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At least 1,693 records · Page 94Linked to original sources
PubMedDate not supplied

Critical evaluation of a new water soluble contrast medium (Iopamidolo) in cervical myelograms.

The Authors report the preliminary results in 96 cervical myelograms performed by percutaneous subarachnoid injection at the level C1-C2 of a new water soluble contrast medium (Iopamidolo*). Compared to other water soluble contrast media Iopamidolo offers some advantages: (1) it is a time stable solution ready for immediate use; (2) it gives an ideal density for the study of the cervical spinal canal; (3) it provides high quality radiograms suitable for magnification of anatomical details which give a more accurate surgical diagnosis; (4) it is well tolerated without significant sequelae; no delayed complications were reported up to 15 months. This contrast medium gives valuable results also in myelograms performed by lumbar route.

Humans↗
PubMed1980

Intercostal nerve block: a roentgenographic anatomic study of technique and absorption in humans.

Roentgenograms of iothalamate meglumine 60% (Conray) injected bilaterally into the intercostal grooves of the ninth or tenth ribs in 30 surgical patients showed extensive spread of the contrast central and peripherally from the site of injection within 30 seconds, with almost complete absorption within 10 minutes 30 seconds. The spread was visualized in two patients for diagnosis using CT (computed tomography) following injection of iothalamate. It was also confirmed by injecting liquid latex into two corpses prior to autopsy. These findings help to explain why the peak plasma level occurs more rapidly and is higher following intercostal nerve block than from other regional nerve blocks when comparable doses are injected. Also, the study revealed that the optimal site for blocking an intercostal nerve is at the angle of the rib and that the optimal needle is one with a short bevel.

Absorption↗
PubMed1981

[In vitro effect of Iopamidol on coagulation, fibrinolysis and complement system (author's transl)].

Experiments on the effect of iopamidol on coagulation, fibrinolysis and complement system by in vitro standard tests were undertaken. No effect on thrombin time and thrombincoagulase time were found in clinically relevant concentration range. In contrast to classical triiodinated contrast media indications of inhibition of fibrin polymerization could only be found at large doses of iopamidol. No generation of fibrinolytic split products as indication of activation of fibrinolysis were found. Crossed immunoelectrophoresis at different concentrations could not detect split products of the complement protein C3.

Blood Coagulation↗
PubMedDate not supplied

Iopamidol: new preclinical and clinical data.

Iopamidol was rapidly eliminated from the central nervous system of dogs (greater than 90% in 24 hours). In rabbits, renal excretion involved tubular mechanisms at low blood levels, and predominant glomerular filtration at higher levels. Injection of iopamidol into the right atriums of rabbits produced hemodynamic effects similar to those of other contrast media, but less severe. The effect of iopamidol on peripheral vascular resistance was significantly lower than that of metrizamide. Iopamidol was found useful in clinical neuroradiology and angiography.

Adult↗
PubMed1981

[Reduction of side effects in aortofemoral angiography: low-osmolar contrast medium compared with conventional contrast medium plus local anaesthetic (author's transl)].

Ioglicinate plus lidocaine and ioxaglate were used for aortofemoral angiography in 15 patients. Side effects of the two contrast media were compared in a double blind study. Injection of ioxaglate caused significantly less vascular pain. With both contrast agents sensation of heat and increase of heart rate were equal. Unlike ioglicinate plus lidocaine ioxaglate did not induce a significant drop of blood pressure. Angiography using low osmolar contrast media causes less side effects than conventional medium plus local anesthetic.

Aged↗
PubMed1981

[Renal tubular damage after rapid intravenous contrast study with iopamidol].

Reference is made to results obtained in 53 nephropathics in the study of urinary elimination of alphaglycosidase and lysozyme before and after rapid contrastography with sodium and meglumine diatrizoate and with iopamidol. A statistically significant difference in alphaglycosidase was evident with both media, whereas no change was noted for lysozyme. As far as the evaluation of alphaglycosidase was concerned, the tubular alteration induced by each medium was the same in terms of statistical comparison of the mean differences before and after urography.

Contrast Media↗
PubMed1981

Formulation and clinical introduction of low osmolality contrast media.

Side-effects like pain or nausea are caused by contrast media of high osmolality. Therefore new compounds of low osmolality (1/3 of old Compounds) have been formulated. Clinical introduction has revealed better tolerance and very low rates of side-effects. Angiographies with Ioxaglate, Iopamidol or Metrizamide have become almost painless Procedures.

Adult↗
PubMed1981

[Experimental investigations of electrolyte metabolism of the myocardium during coronary perfusion of isolated hearts of warm blooded animals with ionic, less ionic, and non-ionic contrast media. Part 5 (author's transl)].

In the isolated guinea pig heart the extracellular metabolism of Sodium, Potassium and Calcium after coronary perfusion of ionic, less ionic and non-ionic contrast media has been examined. Under these conditions there are not significant differences of the extracellular metabolism for these electrolytes. The results are controversial to those gained in the whole-body animal. The causes are being discussed. In clinical treatment better tolerance of the patients after the application of less ionic and non-ionic contrast media was observed during laevocardiography and coronarography.

Animals↗
PubMedDate not supplied

[Comparison between ionic and non ionic contrast media in fast injection nephro-urography (author's transl)].

The authors judged the quality of the films in two groups of patients who underwent fast injection nephro-urography with iopamidol and meglumine sodium diatrizoate. The scores ascribed to the urograms obtained with the two contrast media have been compared. The ionic contrast medium got a higher score, at it allowed a better evaluation of ureters and bladder. Tolerability of the two contrast media has been evaluated.

Adult↗
PubMed1981

[The CT-scan and hypocycloidal cysternography with water soluble non ionic contrast media (metrizamide and iopamidol) in sellar and parasellar lesions (author's transl)].

A group of 30 patients with sellar or parasellar lesions were investigated by CT-scan and hypocycloidal tomography after lumbar injection of water-soluble non ionic contrast media. The combination of the 2 techniques (CT-scan and tomography) allowed very satisfactory diagnostic results and the excellent tolerance of non-ionic contrast was confirmed in this patient series.

Adolescent↗