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PubMedDate not supplied

Changes in lactate and other ions in plaque and saliva after a fluoride rinse and subsequent sucrose administration.

The purpose of this study was to examine plaque and saliva composition after a fluoride rinse and subsequent sucrose application. Fifteen subjects accumulated plaque for 48 h, and then rinsed with a fluoride rinse based on 228 microg/g (ppm) Na2SiF6 and some received no rinse. After 60 min, upper and lower buccal molar plaque samples and 1-min saliva samples were collected. The subjects then rinsed with 10% g/g sucrose solution, and 7 and 15 min later, a second and a third set of samples were collected. Plaque fluid and clarified saliva were then recovered from these samples by centrifugation, and the remaining plaque acid extracted. The plaque fluid, centrifuged saliva, and plaque extract samples were then analyzed using micro techniques for pH, free calcium, phosphate, organic acids (plaque fluid and saliva only) and fluoride. Considering both the fluoride rinse and no-rinse groups, the most notable compositional changes in saliva 7 min after the sucrose rinse were pH -0.40 unit, free calcium 0.42 mM, lactate 5.2 mM, phosphate -1.3 mM, and fluoride 2.8 microM; while in plaque fluid, the corresponding changes were pH -1.59 unit, free calcium 1.5 mM, lactate 35 mM, phosphate -1.6 mM and fluoride -26 microM. After sucrose rinsing, undersaturation was found with respect to dicalcium phosphate dihydrate in saliva and plaque fluid and with respect to tooth enamel in some plaque fluid samples. Plaque fluid composition appeared to be strongly influenced by salivary clearance, diffusive loss of ions into the water phase of the rinse, and lower jaw pooling of the sucrose and fluoride components of the rinses. After the experimental rinse, the fluoride concentration in plaque fluid [86 +/- 22 mM (upper molar site), 162 +/- 150 mM (lower molar site)], saliva (26 +/- 18 mM), and whole plaque [99 +/- 97 microg/g (upper molar site), 197 +/- 412 microg/g (lower molar site)] was comparable to the values in previous studies using this rinse. These very high plaque fluid fluoride concentrations, compared with the 'no-rinse' samples, induced an approximately 0.3-unit increase in the plaque fluid pH 7 min after the sucrose rinse, a small decrease (approximately 20%) in lactate production and a modest increase in enamel saturation. Although these changes were all statistically significant, no correlation was found between the decrease in lactate concentration and plaque fluid fluoride, pH or whole plaque fluoride.

Acetates↗
PubMedDate not supplied

Socio-demographic features and fluoride technologies contributing to higher fluorosis scores in permanent teeth of Canadian children.

OBJECTIVE: To examine levels of fluorosis among children in two Canadian communities exposed to fluoride. BACKGROUND: One community had discontinued fluoride, the other had maintained it. Water supplies, however, were fluoridated for all the children when their esthetically important teeth were mineralized. METHODS: We examined 8,277 children to assess Thystrup-Fejerskov Index (TFI) scores. Multivariate Poisson regression models were used to identify the relationship between TFI and water fluoride status, age, gender, SES, and dietary and fluoride exposure histories (supplements, rinses, toothpaste amount, tooth brushing frequency, and tooth brushing starting age). Parent(s) completed questionnaires. RESULTS: Overall, levels of fluorosis were low to mild, with residents of the fluoridation-ended communities having marginally higher TFI scores than those of the still-fluoridated community. Females had higher TFI scores than males. Children aged 10 years or more had higher TFI scores than younger children. Consuming bottled water between birth and 6 months of age was protective. Exposure to fluoridation technologies was consistently associated with fluorosis experience. Children who began brushing with fluoride toothpaste between their first and second birthdays had higher TFI scores than those who began between their second and third birthdays, regardless of daily brushing frequency. Children who regularly used supplements had higher TFI scores than those who did not. Children with a college-educated father had higher TFI scores than those whose fathers had less education. CONCLUSIONS: Higher fluoride exposure slightly increased the likelihood that a child had a higher TFI score, especially when more fluoridation technologies were used at home.

Age Factors↗
PubMed2000

Effect in vitro acidification on plaque fluid composition with and without a NaF or a controlled-release fluoride rinse.

Plaque fluid ion concentration changes, especially fluoride, in response to the pH decrease associated with a cariogenic episode are important components of the caries process. A "controlled-release" (CR) fluoride rinse, based on the controlled release of fluoride in the presence of calcium, has been shown to form large fluoride reservoirs in resting plaque. In this study, the in vitro acid-induced release of fluoride, and other ions, was examined in 48-hour-fasted plaque fluid from subjects (n = 11) who received no rinse, or who used a 228-ppm CR or NaF fluoride rinse 1 hr before being sampled. After collection, the plaque was centrifuged to yield plaque fluid, acidified (0.1 microL of 0.5 mol/L HCl per milligram plaque), and then re-centrifuged before a second sample was obtained. Although previous studies indicated a higher plaque fluid fluoride after the new rinse relative to NaF, no statistically significant difference was observed here. Average fluoride release after acidification (average pH, 5.2) was statistically greater following the use of the CR rinse (153 micromol/L) compared with the NaF rinse (17 micromol/L). No fluoride release was seen in the no-rinse samples. The pH, free calcium, phosphate, acetate, propionate, and buffer capacity were not affected by the different amounts of fluoride deposited in the plaque. However, following acid addition, an increase in free calcium and phosphate was observed, which was also independent of the rinse. The large release of fluoride following acidification suggests that the new rinse may provide an improved cariostatic effect.

Acetates↗
PubMed1990

Water-borne fluoride and cortical bone mass: a comparison of two communities.

This study investigated the relationship between cortical bone mass in an older female population and their ingestion of fluoride from community water supplies. The study was conducted among lifelong female residents in Lordsburg (3.5 ppm fluoride) and Deming (0.7 ppm fluoride), NM. A total of 151 postmenopausal women ranging in age from 39 to 87 years took part; 69 were residents of the optimal-fluoride community, while the remaining 82 were residents of the high-fluoride community. Although bivariate analyses showed no difference in cortical bone mass between women in the two communities, with multiple regression analyses, significant predictors of bone mass (p less than 0.05) were weight, years since menopause, current estrogen supplementation, diabetes, and fluoride exposure status. Based on a model containing all of these variables, women living in the high-fluoride community had a bone mass ranging from 0.004 to 0.039 g/cm2 less than that of similar women living in the optimum-fluoride community. These results suggest that lifelong ingestion of water containing 3.5 ppm fluoride, compared with water containing 0.7 ppm fluoride, does not increase cortical bone mass in women of similar age, weight, and menopausal status. Under the conditions of this study, cortical bone mass might be reduced in a high-fluoride area.

Adult↗
PubMed1990

Nature and role of loosely bound fluoride in dental caries.

This paper discusses loosely bound fluoride and its role in dental caries and prevention. Loosely bound fluoride (abbr. by Fa) is fluoride adsorbed onto enamel mineral crystallites. Several recent studies indicate that a high total level of fluoride in enamel does not guarantee protection against caries. This leads to the conclusion that a major part of fluoride present in the solid enamel is not active in prevention. The adsorption of Fa to the mineral under acidic conditions is described. Most likely there is a dynamic equilibrium between fluoride in solution and adsorbed Fa at the crystal surface interface. When the crystallite is completely covered by adsorbed Fa, there is a maximum inhibition of dissolution. The rate of dissolution of mineral depends on pH, the actual concentrations of calcium and phosphate in the liquid in contact with the crystallites, and on the fraction of the surface covered by adsorbed fluoride. The fluoride, Fs, localized in the inner part of the crystallites is relatively unimportant. "CaF2-like" material can be formed on and in enamel depending on conditions. The in vivo-formed globular "CaF2-like" material is not pure CaF2 and releases F- ions when dissolving; these ions will also be partly adsorbed as Fa in and on enamel. Presently, the amount and importance of Fa originating from in vivo-formed "CaF2-like" material are not known. The level of fluoride, Fa, necessary for strong inhibition of enamel demineralization in vitro is estimated to correspond to a fluoride concentration, FL, in the liquid phase of 1 ppm or 50 mumol/L fluoride ions.(ABSTRACT TRUNCATED AT 250 WORDS)

Adsorption↗
PubMed1992

Distribution of fluoride in saliva and plaque fluid after a 0.048 mol/L NaF rinse.

An ultramicro method has recently been described for measurement of plaque-fluid fluoride concentration (Vogel et al., 1990a). This method was used: (1) for exploration of the variation in fluoride concentration of plaque fluid collected from the same buccal tooth sites following a 0.048 mol/L NaF (0.2%) rinse, and (2) for examination of the distribution of fluoride in plaque fluid and saliva within one hour after this rinse. Results indicated an average coefficient of variation (CV) of 31% for plaque-fluid fluoride in triplicate samples recovered simultaneously from the buccal-proximal region of two teeth after the rinse. This was similar to the CV found for plaque-fluid fluoride from the same sites after separate administrations of the rinse. A strong linear correlation was found between salivary and plaque-fluid fluoride at 30 and 60 min after rinse administration, showing that plaque-fluid fluoride is influenced by the concentration of salivary fluoride after administration of this rinse. Plaque-fluid fluoride concentrations were higher than that in saliva at baseline, 30, and 60 min. Very large inter-site and intersubject variations in plaque-fluid distribution were observed, with the central incisors showing the slowest clearance. These variations suggest that an examination of plaque-fluid fluoride from specific tooth regions may be essential for understanding the effects of fluoride on the site-specificity of caries.

Adult↗
PubMed1995

Infants' fluoride intake from drinking water alone, and from water added to formula, beverages, and food.

In infants, the majority of total ingested fluoride is obtained from water, formula and beverages prepared with water, baby foods, and dietary fluoride supplements. Few studies have investigated the distribution of fluoride intake from these sources among young children at risk for dental fluorosis. The purpose of this study was to assess estimated water fluoride intake from different sources of water among a birth cohort studied longitudinally from birth until age 9 months. Parental reports were collected at 6 weeks, 3 months, 6 months, and 9 months of age for water, formula, beverage, and other dietary intake during the preceding week. Fluoride levels of home and child-care tap and bottled water sources were determined. This report estimates daily quantities of fluoride ingested only from water--both by itself and used to reconstitute formula, beverages, and food. Daily fluoride intake from water by itself ranged to 0.43 mg, with mean intakes < 0.05 mg. Water fluoride intake from reconstitution of concentrated infant formula ranged to 1.57 mg, with mean intakes by age from 0.18 to 0.31 mg. Fluoride intake from water added to juices and other beverages ranged to 0.67 mg, with means < 0.05 mg. Estimated total daily water fluoride intake ranged to 1.73 mg fluoride, with means from 0.29 to 0.38 mg.

Beverages↗
PubMed2005

Bioavailability of fluoride in drinking water: a human experimental study.

It has been suggested that systemic fluoride absorption from drinking water may be influenced by the type of fluoride compound in the water and by water hardness. Using a human double-blind cross-over trial, we conducted this study to measure c(max), T(max), and Area Under the Curve (AUC) for plasma F concentration against time, following the ingestion of naturally fluoridated hard and soft waters, artificially fluoridated hard and soft waters, and a reference water. Mean AUC over 0 to 8 hours was 1330, 1440, 1679, 1566, and 1328 ng F.min.mL(-1) for naturally fluoridated soft, naturally fluoridated hard, artificially fluoridated soft, artificially fluoridated hard, and reference waters, respectively, with no statistically significant differences among waters for AUC, c(max), or T(max). Any differences in fluoride bioavailability between drinking waters in which fluoride is present naturally or added artificially, or the waters are hard or soft, were small compared with large within- and between-subject variations in F absorption. Abbreviations used: F, fluoride; AUC, Area under the Curve for plasma F concentration against time; AUC(0-3), Area under the Curve for plasma F concentration against time for 0 to 3 hours following water ingestion; AUC(0-8), Area under the Curve for plasma F concentration against time for 0 to 8 hours following water ingestion; c(max), maximum plasma F concentration corrected for baseline plasma F and dose (i.e., F concentration of individual waters); T(max), time of c(max).

Adult↗
PubMed1979

Enhanced anticaries action from drinking water containing 5 ppm fluoride.

Dental examinations were conducted on 1,878 adolescent schoolchildren native to seven US cities in five states, where the water was fluoride-deficient, fluoridated, or contained approximately 5 ppm of naturally occurring fluoride. Dental caries experience was considerably lower in all the communities with fluoridated water than in Boston, which had water deficient in fluoride, and ranged from 38% to 83% fewer mean DMF for the children in the regions with fluoridated water than for the children in Boston. Moreover, dental caries experience was significantly lower in Midland, Tex (5 to 7 ppm fluoride) than in each of the four cities with fluoridated water, and approximately 50% of the children in Midland had no caries. This report provides strong evidence that a much greater protection against human dental caries can result from a higher concentration of fluoride than is customarily recommended as best for prevention of caries. Fluoridating community waters to concentrations higher than 1 to 2 ppm fluoride, however, is not suggested because of the high risk of producing unesthetic enamel fluorosis.

Adolescent↗
PubMed2000

Risk of enamel fluorosis in nonfluoridated and optimally fluoridated populations: considerations for the dental professional.

BACKGROUND: Few studies have evaluated the impact of specific fluoride sources on the prevalence of enamel fluorosis in the population. The author conducted research to determine attributable risk percent estimates for mild-to-moderate enamel fluorosis in two populations of middle-school-aged children. METHODS: The author recruited two groups of children 10 to 14 years of age. One group of 429 had grown up in nonfluoridated communities; the other group of 234 had grown up in optimally fluoridated communities. Trained examiners measured enamel fluorosis using the Fluorosis Risk Index and measured early childhood fluoride exposure using a questionnaire completed by the parent. The author then calculated attributable risk percent estimates, or the proportion of cases of mild-to-moderate enamel fluorosis associated with exposure to specific early fluoride sources, based on logistic regression models. RESULTS: In the nonfluoridated study sample, sixty-five percent of the enamel fluorosis cases were attributed to fluoride supplementation under the pre-1994 protocol. An additional 34 percent were explained by the children having brushed more than once per day during the first two years of life. In the optimally fluoridated study sample, 68 percent of the enamel fluorosis cases were explained by the children using more than a pea-sized amount of toothpaste during the first year of life, 13 percent by having been inappropriately given a fluoride supplement, and 9 percent by the use of infant formula in the form of a powdered concentrate. CONCLUSIONS: Enamel fluorosis in the nonfluoridated study sample was attributed to fluoride supplementation under the pre-1994 protocol and early toothbrushing behaviors. Enamel fluorosis in the optimally fluoridated study sample was attributed to early toothbrushing behaviors, inappropriate fluoride supplementation and the use of infant formula in the form of a powdered concentrate. CLINICAL IMPLICATIONS: By advising parents about the best early use of fluoride agents, health professionals play an important role in reducing the prevalence of clinically noticeable enamel fluorosis.

Adolescent↗
PubMed2003

[Fluoride in drinking water in Cuba and its association with geological and geographical variables].

OBJECTIVE: To determine the association between different concentrations of the fluoride ion in drinking water and some geological and geographical variables in Cuba, by using a geographic information system. METHODS: From November 1998 to October 1999 we studied the fluoride concentration in the sources of drinking water for 753 Cuban localities that had at least 1 000 inhabitants. For the information analysis we utilized the MapInfo Professional version 5.5 geographic information system, using the overlaying method. The study variables were the concentration of the fluoride ion in the water sources, the geological characteristics of the area, the alignments (geological characteristics that were found together), the types of water sources, and whether an area was a plain or mountainous. The results were grouped by locality and municipality. RESULTS: In 83.1% of the localities, the water samples were collected from wells and springs, and the remaining 16.9% came from dams and rivers. Of the 753 localities studied, 675 of them (89.6%) had low or medium fluoride concentrations (under 0.7 mg/L). The eastern region of the country was the one most affected by high fluoride concentrations in the waters, followed by the central region of the country. The majority of the localities with high natural fluoride concentrations were in areas located on Cretaceous volcanic arc rocks. The presence of fluoride in the drinking waters was related to the alignments with the earth's crust, in rock complexes of volcanic-sedimentary origin and of intrusive origin and also in carbonate rocks. However, the highest fluoride concentrations generally coincided with rock complexes of volcanic-sedimentary origin and of intrusive origin. All the localities with high fluoride concentrations in the water were associated with wells. CONCLUSIONS: The fluoride concentration is low or medium in the drinking water sources for 89.6% of the Cuban localities with at least 1 000 inhabitants. Geological and geographical characteristics can help identify areas with optimal or high concentrations of the fluoride ion in the drinking water.

Cuba↗
PubMed2005

Fluoride release/uptake of glass-ionomer cements and polyacid-modified composite resins.

The aim of this study was to investigate the fluoride release and fluoride recharge behaviors of two conventional glass-ionomer cements (GICs) and two polyacid-modified composite resins (PMCRs) after exposure to mouthwash and toothpaste. Fluoride released from the materials was measured at 1st, 2nd, 3rd, 4th, 7th, 14th, 21st, and 28th days. At 28th day, the specimens were divided into three groups. Specimens in the control group were stored in deionized water. For the other two groups, the specimens were exposed to 0.05% NaF solution and fluoridated toothpaste for one month. After refluoridation, fluoride amount was measured at 30th, 31st, 32nd, 36th, 44th, 52nd, and 60th days. All materials released fluoride. The highest amount of fluoride was obtained during the first 24 hours, and there was a statistically significant difference between the amounts of fluoride released from GICs and PMCRs (p < 0.0001). After exposure to mouthwash and fluoridated toothpaste, all materials were recharged and continued releasing fluoride. While the amount of fluoride release from the materials increased after reflouridation, the increase was higher in GICs.

Cariostatic Agents↗
PubMed2000

Fluoride concentrations in bottled water.

Bottled water use and lack of adequate labeling have given rise to questions regarding fluoride intake. This study examined fluoride concentration of commercially available bottled water products, determined if significant differences existed among the products, and explored packaging date as a variable on the concentration of fluoride. The values were compared to the ADA guideline for optimally fluoridated water and the American Academy of Pediatric Dentistry recommended schedule for fluoride supplementation. Five commercial brands were chosen for the study. Three bottles of each brand, each with different batch dates, were purchased. Following calibration, six tests were conducted on each bottle using the Hach DR-100 Colorimeter System for fluoride analysis and the values were recorded. Data were analyzed using a two-tailed ANOVA and Tukey's HSD Test (p = 0.05). The results showed that significant differences in fluoride concentrations existed among the five brands. For three brands, significant differences existed between the batches. All products had fluoride concentrations that fell below the ADA accepted standards for optimally fluoridated water. Due to the significant variability in fluoride concentration between products and batches, dental providers should advise their patients that bottled water might not contain optimal levels of fluoride.

Analysis of Variance↗
PubMedDate not supplied

Fluoride varnishes and caries development in primary tooth enamel: an in vitro study.

This in vitro study evaluated the effect of fluoride varnishes on caries development in primary tooth enamel using polarized light microscopic techniques. A total of forty extracted or exfoliated primary teeth with intact, caries-free smooth surfaces underwent a fluoride-free prophylaxis and soft tissue were assigned to one of the following groups: 1) duraphat (5 percent sodium fluoride, vanish, Colgate, n=10); 2) Duraflor (5 percent sodium fluoride, Pharmascience, n = 10); 3 Cavity Shield (5 percent sodium fluoride varnish, Omni, n=10); and 4) Control (n=10). An acid-resistant coating was applied to the specimens leaving an exposed window of sound enamel (5mm x 1mm). The fluoride varnishes were applied to the primary teeth according to the manufacturer's recommendation. Following thermocycling (500 cycles, 5-50 degrees C) of the fluoride varnish-treated and control teeth, a fluoride-free pumice toothbrushing was performed to remove visible and macroscopically (dissecting microscope at 16x) detectable fluoride varnish. An acid resistant coating was reapplied where necessary, leaving the fluoride varnish treated sound enamel window exposed. Following in vitro caries formation (2.2mM Ca, 2.2mM PO4 50mM acetic acid, 0.5ppm fluoride, pH 3.90), longitudinal sections (5 per specimen) were obtained and evaluated by polarized light microscopy for mean lesion depth. Comparisons were made among treatment and control groups.

Analysis of Variance↗
PubMed2000

Use of fluoride-containing sealant on proximal surfaces.

A visible light curing sealant was developed for the prevention of caries on the smooth surfaces especially on the proximal surfaces. The sealant is mainly composed of dimethacrylate monomers. It contains a total amount of 2.28 mass% fluoride as poly(methyl methacrylate-co-methacryloyl fluoride) and sodium fluoride. The fluoride-containing sealant could be successfully applied to the proximal surfaces between the first and second primary molars by making access to the interproximal space with an orthodontic separating module. Availability of fluoride was assessed by the concentration of fluoride released into 1 ml of distilled water as a function of time from disks 5 mm in diameter and 0.2 mm in thickness. Ten microg of fluoride was measured on the first day; after 3 days the rate remained fairly constant at about 1 pg/day for a period of 28 days. The fluoride uptake and the improved acid solubility were investigated in vitro using bovine incisors. The fluoride of the control, that is enamel without sealant treatment, was not detectable. The fluoride incorporated into enamel after 37 hours application was 2,100 ppm at 2 pm from the enamel surface. The enamel solubility to acids decreased by the fluoride incorporation.

Animals↗
PubMed2005

A comparison of results of fluoride determinations by different laboratories.

With water fluoridation imminent in South Africa, the accurate determination of the fluoride content of water is important. The aim of this study was to compare the fluoride content of water reported by 9 laboratories and the laboratory at the South African Bureau of Standards (SABS). The SABS and 9 South African laboratories were asked to determine the fluoride content of five water samples. The fluoride content of the samples was in a range that could be expected in South African waters. The laboratories were requested to disclose their methods for fluoride determination. The results reported by the laboratories were compared to the results reported by the SABS laboratory. Fluoride concentrations of 0.13, 0.22 and 0.58 mg/litre were reproduced to within 0.05 mg/litre by two, six and three laboratories respectively. At the 1.1 and 1.5 mg/litre concentration no laboratory could achieve this accuracy. Four different methods for the determination of fluoride were used. At present laboratories determining fluoride concentrations are not accurate enough to ensure that the process of water fluoridation will be safe. Laboratories will have to check their procedures to ensure better results before water fluoridation can commence.

Cariostatic Agents↗
PubMed2005

Increasing the public health effectiveness of fluoridated salt.

This paper aims at assessing the public health potential of salt fluoridation schemes. There is now solid evidence which shows that the cariostatic effectiveness of universal salt fluoridation is equivalent to that of water fluoridation in both the permanent and primary dentition. In countries of continental Europe, only domestic salt is fluoridated, and its consistent use may be expected to warrant a 30% reduction of caries prevalence. However, the effectiveness in the population at large is lower because only part of the population uses the fluoridated domestic salt. Under these conditions, it must be assumed that the effectiveness is further reduced because families in low S-E strata use fluoridated salt (FS) less frequently than those in the higher S-E strata who are known to use preventive methods like toothbrushing twice a day with a fluoride dentifrice more regularly. Model calculations tend to show that in Germany, where FS has reached a market share of 60%, the overall effectiveness is 14% instead of 30%. For France with a market share of 30% of the fluoridated domestic salt, model calculations lead to an overall effectiveness of 8%. In order to obtain a substantial decline of caries in the entire population, it is important to aim for a high market share of the FS of 80%, or preferably 90%. This goal can be reached with a relatively small budget. The task of health ministries would be to promote the switch from unfluoridated salt to FS; however, such promotion is often withheld by health ministries. It is possible, through modest price increases of salt, to finance effective campaigns inducing the majority of the population to use the fluoridated variety. On a world wide scale, fluoridation of salt has established itself as an efficient public health measure. It may be particularly beneficial for developing countries because it is by far the cheapest method and it is compatible with the use of fluoridated toothpastes.

Cariostatic Agents↗
PubMed1990

[In situ fluoride uptake of initial caries lesions following application of two children's toothpastes].

Cylindrical blocks of enamel with initial caries lesions were brushed twice a day for 6 days using amine fluoride or monofluorophosphate children's toothpaste (250 ppm F-). Some of the enamel samples were left in the oral cavity for three further days after the end of the trial, during which time a fluoride-free toothpaste was used for daily oral hygiene. Half of the enamel blocks showed plaque formation during this period. The other half were kept clean. Fluoride soluble in KOH was only detected on the enamel blocks that had been brushed with amine fluoride children's toothpaste. The amount of solidly bound fluoride was significantly higher following the use of amine fluoride children's toothpaste than with monofluorophosphate children's toothpaste. The amounts of KOH-soluble fluoride and solidly bound fluoride fell again 3 days after discontinuation of fluoride application. But only the drop in the amount of KOH-soluble fluoride in demineralised tooth enamel after application of the two children's toothpastes can be explained by the differing reaction mechanisms of the two fluoride compounds.

Dental Enamel↗