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PubMed2006

Tetanus in the elderly--An important preventable disease in Australia.

Notification trends from countries with well-established immunisation programs show increasing tetanus cases among the elderly, corresponding to seroepidemiologic data showing declining immunity with advanced age. We examined Australian trends in tetanus to review the likely value of routine funded immunisation at 65 years. Since 1993, 62% (36/58) of notifications, 44% (67/151) of hospitalisations and 83% (10/12) of deaths were in people aged over 65 years. Taking into account higher vaccine coverage at 65 years, versus the current recommended age in Australia of 50 years, we estimate that routine funded tetanus vaccine would prevent 9% more hospitalisations and 28% more deaths than the most favourable outcome from the current unfunded recommendation at 50 years. This is likely to be applicable to other industrialised countries.

Adolescent↗
PubMed1999

Effect of a home monitoring system on hospitalization and resource use for patients with heart failure.

BACKGROUND: Heart failure has a large medical and economic impact on the elderly. Past studies have shown that high-intensity multidisciplinary interventions at academic medical centers can reduce future hospitalizations. Our pilot study examined the effects of a low-intensity monitoring program on hospitalizations and cost of care for patients with heart failure treated by community physicians. METHODS: We enrolled 68 patients with heart failure (mean age 73 +/- 13 years, 53% male) monitored by 31 physicians in a multidisciplinary program of patient education, daily self-monitoring, and physician notification of abnormal weight gain, vital signs, and symptoms. Comparisons of medical claims were made between the patients who received the intervention and a control group of 86 patients matched to the intervention group on medical claims during the preceding year. RESULTS: Compared with the prior year, medical claims per year decreased in the intervention group ($8500 +/- $13,000 to $7400 +/- $11,400), whereas they increased in the control group ($9200 +/- $15,000 to $18,800 +/- $34,000, P <.05). Similar differences were observed for hospitalizations and total hospital days. The program's effectiveness was unrelated to age, sex, or type of left ventricular dysfunction. CONCLUSIONS: These findings suggest that a multidisciplinary program of patient education, monitoring, and physician notification can reduce resource use in patients with heart failure managed in a community setting.

Aged↗
PubMed1995

Newborn screening for congenital adrenal hyperplasia in New Zealand.

OBJECTIVE: To evaluate the efficacy and efficiency of newborn screening for classic congenital adrenal hyperplasia (CAH) in New Zealand. DESIGN: All infants younger than 6 weeks of age identified by newborn screening between December 1984 and December 1993 were included. RESULTS: 23 cases of classic CAH (20 salt-losers) were identified. The incidence of classic CAH was 1 in 23,344. Screening identified 3 of 9 virilized female infants whose disease had not been detected clinically. Screening alone identified all 11 male infants. Notification of cases occurred at 11 +/- 3 days of age. There was a delay in treatment of the group identified by screening alone (n = 14) until 13 days of age (range, 4 to 35 days); at that time 11 infants had hyponatremia and 10 had hyperkalemia. Symptoms of vomiting, poor feeding, and shock were common after 10 days of age (2/10, < 10 days, and 8/8, 11 to 16 days of age). CONCLUSIONS: Newborn CAH screening is the only method of identifying male infants with classic CAH without a family history of CAH before symptoms develop, as well as a significant portion of overlooked virilized female infants. So that clinical or significant biochemical deterioration can be avoided, pediatrician notification of screening results and treatment should be started before 10 days of age.

Adrenal Hyperplasia, Congenital↗
PubMed1996

AIDS dementia complex in the Italian National AIDS Registry: temporal trends (1987-93) and differential incidence according to mode of transmission of HIV-1 infection.

OBJECTIVES: To investigate the occurrence of AIDS dementia complex (ADC) in Italy and its incidence over time, examining possible correlations between this condition and some demographic and immunological variables. DESIGN: Inception cohort. Data collected from the case notification forms of the Italian National AIDS Registry. SUBJECTS: 16813 consecutive AIDS cases reported to the National AIDS Registry from August 1, 1987 through October 31, 1993 were included. STATISTICAL METHODS: All data refer to the time of AIDS diagnosis as reported on the case notification forms. Main analyses of the monthly proportion of ADC cases were by multiple logistic regression. RESULTS: 1364 subjects (8.1%) were reported with a diagnosis of ADC as the first AIDS defining disease, either as the only manifestation or associated with other AIDS defining conditions. At the time of AIDS diagnosis, the observed ADC/AIDS proportion was significantly higher among intravenous drug users (IVDU), 9.1%, compared to heterosexuals, 6.3%, and homo-bisexual men, 5.2%. Simple logistic regression analysis showed a significant (p < 0.0001) quadratic trend in the monthly ADC/AIDS proportion, peaking in March 1990 and decreasing thereafter. Multiple logistic regression, adjusting for month of diagnosis, showed that IVDUs have consistently the highest risk and homo-bisexual men the lowest, although differences tended to decrease with increasing age. Older age, in fact, was highly associated with an increased risk, especially within the homo-bisexual and heterosexual transmission categories. CD4 + cells counts proved to have no significant effect on the risk of progressing to AIDS with ADC rather than with any other AIDS indicative disease. CONCLUSIONS: ADC is a relatively frequent manifestation at diagnosis of AIDS among Italian patients, and particularly in IVDUs. Differences in its occurrence were found according to time of diagnosis, transmission category and age.

AIDS Dementia Complex↗
PubMed1992

Estimating the chance of an inadequately immunised child getting pertussis.

Before informed advice can be given to parents and health care workers about the need for pertussis immunisation, an estimate of the risk of inadequately immunised children contracting pertussis is needed. The study reported here was conducted because the literature contains no such estimates of risk. Analysis was made of a county's Notification of Disease Reports. Computation was carried out of age-specific annual notification rates of pertussis amongst adequately and inadequately immunised children. It was found that inadequately immunised one-year-old children probably have more than a one in six chance of developing pertussis before age ten.

Child↗
PubMed1992

The problems of monitoring tuberculosis in an inner-city health district: integrated information is required.

This paper discusses the difficulties in monitoring tuberculosis in an inner-city district health authority. Tuberculosis incidence was reviewed between 1981 and 1989 using several data sources: statutory notifications, hospital activity analysis, death certificates and chest clinic records. The overall notification rate declined but remained higher than national rates; the age-sex distribution was similar to national studies. However, interpretation was limited by the problems of small numbers, the difficulty in obtaining reliable numerator and denominator estimates of ethnic groups, the limited data available about sub-groups of concern such as the homeless, and finally by the incompleteness of the data. Improved methods of data linkage are required to facilitate more complete ascertainment and validation of the diagnosis.

Adolescent↗
PubMedDate not supplied

Tuberculosis in health care workers in Malawi.

Although sub-Saharan Africa has the highest rates of tuberculosis (TB) and human immunodeficiency virus (HIV) infection in the world, the rates of TB amongst its health care workers (HCWs) are poorly documented. We therefore conducted a country-wide investigation. All district/government and mission hospitals in Malawi that diagnose and care for TB patients were visited in order to obtain information on hospital-based HCWs and their incidence of TB in 1996. Hospital TB case loads, country-wide TB notification numbers and national population estimates for 1996 were obtained, which enabled TB case notification rates to be calculated. In 1996, 108 (3.6%) of 3042 HCWs from 40 hospitals were registered and treated for TB: 22 with smear-positive pulmonary TB (PTB), 40 with smear-negative PTB and 46 with extrapulmonary TB. The overall case fatality rate was 24%. Compared with the adult general population aged > or = 15 years, the relative risk [95% confidence interval (CI)] in HCWs of all types of TB was 11.9 [9.8-14.4], of smear-positive PTB 5.9 [3.9-9.0], of smear-negative PTB 13.0 [9.5-17.7] and of extrapulmonary TB 18.4 [13.8-24.6], P < 0.05. The 1996 hospital TB case load ranged from 29 to 915: there were no cases of TB in HCWs in hospitals whose case load was < or = 100 patients, while the TB case rate among HCWs was similar in hospitals with annual case loads of 101-300 or > 300. The annual risk of TB was high among all categories of HCW, especially clinical officers. This study shows a high rate of TB in HCWs in Malawi, and emphasizes the need for practical and affordable control measures for the protection of HCWs from TB in low-income countries.

Adolescent↗
PubMed1999

Emerging technology for vehicular safety and emergency response to roadway crashes.

Emerging technology for vehicular safety and emergency response to roadway crashes is the topic of this article. Reduction in emergency medical services system notification time, improvements in vehicular safety, crash avoidance and protection, post-crash injury control, triage, national automatic crash notification systems, and technologic improvements in emergency diagnostics and treatment during the past year are discussed.

Accidents, Traffic↗
PubMed2000

Algal growth inhibition: effect of the choice of growth rate or biomass as endpoint on the classification and labelling of new substances notified in the EU.

From the complete base set notifications of new substances currently available, we have investigated what effects the choice of using growth rate or biomass in the algal growth inhibition test has on the relative sensitivity of the three aquatic toxicity tests. Both parameters derived from the algal test were more sensitive than either fish or Daphnia tests. Changes in the classification of substances after the removal of either algae, Daphnia or fish data from the base set, when applying current legal practice, occur in 22.9%, 6.6% and 4.8% of the notifications, respectively. When always using growth rate as a parameter, these numbers change to 15.4%, 9.2% and 7.2%, respectively.

Animals↗
PubMed1976

Tuberculosis in the Potteries 1971-74.

Notification rates of all forms of tuberculosis have increased in all age-groups in the Potteries, in a stable population which includes only a small immigrant community. The increase is greatest in both males and females over the age of 65 years and under 15 years. High notification rates have been recorded in workers in the pottery and mining industries and were unrelated to pneumoconiosis. Discrepancies have been found between the numbers of notified cases and the numbers of laboratory isolates of tubercle bacilli, particularly in cases of non-respiratory disease. This indicates that not all proven cases of tuberculosis are notified. The study has revealed serious deficiencies in the contact-tracing procedure in certain areas of the Potteries consequent upon the closure and reorganisation of outlying chest clinics.

Adolescent↗
PubMed1997

Assessment of worldwide tuberculosis control. WHO Global Surveillance and Monitoring Project.

BACKGROUND: Because worldwide tuberculosis (TB) control had never been assessed, WHO set up a surveillance and monitoring project in 1995. The objectives were to assess the performance of national TB programmes; to assess the extent of implementation of the WHO strategy of TB control; and to attempt a comparison between regions that had adopted the WHO strategy and those that had not. METHODS: In June, 1996, we sent data-collection forms requesting information on national TB programmes' control policies, 1995 case notifications, and 1994 treatment results to 216 countries, areas, and territories. We assessed the performance of national TB programmes by comparing case notifications with estimated incidence and by outcome of treatment in cohorts of patients. We also investigated worldwide treatment success and case detection among sputum-smear-positive patients. FINDINGS: 180 (83%) of the 216 countries, areas, and territories surveyed replied to WHO (98% of the worldwide population). In 1995, the WHO control strategy had been implemented in 75 countries, and in 39 of these implementation was countrywide. UP to 23% of the worldwide population lived in regions where the strategy was available. In 1995, 3 297 688 cases of TB (all types) were reported, of which 1161411 (35%) were sputum-smear positive. 54% of all reported cases in countries that used the WHO strategy were sputum-smear positive, compared with 30% in other countries. The worldwide case-detection rate of new sputum-smear-positive cases was 35%. 92% of cases registered for treatment in 1994 in regions that used WHO strategy were assessed for outcome and 76% were treated successfully, compared with 54% and 42%, respectively, in regions that had not implemented the WHO strategy. Among cases reported worldwide in 1994, the documented treatment-success rate was 43%. INTERPRETATION: National TB programmes that have adopted the WHO TB control strategy achieve higher cure rates, but their impact on TB is modest on a worldwide scale. Wider continuous coverage with the WHO strategy is needed for effective worldwide TB control.

Communicable Disease Control↗
PubMed1999

Late diagnosis of congenital dislocation of the hip and presence of a screening programme: South Australian population-based study.

BACKGROUND: The Medical Research Council Working Party on Congenital Dislocation of the Hip have reported an ascertainment-adjusted incidence of a first operative procedure for congenital dislocation of the hip (CDH) of 0.78 per 1000 livebirths, which is similar to the incidence of CDH before the start of the UK screening programme. The report showed that CDH had not been detected by routine screening before age 3 months in 70% of children reported to the national orthopaedic surveillance scheme. This report raised concerns about the merit of screening at birth for CDH. We aimed to find out the incidence of an operative procedure for CDH in the first 5 years of life among children born in South Australia between 1988 and 1993, and the proportion of these patients that were detected at age 3 months or older. METHODS: The state's database for inpatient separations between January, 1988, and April, 1998 was searched. Case records were examined for the age and circumstances of diagnosis, and type of operative procedures. Prevalence rates of CDH were obtained from the South Australian Birth Defects Register, which receives notifications from a statutory perinatal data collection of birth defects detected at birth and subsequent voluntary notifications for children up to age 5 years. FINDINGS: Of the 55 children born in South Australia between 1988 and 1993 identified as having non-teratological CDH and operative procedures, only 22 (40%) had been diagnosed at age 3 months or older. 18 had an open reduction of the hip joint or osteotomy, or both, and the remainder had arthrograms, closed reductions, and/or tenotomy. The prevalence of non-teratological CDH in children was 7.74 per 1000 livebirths. The incidence of surgery for CDH in the first 5 years of life was 0.46 per 1000 livebirths (95% CI 0.34-0.59) and only 0.19 per 1000 livebirths (0.11-0.26) for those diagnosed late (age 3 months or older). These children diagnosed late represented 2.4% of all known cases of CDH. INTERPRETATION: Only 2.4% of known cases of CDH in children born in South Australia had been detected late and required surgery. These results show that a screening programme for CDH can be successful, contrary to the findings of the UK Medical Research Council Working Party.

Child, Preschool↗
PubMed2003

Nine years after child sexual abuse.

OBJECTIVE: During 1988-1990, 103 children presented to Child Protection Units (CPU) at two children's hospitals in Sydney, Australia. Nine years later, the psychological adjustment of these young people (mean age=19.1 years, SD=3.4 years; range=14-25 years) was compared with that of non-abused young people of similar age and gender to assess group differences and examine potential risk factors. METHOD: At intake, data on the nature of the index sexual abuse, demographics and the family environment were collected by clinicians. A comparison group, of similar age and gender, was selected from schools in the catchment area of the CPUs. Six years after presentation for the abuse, records of the statutory child protection authority were checked to determine any further notifications for abuse and/or neglect. Nine years after intake, 49 of the abused young people and 68 of the non-abused young people and/or their parents were interviewed and assessed. RESULTS: The sexually abused young people performed more poorly than non-abused young people on psychometric tests of depression (p=.001), self-esteem (p<.001), anxiety (p<.001), behavior (Child Behavior Checklist: p=.01; Youth Self Report: p=.01; Young Adult Self Report: p<.001), and despair (p=.001). They were also more likely to have a history of bingeing (p=.002), self-inducing vomiting (p=.02), smoking cigarettes (p=.01), and using amphetamines (p=.002), ecstasy (p=.002) and cocaine (p=.004). Potential risk factors were in two groups, family and child. Family factors: family functioning, parental drug/alcohol problems, mother's sexual abuse history, mother's depression and socio-economic status. Child factors: despair and hopefulness, number of negative life events, ratings of their father's care, previous notifications for child sexual abuse and placements in out-of-home care by the statutory child protection authority. In the presence of other risk factors, child sexual abuse was a significant predictor of self-esteem, behavior and bingeing. CONCLUSIONS: Rather than focusing only on the individual's child sexual abuse, treatment may also need to address the family's functioning and the individual's feelings of despair.

Adaptation, Psychological↗
PubMed1985

The incidence of bacterial meningitis in the Netherlands--a comparison of three registration systems, 1977-1982.

Data on the incidence of bacterial meningitis (BM) in the Netherlands are important for a cost-benefit analysis of new effective vaccines. During the period 1977-1982 we compared the notifications of meningococcal meningitis, diagnoses on discharge from hospital of all causes of BM (Stichting Medische Registratie, Medical Registration Foundation; SMR) and bacteriological data (Netherlands Reference Laboratory for Bacterial Meningitis; RBM). Notifications of meningococcal meningitis were 42% lower than SMR-data. RBM-registration of meningococcal, haemophilus and pneumococcal meningitis was 20% lower than SMR. Reviewing patient-records we found that these diseases had not been reported in 16% (RBM) and 11% (SMR) of cases. We estimate the incidence of BM during an endemic period at 8.0 per 100 000 population per year, to which the meningococcus contributes 20-25%. In children under 5 years of age the age-specific incidence of haemophilus meningitis is 22/100 000.

Adolescent↗
PubMed2000

Substantial equivalence of antinutrients and inherent plant toxins in genetically modified novel foods.

For a safety evaluation of foodstuff derived from genetically modified crops, the concept of the substantial equivalence of modified organisms with their parental lines is used following an environmental safety evaluation. To assess the potential pleiotropic effect of genetic modifications on constituents of modified crops data from US and EC documents were investigated with regard to inherent plant toxins and antinutrients. Analysed were documents of rape (glucosinolates, phytate), maize (phytate), tomato (tomatine, solanine, chaconine, lectins, oxalate), potato (solanine, chaconine, protease-inhibitors, phenols) and soybean (protease-inhibitors, lectins, isoflavones, phytate). In several documents used for notifications no declarations even on essential inherent plant toxins and antinutrients could be found, for instance data on phytate in modified maize were provided only in one of four documents. Significant variations in the contents of these compounds in parental and modified plants especially due to environmental influences were observed: drought stress, for example, was made responsible for significantly increased glucosinolate levels of up to 72.6micromol/g meal in modified and parental rape plants in field trials compared to recommended standard concentrations of less than 30micromol/g. Taking into account these wide natural variations generally the concentrations of inherent plant toxins and antinutrients in modified products were in the range of the concentrations in parental organisms. The results presented indicate that the concept of the substantial equivalence is useful for the risk assessment of genetically modified organisms (GMOs) used for novel foods but possible environmental influences on constituents of modified crops need more attention. Consistent guidelines, specifying data of relevant compounds which have to be provided for notification documents of specific organisms have to be established. Because of the importance of inherent plant toxins and antinutrients on nutritional safety, also coherent databases of standard parental lines and clear criteria for mandatory declarations are necessary.

Crops, Agricultural↗
PubMed2003

Mortality trend from sporadic Creutzfeldt-Jakob disease (CJD) in Italy, 1993-2000.

The objective was to identify any possible cases of variant Creutzfeldt-Jakob disease (CJD) in Italy, and to estimate the trends in mortality from sporadic CJD for 1993-2000. CJD cases were ascertained through direct notification to the Registry; 382 definite or probable sporadic CJD patients, but no cases of variant CJD were identified. The average yearly mortality rate was 1.04 cases per million inhabitants, with an increase in deaths in the 60-69 and > or =70 year age groups. Survival was shorter in male respect to female and in patients with an age at onset > or =65 years. CJD cases were uneven distributed among different regions in the period 1993-1995, but not herein after. The rise in mortality from sporadic CJD in Italy likely reflects increased awareness and better diagnosis during the years. However, continuous notification and postmortem examination of all suspected cases are recommended for optimal surveillance.

Adult↗
PubMed2005

[Epidemiology of tuberculosis in France].

Tuberculosis remains one of the leading cause of death from infectious disease in the world. Tuberculosis control is one of the Word Health Organisation priority. One third of the population was estimated to be bacillus tuberculosis carrier responsible for 8 million of new tuberculosis cases occurring each year and nearly 2 million deaths. In Europe near 400,000 cases have been declared in 2001 with a west-east gradient in the incidence rate: 11 cases for 100,000 in west european countries, 41 per 100,000 in central european countries and 92 per 100,000 in east european countries. The number of tuberculosis cases decreased in France with an average annual decline of 7.5% between 1972 and 1988. This trend discontinued in 1989. Between 1991 and 1993 the number of reported tuberculosis increased. This excess of cases is attributable partly to HIV infection, but also to worsening in socio-economic conditions. From 1993 to 1997 the number of cases decreases again and the incidence rate is about 11 p. 100,000 and remains stable. In 2002, 6322 cases have been declared in France. There are important geographic differences. The Ile de France region has the highest incidence rate: 27.1 per 100,000. The rates of the other regions are much lower. The infection risk is different according to age, sex and nationality. People over 75 are one of the most affected age group. Children under 15 years of age represent 4.3% of cases with half of these cases before 5 years of age. As in adult, incidence rate of tuberculosis is 11 fold higher in migrants children than in french children. Less than 10 cases of tuberculous meningitis are reported annually under 15 years of age. Since 2003, mandatory notification includes tuberculous infection for children under 15 years of age. Data recorded in mandatory notification might be useful to improve tuberculosis control in France.

AIDS-Related Opportunistic Infections↗
PubMed1994

The political history of syphilis and its application to the AIDS epidemic.

The history of syphilis control from the mid-19th century through the present time is a strong argument for the need to enhance the public health efforts to find cases of human immunodeficiency virus (HIV) infection and to notify the partners of infected individuals. To do this, public policy must be changed to allow better case-finding (mandatory testing) and partner notification (mandatory reporting). The history of syphilis is such that one person in 22 was infected in this country in 1918. If we are to use this history to control the current HIV epidemic, control measures used for syphilis (before penicillin) are needed; these are equal attention to education, available health care, case-finding, and partner notification.

AIDS Serodiagnosis↗