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At least 1,675 records · Page 93Linked to original sources
PubMed1980

Serum calcitonin in patients with osteolytic and osteosclerotic metastases from mammary carcinoma.

Serum concentrations of calcitonin, calcium, phosphorus and alkaline phosphatase were measured in 19 patients with osteolytic metastases and in 8 patients with osteosclerotic metastases from mammary carcinoma. A significantly higher mean S-iCT concentration was found in patients with osteolytic metastases as compared with those with osteosclerotic. No significant difference was found in S-calcium, S-phosphorus or S-alkaline phosphatase between the two groups.

Adult↗
PubMed1989

The calcaneus in ankylosing spondylitis. A radiographic study of 43 patients.

A prospective study analysing the radiological findings of calcaneus bone in ankylosing spondylitis is presented. It includes 43 patients with a relatively low mean age (33.5 years). The morphology of their lesions correlated with disease duration. Abnormal radiological findings were observed in 63% of the patients and in 58% of the radiographs, but in only 3 of 20 normal subjects. Erosive lesions were more frequently found in early stages, whereas sclerotic and proliferative lesions were typical of advanced stages of the disease. Only one patient suffered relevant local pain. No clinico-radiological correlation could be established.

Adult↗
PubMed1985

Ophthalmological complications in the sclerosing bone dysplasias.

The sclerosing bone dysplasias are a group of rare genetic disorders in which overgrowth of the cranio-facial skeleton causes a variety of ophthalmological complications. During the past decade more than 100 South Africans with conditions in this category have been investigated and their ocular manifestations have been appraised. Sclerosteosis was diagnosed in 45 persons. In 70% of the affected adults progressive thickening of the skull led to elevation of intracranial pressure and papilloedema. Proptosis and divergent strabismus was present in 25%, while excessive lacrimation due to bone obstruction of the tear ducts was seen in 28%. Evidence of compression of cranial nerves was present in the majority of patients, but visual loss due to involvement of the second cranial nerve did not occur. Three related patients with the severe autosomal recessive form of oculodento-osseous dysplasia had visual impairment with microphthalmia, microcornea and cataracts, which had been present since birth. The severe autosomal recessive form of osteopetrosis was encountered in two infants, both of whom developed optic atrophy and became blind. The benign autosomal dominant form of osteopetrosis was diagnosed in ten persons; none had ocular involvement. Other sclerosing bone dysplasia patients with ocular involvement included two males with frontometaphyseal dysplasia and gross supra-orbital enlargement and five children with pycnodysostosis and scleral blueing.

Adult↗
PubMed1979

Bone thickening in osteoarthrosis. Observations of an osteoarthrosis-prone strain of mouse.

Estimations were made of the amount of bone (histologically) and the rate of bone formation (85Sr incorporation) in the epiphyses of the knees of osteoarthrosis-prone (STR/ORT) and normal (CBA/ORT) mice. Though the bone was significantly thicker in the STR/ORT mice, this was not the cause of the articular degeneration. Bone sclerosis and cartilage breakdown were chronologically very closely related with perhaps the cartilage changes occurring initially. In male STR/ORT mice bone formation was depressed in the cancellous bone of the epiphyses as, unlike the normal mice, it was at the same level as the compact bone of the femoral shaft. As there was no elevation of the osteoblastic activity in knee joints with developing osteoarthrosis, it would appear that bone sclerosis associated with the disease was due to decreased osteoclasis.

Animals↗
PubMed1983

A radiographic five-year follow-up of femoral neck fractures.

Forty femoral neck fractures were followed for 5 years in a prospective clinical, roentgenographic and scintimetric investigation. Thirteen cases had uncomplicated healing, 22 necrosis and five non-union. The diagnostic value of radiographic changes was analysed with reference to development of necrosis of the femoral head or non-union. Sclerosis of the femoral head, and compression and displacement of the fracture were compatible with eventual healing and clinical recovery. Subchondral fracture and collapse of the load-bearing surface, diagnostic for necrosis, were observed in only 7 of 22 cases at 1 year and as late as 3-5 years in three cases. By contrast, four out of five non-union cases were established radiographically within 1 year. Patients needing an arthroplasty after fracture of the femoral neck should be identified on clinical grounds after early radionuclide scintimetry. Waiting for radiographic documentation of necrosis in cases with pain will increase the risk for physical and social impairment associated with poor function of the hip.

Adult↗
PubMed1988

Giant cell tumor in a patient with osteopoikilosis.

A giant cell tumor developed in the distal femur of a 26-year-old man with preexisting osteopoikilosis. The authors are not aware of previous similar reports. Both conditions are rare, but a causal relationship between them remains unconfirmed.

Adult↗
PubMed1991

A case of mastocytosis involving bone.

A case of mastocytosis of the bone associated with urticaria pigmentosa was first suspected of being a generalized metastatic malignancy, for the radiographic manifestations were not connected by us with the patient's skin disease. The histologic diagnosis of systemic mastocytosis was also missed primarily, because mast cells are not visualized in the conventional hematoxylin and eosin staining of the histologic sections. Special stainings revealed mastocytosis. Irregular remodeling of the bone was also seen, which was consistent with the radiographically irregular bone structure.

Adult↗
PubMed1999

Erdheim-Chester disease: a case report.

A 42-year-old man with Erdheim-Chester disease (EC) is presented. This is the first case of this disease reported in Korea. The patient complained of knee pain and plain roentgenogram of the bilateral legs revealed diffusely increased density, coarsened trabecular pattern, and cortical thickening in the diaphysis, and metaphysis as well as epiphysis. Magnetic resonance imaging revealed that the lesions showed low signal intensity on T1-weighted images and heterogeneously low and high signal intensity on T2-weighted images. Histological examination of the biopsy specimen showed a xanthogranulomatous lesion consisting aggregations of foamy histiocytes and Touton-type giant cells. Immunohistochemical staining showed positive reaction to anti-S-100 and lysozyme in the cytoplasm of the giant cells.

Adult↗
PubMedDate not supplied

Osteosarcoma in blood relatives.

Osteosarcoma is an uncommon tumor. Family occurrence of osteosarcoma is even rarer. Four cases of osteosarcoma in two siblings and in a father and son treated at our Institute with surgery and chemotherapy are reported. These patients had no other tumors in their family history, and had negative p53 mutations in exons 5-9 by SSCP analysis. RB, CDK4, MDM2, c-myc, c-fos, and p53 gene expression, which are the major genes involved in osteosarcoma susceptibility, were studied. Our results revealed an inactive form of p53 sporadically seen in the samples, a total loss of Rb protein expression, an increased expression of Cdk4, MDM2, c-fos, and c-myc proteins which literature currently reports being the principal alterations found in osteosarcoma. These findings confirm that specific genetic alterations occur in osteosarcoma pathogenesis.

Adolescent↗