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PubMed1995

Effect of neurotensin and substance P on adrenal cortex regeneration.

The influence of neurotensin (NT) and substance P (SP) on the early stage of adrenal regeneration was investigated. Neurotensin (5 and 50 micrograms/kg) and SP (10 and 100 micrograms/kg) were given to rats subjected to adrenal enucleation combined with contralateral adrenalectomy. The mitotic index was employed to assess cell growth, and plasma corticosterone was determined by a radioimmunological assay. The animals were killed 4 and 8 days after operation. Neurotensin did not evoke any significant changes either in the proliferation ratio or corticosterone production of regenerating adrenal cortex. However, it was found that SP (100 micrograms/kg) stimulated both the proliferation and steroidogenesis on the eighth day after operation.

Adrenal Cortex↗
PubMedDate not supplied

[Effect of N-acylethanolamines on adrenal cortex function].

The possibility of NAE to take part in the regulation of the function of adrenal glands was studied. It was shown that two times NAE (18:0) injection in a dose 5 mg/kg of weight increased the content of 11-hydroxysteroids in blood of intact male rats. NAE caused the raise of the blood hormone content by 4 times under the immobilization stress. It is apparent that augment of stress response under the influence of NAE in vivo is explained by the activation of hypophysis-adrenal cortex system. In vitro NAE lowered steroidogenesis by near 40%. One can suggest that this decrease is caused by membranotropic properties of NAE.

Adrenal Cortex↗
PubMedDate not supplied

[Investigation of N-acylethanolamines on adrenal cortex function].

The possibility of NAE to take part in the regulation of the function of adrenal glands was studied. It was shown that two times NAE (18:0) injection in a dose 5 mg/kg of weight increased the content of 11-hydroxysteroids in blood of intact male rats. NAE caused the raise of the blood hormone content in 4 fold under the immobilization stress. It is apparent that augment of stress response under the influence of NAE in vivo is explained by the activation of hypophysis-adrenal cortex system. In vitro NAE lowered steroidogenesis by near 40%. One can suggest that this decrease is caused by membranotropic properties of NAE.

Adrenal Cortex↗