Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Inversion”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,675 records · Page 93Linked to original sources
PubMed2000

Inverse association of soy product intake with serum androgen and estrogen concentrations in Japanese men.

The cross-sectional relationships of soy product intake and serum testosterone, estrone, estradiol, sex hormone-binding globulin, and dihydrotestosterone were examined in 69 Japanese men. Soy product intake was estimated from a semiquantitative food frequency questionnaire. Serum estradiol concentration was significantly inversely correlated with soy product intake (r = -0.32, p = 0.009), and serum estrone concentration was nonsignificantly inversely correlated with soy product intake (r = -0.24, p = 0.05) after controlling for age, body mass index, smoking status, and ethanol intake. Total and free testosterone concentrations were inversely correlated with soy product intake after controlling for the covariates, but these correlations were of border line significance (r = -0.25, p = 0.05 and r = -0.25, p = 0.06, respectively). Similar correlations were observed for these hormones with isoflavone intake from soy products. The data suggest that soy product intake may be associated with the endogenous hormone levels in Japanese men.

Aged↗
PubMed2003

Corepressor excess shifts the two-side chain vitamin D analog Gemini from an agonist to an inverse agonist of the vitamin D receptor.

The vitamin D receptor (VDR) is an endocrine nuclear receptor that binds with high affinity its natural ligand 1alpha,25-dihydroxyvitamin D3. Gemini is a 1alpha,25-dihydroxyvitamin D3 analog with two identical side chains that, despite its significantly increased volume, binds to the VDR and can function as a potent agonist. This study demonstrates that, at excess corepressor (CoR) levels, Gemini shifts from an agonist to an inverse agonist that actively recruits CoR proteins to the VDR and mediates superrepression. Under these conditions Gemini stabilizes the VDR into a silent conformation, in which helix 12 of the ligand-binding domain is repositioned and thus unable to contribute to coactivator interaction. Amino acid F422 has been described as the lock of helix 12 and seems to be the most critical VDR residue in the inverse agonistic action of Gemini. Molecular dynamics simulations of the Gemini-VDR complex support these observation by indicating that the second side chain of Gemini induces tension to the receptor structure that can be released by a shift of helix 12. Taken together, Gemini is the first described (conditional) inverse agonist to an endocrine nuclear receptor and may function as a sensor for the cell-specific coactivator/CoR ratio.

Animals↗
PubMed2001

AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor.

The central melanocortin (MC) system has been demonstrated to act downstream of leptin in the regulation of body weight. The system comprises alpha-MSH, which acts as agonist, and agouti-related protein (AgRP), which acts as antagonist at the MC3 and MC4 receptors (MC3R and MC4R). This property suggests that MCR activity is tightly regulated and that opposing signals are integrated at the receptor level. We here propose another level of regulation within the melanocortin system by showing that the human (h) MC4R displays constitutive activity in vitro as assayed by adenylyl cyclase (AC) activity. Furthermore, human AgRP(83-132) acts as an inverse agonist for the hMC4R since it was able to suppress constitutive activity of the hMC4R both in intact B16/G4F melanoma cells and membrane preparations. The effect of AgRP(83-132) on the hMC4R was blocked by the MC4R ligand SHU9119. Also the hMC3R and the mouse(m)MC5R were shown to be constitutively active. AgRP(83-132) acted as an inverse agonist on the hMC3R but not on the mMC5R. Thus, AgRP is able to regulate MCR activity independently of alpha-MSH. These findings form a basis to further investigate the relevance of constitutive activity of the MC4R and of inverse agonism of AgRP for the regulation of body weight.

Adenylyl Cyclases↗
PubMed2001

A comparison of (18)F-dopa PET and inversion recovery MRI in the diagnosis of Parkinson's disease.

OBJECTIVE: To quantify structural changes in the substantia nigra of patients with PD with inversion recovery MRI and to compare these with striatal dopaminergic function measured with (18)F-dopa PET. METHODS: The authors studied 10 patients with PD and eight age-matched control subjects with a combination of MR sequences previously reported to be sensitive to nigral cell loss. Striatal regions of interest were defined on T1-weighted MRI coregistered to (18)F-dopa PET in all subjects. RESULTS: Discriminant function analysis of the quantified MR nigral signal correctly classified 83% of the combined PD patient/control group; three of 10 PD cases were incorrectly classified as "normal" (Wilks' lambda = 0.724, p > 0.05). Discriminant function analysis correctly classified 100% of PD patients and control subjects with (18)F-dopa PET based on mean caudate and putamen K(i) values (Wilks' lambda = 0.065, p < 0.001). Correlations between mean putamen K(i) and rostral and caudal nigral MR signal changes and mean caudate K(i) and caudal nigral MR signal changes were found (r = -0.76, -0.69, -0.80, p < 0.05). CONCLUSION: (18)F-dopa PET is more reliable than inversion recovery MRI in discriminating patients with moderately severe PD from normal subjects. However, the structural changes detected within the substantia nigra of patients with PD found using inversion recovery MRI correlate with measures of striatal dopaminergic function using (18)F-dopa PET.

Brain↗
PubMed1981

Inverse solution in electrocardiography: determining epicardial from body surface maps by using the finite element method.

A new method of determining epicardial potentials from body surface maps is presented. Epicardial potentials can be estimated via the forward transfer matrix computed by using the finite element method. Due to smoothing and decrease in value in potential distribution of the body surface, the inverse problem involved becomes, in nature, ill-conditioned and direct application of the usual inversion technique will give an extremely oscillatory solution. Therefore, in order to obtain a practically meaningful solution, an appropriate regularizing procedure must be developed and, in the present paper, an effective regularization based on the generalized inverse matrix is proposed and its usefulness is demonstrated. Numerical experiments suggest that if the epicardial map includes high components of spatial frequency the inverted epicardial map will have poor resolution. This is especially true at the epicardial surface distant from the body surface, such as on the diaphragmatic side of the ventricle. If the epicardial maps have to be inverted over the entire region of the epicardium with a clinically allowable accuracy, about 180 body surface lead points and 3 significant figures in the measurements of body surface potentials will be needed.

Computers↗
PubMed1997

Narrative inversion: the biblical heritage of The well of loneliness and Desert of the heart.

The Bible acts as an epistemological anchor for the English Bildungsroman; however, the biblical narratives are themselves in flux, especially with regard to representations of spiritual development gendered feminine. The extent to which one can consider the traveling/travailling mother a spiritually coherent figure who exists independent of male spiritual authority seems only possible insofar as one adopts the position of the perverse reader, who envisions the envelopment of her stories as narrative inversion. To do so is to believe that accounts of female heroism need not narratively depend on those of male heroism. The term narrative inversion in turn allows the perverse reader to recognize a narrative desire that, because it does not conform to but indeed suggests an alternative narrative possibility for the homosocial plot, remains enfolded within the plot. Inhabiting precisely this paradox of narrative inversion are the lesbian heroines who follow in the Bible's wake.

Bible↗
PubMed2002

Effects of polydispersity of chainlike aggregates on light-scattering properties and data inversion.

A systematic evaluation of the effects of polydispersity of chainlike aggregates in terms of primary particle number density and size on the scattering quantities and data inversion is presented. For aggregates with refractive index in the range absolute value(m-1) = 0.8-1.2, average size parameter x < 0.40, and primary particle number Np < 20, it is shown that the effects of polydispersity of primary particle size on the light-scattering quantities are much stronger than the polydispersity of the number of primary particles per aggregate. For aggregates with polydisperse primary particle size, the assumption of monodispersity tends to underestimate the real and imaginary parts of the refractive index and the number of primary particles. Specifically, for values of the distribution width sigma greater than 0.10, the effect of polydispersity of the size of primary particles must be considered in the data inversion schemes. Furthermore, in the same range of values for the refractive index, particle size parameter, and primary particle number, the assumption of monodispersity for aggregates with polydisperse particle number tends to underestimate the value of the real part of the refractive index and overestimate the value of the imaginary part of the refractive index and primary particle size. However, for values of the distribution width sigma less than 0.60, the effects of polydispersity of primary particle number can be neglected. In addition, the suitable pairing sets of the measured scattering quantities for data inversion are presented and discussed.

Journal Article↗
PubMed2004

Inversion of multiwavelength Raman lidar data for retrieval of bimodal aerosol size distribution.

We report on the feasibility of deriving microphysical parameters of bimodal particle size distributions from Mie-Raman lidar based on a triple Nd:YAG laser. Such an instrument provides backscatter coefficients at 355, 532, and 1064 nm and extinction coefficients at 355 and 532 nm. The inversion method employed is Tikhonov's inversion with regularization. Special attention has been paid to extend the particle size range for which this inversion scheme works to approximately 10 microm, which makes this algorithm applicable to large particles, e.g., investigations concerning the hygroscopic growth of aerosols. Simulations showed that surface area, volume concentration, and effective radius are derived to an accuracy of approximately 50% for a variety of bimodal particle size distributions. For particle size distributions with an effective radius of < 1 microm the real part of the complex refractive index was retrieved to an accuracy of +/- 0.05, the imaginary part was retrieved to 50% uncertainty. Simulations dealing with a mode-dependent complex refractive index showed that an average complex refractive index is derived that lies between the values for the two individual modes. Thus it becomes possible to investigate external mixtures of particle size distributions, which, for example, might be present along continental rims along which anthropogenic pollution mixes with marine aerosols. Measurement cases obtained from the Institute for Tropospheric Research six-wavelength aerosol lidar observations during the Indian Ocean Experiment were used to test the capabilities of the algorithm for experimental data sets. A benchmark test was attempted for the case representing anthropogenic aerosols between a broken cloud deck. A strong contribution of particle volume in the coarse mode of the particle size distribution was found.

Journal Article↗
PubMed2004

Effects of noise on lidar data inversion with the backward algorithm.

The lidar data-inversion algorithm widely known as the Klett method (and its more elaborate variants) has long been used to invert elastic-lidar data obtained from atmospheric sounding systems. The Klett backward algorithm has also been shown to be robust in the face of uncertainties concerning the boundary condition. Nevertheless electrical noise at the photoreceiver output unavoidably has an impact on the data-inversion process, and describing in an explicit way how it affects retrieval of the atmospheric optical coefficients can contribute to improvement in inversion quality. We examine formally the way noise disturbs backscatter-coefficient retrievals done with the Klett backward algorithm, derive a mathematical expression for the retrieved backscatter coefficient in the presence of noise affecting the signal, and assess the noise impact and suggest ways to limit it.

Journal Article↗
PubMed2005

Inclusion of a priori information in an analytic eigenfunction inversion of Mie extinction measurements.

The analytic eigenfunction inversion technique to retrieve aerosol columnar size distributions from Mie extinction measurements has been extended to include a priori information, specifically surface area. The earlier (standard) and new (subtracted) techniques are compared by use of synthetic data that cover typical aerosol size distributions. Two different measurement wavelength ranges are considered. It is shown that the most appropriate inversion technique depends on the particle sizes, with the standard technique being more appropriate for small particles and the subtracted being more appropriate for large particles. Also presented is a simple method to determine whether a particular inversion technique is likely to produce meaningful results with a particular data set.

Journal Article↗
PubMed2000

Inverse source problem and minimum-energy sources.

We present a new linear inversion formalism for the scalar inverse source problem in three-dimensional and one-dimensional (1D) spaces, from which a number of previously unknown results on minimum-energy (ME) sources and their fields readily follow. ME sources, of specified support, are shown to obey a homogeneous Helmholtz equation in the interior of that support. As a consequence of that result, the fields produced by ME sources are shown to obey an iterated homogeneous Helmholtz equation. By solving the latter equation, we arrive at a new Green-function representation of the field produced by a ME source. It is also shown that any square-integrable (L2), compactly supported source that possesses a continuous normal derivative on the boundary of its support must possess a nonradiating (NR) component. A procedure based on our results on the inverse source problem and ME sources is described to uniquely decompose an L2 source of specified support and its field into the sum of a radiating and a NR part. The general theory that is developed is illustrated for the special cases of a homogeneous source in 1D space and a spherically symmetric source.

Computers↗
PubMed2000

Second-order iterative approach to inverse scattering: numerical results

We introduce an iterative algorithm for the reconstruction of dielectric profile functions from scattered field data, in which each step corresponds to the solution of a quadratic inversion problem. This means that, at each iteration, we perform a second-order approximation of the scattering operator connecting the unknown profile to the data about a reference profile function. This procedure is then compared with a linear iterative inversion algorithm, and it is pointed out that, within a prescribed class of profile functions, the linear iterative inversion does not converge to the actual solution, whereas the proposed approach does. This feature can be explained by reference not only to the improved approximation provided by the addition of a further term for profile functions of a larger norm but also to the different classes of functions that can be reconstructed by either the linear or the quadratic model. Numerical examples of profile reconstruction in the scalar two-dimensional geometry, with far-zone scattered field data at a fixed frequency, confirm the theoretical analysis.

Journal Article↗
PubMed2001

Degree of nonlinearity and a new solution procedure in scalar two-dimensional inverse scattering problems.

Within the framework of inverse scattering problems, the quantifying of the degree of nonlinearity of the problem at hand provides an interesting possibility for evaluating the validity range of the Born series and for quantifying the difficulty of both forward and inverse problems. With reference to the two-dimensional scalar problem, new tools are proposed that allow the determination of the degree of nonlinearity in scattering problems when the maximum value, dimensions, and spatial-frequency content of the unknown permittivity are changed at the same time. As such, the proposed tools make it possible to identify useful guidelines for the solution of both forward and inverse problems and suggest an effective solution procedure for the latter. Numerical examples are reported to confirm the usefulness of the tools introduced and of the procedure proposed.

Journal Article↗
PubMed2004

Application of evolution strategies for the solution of an inverse problem in near-field optics.

We introduce an inversion procedure for the characterization of a nanostructure from near-field intensity data. The method proposed is based on heuristic arguments and makes use of evolution strategies for the solution of the inverse problem as a nonlinear constrained-optimization problem. By means of some examples we illustrate the performance of our inversion method. We also discuss its possibilities and potential applications.

Journal Article↗
PubMed2006

Inverse scattering and diffraction tomography in cylindrical background media.

A recently developed inverse scattering method based on the distorted-wave Born approximation (DWBA) that applies to objects embedded in known background media [Inverse Probl.19, 855 (2003);20, 1307 (2004)] is implemented for the special case of circularly symmetric scatterers embedded in circularly symmetric backgrounds. The newly developed scheme is applied in a computer-simulation study of optical diffraction tomography (ODT), and the results are compared and contrasted with reconstructions obtained using the filtered backpropagation algorithm (FBP algorithm). Unlike the DWBA-based inversion algorithm, the FBP algorithm does not take into account multiple scattering within the known background, and it is found that the newly implemented scheme yields reconstructions much superior to those obtained using the FBP algorithm. The research reported applies to a number of important applications that include ultrasound nondestructive evaluation testing of cylinders for defects as well as ODT.

Journal Article↗
PubMed2005

Joint inversion of multi-modal spectroscopic data of wheat flours.

The application of calibration and prediction (CAP) to joint measurements of near-infrared (NIR) and Raman spectra for the same reference data requires the development of joint inversion methodologies for the implementation of the calibration step. Joint inversion has been successfully utilized in geophysical prospecting and in medical diagnosis, where the need to perform CAP is not involved. However, the obvious ways in which joint inversion might be implemented in spectroscopy, where some form of CAP must be performed, do not appear to work. Here, a new methodology, leap-frog calibration and prediction (LF-CAP), is proposed. It allows naturally for the information in the joint NIR and Raman spectra to yield a quite robust predictor of the property of interest. This new procedure is examined in some detail. The major limitation of CAP, as a strategy for recovering information from indirect measurements, is that it is a one-step process, in that the calibration step can only be applied once. If multiple independent spectral data are available for the same reference data, then the leap-frog implementation of CAP turns the recovery of information into an iterative process that converges under a wide range of circumstances.

Algorithms↗
PubMed1992

Giant T-wave inversion in patients with acute coronary insufficiency.

We have observed an electrocardiographic (ECG) pattern of deep T-wave or "giant T wave" inversion in patients with acute coronary insufficiency. We reviewed the ECGs of 936 patients admitted to our coronary care unit during a one-year period. We found the pattern of giant T-wave inversion was present in nine patients (1 percent). We examined the echocardiograms of all of these patients and we analyzed the coronary angiograms on the seven patients in whom it was performed. We found that giant T-wave inversion was usually found in patients with stenosis in the left coronary system. In addition, the majority of these patients also had echocardiographic evidence of left ventricular hypertrophy. We conclude that the high frequency of a partially patent vessel in the left coronary system suggests that this ECG pattern may be useful in identifying patients who might benefit from coronary revascularization.

Acute Disease↗
PubMed1992

Effects of inverse ratio ventilation on cardiorespiratory parameters in severe respiratory failure.

Inverse ratio ventilation, with prolonged inspiratory times, appears to improve gas exchange and arterial oxygenation in patients with severe respiratory failure; however, in previous studies, pressure-controlled inverse ratio ventilation (PC-IRV), which uses a rapidly decelerating inspiratory flow pattern, was compared to conventional volume-controlled ventilation, which uses a constant inspiratory flow rate. Pressure-controlled ventilation (PCV), with a decelerating inspiratory flow pattern and conventional inspiratory-to-expiratory (I/E) ratios, also has been shown to produce improvement in PaO2 when compared to volume-controlled ventilation. It therefore is unknown if the potentially beneficial effects of PC-IRV are due to the reversal of I/E ratios or to the use of the rapidly decelerating inspiratory flow pattern. In order to investigate this issue, cardiorespiratory values were measured in ten patients with severe respiratory failure ventilated first with PCV, then PC-IRV, and finally with a second period of PCV. Tidal volume, respiratory rate, end-expiratory pressure, and fraction of oxygen in inspired gas (FIO2) were maintained at the same value for both ventilatory modalities. The PC-IRV was associated with significant increases in PaO2, arterial pH, and mean airway pressure. Significant decreases in pulmonary shunt fraction, PaCO2, and cardiac index were found with PC-IRV. No significant changes in tissue oxygen delivery or consumption occurred with either PCV or PC-IRV. These results demonstrate that inversion of conventional I/E ratios produces no significant improvement in the overall cardiorespiratory profile of critically ill patients. This study also suggests that the clinical utility of PC-IRV is limited except in the setting of the adult respiratory distress syndrome with hypoxemia or hypercapnia refractory to other therapeutic options.

Adult↗