Uptake of adenovirus by intestinal absorptive cells of the suckling rat. II. The neonatal jejunum.
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The paper deals mainly with the principles and the basic mechanisms underlying the transport processes of molecules across biological membranes. The simple diffusion of electrolytes and non-electrolytes, the chemically-facilitated diffusion and the active transport are briefly discussed. These transport mechanisms are utilized also by substances moving through the intestinal epithelium even if this tissue has a rather complex structure.
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In this review experimental data are summarized which indicate that at least four different transport mechanisms account for net movement of bile acids across the gastrointestinal tract. These are active transport and the passive mechanisms of ionic, nonionic, and micellar diffusion. Of these four, active transport and passive nonionic diffusion are quantitatively of the greatest importance. Active transport is confined to the ileum and probably plays a dominant role in the absorption of conjugated bile acids. Passive nonionic diffusion may occur at any level of the gastrointestinal tract and probably is the major mechanism for the absorption of unconjugated bile acids.
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