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At least 1,693 records · Page 94Linked to original sources
PubMed2006

Pediatric anorectal impalement with bladder rupture: case report and review of the literature.

Rectal impalement involves foreign body trauma to the anus or rectum resulting in intra- or extraperitoneal rupture. Evaluation of suspected rectal impalement injury involves careful history and physical examination. Ruling out rectal perforation in patients with reported impalement is critical even if there is no evidence of trauma to the perineum. There are few reports on pediatric impalement and only 1 reported case of pediatric rectal impalement with bladder rupture. We report a rectal impalement with extraperitoneal bladder injury in a 12-year-old boy and review the literature on treatment of these injuries.

Child↗
PubMed2004

Blockade of neuronal nitric oxide synthase abolishes the toxic effects of Tx2-5, a lethal Phoneutria nigriventer spider toxin.

The primary goal of this study was to determine whether Tx2-5, a sodium channel selective toxin obtained from the venom of the spider Phoneutria nigriventer, produced penile erection by means of nitric oxide mechanism. Toxin identity was analyzed by MALDI-TOF, ES-MS and N-terminal amino acid sequencing. Pretreating mice with the non-selective nitric oxide synthase (NOS) inhibitor N(omega)-Nitro-L-arginine methyl ester hydrochloride (L-NAME) and the selective neuronal-NOS inhibitor 7-Nitroindazole (7-NI) prior to Tx2-5 i.p. (10 microg/25 g mouse) injection challenged the hypothesis above. Controls were injected with the D-isomer or DMSO or saline. Results demonstrated that L-NAME inhibited penile erections in about half the animals treated, while 7-NI completely abolished this effect. Interestingly 7-NI also abolished all the other symptoms of intoxication induced by Tx2-5, including salivation, respiratory distress and death. Tx2-5 killed all the animals of the control group and no one in the 7-NI-treated group. We conclude that (1) intraperitoneal injections of Tx2-5 induce a toxic syndrome that include penile erection, hypersalivation and death by respiratory distress or pulmonary edema; (2) pretreatment with the non-selective NOS inhibitor L-NAME reduces the penile erection and partially protects from the lethal effects of Tx2-5; (3) pretreatment with the nNOS-selective inhibitor 7-NI completely abolishes all the toxic effects of Tx2-5, including penile erection and death suggesting that nNOS is the major player in this intoxication; (4) toxins from other animals that affect sodium channels in the same way as Tx2-5 and induce similar toxic syndromes may have as a major common target, the activation of nitric oxide synthases.

Analysis of Variance↗
PubMed2004

Arteriovenous intracavernous post-traumatic fistula: clinical management and treatment by superselective embolization.

Arteriovenous intracavernous post-traumatic fistula (FAV) is a rare post-traumatic lesion for which the first choice of treatment is superselective embolization. We present a case of post-traumatic fistula in a 45-year-old patient. The patient underwent penile blood gas analysis and color Doppler ultrasonography and was treated with superselective embolization with an acrylic co-polymer. Postoperative arteriography showed obliteration of the fistula. Color Doppler ultrasonography 60 days after the procedure showed reacquired physiologic patency of the cavernous artery with normal flow parameters. The results of this case confirm superselective embolization as the reference standard treatment of FAV. We propose the use of an acrylic co-polymer as a new, effective embolizing medium.

Acrylic Resins↗
PubMed1989

Incidence, possible causes and followup of idiopathic prolonged penile erection in the newborn.

From 1974 to 1988, 4 cases of neonatal idiopathic prolonged penile erection were recorded, for an incidence of 0.15 per thousand or 1 case for 6,673 male newborns. Our first patient was case 7 described in the literature and the first observed in 1 of nonidentical twins. Followup for 2 to 8 years revealed no urogenital problems but a longer period (at least until puberty) is needed. Clinical and etiological aspects of this entity are discussed. Many of the etiological factors cited as possible causes of prolonged erection at this patient age represent only predisposing conditions for the occurrence of penile erection. Because of the spontaneous disappearance of prolonged penile erection, observation rather than surgical or medical management is advocated for the newborn. Only in selected patients should the limit of expectation, and the best time for and type of surgical intervention be established.

Cohort Studies↗