The effect of muscle relaxants on peripheral blood flow.
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We have developed a BASIC program for the Apple II microcomputer which can simulate the effect (degree of paralysis) time curve obtained following bolus intravenous administrations of pancuronium. The program is based on a combined pharmacokinetic/pharmacodynamic model and has practical application to the anaesthetist under operating room conditions. Knowing the disease state of the patient and the doses and times of administration of pancuronium the microcomputer can predict the degree of paralysis which exists at any time and so assists in the timing of the next dose of relaxant and in deciding when to effect reversal.
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22 subjects seeking psychological help for problems of insomnia were trained to use a self-administered treatment package which contained a booklet explaining the problem and outlining the training program in detail and a tape with three versions of progressive relaxation training. A follow-up study one year later indicated that 90% of the subjects had trained according to the instructions and that 82% experienced a positive effect on sleep both with respect to falling asleep, staying asleep, and consumption of sleeping pills. It was concluded that self-administered relaxation training seems a cheap, convenient, and effective means of treating insomnia.