.

The central nucleus of the inferior colliculus (ICC) is particularly important for the processing of interaural time differences (ITDs). In the barn owl, neuronal best frequencies in a subnucleus of the ICC, the ICCcore, span the animal's entire hearing range (approximately equal to 200-10 000 Hz). This means that low-frequency ITD-sensitive ICCcore neurons in the owl can be directly compared to ITD-sensitive mammalian ICC neurons with similar best frequencies as well as to the high-frequency ITD-sensitive neurons usually studied in owls. This report represents a first attempt to systematically describe important physiological properties of ICCcore neurons in the barn owl, with particular attention to the low-frequency region (< 2 kHz). Responses were obtained from 133 neurons or small clusters of neurons; recording sites were confirmed by histological reconstruction of electrode tracks based on electrolytic lesions. Iso-intensity frequency response functions were typically approximately equal to 1 octave wide in the low-frequency range and approximately equal to 1/3 octave wide in the high-frequency range. Most neurons were ITD-tuned; both noise and pure tone stimuli yielded periodic ITD tuning curves with several equivalent response maxima. In most cases ITD tuning curves had a response peak within the barn owl's physiological ITD range. ITD tuning widths were inversely correlated with neuronal best frequency. None of the ICCcore neurons studied were sensitive to interaural level differences. Monaural inputs to ICCcore cells were typically binaurally balanced, i.e. they exhibited similar response thresholds, dynamic ranges, slopes and saturation levels, for both left and right ear monaural stimulation.

Acoustic Stimulation↗
PubMed2002

The effect of whole-body tilt on sound lateralization.

The effect of passive whole-body tilt in the frontal plane on the lateralization of dichotic sound was investigated in human subjects. Pure-tone pulses (1 kHz, 100 ms duration) with various interaural time differences were presented via headphones while the subject was in an upright position or tilted 45 degrees or 90 degrees to the left or right. Subjects made two-alternative forced-choice (left/right) judgements on the intracranial sound image. During body tilt, the auditory median plane of the head, computed from the resulting psychometric functions, was always shifted to the upward ear, indicating a shift of the auditory percept to the downward ear, that is, in the direction of gravitational linear acceleration. The mean maximum magnitude of the auditory shift obtained with 90 degrees body tilt was 25 micro s. On the one hand, these findings suggest a certain influence of the otolith information about body position relative to the direction of gravity on the representation of auditory space. However, in partial contradiction to previous work, which had assumed existence of a significant 'audiogravic illusion', the very slight magnitude of the present effect rather reflects the excellent stability in the neural processing of auditory spatial cues in humans. Thus, it might be misleading to use the term 'illusion' for this quite marginal effect.

Adult↗
PubMed2003

Mapping responses to frequency sweeps and tones in the inferior colliculus of house mice.

In auditory maps of the primary auditory cortex, neural response properties are arranged in a systematic way over the cortical surface. As in the visual system, such maps may play a critical role in the representation of sounds for perception and cognition. By recording from single neurons in the central nucleus of the inferior colliculus (ICC) of the mouse, we present the first evidence for spatial organizations of parameters of frequency sweeps (sweep speed, upward/downward sweep direction) and of whole-field tone response patterns together with a map of frequency tuning curve shape. The maps of sweep speed, tone response patterns and tuning curve shape are concentrically arranged on frequency band laminae of the ICC with the representation of slow speeds, build up response types and sharp tuning mainly in the centre of a lamina, and all (including high) speeds, phasic response types and broad tuning mainly in the periphery. Representation of sweep direction shows preferences for upward sweeps medially and laterally and downward sweeps mainly centrally in the ICC (either striped or concentric map). These maps are compatible with the idea of a gradient of decreasing inhibition from the centre to the periphery of the ICC and by gradients of intrinsic neuronal properties (onset or sustained responding). The maps in the inferior colliculus compare favourably with corresponding maps in the primary auditory cortex, and we show how the maps of sweep speed and direction selectivity of the primary auditory cortex could be derived from the here-found maps of the inferior colliculus.

Acoustic Stimulation↗
PubMedDate not supplied

[Music therapy for prematures].

BACKGROUND: More than ever before the neonatal care besides the medical and nursing work has to been balanced between protecting the child against over extension due to the concept of "minimal handling" and on the other hand the necessary fostering of the young patients psychic and sensomotor development during the long stationary treatment. In addition to known approaches of auditive stimulation as receptive music therapy a concept of active music therapy methods based on the Nordoff/Robbins creative music-therapy (University Witten/Herdecke) is presented in a case-report. PATIENT AND METHODS: The report describes in a single case-report the music-therapeutic work with a premature of the 23 + 3 (th) week of pregnancy at the neonatological unit of the Vestische Kinder- und Jugendklinik Datteln, Universität Witten/Herdecke. The main focus was the observation of the prematures reactions on specific synchronisation of motoric, sensor and acoustical stimulation. RESULTS: Positive reactions allow to presume the effectiveness of music therapy with early born children as they are already shown in clinical studies about receptive music therapy. On the level of involuntary motional actions in the area of head-, face- and hand movements increased directly reactions of awareness on the coordination of sensomotor and acoustical stimulation have been observed. Temporary increase of oxygen partial pressure and reduction of heart/pulse rate seem to cause positive physiological effects. CONCLUSIONS: Active music therapeutic treatment does not seem to be an other risk of over-tension for prematures, but offers through the coordination of different levels of perception an adequate development fostering stimulation.

Arousal↗
PubMed1992

Phenylethylamine and piperidine alkaloids in aloe species.

Of the approximately 300 species of ALOE (Liliaceae) native to Africa and Arabia, leaf extracts of 224 species have been examined chromatographically for alkaloids using ninhydrin, Dragendorff's reagent, nitroprusside, and iodoplatinate as revealing agents. From these, 48 (21%) species contained compounds giving a strong colorimetric reaction with at least one of these reagents. Tyramine derivatives were identified in 18 species and piperidine derivatives in a further 6 species. The other coloured zones remain unidentified but often appeared to represent common amino acids. Some taxonomic correlations are suggested. The presence of the toxic hemlock alkaloids in aloes readily available for potential medicinal use by local inhabitants sounds a note of caution against the unthinking use of these otherwise useful plants.

Journal Article↗
PubMed1993

[Early detection of hearing disorders. 10 years experience with screening more than 8,000 infants].

Prevention and early detection of deficits of the developing human being demand more and more complex solutions. Screening programmes have been developed to detect deficits and diseases before they cause symptoms. A well-organised and accurately performed screening programme can detect preliminary signs of diseases and may prevent irreversible damage. Early detection of deficits only makes sense if it is followed by consequences. Not only early detection of impairment or of children which are threatened by impairment is a very important medical task, but also the interdisciplinary cooperation in therapy. The most serious impact of hearing deficits in newborn is on the lack of speech-acquisition. It is an indisputable fact that the early detection of hearing impairment in newborn markedly improves the prognosis for further language development if early medical and/or rehabilitative therapy takes place. The following description of 10 years of experience with a newborn hearing screening programme that is effected in cooperation with the maternity ward and the ENT-clinic since 1981, can supply further arguments in favour of the need for early detection, the discussion on reflex audiometry, and to emphasise the need for cooperation of all relevant specialists.

Acoustic Stimulation↗
PubMedDate not supplied

[Orthopedic diagnostics using acoustic phenomena].

The clinical analysis of joint noises has practical significance in orthopedics. It has been attempted from time to time in the past 100 years to amplify, analyse and record joint noises. Despite the increased effort from decade to decade, the method of phonoarthrography has not been able to establish itself, since the measurements are complex and poorly reproducible. Artifacts can easily be confused with pathological findings. Finally, because of the different physical properties of light, the sense of vision has essential advantages compared with the sense of hearing, which can localize a sound source only insufficiently accurately.

Arthrography↗
PubMed1981

Neonatal localisation of a sound in visual space.

A tone was played to neonates in one of four conditions: in an unstructured visual field; spatially concordant with a single visual target; spatially discordant with a single visual target; or spatially concordant with one of two identical visual targets at different locations. Auditory-oculomotor spatial coordination, contingent on sound, was enhanced by the presence of a target in the visual field. Audition and vision are mutually supportive in auditory localisation from birth.

Acoustic Stimulation↗
PubMed1982

Locomotion of the blind controlled by natural sound cues.

Measures of the accuracy of locomotion control were taken with blind and blindfolded sighted subjects using the natural auditory obstacle sense to locate a travel path. These measures were compared with the accuracy of visual guidance. While the blind show a greater skill than blindfolded sighted subjects in using auditory cues for guidance, auditory guidance is notably inferior to visual guidance and deteriorates markedly when smaller targets are used to define the travel path. The natural obstacle sense thus appears to give only a rudimentary perception of the presence of objects and does not provide sufficient spatial information to allow accurate locomotion control.

Adult↗
PubMed1984

Acuity of sound localisation: a topography of auditory space. I. Normal hearing conditions.

Eight subjects were required to localise a sound source (white noise through a speaker) which varied in position on both sides of the head over a range of elevations (-40 degrees to +40 degrees) and azimuths (0 degree to 180 degrees) at 10 degrees intervals. The perceived position of the source was indicated by pointing a special gun. Depression of the trigger activated a photographic system which recorded two views of the subject, the sound source, and the gun. The absolute and algebraic, azimuth and elevation errors were measured for all subjects at each position of the source. The variability of azimuth and elevation error was also computed. In a second experiment, four of the same subjects performed the same task but in this case visually located the sources. This experiment provided an estimate of inherent motor error in the pointing task. No differences in localisation acuity between sides were found, but there were significant differences between front and back regions. Azimuth and elevation error were well matched and low in the front. However, azimuth error increased in the regions behind the head, particularly for azimuth positions 120 degrees to 160 degrees. Larger increases were found for positions in the upper elevations of this region. Elevation error also increased in the upper elevations behind the head. A comparison of the auditory and visual data indicates that this pattern of error is not due to motor factors. The results are discussed in relation to the structural characteristics of the pinnae and modifications that they impose on incoming sound energy.

Adolescent↗
PubMed1984

Acuity of sound localisation: a topography of auditory space. II. Pinna cues absent.

The acuity of azimuth and elevation discrimination was measured under conditions in which the cues to localisation provided by the pinnae were removed. Four subjects localised a sound source (white noise through a speaker) which varied in position over a range of elevations (-40 degrees to +40 degrees) and azimuths (0 degree to 180 degrees), at 10 degrees intervals, on the left side of the head. Pinna cues were removed by the insertion of individually cast moulds in both pinnae. Each mould had an access hole to the auditory canal. The absolute and algebraic, azimuth and elevation errors were measured for all subjects at each position of the source. The variability of azimuth and elevation error was also computed. The performance of the subjects was compared to their performance under normal hearing conditions. Insertion of the pinnae moulds was found to increase substantially elevation error and the number of front/back reversals. The importance of the cues provided by the pinnae in these discriminations was thus confirmed. However, the increase in elevation error did not result in a corresponding increase in azimuth error. These findings provide support for the proposition that azimuth and elevation discrimination are coded independently.

Adolescent↗
PubMed1985

Dynamic visual capture: apparent auditory motion induced by a moving visual target.

Apparent motion of a sound source can be induced by a moving visual target. The direction of the perceived motion of the sound source is the same as that of the visual target, but the subjective velocity of the sound source is 25-50% of that of the visual target measured under the same conditions. Eye tracking of the light target tends to enhance the apparent motion of the sound, but is not a prerequisite for its occurrence. The findings are discussed in connection with the 'visual capture' or 'ventriloquism' effect.

Adult↗
PubMed1986

Acuity of sound localisation: a topography of auditory space. III. Monaural hearing conditions.

A study is reported in which the acuity of azimuth and elevation discrimination under monaural listening conditions was measured. Six subjects localised a sound source (white noise through a speaker) which varied in position over a range of elevations (-40 degrees to +40 degrees) and azimuths (0 degrees to 180 degrees), at 10 degrees intervals, on the left side of the head. Monaural listening conditions were established by the fitting of an ear defender and one earmuff to the right ear. The absolute and algebraic, azimuth and elevation errors were measured for all subjects at each position of the source. The results indicate that all subjects suffered a marked reduction of azimuth acuity under monaural conditions, although a coarse capacity to discriminate azimuth still remained. Considerable between-subject variability was observed. Front/back discrimination was retained, although it was slightly impaired compared to that observed under normal listening conditions. Elevation discrimination was, on the whole, quite good under monaural conditions. However, a comparison of the performance of these subjects under monaural conditions with that observed under normal listening conditions indicated that some reduction in elevation localisation acuity occurred in the frontal quadrants in the median plane and in the upper quadrants of more lateral source positions. The reduction in acuity seen in these regions is attributed to the loss of information from the pinna of the occluded ear rather than to the observed reduction in azimuth error. The results provide partial support for the binaural pinna disparity model.

Adolescent↗
PubMed1987

Relative effectiveness of three stimulus variables for locating a moving sound source.

A study is reported in which it is shown that observers can use at least three types of acoustic variables that indicate reliably when a moving sound source is passing: interaural temporal differences, the Doppler effect, and amplitude change. Each of these variables was presented in isolation and each was successful in indicating when a (stimulated) moving sound source passed an observer. These three variables were put into competition (with each indicating that closest passage occurred at a different time) in an effort to determine their relative importance. It was found that amplitude change dominated interaural temporal differences which, in turn, dominated the Doppler effect stimulus variable. The results are discussed in terms of two interpretations. First, it is possible that subjects based their judgements on the potential discriminability of each stimulus variable. However, because the stimuli used involved easily discriminable changes, subjects may instead have based their judgements on the independence of a stimulus variable from different environmental situation conditions. The dominance ordering obtained supports the second interpretation.

Attention↗
PubMed1989

Effects of room reflectance and background noise on perceived auditory distance.

Perceptions of egocentric auditory distance were investigated within an environment for which the reverberation time could be systematically varied without changes in the size or shape of the room. Two levels of wide-band background noise, differing by 20 dB, were used as a masking stimulus. Target sounds were presented from distances between 0.75 and 6.0 m and verbal reports of distance were collected from 288 listeners in two separate experiments. Changes in physical distance produced variation in reported distance in each configuration. Reported distance was generally proportional to real distance, but considerably underestimated when room reflectance was low. When room reflectance was high (T60 approximately 1.7 s for the range of frequencies used), initial reports of distance were often overestimates; upon repeated presentation, judgments in the high reflectance room became more nearly veridical. The effect of increasing the background noise level was to decrease the perceived distance. These findings are in accord with expectations based upon the importance of reverberation cue(s) to distance and upon previous analyses from this laboratory.

Acoustics↗
PubMed1995

The influence of visual cues on the localisation of circular auditory motion.

A relative inability of listeners to refer auditory motion properly to the front hemifield when a rapid circular trajectory is traced around them in the horizontal plane was investigated. It was hypothesised that the representations of visual space and auditory frontal space are linked in such a way that auditory cues alone are insufficient to determine the veridical path in the front hemifield when both the front and the rear hemifield receive circular auditory input in rapid sequence. Listeners discriminated the direction of a rapid apparent trajectory created by the sequential activation of various combinations of loudspeakers and light-emitting diodes spaced evenly in a circular array. The addition of visual stimuli to the front hemifield, even when lacking motional cues, improved discrimination significantly. Conversely, when the same portion of the trajectory presented to the front hemifield consisted only of visual stimuli, performance decreased markedly. Additional conditions, in which the trajectory was restricted to a 120 deg path in the frontal plane, confirmed these effects. The findings suggest that the presence of a visual cue enhances the perception of auditory directionality, even when it does not itself provide any motion information.

Adult↗
PubMed1996

Auditory stimulus detection is not suppressed during saccadic eye movements.

Auditory detection and pitch discrimination thresholds were measured during saccades and during periods of fixation. The accuracy of auditory localisation under these two conditions was also measured. These thresholds were unaffected by whether the sound was presented during a saccade or during periods of steady fixation: there is no evidence for saccadic suppression of auditory processing.

Auditory Perception↗