For the good of the state.
Recent advances in biology and medicine, from the sequence of the human genome to the cloning of mammals have made many lay people profoundly uneasy about the future of humanity.
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Recent advances in biology and medicine, from the sequence of the human genome to the cloning of mammals have made many lay people profoundly uneasy about the future of humanity.
This bibliography is a resource for further information about Women and Reproductive Technologies. The references are categorized as General Information, Law and Policy Considerations, and Information about Specific Technologies. It also lists periodicals, organizations, and other bibliographies relating to this subject and is current through March 1986.
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The author reflects on the lessons of the Holocaust Memorial Museum's exhibition "Deadly Medicine: Creating the Master Race." The exhibition is about problems universal to science and medicine. Eugenics was not a crazed Hitlerian fantasy, and eugenicists were within the scientific mainstream. To the extent that American science pursues an openness and transparency that was absent from Nazi science, it may insulate itself from ethical dangers. But "Deadly Medicine" diagnoses patterns of thought that persist in science and social thinking. The exhibition reminds us that when faced with fears and anxieties similar to those that led to Auschwitz, we have scientific, historical, legal, and social precedents that can turn us toward an ethical confusion and uncertainty that is healthier than the certainty with which Nazi science proceeded down its grisly road.
Studies on a base population of mice were used to establish an index of components of litter size and a physiological model for measuring uterine capacity to be used subsequently in a selection experiment evaluating alternative methods for practicing selection to increase litter size. Heritability estimates of litter size, ovulation rate and ova success (fraction of ova resulting in fully formed pups) were .18, .33 and .15, respectively. No significant genetic or phenotypic correlation was found between overall ovulation rate and ova success. Phenotypic means and genetic variances were higher for characteristics measured on the right than on the left side of the reproductive tract. Linear and quadratic selection indexes, derived for a quadratic definition of breeding value, were compared. The linear index was predicted to be .99 as efficient as the quadratic one. Due to simplicity, the linear index (I = 1.21 x ovulation rate + 9.05 x ova success), scaled to have variance the same as litter size, was chosen for use. Ovulation rate in unilaterally ovariectomized females was .95 of that in females with both ovaries. No hypertrophy of the ipsilateral uterine horn in unilaterally ovariectomized females was found before implantation of embryos. Thus, unilateral ovariectomy appears to provide a physiological state to measure uterine capacity (as litter size) in the mouse.
A full-term female newborn calf of the Japanese black short-horn breed which was two-headed (dicephalus) and had two incomplete necks was carefully dissected. The calf was one of twins, the other being a normal male. There was no record of reproductive problems with the cow. The left and right heads were of almost the same size and shape. Each head had a nose, mouth, eyeballs, and ears. The brains were very congested. That is to say, in both the left and right brains, the longitudinal fissure was unclear, and these was narrower pattern in the cerebral gyri. The surfaces of the two brains displayed poly- or microgyria-like features. The cerebellar gyri ran longitudinally among the occipital lobes of the cerebral hemispheres. The caudal half of the cerebrum, the cerebellum and the brain stem were distorted ventrally at an angle of approximately 80 degrees. Twisting of the brain stem was observed in the right brain. The end of the medulla oblongata and a tongue-like process of the cerebellum extended through the foramen magnum of the skull into each enlarged vertebral canal (Arnold-Chiari malformation). They extended under the arch of the each 2nd cervical vertebra. The 4th ventricle was also displaced and irregularly dilated. The two necks were conjoined in the single 3rd cervical vertebra at an angle of approximately 45 degrees to each other. The one trunk was slightly distorted. The ribs revealed the presence of a left 14th extra tib. In the lumbar region, spina bifida was apparent. The pelvis was distorted asymmetrically. The tail was short. The viscera appeared as one set, but the rectum and anus were duplicated. Although the calf displayed female features, the vagina was undeveloped. The four limbs appeared normal and the joints moved freely.
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