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PubMed2001

Comparative study of two series of distally based fasciocutaneous flaps for coverage of the lower one-fourth of the leg, the ankle, and the foot.

Skin defects over the lower one-fourth of the leg and over the foot are difficult to cover. Two types of pedicled fasciocutaneous flaps used to cover such defects were studied: the lateral supramalleolar flap and the distally based sural neurocutaneous flap. The series consisted of 27 and 36 cases, respectively. The lateral supramalleolar flap was used 27 times: for skin defects over the ankle (4), foot (16), and leg (7). The distally based sural neurocutaneous flap was used 42 times: over the foot (24), ankle (13), and leg (5). Fourteen of these patients were 65 years of age or older, and local vascularity was diminished in 16 cases. The flaps were evaluated clinically twice: in the immediate postoperative period for survival or for partial or total flap necrosis, and again to determine the presence of pain at the donor or recipient sites and the cosmetic appearance. Thirty-nine patients (62 percent) were reviewed subsequently, with a mean follow-up of 5 years for the supramalleolar flap and 2 years for the sural neurocutaneous flap. The results were evaluated for the presence or absence of pain, the appearance of the flap, the disability due to the insensate nature of the flap, and the presence or absence of secondary ulceration. Painful neuromata were noted in three cases with the sural neurocutaneous flap, whereas complete necrosis of the supramalleolar artery flap occurred in three patients. The distally based sural neurocutaneous island flap is very reliable, even in debilitated patients. Though the lateral supramalleolar artery flap offers the possibility of covering the same areas as the sural neurocutaneous flap, it is much less reliable in the presence of diminished local vascularity (18.5 percent failure rate as compared with 4.8 percent for the sural neurocutaneous flap). Because the procedure can cover extensive defects and is easy to perform, the distally based sural neurocutaneous flap was the method of choice for covering skin defects over the foot, heel, ankle, and the lower one-fourth of the leg. The lateral supramalleolar artery flap is indicated only when the sural neurocutaneous flap is contraindicated.

Adolescent↗
PubMed1990

Diurnal changes in straight leg raising.

Diurnal changes in straight leg raising were measured in 28 patients with criteria of lower lumbar disc protrusion, having first established an acceptable intra-observer repeatability using an oil-filled precision goniometer. Eight patients showed little change between the straight leg raising after a night of recumbancy, and after 180 minutes in the upright posture. Twenty patients, however, had 10 or more degrees of improvement in straight leg raising, with a mean improvement of 16.9 degrees (SD 7.1 degrees); most of the increase occurred in the first hour of being upright. The measurement returned again to the base level after 120 minutes of further recumbancy. Five of the eight patients who showed little diurnal change had discectomy, and four had a complete annular tear. Only one of the 20 patients with more than 10 degrees of diurnal change required surgery. Diurnal change in straight leg raising is probably related to the disc's proteoglycan content, its hydration, the tension of the protrusion and the presence of intact peripheral annular fibers.

Circadian Rhythm↗
PubMed1993

The effect of imposed leg length difference on pelvic bone symmetry.

This study was designed to examine the effect of varying degrees of imposed leg length difference on symmetry of the innominate bones in healthy college women with relatively equal leg lengths. Subjects' leg length was determined by clinical and roentgenographic procedures. Position of the innominate bones with and without lifts under one foot was measured with respect to the transverse plane using the Waterloo Spatial Motion and Recording Technique (WATSMART; Northern Digital, Inc., Waterloo, Ontario, Canada), which allows very high spatial resolution. Our results show that posterior innominate bone rotation occurs on the side of the lengthened limb, and anterior rotation occurs on the shorter limb. The amount of pelvic obliquity increased in an approximately linear fashion as the leg length difference was increased from 2/8 to 7/8 inch. Some individual differences were evident.

Adult↗
PubMed2003

Correction of leg-length discrepancy after hip transposition.

Four patients were treated with limb lengthening to correct a leg-length discrepancy that developed after a hip transposition after pelvic resection for sacroma of the pelvis. Three patients had Ewing's sacroma and one patient had osteosarcoma. All patients received chemotherapy; radiotherapy also was administered to the three patients with Ewing's sacroma. Femur lengthening was started at an average of 5.7 years (range, 4.4-6.8 years) after tumor surgery. At the start of elongation, the average age of the patients was 17.3 years (range, 10.3-20.8 years). The average leg-length discrepancy was 10.3 cm (range, 6-12 cm). The average of achieved lengthening was 6.4 cm (range 6-7.5 cm). The average healing index was 32 days (range, 27-40 days) per 1-cm elongation. According to the classification of Paley, two problems and two minor complications were treated by additional interventions. At the final followup, the average functional score was 22 (73%) according to the system of the Musculoskeletal Tumor Society. Leg-length discrepancy after hip transposition can be corrected with distraction osteogenesis. All patients who wore a stiff ankle-foot orthosis before lengthening wore an ordinary shoe lift after lengthening. The problems of the lengthening procedure are similar to the general complication rate of bone lengthening. Because the 5-year survival after resection of a pelvic sarcoma is only 20% to 30%, leg lengthening after hip transposition should be offered only to long-term survivors with at least 5 years event-free survival.

Adolescent↗
PubMed2003

Changes in nerve root motion and intraradicular blood flow during an intraoperative straight-leg-raising test.

STUDY DESIGN: An intraoperative straight-leg-raising (SLR) test was conducted to investigate patients with lumbar disc herniation to observe the changes in intraradicular blood flow, which then were compared with the clinical features. OBJECTIVE: The legs of each patient were hung down from the operating table as a reverse SLR test during surgery, and intraradicular blood flow was measured. SUMMARY OF BACKGROUND DATA: It is not known whether intraradicular blood flow changes during the SLR test in patients with lumbar disc herniation. METHODS: The subjects were 12 patients with lumbar disc herniation who underwent microdiscectomy. The patients were asked to adopt the prone position immediately before surgery, so that their legs hung down from the operating table. A reverse SLR test was performed to confirm the angle at which sciatica developed. During the operation, the nerve roots affected by the hernia were observed under a microscope. Then the needle sensor of a laser Doppler flow meter was inserted into each nerve root immediately above the hernia. The patient's legs were allowed to hang down to the angle at which sciatica had occurred, and the change in intraradicular blood flow was measured. After removal of the hernia, a similar procedure was repeated, and intraradicular blood flow was measured again. RESULTS: Intraoperative microscopy showed that the hernia was adherent to the dura mater of the nerve roots in all patients. The intraoperative reverse SLR test showed that the hernia compressed the nerve roots, and that there was marked disturbance of gliding, which was reduced to only a few millimeters. During the test, intraradicular blood flow showed a sharp decrease at the angle that produced sciatica, which lasted for 1 minute. Intraradicular flow decreased by 40% to 98% (average, 70.6% +/- 20.5%) in the L5 nerve root, and by 41% to 96% (average, 72.0% +/- 22.9%) in the S1 nerve roots relative to the blood flow before the test. At 1 minute after completion of the test, intraradicular blood flow returned to the value obtained at baseline. After removal of the hernia, all thepatients showed smooth gliding of the nerve roots during the second intraoperative test, and there was no marked decrease in intraradicular blood flow. CONCLUSIONS: This study demonstrated that the blood flow in the nerve root is reduced when the nerve root is compressed in vivo.

Adult↗
PubMed2006

Intrinsic factors associated with exercise-related leg pain in collegiate cross-country runners.

OBJECTIVES: This study (1) examined the occurrence of exercise-related leg pain (ERLP) in collegiate cross-country athletes and (2) compared structural factors in runners with and without ERLP history. STUDY DESIGN: Cross-sectional design comparing 2 groups of cross-country athletes (with and without ERLP history). SETTING: Intercollegiate athletics. PARTICIPANTS: A total of 63 athletes (30 males, 33 females) representing 2 cross-country teams consented to participate. MEASURES: Athlete examination included self-report of ERLP history, active ankle dorsiflexion with knee extended and flexed, navicular drop (ND), and 1st ray length. ND index was calculated by dividing ND by 1st ray length. Athletes on 1 team (n = 32) were followed through 1 season to identify incidence of ERLP over the course of 1 season. Independent t tests were used to compare structural measures of those with and without ERLP history, and chi2 was used to examine frequencies. RESULTS: Of the 63 athletes, 33 (52%) reported ERLP history; most reported medial leg pain and also bilateral symptoms. No differences in structural measures were found between those with and without ERLP history. Ten of 32 athletes (31%) reported the occurrence of ERLP during the fall season, 8 of whom had a history of ERLP. CONCLUSIONS: Exercise-related leg pain was a common complaint among these athletes, usually occurring bilaterally and located along the medial leg. Athletes with ERLP history did not have a greater foot pronation as measured by ND, nor was there limited ankle range of motion as compared with those without ERLP history. Further research is needed to identify factors associated with the development of ERLP.

Adolescent↗
PubMed2005

The medial adiposofascial flap of the leg: anatomical basis and clinical applications.

Despite recent advances in microsurgical techniques, coverage of lower leg defects by locoregional flaps remains indicated in selected cases. The interest in these types of flaps has improved because recent clinical work advocates that fascial and fasciocutaneous flaps can be well indicated for bone coverage. The anatomical study of the medial adiposofascial flap is presented in this article. The flap is based on the rich vascular network supplied by the saphenous artery and the posterior tibial artery perforators. This flap can be harvested on the anteromedial aspect of the leg and can be mobilized to cover defects located between the patella and the heel. This multiple blood supply makes it possible to harvest this flap in various ways, so various defects can be covered. To confirm and prove the versatility and clinical value of this flap, the authors have studied a series of 22 cases in which this flap was used for coverage of lower leg defects. For these defects, especially when situated in the lower third or around the heel and ankle, coverage by a free flap is most often the only proposed solution. However, the authors have obtained excellent results in the majority of these cases, avoiding a free flap procedure. Moreover, in this way, the option of using a free flap remains possible if needed. There is minimal donor-site morbidity and a high functional and aesthetic outcome, making this flap a first-choice flap in selected cases of lower leg defects.

Adult↗
PubMed2005

Bone exposure in the leg: is a free muscle flap mandatory?

BACKGROUND: In lower leg defects with bone, hardware, or articular exposure, a free tissue transfer is often the only valuable option. However, in well-selected clinical cases, pedicled flaps are still indicated because they provide an alternative for the more demanding and risky microsurgical procedure. The medial adipose-fascial flap of the leg represents an ideal local regional fascial flap. METHODS: Twenty-two medial adipose-fascial flaps (performed in 21 patients) were reviewed retrospectively and compared with a series of 22 free gracilis flaps (22 patients) selected out of 150 muscular free flaps for lower leg reconstruction. All patients with defects larger than 40 cm, peripheral vascular disease, deep defects, and osteomyelitis were excluded in order to obtain the same surgical indications in which the local medial adipose-fascial flap could have been used. RESULTS: The overall surgical results were comparable, but more medical complications, a longer operative time, and a longer hospital stay were seen in the free muscle group. Moreover, patients reconstructed with a medial adipose-fascial flap appeared to be more satisfied with the aesthetic result of their reconstruction. CONCLUSIONS: Muscle coverage is not mandatory to cover bone in the lower leg. The medial adipose-fascial flap can provide a good alternative for free flap coverage. This flap seems to have fewer medical complications, requires a shorter operative time and hospital stay, and can provide better aesthetic results than a free muscle flap.

Adult↗
PubMed2006

Augmentation of the lower leg: a new combined calf-tibial implant.

BACKGROUND: The underdeveloped lower leg can be a source of embarrassment. Underdevelopment or atrophy may be associated with asymmetry, congenital deformity (tibial torsion, pes planus, genu valgus), traumatic nerve damage, or disease (polio). In some people, muscular development simply fails to respond to exercise. Augmentation of the calves with subfascial silicone implants has been practiced for 25 years and is a reliable procedure. The implant is placed through a transverse popliteal incision in a plane dissected between the gastrocnemius fascia and muscle. One or both heads of the gastrocnemius are augmented-a larger size is usually used medially. When the lower portion of the leg is also thin, and especially when there is tibial torsion, augmentation of the calf alone may exaggerate the deformity. METHODS: A new one-piece combined medial calf-medial leg implant has been developed and used in 15 patients (n = 30 implants). RESULTS: Augmentation/correction has met with complete patient approval (except for one patient who wished to have a larger size). CONCLUSION: A new and effective implant to correct various deformities or lack of development of the lower leg is presented.

Adult↗
PubMed2004

Amorphous silicon, flat-panel, x-ray detector: reliability of digital image fusion regarding angle and distance measurements in long-leg radiography.

RATIONALE AND OBJECTIVES: To evaluate composed long-leg images acquired with a large-area, flat-panel x-ray detector with regard to angle and distance measurements. METHODS: Radiographs of a long-leg phantom were acquired at 13 different angle settings with a 43-cm x 43-cm digital x-ray detector based on cesium iodide (CsI) and amorphous silicon (a-Si) technology. Three overlapping single images of the phantom were reconstructed at a workstation using a generalized correlation method. Four blinded observers were instructed to determine the angle of the axis of the long-legs as well as the length of "femur" and "tibia" on soft-copy displays. For that, the angle and distance measurement software integrated in the workstation was used. The images were analyzed with and without prior manual fine tuning of the primary composition result according to a mapped scale. Standard of reference was angle and distance determination at the phantom. RESULTS: On average, the difference between the observers' angle measurements and the standard of reference was 0.4 degrees for both images with and without prior manual correction. Regarding distance measurements, the average discrepancies to the standard were 0.2 cm (femur) and 0.1 cm (tibia) when analyzing images that had undergone manual fine tuning and 0.5 cm and 0.7 cm, respectively, for images without manual correction. CONCLUSIONS: The evaluated image fusion algorithm in conjunction with a 43-cm x 43-cm flat-panel detector is feasible regarding angle and distance measurements on long-leg images. In the case of inaccurate primary composition, results can be corrected easily by manual fine tuning.

Algorithms↗
PubMed1991

The value of serial leg measurements for monitoring deep vein thrombosis in spinal cord injury.

Deep vein thrombosis (DVT) is a common complication of spinal cord injury (SCI). Many specialized SCI nursing units use serial leg measurements to establish clinical diagnosis of DVT, in spite of extensive studies showing that clinical signs and symptoms of DVT have a specificity and sensitivity hardly better than chance. For 30 patients who spent 920 days in an SCI intensive care unit, we collected daily serial calf and thigh measurements and the results of radiofibrinogen uptake test (RFUT) performed about every third day. Three criteria for clinical diagnosis of DVT found in the literature were used: an increase from baseline, an increase from the previous day or a right-left difference of a specific minimal size. The cut-off points for minimal size used were also those suggested by the literature: over .5 inch, over 1 cm, or 1.2 cm and over for women, 1.5 cm and over for men. We found such changes or differences correlated weakly or not at all with RFUT results, and symptomatic increases or differences occurred very frequently. Major factors presumably underlying the variability of measurements and their lack of sensitivity and specificity are: premorbid leg asymmetry; atrophy of the legs after SCI; true changes in circumference due to factors other than DVT; and lack of measurement reliability. It was concluded taking serial leg measurements is of no value in the SCI population. For those reluctant to abandon tradition, suggestions are provided for improving the quality of measurements and related decision making. Further research is needed.

Adolescent↗
PubMed1993

Leg elevation and wrapping in the prevention of hypotension following spinal anaesthesia for elective caesarean section.

Ninety-seven parturients undergoing elective Caesarean section were allocated randomly to have their legs elevated to approximately 30 degrees on pillows or elevated and wrapped with elasticated Esmarch bandages or neither (controls) following spinal anaesthesia. All patients received intravenous crystalloid (20 ml.kg-1 over 20 min) prior to spinal injection and were placed in the left lateral tilt position. Significant hypotension was treated with intravenous ephedrine in 5 mg bolus doses. Leg wrapping resulted in a significant reduction in the incidence of postspinal hypotension in comparison to the control group (18% compared to 53%, p = 0.004). This represents a five-fold reduction in the likelihood of postspinal hypotension (odds ratio 5.3, 95% CI 1.7-16.3). Leg elevation alone did not significantly reduce the incidence of hypotension (39%). There was no significant difference in the time of onset of hypotension between the groups. For those patients requiring ephedrine, there was no significant difference in mean dose requirements between the groups. The use of leg compression immediately postspinal provides a simple means of reducing the accompanying hypotension and should be used more widely.

Adult↗
PubMed1993

Capillary underperfusion in chronic venous insufficiency: a cause for leg ulceration?

Dermal capillaries in the goiter area of the lower leg were examined by video-microscopy before and after the administration of intravenous fluorescein in 13 patients with chronic venous insufficiency (CVI) who were at risk of developing leg ulceration, and in 13 normal controls. The influence of posture on capillary perfusion was determined by viewing the same area of skin with the leg in both the supine and dependent positions. Capillary density was lower in patients than in controls, irrespective of the position of the leg (P < 0.01). Fluorescence angiography studies in normal controls showed a reduction in capillary density with dependency (P < 0.01), but patients with CVI showed no significant change. Fluorescence angiography revealed a greater number of capillaries than seen during native capillaroscopy (P < 0.05). The decreased capillary density, and the loss of the postural vasoconstrictor reflex in patients with chronic venous incompetence may play a role in the pathogenesis of ulceration.

Adult↗
PubMed2005

Mast cell tryptase and chymase in chronic leg ulcers: chymase is potentially destructive to epithelium and is controlled by proteinase inhibitors.

BACKGROUND: Numerous mast cells are present in chronic leg ulcers. Tryptase and chymase are the major mediators of mast cells, but their significance is mostly dependent on their activity. In addition, the proteinases may affect ulcer epithelialization. OBJECTIVES: To study levels and activity of tryptase and chymase in wash samples and biopsies from chronic leg ulcers and the possible effect of these proteinases on keratinocyte growth and adherence. METHODS: Wash samples were taken from 16 patients and a superficial shave biopsy was taken in eight of these patients; a second biopsy series was obtained from the edge of chronic venous leg ulcers (n = 6). RESULTS: Significant levels of soluble tryptase activity and histamine, but low levels of chymase activity, were measured in wash samples from chronic ulcers. No tryptase-inhibiting activity, but clear chymase-inhibiting activity, was detected in the wash samples. In superficial wound bed biopsies, relatively marked levels of chymase activity together with histamine and tryptase activity were detected. In the second biopsy series, about 80% of the mast cells belonged to the MC(TC) type (tryptase- and chymase-immunopositive). However, about 55-61% of the chymase-immunopositive cells displayed chymase activity and 64 +/- 17% of the tryptase-positive cells revealed immunoreactivity of alpha(1)-antichymotrypsin. As the activity of chymase and tryptase was detected in the ulcer base in a ratio of 1:8, a preparation containing both chymase and tryptase was partially purified from human skin yielding a similar activity ratio of 1:11-13. Treatment of fibronectin-coated plastic surfaces with this preparation decreased the adherence of cultured human keratinocytes, this effect being attributable mainly to chymase. In 2-day cultures using growth factor/serum-deficient low- or high-calcium medium, the tryptase-chymase preparation inhibited the slow growth and at higher concentrations it even induced detachment of keratinocytes. This effect was attributed to chymase, and it was partially regulated by heparin and histamine. CONCLUSIONS: Even though chymase is partially inactivated in chronic leg ulcers, accumulated mast cells in the close proximity of the epithelium edge and their chymase may impair keratinocyte adherence and migration.

Adult↗
PubMed2006

Leg ulcer in a patient associated with hydroxyurea therapy.

Hydroxyurea is a hydroxylated derivate of urea commonly used in the treatment of various hematologic disorders. Cutaneous side-effects such as alopecia, diffuse hyperpigmentation, scaling, poikiloderma, atrophy of the skin and subcutaneous tissues or nail changes can develop after long-term treatment with hydroxyurea. Painful leg ulcers in association with hydroxyurea have only rarely been reported. We present a report of a 52-year-old patient with essential thrombocythemia suffering from painful leg ulcers 3 years after starting therapy with hydroxyurea. We decided to treat the leg ulcers following a modern phase-adapted wound-healing strategy and continued hydroxyurea therapy until complete healing of the ulcers. In conclusion, cutaneous ulceration of the leg is one adverse effect in patients with essential thrombocythemia during hydroxyurea therapy. Healing does not necessarily require discontinuation of the drug. Therefore, therapists should first optimize a conservative and systematic wound-healing strategy. If these interventions fail, discontinuation of hydroxyurea therapy is advisable.

Alginates↗
PubMed1991

Cell line segregation in a 45,X/46,XY mosaic child with asymmetric leg growth.

Clinical evaluation of a 13 1/2-year-old male revealed a 4.4-cm leg length discrepancy and a small penis with a normal endocrine evaluation. Cytogenetic analysis of peripheral blood lymphocytes and skin fibroblasts derived from the back showed 45,X/46,XY mosaicism with similar percentages of 45,X cells, 36% and 30% respectively. However, two separate skin fibroblast cultures derived from the thigh and calf of the short (right) leg showed significant lack of Y-bearing cells with 100% and 80% 45,X, respectively. In contrast, skin biopsies of the thigh and calf of the normal (left) leg both showed 100% 46,XY. Similar evidence for differences in the percentages of Y-bearing cells in the left versus right leg fibroblast cultures was obtained using densitometric scanning of dot blots following DNA hybridization with a Y-specific probe at the DYZ4 locus. Asymmetric limb growth in cases of X/XY lymphocyte mosaicism warrants further cytogenetic investigation to substantiate possible genotype-phenotype correlations which may help uncover the fundamental growth deficiency in Turner syndrome.

Adolescent↗
PubMed2004

Graduated compression stockings (20-30 mmHg) do not compress leg veins in the standing position.

BACKGROUND: Since graduated compression stockings (GCS) reduce the risk of deep venous thrombosis (DVT) in both hospital and ambulant patients, we checked the compressive efficiency of 20-30 mmHg GCS in the standing position. METHODS: In 30 volunteers (17 normal legs, 13 varicose legs), duplex ultrasound was used to measure the internal diameters of the long saphenous vein, posterior tibial veins, peroneal veins, and soleal veins in the lying and standing position and with and without 20-30 mmHg GCS. RESULTS: Graduated compression stockings effectively compressed both superficial and deep veins in supine individuals but not the superficial or the deep veins when standing. In the varicose leg, the stockings did not compress the long saphenous vein at the mid-calf level even when supine. In the varicose leg the long saphenous vein was constricted at the upper band of the stocking, which might explain why superficial venous thrombosis is more common when compression stockings are worn. CONCLUSIONS: In the standing position, GCS did not compress the deep or superficial veins of the calf.

Bandages↗
PubMed2004

Epidemiology of restless legs in The Netherlands.

The prevalence of restless legs syndrome (RLS) in various regions in the world has been estimated between 2.5 and 29%. For The Netherlands these figures are not known. Our observational and cross-sectional study was performed to estimate the prevalence of RLS in The Netherlands. A cross-sectional survey by postal questionnaire was carried out through a general practice in a small town in which one general practice serves 93% of the population. All men and women aged 50 years and older were invited to fill out the questionnaire on leg movements, quality of sleep and daytime symptoms. A total of 1485 (88.2%) persons returned their questionnaire and 1437 (85.4%) patients answered the questions on leg movements. A total of 102 (7.1%) inhabitants answered positively to the questions on leg movements and probably have RLS. The prevalence was higher in women and increased with age. People who complain of RLS have significantly more complaints of disturbances in initiating and maintaining sleep, sleepiness, tiredness during the day and less refreshing sleep. RLS is common in The Netherlands with an estimated prevalence of 7.1% in the population over 50 years of age.

Adult↗