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PubMed1968

Drug-induced coma.

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Alcoholic Intoxication↗
PubMed1985

Different effects of psychotropic drugs on delayed hypersensitivity responses in mice.

The influence of certain psychotropic drugs on the delayed-type hypersensitivity (DTH) response to sheep red blood cells in BALB/c mice was studied. The effects on the overall response and the induction and elicitation phases were evaluated, using two alternative dosage schedules for each agent. It was found that diazepam had no effect on the DTH reaction but the administration of imipramine, haloperidol, chlorpromazine or meprobramate all resulted in depression of the response, impairing both the induction or elicitation phases. The results indicate that psychotropic drugs may produce in vivo depression of cell-mediated immunity by different mechanisms.

Animals↗
PubMedDate not supplied

[Value of electroencephalographic serveillance in the framework of resuscitation in coma caused by acute drug intoxication].

The authors carried out long-term clinical and E.E.G. studies on 100 cases of acute drug poisoning. They made the following conclusions: - in unexplained coma, the E.E.G. can indicate toxic aetiology and may sometimes even suggest which drug is responsible, especially for certain chemical groups (barbiturates, phenothiasines, benzodiazepines); - the E.E.G. picture contributes a valuable indication of the depth of coma; the way in which it evolves affects the prognosis; - the effectiveness of therapy may be judged by monitoring cerebral electrical activity.

Acute Disease↗
PubMed1982

[EEG in the prognosis of toxic coma: reflections apropos of unusual data].

During acute intoxications, the first EEG may show persistence or abolition of cerebral activity, but the possibility of recovery after isoelectric tracing in toxic comas must be emphasized. EEG patterns frequently suggest the probability of hypnotic tranquilizer poisoning; 4 types of EEG are encountered corresponding to different grades of toxic coma. Recurrent periods of electrical silence alternating with bursts of activity are habitually recorded in carus comas with hypothermia due to acute barbiturate intoxication, with good prognosis. The possibility of a neurological disturbance associated with drug overdose must be raised whenever an asymmetric tracing is encountered. Serial recordings may detect complications such as: a localized lesion, anoxia or, very rarely, typical paroxysmal abnormalities reappearing in comitial patients before emergence from a toxic coma. Paradoxical monomorphic delta activity corresponding to improvement must not be considered as an aggravation. Peculiar EEG findings occur after oral trichlorethylene poisoning, with temporary clinical deterioration and intermittent periods of electrical silence; recovery is possible. An alpha-like pattern after cardiac arrest of toxic origin has a poor prognosis. The appearance of alternating patterns suggests the development of irreversible brain damage.

Alpha Rhythm↗
PubMed1983

[Topographic aspects of drug-induced fast rhythms in quantitative topo-electroencephalography].

The topographical aspects of fast rhythms induced by different psychotropic drugs have been studied in patients by means of a previously described method. This method is based on the spectral analysis of 28 EEG channels over both cerebral hemispheres. The spectral parameters, computed over 2 min 40 sec, are put into a data base. The clinician can then decide which of these parameters will be extracted from the data base and then displayed by means of maps on a graphic terminal. Those maps are useful for immediate comparison not only of the fast rhythms' characteristic values but also of those from other spectral bands. As quantitative EEG analysis is more and more frequently used in psychotropic drug studies, a good knowledge of the topography of the rhythms induced by these drugs will help in the selection of the most useful derivations.

Adult↗