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At least 1,693 records · Page 94Linked to original sources
PubMed2002

Arteriovenous brain malformations: is functional MR imaging reliable for studying language reorganization in patients? Initial observations.

PURPOSE: To determine whether the blood flow abnormalities frequently associated with arteriovenous malformations (AVMs) can alter functional magnetic resonance (MR) imaging evaluation of language lateralization and whether reorganization of language function occurs in patients with brain AVMs. MATERIALS AND METHODS: Eleven patients with left-hemisphere brain AVMs and 10 age-matched control subjects were examined with 1.5-T blood oxygen level-dependent (BOLD) functional MR imaging. Verbal fluency, sentence repetition, and story listening tasks were performed. The functional MR imaging laterality index in the frontal and temporal lobes was defined as the (L - R)/(L + R) ratio, where L and R are the numbers of activated pixels in the left and right hemispheres, respectively. Statistical analyses were performed with Wilcoxon signed rank, Fisher exact, and Kruskal-Wallis tests. RESULTS: Control subjects had left-sided language dominance, although symmetric pixel counts were observed in the frontal lobes in two subjects and in the temporal lobes in one subject. Six patients had left-sided language dominance similar to that observed in control subjects. Five of these patients had AVMs outside frontal or temporal language areas, without flow abnormalities. Five patients had abnormally right-sided asymmetric indexes (below mean control subject value - 2 SDs), which suggested language reorganization (P <.05). Results of Wada examination and/or postembolization functional MR imaging performed in two of these patients showed that the abnormal laterality indexes were at least partly due to severe flow abnormalities that impaired detection of BOLD MR imaging signal intensity. CONCLUSION: These data suggest that flow abnormalities may interfere with language lateralization assessment with functional MR imaging.

Adult↗
PubMed1993

Alien hand sign in association with Alzheimer's histopathology.

A 68 year old man is described with an alien left hand, cortical myoclonus, bilateral parietal lobe dysfunction and memory impairment but preserved language skills. The clinical diagnosis was of corticobasal degeneration but at necropsy, four years after the onset of symptoms, the pathology was of Alzheimer's disease together with some scattered chromatolytic pale neurons in the cerebral cortex. The alien hand sign has not previously been described in Alzheimer's dementia and is an illustration of the clinical heterogeneity that may occur in association with Alzheimer histopathology.

Aged↗
PubMed1999

Deaf children's spelling: does it show sensitivity to phonology?

A written pictures to spelling task was given to two groups of children, 17 deaf children from signing schools (average age = 10.7) and 20 hearing children learning English as a second language (ESL, average age = 10.4). The stimuli were equally divided according to frequency, phonological regularity, and orthographic regularity. We predicted that the deaf group would not differ from the ESL group in the pattern of their responses across word classes, categorized in terms of the effect of frequency and phonological and orthographic regularity. Results showed that broadly this was the case, but more detailed analysis showed that the approach of the two groups was different. More specifically, the deaf children appeared to be sensitive to, but not aware of, phonology in their spelling, whereas the ESL group showed awareness of, as well as sensitivity to, phonology in their spelling.

Journal Article↗
PubMed2003

About the language of Hungarian discharge reports.

Concerning use of terminological systems translated to any particular language or computer assisted translation of patient records the daily medical language has to be taken into account rather than the pure academic language. The aim of this study to investigate the language of the diagnosis of the Hungarian hospital discharge reports. Word of collection of discharge diagnoses were categorised according to the language and form (normal words, abbreviations, acronyms). It was found that Latin is still a dominant, but the language is rather a mixture, where local jargon, non standardised abbreviations occur frequently. Some signs show, that discharge reports are not used primarily as a tool of communication of physicians, rather serve local administrative purposes.

Hospital Information Systems↗
PubMedDate not supplied

Asymmetrical cerebral atrophy in Alzheimer's disease.

In most Alzheimer patients brain atrophy seems to be symmetrical. Recent neuropsychological and brain imaging investigations suggest, however, that in some patients one hemisphere is more severely affected from the onset of symptoms. We have observed four Alzheimer patients with grossly asymmetrical cerebral atrophy at autopsy, in whom the topography of the most severe atrophy was consistent with the earliest clinical signs of focal brain damage. In the three patients who at onset had relevant language disorders, atrophy of the brain was more severe in the association areas surrounding the left sylvian fissure. In the fourth patient, who first complained of visuospatial troubles, the right, nondominant hemisphere was more affected. These clinical and pathological findings suggest that association areas of one hemisphere were involved quite early in the evolution of the disease, conceivably at the same time as the hippocampus and related limbic structures. In these patients, a morphometric analysis of cortical changes in homologous areas of the cortex (area 22) was carried out in order to investigate the effect of the evolution of the disease upon cortical changes. This analysis showed that the numerical densities of nerve cells and tangle-bearing neurons were lower on the more atrophied side and suggested that the severity of cortical atrophy might have affected the size, but not the density, of senile plaques.

Aged↗
PubMed1985

Audiologic evaluation in infancy and childhood.

The identification and measurement of hearing loss in infants and young children is necessary to implement appropriate medical treatment, to diagnose other conditions that may have hearing loss as an associated sign, and to implement habilitative measures that should prevent the delay of speech and language acquisition, psychosocial developmental problems and educational handicaps. Testing hearing in the 0 to 5-year-old age group is difficult but not impossible. Technological advances of the past 15 years have made reliable hearing test results rather common even with very young infants. The pediatrician is the first line of defense against the potentially serious effects of hearing loss. While the actual testing that can be done in the pediatrician's office is quite limited with the very young age group, suspicion of hearing loss is most frequently created through history and observational data. When suspicion exists, diagnostic facilities are available that can provide the instrumentation and techniques to determine the patient's auditory status.

Acoustic Impedance Tests↗
PubMed1993

Neuronal correlate of the higher-order semantic code in human prefrontal cortex in language tasks.

Recently, Posner et al. (Science, 1988, 240: 1627-1631) have shown by means of positron-emission tomography (PET) that the highest activation related to the higher-order semantic encoding in language tasks is revealed in the anterior inferior region of the left prefrontal cortex. We had a case where we explored the neuronal activity in this cerebral area in a patient with diagnostic intracerebral electrodes. Neurons of the left cortical areas 10 and 46 exhibited responses related to the processing of semantic and grammatic signs of the presented phrases. Specific responses in neuronal activity of the same cells in other higher-order language tasks, in discrimination of concrete and abstract words, and the absence of significant responses in other relatively simpler language tasks, such as object naming and lexical decision, supports the PET finding on the selective participation of this cerebral area in the higher-order semantic encoding and discovers new neuronal mechanisms of this encoding.

Adult↗
PubMed1996

Methodological issues for eliciting local signs/symptoms/illness terms associated with acute respiratory illnesses.

Acute respiratory infections (ARI) are among the principal causes of mortality of children under 5 years of age. Most deaths are due to pneumonia, which, when timely identified and properly treated, could be avoided. An effective case management scheme, based on early recognition of pneumonia and prompt antibiotic treatment, relies on early recognition of alarm signs by mothers and community health workers. For mothers to understand and act on advice from health workers, language and concepts commonly used by mothers should be utilized. The present study was carried out to compare the relative effectiveness of two different methods to elicit local terms used by mothers to refer to ARI symptoms/signs/treatments. A comparison was made among the terms elicited by a free listing of common terms mentioned by mothers in relation to ARI, and the terms they recognized when looking at a video that showed children with different ARI signs. The video was shown in a community and a clinical setting, in order to identify strengths and weaknesses of showing it in these settings. The video elicited more signs dealing with serious illness, respiratory distress and general malaise, but missed non-visual signs, such as fever, lack of appetite or pain. Also, mothers tended to be distracted by trivial signs, such as skin color. Free listing was easier to administer and elicited more non-life-threatening symptoms/signs, but mothers were more prone to drift away and mention terms not related to respiratory illness. Showing the video in the clinic elicited more medical-related terms, and was easier to show than in the community. In conclusion, choice of either of the two methods depends on the researcher's purpose. Using both methods produced a larger list of terms associated with ARI.

Academies and Institutes↗
PubMed2002

Learning disability subtypes: classification of high functioning hyperlexia.

This study examined 30 children with hyperlexic reading patterns and average intelligence to determine if established learning disability subtypes could be applied to these children with hyperlexia. Two groups emerged. One type showed language learning disorder patterns with good visual memory. This group also showed a high percentage of phonetic word errors. A second hyperlexic group showed signs of nonverbal learning disorder with visual spatial deficits and impaired visual memory. This latter subgroup showed few phonetic errors with more sight word errors. These findings suggest subtypes of high functioning hyperlexia, one showing language deficits characteristic of dysphasia and one showing patterns similar to visual spatial dyslexia.

Adolescent↗
PubMed1999

Language development in children implanted with the CLARION cochlear implant.

This study examined the development of language skills in 23 prelingually, profoundly deaf children following implantation with the CLARION Multi-Strategy Cochlear Implant. Language skills were assessed with the Reynell Developmental Language Scales (RDLS) preoperatively with hearing aids, and compared to postoperative performance after 6 months of Clarion use. The RDLS was administered in each child's preferred mode of communication, either spoken English alone or simultaneous spoken and signed English. Significant improvements were observed in average age-equivalent scores over time, both for receptive and expressive skills, although the absolute language levels of the implanted children remained delayed relative to those of hearing peers of the same chronological age. The children's rate of language growth in the first 6 months of implant use also was calculated. The results from this analysis showed that the Clarion children, on average, progressed at a rate that exceeded that of normal-hearing children of the same language age. There was no significant difference between the language performance of children who used oral versus total communication.

Aging↗
PubMed1998

Der Placebo-Effekt in biosemiotischer Sicht.

Placebo from a Biosemiotic Point of View The rise and success of modern science, first in physics, later in medicine, was based on a mechanic linear model of causality. Its only category of explanation of natural processes is the mechanical machine. As human beings using and processing signs we cannot recognize ourselves in this reductionistic model. As all living creatures we perceive, interpret and answer the stimuli of the environment. To explain the behaviour of organisms we need a semiotic-circular causality. Semiotics, the study of signs, can be subdivided in semantics, the theory of meaning of signs, in syntax, the theory of the forms and the arrangement of signs, and in pragmatics, the theory of the contextual rules of communication. Semiotics is not exclusively concerned with language, but helps as so-called biosemiotics also to explain the network of communication of a living organism. The 'Denkstil' of established pharmacology is likewise restricted to mechanistic causality. One of the consequences is the fact that theplacebo effect is defined as 'non-specific' or 'non-characteristic'. Such negative definitions exclude concrete questions of investigation. We have to accept a biosemiotic view in pharmacology, to see drugs as signs consisting of a physical vehicle equipped with meaning. The therapy with drugs must be seen in a broader treatment context investigated by pharmacopragmatics. The semiotic expansion of pharmacology does not invalidate the achievements of classic pharmacology, but elucidates in addition a view of the pragmatic components and makes the scientific integration of the placebophenomenon into drug therapy possible. The placebo effect loses its inconsistency.

Journal Article↗
PubMed2005

A retrospective journal-based case study of an infant with autism and his twin.

This report describes the development of an infant who was later diagnosed with autism, and a direct comparison of his development to that of his twin, from a prenatal period through the age of 4 years, through the examination of personal journals and medical records kept by the mother of the twins. Examination of these journals revealed several differences in development between the twins, some as early as 6 months of age. In the first year of life, the infants already differed in language development, social development, sleep patterns, and sensitivity to pain. This rare opportunity to view early autistic development gives direction to developmental theories of autism and clinically useful cues to early signs of autism.

Autistic Disorder↗
PubMed2005

Ictal vomiting in a left hemisphere language-dominant patient with left-sided temporal lobe epilepsy.

Ictal vomiting in patients with focal epilepsy has mostly been associated with an epileptogenic zone in the non-language-dominant hemisphere. Here we present the case of a left hemisphere language-dominant patient suffering from typical mesial temporal lobe epilepsy with histologically proven hippocampal sclerosis and ictal vomiting during complex partial seizures. He became seizure-free after selective left-sided amygdalohippocampectomy. This case implies that ictal vomiting may not necessitate invasive electrophysiological exploration of left hemisphere language-dominant patients with temporal lobe epilepsy if surface EEG and MRI indicate a left-sided epileptogenic zone. It thus corroborates that with concordant imaging and neurophysiological data, clinical signs become less valuable.

Adult↗
PubMedDate not supplied

Depression and anxiety among Cambodian refugee women in France and the United States.

This study reports on Cambodian refugee data related to signs symptomatic of depression and anxiety, the tendency to worry or ruminate over past events (a culture-bound syndrome called "Khoucherang"), and differences that might be influenced by social system and cultural practice. A sample consisting of 155 women of Cambodian national origin were interviewed in their homes in the USA and France. Answers to the research questions were collected by a focused interview to elicit demographic information, and the Hopkins Symptom Checklist (HSCL) in the Cambodian language to elicit depression and anxiety scores. Women residing in France (87%) were significantly more likely to show signs symptomatic of depression than women residing in the USA (65%). Women in the study reported about three times as much depression as the average American woman. Large numbers of women residing in both countries were symptomatic of anxiety (82% on average). Both groups experienced extreme symptoms of the culture-bound syndrome, "Khoucherang," and appeared to be strongly influenced by the different social systems of the two countries.

Adult↗
PubMed2003

Blood, sweat, and fears: the autonomic architecture of emotion.

The autonomic nervous system (ANS) plays a critical role in emotion, providing metabolic support for adaptive action, generating appearance changes with high signal value for conspecifics, and producing visceral sensations that shape subjective emotional experience. In this chapter, I consider several of the most important ways that the ANS is involved in emotion, including: (a) peripheral activation of emotion; (b) autonomic influences on emotional language and the labeling of subjective emotional experience; (c) positive emotion and autonomic soothing; (d) expressive signs of autonomic origin; (e) autonomic substrates of emotional contagion and empathy; and (f) autonomic consequences of emotion regulation. For each, I describe relevant research from our laboratory and discuss implications for an evolutionary account of emotion. In these and many other ways the autonomic architecture of human emotion has evolved not only to move blood and tears in the service of fears, but also to provide us with a rich set of tools that help us communicate and signal the nature of our internal emotional experiences, understand the emotions of others, calm ourselves and others, and give us some modicum of control over harmful and unproductive emotions.

Affect↗
PubMed2003

An interdisciplinary team approach to providing dysphagia treatment in the schools.

The diagnosis and treatment of pediatric dysphagia in school systems are still in the infancy stages. They are being addressed in a variety of ways and by a variety of personnel. Speech-language pathologists (SLPs) in school systems throughout the country are faced with students who exhibit the signs and symptoms of dysphagia; however, there is a lack of organized procedures for the diagnosis and treatment of dysphagia in the schools. In some cases, SLPs are asked to treat a disorder for which they have no training. In both scenarios there are concerns about the services that students are receiving as well as professional liability. The purpose of this article is to address some of the more pressing issues related to the diagnosis and treatment of dysphagia in the schools and to provide the school-based SLP with some solutions to these problems. The question to be answered is, What is the best way to address dysphagia in the schools?

Child↗
PubMed1996

Is there any intermediate stage between animal communication and language?

Animal communication and human language have fundamental differences in their structures and functions. Furthermore, there is no living species demonstrating an intermediate stage of language evolution. Thus, we have difficulty in finding characteristics attributable to a communication system which can already be considered as a starting point for linguistic evolution. However, some findings coming from neurolinguistic research give us the opportunity to suppose that varying and arranging linguistic elements can be detached from other grammatical functions. Further information in this direction comes from apes' language-teaching experiments; namely bonobos (Pan paniscus) are able to understand and produce differences in meaning by varying word arrangements. Based on these results one can suppose that an acoustic signal system, which possesses discrete units for variable use, might be very ancient and might exist independent and prior to a more advanced language state. In the natural setting, acoustic territorial marking behaviour is exposed to selection pressure to elaborate sign systems built up from discrete, variable units. In addition to the well-known territorial bird songs, some monkey species and all species of lesser apes have territorial songs fitting these criteria. The analyses of the so-called long calls in chimpanzees and bonobos make it likely that the group-living great apes preserved the ability to create syntactically different calls, which would be developed by requirements of social life. A call repertoire emerged in these species, which contained a large number of call variants at group level available for each group member via social learning. This type of animal call is different from ordinary animal communication; it shows some features of human language. It can represent an intermediate stage between animal communication and language, and communication systems similar to this one can be considered as a starting point or first stage of language evolution.

Animal Communication↗