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PubMed1983

[State of regenerative processes in the mucosa of the small intestine in celiac disease in adults (gluten enteropathy)].

Biopsies of the small intestine mucosa were studied in 60 patients among which celiac disease was diagnosed in 35 after clinico-morphological examinations and chronic enteritis in 25. Apart from histological and histochemical methods, autoradiography of biopsies with 3H-thymidine was used. The study showed that atrophy of the small intestine mucosa in celiac disease in adults was of hyperregeneratory nature which was manifested by deepening of the crypts and increased number of DNA-synthesizing enterocytes. Due to enhanced proliferation incompletely differentiated cells appear on the villae which are incapable of completely performing the functions of membrane digestion and absorption. These enterocytes are histochemically similar with crypt epithelium and, like the latter, are more stable to autolysis. Functionally, the presence on the villae of incompletely differentiated epithelium is more significant than villi atrophy. Treatment with aglutenic diet eliminates the syndrome of disturbed absorption despite persisting atrophy. The processes of cell renewal become normalized as proved by the appearance of high epithelium on the villae and decreased label index.

Adult↗
PubMed1984

[Immunogenetic findings in Crohn disease, ulcerative colitis and gluten sensitive enteropathy].

Immunogenetics explain the influence of genetic dispositions and regulation mechanisms on the defence mechanisms of organisms. In this paper the interrelationship between immunogenetic findings and Crohn's disease, ulcerative colitis and glutensensitive enteropathy are presented. The association with HLA-antigens and the complement factors Bf and C 4 are described. An increased association of HLA-antigens with Crohn's disease and ulcerative colitis have not been observed, with one exception, the association between HLA-Bw 35 (53%) and ulcerative colitis in a particular ethnic group in Israel. In contrast, there is a distinct association between the complement allotype Bf-F and Crohn's disease (68%) and ulcerative colitis (50%), compared with controls (29%). Glutensensitive enteropathy shows no increased occurrence of complement factors however there is an association with HLA-B8 (83%) DR 3 (94%) and DR 7 (61%). The phenotype description of the genes of the main histocompatibility complexes allows, amongst others, a conclusion concerning the pathogenesis and diagnosis of certain diseases. A new approach to these diseases has been introduced.

Celiac Disease↗